Minireview:

Sean Ekins, Marcel J. de Groot, and Jeffrey P. Jones

Pharmacophore and Three-Dimensional Quantitative Structure Activity Relationship Methods for Modeling Cytochrome P450 Active Sites
Drug Metab Dispos 2001 29: 936-944. [Abstract] [Full Text] [PDF]  

Commentary:

David D. Christ

Cassette Dosing Pharmacokinetics: Valuable Tool or Flawed Science?
Drug Metab Dispos 2001 29: 935. [Full Text] [PDF]  

Short Communications:

Won-Son Choi, Guang-Jin Im, Dae-Kee Kim, Tae-Kon Kim, Inho Jung, Taek-Soo Kim, Sung-Jae Lee, Namkyu Lee, Young-Woo Kim, Jae-Sun Kim, and Kieyoung Chang

Pharmacokinetic Studies of 2-Amino-9-(3-acetoxymethyl-4-isopropoxycarbonyl-oxybut-1-yl)purine, an Oral Prodrug for the Antiviral Agent Penciclovir
Drug Metab Dispos 2001 29: 945-949. [Abstract] [Full Text] [PDF]  

Diane L. Lanza and Garold S. Yost

Selective Dehydrogenation/Oxygenation of 3-Methylindole by Cytochrome P450 Enzymes
Drug Metab Dispos 2001 29: 950-953. [Abstract] [Full Text] [PDF]  

Elke Störmer, Michael D. Perloff, Lisa L. von Moltke, and David J. Greenblatt

Methadone Inhibits Rhodamine123 Transport in Caco-2 Cells
Drug Metab Dispos 2001 29: 954-956. [Abstract] [Full Text] [PDF]  

Ronald E. White and Prasarn Manitpisitkul

Pharmacokinetic Theory of Cassette Dosing in Drug Discovery Screening
Drug Metab Dispos 2001 29: 957-966. [Abstract] [Full Text] [PDF]  

T. Kerbusch, R. A. A. Mathôt, H. J. Keizer, G. P. Kaijser, J. H. M. Schellens, and J. H. Beijnen

Influence of Dose and Infusion Duration on Pharmacokinetics of Ifosfamide and Metabolites
Drug Metab Dispos 2001 29: 967-975. [Abstract] [Full Text] [PDF]  

M. J. Blom, M. Groot Wassink, F. van Wijk, A. G. H. Ederveen, H. J. Kloosterboer, C. H. J. Verhoeven, J. G. D. Lambert, and H. J. Th. Goos

Metabolism of Norethisterone and Norethisterone Derivatives in Rat Uterus, Vagina, and Aorta
Drug Metab Dispos 2001 29: 976-982. [Abstract] [Full Text] [PDF]  

Ken-ichi Fujita and Tetsuya Kamataki

Screening Of Organosulfur Compounds as Inhibitors of Human CYP2A6
Drug Metab Dispos 2001 29: 983-989. [Abstract] [Full Text] [PDF]  

Stanley R. Howell, Michael A. Shirley, Timothy A. Grese, David A. Neel, Kirk E. Wells, and Edgar H. Ulm

Bexarotene Metabolism in Rat, Dog, and Human, Synthesis of Oxidative Metabolites, and in Vitro Activity at Retinoid Receptors
Drug Metab Dispos 2001 29: 990-998. [Abstract] [Full Text] [PDF]  

Dilip D. Vakharia, Ning Liu, Ronald Pause, Michael Fasco, Erin Bessette, Qing-Yu Zhang, and Laurence S. Kaminsky

Polycyclic Aromatic Hydrocarbon/Metal Mixtures: Effect on PAH Induction of CYP1A1 in Human HepG2 Cells
Drug Metab Dispos 2001 29: 999-1006. [Abstract] [Full Text] [PDF]  

Anne-Marie Bleau, Caroline Fradette, Ayman O. S. El-Kadi, Marie-Claude Côté, and Patrick du Souich

Cytochrome P450 Down-Regulation by Serum from Humans with a Viral Infection and from Rabbits with an Inflammatory Reaction
Drug Metab Dispos 2001 29: 1007-1012. [Abstract] [Full Text] [PDF]  

J. W. Nichols, P. N. Fitzsimmons, F. W. Whiteman, D. W. Kuehl, B. C. Butterworth, and C. T. Jenson

Dietary Uptake Kinetics of 2,2',5,5'-Tetrachlorobiphenyl in Rainbow Trout
Drug Metab Dispos 2001 29: 1013-1022. [Abstract] [Full Text] [PDF]  

Melissa A. Bruce, Stephen D. Hall, Barbara D. Haehner-Daniels, and J. Christopher Gorski

In Vivo Effect of Clarithromycin on Multiple Cytochrome P450s
Drug Metab Dispos 2001 29: 1023-1028. [Abstract] [Full Text] [PDF]  

J. Matthew Hutzler, Michael J. Hauer, and Timothy S. Tracy

Dapsone Activation of CYP2C9-Mediated Metabolism: Evidence for Activation of Multiple Substrates and a Two-Site Model
Drug Metab Dispos 2001 29: 1029-1034. [Abstract] [Full Text] [PDF]  

Chun-Lin Chen, T. K. Venkatachalam, Zhao-Hai Zhu, and Fatih M. Uckun

In Vivo Pharmacokinetics and Metabolism of Anti-Human Immunodeficiency Virus Agent d4T-5'-[p-Bromophenyl Methoxyalaninyl Phosphate] (SAMPIDINE) in Mice
Drug Metab Dispos 2001 29: 1035-1041. [Abstract] [Full Text] [PDF]  

Nicola J. Hewitt, Karl-Uhlrich Bühring, Johannes Dasenbrock, Jutta Haunschild, Bernhard Ladstetter, and Dietmar Utesch

Studies Comparing in Vivo:in Vitro Metabolism of Three Pharmaceutical Compounds in Rat, Dog, Monkey, and Human Using Cryopreserved Hepatocytes, Microsomes, and Collagen Gel Immobilized Hepatocyte Cultures
Drug Metab Dispos 2001 29: 1042-1050. [Abstract] [Full Text] [PDF]  

Ümit Yasar, Gunnel Tybring, Mats Hidestrand, Mikael Oscarson, Magnus Ingelman-Sundberg, Marja-Liisa Dahl, and Erik Eliasson

Role of CYP2C9 Polymorphism in Losartan Oxidation
Drug Metab Dispos 2001 29: 1051-1056. [Abstract] [Full Text] [PDF]  

R. Scott Obach

Cytochrome P450-Catalyzed Metabolism of Ezlopitant Alkene (CJ-12,458), a Pharmacologically Active Metabolite of Ezlopitant: Enzyme Kinetics and Mechanism Of an Alkene Hydration Reaction
Drug Metab Dispos 2001 29: 1057-1067. [Abstract] [Full Text] [PDF]  

Michi Ishigami, Kiyoshi Kawabata, Wataru Takasaki, Toshihiko Ikeda, Toru Komai, Kiyomi Ito, and Yuichi Sugiyama

Drug Interaction Between Simvastatin and Itraconazole in Male and Female Rats
Drug Metab Dispos 2001 29: 1068-1072. [Abstract] [Full Text] [PDF]  

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