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Drug Metabolism & Disposition

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Latest Articles

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    Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes
    Yasuo Uchida, Ryohei Goto, Hina Takeuchi, Magdalena Łuczak, Takuya Usui, Masanori Tachikawa and Tetsuya Terasaki
    Drug Metabolism and Disposition November 26, 2019, dmd.119.089516; DOI: https://doi.org/10.1124/dmd.119.089516
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    Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-mediated Uptake
    Bridget L. Morse, Anil Kolur, Loyd R Hudson, Andrew T. Hogan, Lisa Hong Chen, Ryan M. Brackman, Geri A. Sawada, John K. Fallon, Philip C. Smith and Kathleen M. Hillgren
    Drug Metabolism and Disposition November 26, 2019, dmd.119.088781; DOI: https://doi.org/10.1124/dmd.119.088781
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    Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate
    Aaron G. Bart, Ryan H. Takahashi, Xiaojing Wang and Emily E. Scott
    Drug Metabolism and Disposition November 22, 2019, dmd.119.089607; DOI: https://doi.org/10.1124/dmd.119.089607
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    Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Cyp2abfgs-Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity
    Nataliia Kovalchuk, Qing-Yu Zhang, Jacklyn Kelty, Laura Van Winkle and Xinxin Ding
    Drug Metabolism and Disposition December 2019, 47 (12) 1469-1478; DOI: https://doi.org/10.1124/dmd.119.088930
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    Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo
    Congrong Niu, Yujin Wang, Xiaofeng Zhao, Sam Tep, Eisuke Murakami, Raju Subramanian, Bill Smith and Yurong Lai
    Drug Metabolism and Disposition December 2019, 47 (12) 1433-1442; DOI: https://doi.org/10.1124/dmd.119.088922
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    Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges
    Simone Schadt, Simon Hauri, Filipe Lopes, Martin R. Edelmann, Roland F. Staack, Roberto Villaseñor, Hubert Kettenberger, Adrian B. Roth, Franz Schuler, Wolfgang F. Richter and Christoph Funk
    Drug Metabolism and Disposition December 2019, 47 (12) 1443-1456; DOI: https://doi.org/10.1124/dmd.119.088997
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    An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects
    Andrew W. Harrell, Robert Wilson, Yau Lun Man, Kylie Riddell, Emily Jarvis, Graeme Young, Robert Chambers, Lee Crossman, Alex Georgiou, Adrian Pereira, David Kenworthy, Claire Beaumont, Miriam Marotti, Denisa Wilkes, Edith M. Hessel and William A. Fahy
    Drug Metabolism and Disposition December 2019, 47 (12) 1457-1468; DOI: https://doi.org/10.1124/dmd.119.088344
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    Piperine is a Mechanism-based inactivator of CYP3A
    Tiantian Cui, Qian Wang, Xiaoxiao Tian, Kehan Zhang, Ying Peng and Jiang Zheng
    Drug Metabolism and Disposition November 20, 2019, dmd.119.088955; DOI: https://doi.org/10.1124/dmd.119.088955
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    CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats
    Hongqiu Zhou, Li Yang, Changsuo Wang, Zhiqiang Li, Zhen Ouyang, Mangting Shan, Jun Gu and Yuan Wei
    Drug Metabolism and Disposition December 2019, 47 (12) 1425-1432; DOI: https://doi.org/10.1124/dmd.119.088526
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    Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes
    Katsuaki Ito, Noora Sjostedt and Kim L. R. Brouwer
    Drug Metabolism and Disposition November 19, 2019, dmd.119.088898; DOI: https://doi.org/10.1124/dmd.119.088898

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