Data Supplement
Files in this Data Supplement:
- Supplemental Figures -
Supplemental Figure 1 - A) Metabolites (M12, M18 and M19) of cobimetinib observed in plasma from transgenic mice (also observed in circulation in human)...
Supplemental Figure 2 - Exposure of itrazonzole (100 mg/kg) and rifampin (10 mg/kg) in transgenic mice after multiple oral doses
Supplemental Figure 3 - Hepatic gene expression measured by RT-PCR in Cyp3a /-Tg-3A4Hep (n=2), Cyp3a-/-Tg-3A4Int (n=3) and Cyp3a-/-Tg-3A4Hep/Int (n=3)
Supplemental Figure 4 - Duodenal gene expression measured by RT-PCR in Cyp3a-/-Tg-3A4Hep (n=2), Cyp3a-/-Tg-3A4Int (n=3) and Cyp3a-/-Tg-3A4Hep/Int (n=3)