Articles:

Bennett Ma, Thomayant Prueksaritanont, and Jiunn H. Lin

Drug Interactions with Calcium Channel Blockers: Possible Involvement of Metabolite-Intermediate Complexation with CYP3A
Drug Metab Dispos 2000 28: 125-130. [Abstract] [Full Text] [PDF]  

Vikram Arora and Patrick L. Iversen

Antisense Oligonucleotides Targeted to the p53 Gene Modulate Liver Regeneration In Vivo
Drug Metab Dispos 2000 28: 131-138. [Abstract] [Full Text] [PDF]  

Lourdes Estrada, Kimon C. Kanelakis, Gerald N. Levy, and Wendell W. Weber

Tissue- and Gender-Specific Expression of N-Acetyltransferase 2 (Nat2*) during Development of the Outbred Mouse Strain CD-1
Drug Metab Dispos 2000 28: 139-146. [Abstract] [Full Text] [PDF]  

David A. Durden, Lillian E. Dyck, Bruce A. Davis, Ya-Dong Liu, and Alan A. Boulton

Metabolism and Pharmacokinetics, in the Rat, of (R)-N-(2-Heptyl)Methyl-Propargylamine (R-2HMP), A New Potent Monoamine Oxidase Inhibitor and Antiapoptotic Agent
Drug Metab Dispos 2000 28: 147-154. [Abstract] [Full Text] [PDF]  

Anne Plum, Henrik Agersø, and Lennart Andersen

Pharmacokinetics of the Rapid-Acting Insulin Analog, Insulin Aspart, in Rats, Dogs, and Pigs, and Pharmacodynamics of Insulin Aspart in Pigs
Drug Metab Dispos 2000 28: 155-160. [Abstract] [Full Text] [PDF]  

Christopher Kohl and Michael Steinkellner

Prediction of Pharmacokinetic Drug/Drug Interactions from In Vitro Data: Interactions of the Nonsteroidal Anti-Inflammatory Drug Lornoxicam with Oral Anticoagulants
Drug Metab Dispos 2000 28: 161-168. [Abstract] [Full Text] [PDF]  

John R. Cashman, Beverly R. Akerman, Susan M. Forrest, and Eileen P. Treacy

Population-Specific Polymorphisms of the Human FMO3 Gene: Significance for Detoxication
Drug Metab Dispos 2000 28: 169-173. [Abstract] [Full Text] [PDF]  

Zoltán Szilágyi and Catherine Fenselau

Molecular Dynamics Simulation of Metallothionein-Drug Complexes
Drug Metab Dispos 2000 28: 174-179. [Abstract] [Full Text] [PDF]  

Eberhard Schrader, Karen I. Hirsch-Ernst, Ekkehard Scholz, Georg F. Kahl, and Heidi Foth

Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Primary Cultures of Rat Alveolar Type II Cells
Drug Metab Dispos 2000 28: 180-185. [Abstract] [Full Text] [PDF]  

Weizhu Zhu, Li Song, He Zhang, Lynn Matoney, Edward LeCluyse, and Bingfang Yan

Dexamethasone Differentially Regulates Expression of Carboxylesterase Genes in Humans and Rats
Drug Metab Dispos 2000 28: 186-191. [Abstract] [Full Text] [PDF]  

Kathleen P. Plotzke, Steven D. Crofoot, Eckhardt S. Ferdinandi, J. Gregory Beattie, Richard H. Reitz, Debra A. McNett, and Robert G. Meeks

Disposition of Radioactivity in Fischer 344 Rats after Single and Multiple Inhalation Exposure to [¹⁴C]Octamethylcyclotetrasiloxane ([¹⁴C]D₄)
Drug Metab Dispos 2000 28: 192-204. [Abstract] [Full Text] [PDF]  

François Le Doze, Daniele Debruyne, Françoise Albessard, Louisa Barre, and Gilles Louis Defer

Pharmacokinetics of All-trans Retinoic Acid, 13-cis Retinoic Acid, and Fenretinide in Plasma and Brain of Rat
Drug Metab Dispos 2000 28: 205-208. [Abstract] [Full Text] [PDF]  

James L. Maggs, Laurence P. D. Bishop, Geoffrey Edwards, Paul M. O'Neill, Stephen A. Ward, Peter A. Winstanley, and B. Kevin Park

Biliary Metabolites of -Artemether in Rats: Biotransformations of an Antimalarial Endoperoxide
Drug Metab Dispos 2000 28: 209-217. [Abstract] [Full Text] [PDF]  

Stephanie L. Born, Joanna K. Hu, and Lois D. Lehman-McKeeman

o-Hydroxyphenylacetaldehyde Is a Hepatotoxic Metabolite of Coumarin
Drug Metab Dispos 2000 28: 218-223. [Abstract] [Full Text] [PDF]  

Diem Cong, Margaret Doherty, and K. Sandy Pang

A New Physiologically Based, Segregated-Flow Model to Explain Route-Dependent Intestinal Metabolism
Drug Metab Dispos 2000 28: 224-235. [Abstract] [Full Text] [PDF]  

Maree T. Smith, Carsten K. Nielsen, Megan Y. C. Lim-Fraser, Andrew W. E. Wright, and Michael Lau

Systemic Coadministration of Chloramphenicol with Intravenous but not Intracerebroventricular Morphine Markedly Increases Morphine Antinociception and Delays Development of Antinociceptive Tolerance in Rats
Drug Metab Dispos 2000 28: 236-244. [Abstract] [Full Text] [PDF]  

SHORT COMMUNICATION:

Andrew M. Davis, Peter J. H. Webborn, and David W. Salt

Robust Assessment of Statistical Significance in the Use of Unbound/Intrinsic Pharmacokinetic Parameters in Quantitative Structure-Pharmacokinetic Relationships with Lipophilicity
Drug Metab Dispos 2000 28: 103-106. [Abstract] [Full Text] [PDF]  

Espen Molden, Hege Christensen, and Reidar Bredo Sund

Extensive Metabolism of Diltiazem and P-Glycoprotein-Mediated Efflux of Desacetyl-Diltiazem (M1) by Rat Jejunum In Vitro
Drug Metab Dispos 2000 28: 107-109. [Abstract] [Full Text] [PDF]  

Tomoyuki Ohe, Masaaki Hirobe, and Tadahiko Mashino

Novel Metabolic Pathway of Estrone and 17-Estradiol Catalyzed by Cytochrome P-450
Drug Metab Dispos 2000 28: 110-112. [Abstract] [Full Text] [PDF]  

Peter R. Stout and James A. Ruth

Histologic Localization of Serum Constituents, ⁴⁵Ca²⁺, ³⁶Cl, [¹⁴C]Urea, and [³⁵S]Cysteine in Forming Hair after Systemic Administration
Drug Metab Dispos 2000 28: 113-117. [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Amit Banerjee, Thomas A. Kocarek, and Raymond F. Novak

Identification of a Ubiquitination-Target/Substrate-Interaction Domain of Cytochrome P-450 (CYP) 2E1
Drug Metab Dispos 2000 28: 118-124. [Abstract] [Full Text] [PDF]  

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