Minireviews:

Sanjay Awasthi, Rajendra Sharma, Sharad S. Singhal, Piotr Zimniak, and Yogesh C. Awasthi

RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics
Drug Metab Dispos 2002 30: 1300-1310. [Abstract] [Full Text] [PDF]  

Articles:

Rae Yuan, Soraya Madani, Xiao-Xiong Wei, Kellie Reynolds, and Shiew-Mei Huang

Evaluation of Cytochrome P450 Probe Substrates Commonly Used by the Pharmaceutical Industry to Study in Vitro Drug Interactions
Drug Metab Dispos 2002 30: 1311-1319. [Abstract] [Full Text] [PDF]  

G. Elaut, G. Török, M. Vinken, G. Laus, P. Papeleu, D. Tourwe, and V. Rogiers

Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes
Drug Metab Dispos 2002 30: 1320-1328. [Abstract] [Full Text] [PDF]  

Yiding Hu and David Kupfer

Enantioselective Metabolism of the Endocrine Disruptor Pesticide Methoxychlor by Human Cytochromes P450 (P450s): Major Differences in Selective Enantiomer Formation by Various P450 Isoforms
Drug Metab Dispos 2002 30: 1329-1336. [Abstract] [Full Text] [PDF]  

B. Rege, K. M. Carter, M. A. Sarkar, G. E. Kellogg, and W. H. Soine

Irreversible Inhibition of CYP2D6 by ()-Chloroephedrine, a Possible Impurity in Methamphetamine
Drug Metab Dispos 2002 30: 1337-1343. [Abstract] [Full Text] [PDF]  

Chyung S. Cook, Loren M. Berry, David H. Kim, Earl G. Burton, Jeremy D. Hribar, and Liming Zhang

Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5
Drug Metab Dispos 2002 30: 1344-1351. [Abstract] [Full Text] [PDF]  

Jun-Sheng Wang, Mikko Neuvonen, Xia Wen, Janne T. Backman, and Pertti J. Neuvonen

Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes
Drug Metab Dispos 2002 30: 1352-1356. [Abstract] [Full Text] [PDF]  

John C. Connelly, Susan C. Connor, Soria Monte, Nigel J.C. Bailey, Nathan Borgeaud, Elaine Holmes, Jeff Troke, Jeremy K. Nicholson, and Claire L. Gavaghan

Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and ¹H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in Sprague-Dawley Rats
Drug Metab Dispos 2002 30: 1357-1363. [Abstract] [Full Text] [PDF]  

Gladys R. Rios and Thomas R. Tephly

Inhibition and Active Sites of UDP-Glucuronosyltransferases 2B7 and 1A1.
Drug Metab Dispos 2002 30: 1364-1367. [Abstract] [Full Text] [PDF]  

Rajaa A. Mirghani, Ümit Yasar, Tao Zheng, James M. Cook, Lars L. Gustafsson, Gunnel Tybring, and Örjan Ericsson

Enzyme Kinetics for the Formation of 3-Hydroxyquinine and Three New Metabolites of Quinine in Vitro; 3-Hydroxylation by CYP3A4 is Indeed the Major Metabolic Pathway
Drug Metab Dispos 2002 30: 1368-1371. [Abstract] [Full Text] [PDF]  

Larry C. Wienkers and Michael A. Wynalda

Multiple Cytochrome P450 Enzymes Responsible for the Oxidative Metabolism of the Substituted (S)-3-Phenylpiperidine, (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride, in Human Liver Microsomes
Drug Metab Dispos 2002 30: 1372-1377. [Abstract] [Full Text] [PDF]  

James C. Dabrowiak, Jerry Goodisman, and Abdul-Kader Souid

Kinetic Study of the Reaction of Cisplatin with Thiols
Drug Metab Dispos 2002 30: 1378-1384. [Abstract] [Full Text] [PDF]  

Anahita Bhathena, Chunja Lee, and David S. Riddick

Suppression of Cytochrome P450 2C11 by Aromatic Hydrocarbons: Mechanistic Insights from Studies of the 5'-Flanking Region of the CYP2C11 Gene
Drug Metab Dispos 2002 30: 1385-1392. [Abstract] [Full Text] [PDF] ERRATUM  

Takashi Suzuki, Yukio Kato, Hiroyuki Sasabe, Minoru Itose, Gohachiro Miyamoto, and Yuichi Sugiyama

Mechanism for the Tissue Distribution of Grepafloxacin, a Fluoroquinolone Antibiotic, in Rats
Drug Metab Dispos 2002 30: 1393-1399. [Abstract] [Full Text] [PDF]  

Thomas A. Kocarek, Michael S. Dahn, Hongbo Cai, Stephen C. Strom, and Nancy A. Mercer-Haines

Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes
Drug Metab Dispos 2002 30: 1400-1405. [Abstract] [Full Text] [PDF]  

Su-Jun Lee and Donald R. Buhler

Functional Properties of a Rainbow Trout CYP3A27 Expressed by Recombinant Baculovirus in Insect Cells
Drug Metab Dispos 2002 30: 1406-1412. [Abstract] [Full Text] [PDF]  

Ping Zhao and John T. Slattery

Effects of Ethanol Dose and Ethanol Withdrawal on Rat Liver Mitochondrial Glutathione: Implication of Potentiated Acetaminophen Toxicity in Alcoholics
Drug Metab Dispos 2002 30: 1413-1417. [Abstract] [Full Text] [PDF]  

Jean-Paul Payan, Dominique Beydon, Jean-Paul Fabry, Isabelle Boudry, Benoit Cossec, and Elisabeth Ferrari

Toxicokinetics and Metabolism of N-[¹⁴C]Methylpyrrolidone in Male Sprague-Dawley Rats. A Saturable NMP Elimination Process
Drug Metab Dispos 2002 30: 1418-1424. [Abstract] [Full Text] [PDF]  

Micha Levi, James A. Knol, William D. Ensminger, Susan J. DeRemer, Chunzhi Dou, Susan M. Lunte, Heather S. Bonner, Leslie M. Shaw, and David E. Smith

Regional Pharmacokinetics of Amifostine in Anesthetized Dogs: Role of the Liver, Gastrointestinal Tract, Lungs, and Kidneys
Drug Metab Dispos 2002 30: 1425-1430. [Abstract] [Full Text] [PDF]  

Patricia E. Schroeder, Jeffrey N. Davidson, and Brian B. Hasinoff

Dihydroorotase Catalyzes the Ring Opening of the Hydrolysis Intermediates of the Cardioprotective Drug Dexrazoxane (ICRF-187)
Drug Metab Dispos 2002 30: 1431-1435. [Abstract] [Full Text] [PDF]  

Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara, and Takao Hashimoto

Kinetics of Sequential Metabolism from D-Leucine to L-Leucine via -Ketoisocaproic Acid in Rat
Drug Metab Dispos 2002 30: 1436-1440. [Abstract] [Full Text] [PDF]  

Thanh Huu Tran, Lisa L. von Moltke, Karthik Venkatakrishnan, Brian W. Granda, Megan A. Gibbs, R. Scott Obach, Jerold S. Harmatz, and David J. Greenblatt

Microsomal Protein Concentration Modifies the Apparent Inhibitory Potency of CYP3A Inhibitors
Drug Metab Dispos 2002 30: 1441-1445. [Abstract] [Full Text] [PDF]  

Yau Yi Lau, Elpida Sapidou, Xiaoming Cui, Ronald E. White, and K.-C. Cheng

Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes
Drug Metab Dispos 2002 30: 1446-1454. [Abstract] [Full Text] [PDF]  

Jian-Feng Lu, Terrence F. Blaschke, Charles Flexner, Susan L. Rosenkranz, and Lewis B. Sheiner

Model-based Analysis of the Pharmacokinetic Interactions Between Ritonavir, Nelfinavir, and Saquinavir after Simultaneous and Staggered Oral Administration
Drug Metab Dispos 2002 30: 1455-1461. [Abstract] [Full Text] [PDF]  

Yuichiro Watanabe, Miki Nakajima, and Tsuyoshi Yokoi

Troglitazone Glucuronidation in Human Liver and Intestine Microsomes: High Catalytic Activity of UGT1A8 and UGT1A10
Drug Metab Dispos 2002 30: 1462-1469. [Abstract] [Full Text] [PDF]  

Jason S. Halladay, Carl R. Mackerer, Lorraine E. Twerdok, and I. Glenn Sipes

Comparative Pharmacokinetic and Disposition Studies of [1-¹⁴C]1-Eicosanylcyclohexane, a Surrogate Mineral Hydrocarbon, in Female Fischer-344 and Sprague-Dawley Rats
Drug Metab Dispos 2002 30: 1470-1477. [Abstract] [Full Text] [PDF]  

Omar Ghosheh and Edward M. Hawes

Microsomal N-Glucuronidation of Nicotine and Cotinine: Human Hepatic Interindividual, Human Intertissue, and Interspecies Hepatic Variation
Drug Metab Dispos 2002 30: 1478-1483. [Abstract] [Full Text] [PDF]  

Miki Nakajima, Eriko Tanaka, Jun-Tack Kwon, and Tsuyoshi Yokoi

Characterization of Nicotine and Cotinine N-Glucuronidations in Human Liver Microsomes
Drug Metab Dispos 2002 30: 1484-1490. [Abstract] [Full Text] [PDF]  

Pei-Shan Shih and Jin-Ding Huang

Pharmacokinetics of Midazolam and 1'-Hydroxymidazolam in Chinese with Different CYP3A5 Genotypes
Drug Metab Dispos 2002 30: 1491-1496. [Abstract] [Full Text] [PDF]  

Rupert P. Austin, Patrick Barton, Scott L. Cockroft, Mark C. Wenlock, and Robert J. Riley

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
Drug Metab Dispos 2002 30: 1497-1503. [Abstract] [Full Text] [PDF]  

Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara, and Hiroyuki Kobayashi

Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities
Drug Metab Dispos 2002 30: 1504-1511. [Abstract] [Full Text] [PDF]  

Aleksandra Galetin, Stephen E. Clarke, and J. Brian Houston

Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach
Drug Metab Dispos 2002 30: 1512-1522. [Abstract] [Full Text] [PDF]  

Chun-Lin Chen, Gengli Yu, T. K. Venkatachalam, and Fatih M. Uckun

Metabolism of Stavudine-5'-[p-Bromophenyl Methoxyalaninyl Phosphate], Stampidine, in Mice, Dogs, and Cats
Drug Metab Dispos 2002 30: 1523-1531. [Abstract] [Full Text] [PDF]  

SHORT COMMUNICATION:

Osamu Ueda, Shigeyuki Kitamura, and Shigeru Ohta

Deacylation of N-Arylformamides and N-Arylacetamides by Formamidase in Rat Liver
Drug Metab Dispos 2002 30: 1297-1299. [Abstract] [Full Text] [PDF]  

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