Articles:

Kumar Ramu, Gilbert N. Lam, and Helen Hughes

In Vivo Metabolism and Mass Balance of 4-[4-Fluorophenoxy]benzaldehyde Semicarbazone in Rats
Drug Metab Dispos 2000 28: 1153-1161. [Abstract] [Full Text] [PDF]  

Kunihiro Yoshisue, Hirotoshi Masuda, Eiji Matsushima, Kazumasa Ikeda, Sekio Nagayama, and Yasuro Kawaguchi

Tissue Distribution and Biotransformation of Potassium Oxonate after Oral Administration of a Novel Antitumor Agent (Drug Combination of Tegafur, 5-Chloro-2,4-dihydroxypyridine, and Potassium Oxonate) to Rats
Drug Metab Dispos 2000 28: 1162-1167. [Abstract] [Full Text] [PDF]  

Elke Störmer, Lisa L. von Moltke, Richard I. Shader, and David J. Greenblatt

Metabolism of the Antidepressant Mirtazapine In Vitro: Contribution of Cytochromes P-450 1A2, 2D6, and 3A4
Drug Metab Dispos 2000 28: 1168-1175. [Abstract] [Full Text] [PDF]  

Leah M. Hesse, Karthik Venkatakrishnan, Michael H. Court, Lisa L. von Moltke, Su X. Duan, Richard I. Shader, and David J. Greenblatt

CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants
Drug Metab Dispos 2000 28: 1176-1183. [Abstract] [Full Text] [PDF]  

Abby C. Collier, Malcolm D. Tingle, Jeffrey A. Keelan, James W. Paxton, and Murray D. Mitchell

A Highly Sensitive Fluorescent Microplate Method for the Determination of UDP-Glucuronosyl Transferase Activity in Tissues and Placental Cell Lines
Drug Metab Dispos 2000 28: 1184-1186. [Abstract] [Full Text] [PDF]  

Jeannine M. Margolis, John P. O'Donnell, Dayna C. Mankowski, Sean Ekins, and R. Scott Obach

(R)-, (S)-, and Racemic Fluoxetine N-Demethylation by Human Cytochrome P450 Enzymes
Drug Metab Dispos 2000 28: 1187-1191. [Abstract] [Full Text] [PDF]  

Vsevolod E. Kostrubsky, Jacqueline F. Sinclair, Vinod Ramachandran, Raman Venkataramanan, Yuan Hua Wen, Erick Kindt, Vladimir Galchev, Kelly Rose, Michael Sinz, and Stephen C. Strom

The Role of Conjugation in Hepatotoxicity of Troglitazone in Human and Porcine Hepatocyte Cultures
Drug Metab Dispos 2000 28: 1192-1197. [Abstract] [Full Text] [PDF]  

Michael L. Schrag and Larry C. Wienkers

Topological Alteration of the CYP3A4 Active Site by the Divalent Cation Mg²⁺
Drug Metab Dispos 2000 28: 1198-1201. [Abstract] [Full Text] [PDF]  

Anthony B. Renwick, Patricia S. Watts, Robert J. Edwards, Paula T. Barton, Isabelle Guyonnet, Roger J. Price, J. Michael Tredger, Olavi Pelkonen, Alan R. Boobis, and Brian G. Lake

Differential Maintenance of Cytochrome P450 Enzymes in Cultured Precision-Cut Human Liver Slices
Drug Metab Dispos 2000 28: 1202-1209. [Abstract] [Full Text] [PDF]  

Piotr J. Czernik, Joanna M. Little, Gary W. Barone, Jean-Pierre Raufman, and Anna Radominska-Pandya

Glucuronidation of Estrogens and Retinoic Acid and Expression of UDP-Glucuronosyltransferase 2B7 in Human Intestinal Mucosa
Drug Metab Dispos 2000 28: 1210-1216. [Abstract] [Full Text] [PDF]  

Connie Y. Ng, Hany Ghabrial, Denis J. Morgan, Michael S. Ching, Richard A. Smallwood, and Peter W. Angus

Impaired Elimination of Propranolol Due to Right Heart Failure: Drug Clearance in the Isolated Liver and Its Relationship to Intrinsic Metabolic Capacity
Drug Metab Dispos 2000 28: 1217-1221. [Abstract] [Full Text] [PDF]  

Stephanie R. Faucette, Roy L. Hawke, Edward L. Lecluyse, Stacy S. Shord, Bingfang Yan, Ronald M. Laethem, and Celeste M. Lindley

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity
Drug Metab Dispos 2000 28: 1222-1230. [Abstract] [Full Text] [PDF]  

Taisei Mushiroda, Rika Douya, Eiji Takahara, and Osamu Nagata

The Involvement of Flavin-Containing Monooxygenase but Not CYP3A4 in Metabolism of Itopride Hydrochloride, a Gastroprokinetic Agent: Comparison with Cisapride and Mosapride Citrate
Drug Metab Dispos 2000 28: 1231-1237. [Abstract] [Full Text] [PDF]  

Iichiro Kawahara, Yukio Kato, Hiroshi Suzuki, Meguru Achira, Kiyomi Ito, Charles L. Crespi, and Yuichi Sugiyama

Selective Inhibition of Human Cytochrome P450 3A4 by N-[2(R)-Hydroxy-1(S)-indanyl]-5-[2(S)-(1,1-dimethylethylaminocarbonyl)-4-[(furo[2,3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethylpentanamide and P-glycoprotein by Valspodar in Gene Transfectant Systems
Drug Metab Dispos 2000 28: 1238-1243. [Abstract] [Full Text] [PDF]  

Rita A. Halpin, Leslie A. Geer, Kanyin E. Zhang, Tina M. Marks, Dennis C. Dean, Allen N. Jones, David Melillo, George Doss, and Kamlesh P. Vyas

The Absorption, Distribution, Metabolism and Excretion of Rofecoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Rats and Dogs
Drug Metab Dispos 2000 28: 1244-1254. [Abstract] [Full Text] [PDF]  

Barry H. Dvorchik and Judith K. Marquis

Disposition and Toxicity of a Mixed Backbone Antisense Oligonucleotide, Targeted against Human Cytomegalovirus, after Intravitreal Injection of Escalating Single Doses in the Rabbit
Drug Metab Dispos 2000 28: 1255-1261. [Abstract] [Full Text] [PDF]  

SHORT COMMUNICATION:

Eric Brouwer, Jaap Verweij, Peter De Bruijn, Walter J. Loos, Marrimuthoo Pillay, Dirk Buijs, and Alex Sparreboom

Measurement of Fraction Unbound Paclitaxel in Human Plasma
Drug Metab Dispos 2000 28: 1141-1145. [Abstract] [Full Text] [PDF]  

Yukio Kato, Takashi Igarashi, Yuichi Sugiyama, and Akiko Nishino

Both cMOAT/MRP2 and Another Unknown Transporter(s) Are Responsible for the Biliary Excretion of Glucuronide Conjugate of the Nonpeptide Angiotensin II Antagonist, Telmisaltan
Drug Metab Dispos 2000 28: 1146-1148. [Abstract] [Full Text] [PDF]  

Susanne Ammon, Oliver von Richter, Ute Hofmann, Klaus-Peter Thon, Michel Eichelbaum, and Gerd Mikus

In Vitro Interaction of Codeine and Diclofenac
Drug Metab Dispos 2000 28: 1149-1152. [Abstract] [Full Text] [PDF]  

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