Minireview:

J. Matthew Hutzler and Timothy S. Tracy

Atypical Kinetic Profiles in Drug Metabolism Reactions
Drug Metab Dispos 2002 30: 355-362. [Full Text] [PDF]  

Articles:

Yan Liu and Ming Hu

Absorption and Metabolism of Flavonoids in the Caco-2 Cell Culture Model and a Perused Rat Intestinal Model
Drug Metab Dispos 2002 30: 370-377. [Abstract] [Full Text] [PDF]  

Thomas K. H. Chang, Jie Chen, and Salete A. Benetton

In Vitro Effect of Standardized Ginseng Extracts and Individual Ginsenosides on the Catalytic Activity of Human CYP1A1, CYP1A2, and CYP1B1
Drug Metab Dispos 2002 30: 378-384. [Abstract] [Full Text] [PDF]  

Timothy S. Tracy, J. Matthew Hutzler, Robert L. Haining, Allan E. Rettie, Matthew A. Hummel, and Leslie J. Dickmann

Polymorphic Variants (CYP2C9*3 and CYP2C9*5) and the F114L Active Site Mutation of CYP2C9: Effect on Atypical Kinetic Metabolism Profiles
Drug Metab Dispos 2002 30: 385-390. [Abstract] [Full Text] [PDF]  

Nobumitsu Hanioka, Shogo Ozawa, Hideto Jinno, Toshiko Tanaka-Kagawa, Tetsuji Nishimura, Masanori Ando, and Jun-ichi Sawada

Interaction of Irinotecan (CPT-11) and Its Active Metabolite 7-Ethyl-10-Hydroxycamptothecin (SN-38) with Human Cytochrome P450 Enzymes
Drug Metab Dispos 2002 30: 391-396. [Abstract] [Full Text] [PDF]  

Zhong Zheng, Jia-Long Fang, and Philip Lazarus

Glucuronidation: An Important Mechanism for Detoxification of Benzo[a]Pyrene Metabolites in Aerodigestive Tract Tissues
Drug Metab Dispos 2002 30: 397-403. [Abstract] [Full Text] [PDF]  

Sebastien Bolze, Norbert Bromet, Croisine Gay-Feutry, Frederic Massiere, Roselyne Boulieu, and Thierry Hulot

Development of an in Vitro Screening Model for the Biosynthesis of Acyl Glucuronide Metabolites and the Assessment of Their Reactivity toward Human Serum Albumin
Drug Metab Dispos 2002 30: 404-413. [Abstract] [Full Text] [PDF]  

Shigeyuki Kitamura, Yoichi Kohno, Yuji Okamoto, Mitsuhiro Takeshita, and Shigeru Ohta

Reductive Metabolism of an ,-Ketoalkyne, 4-Phenyl-3-Butyn-2-One, by Rat Liver Preparations
Drug Metab Dispos 2002 30: 414-420. [Abstract] [Full Text] [PDF]  

Andrew A. Acheampong, Martha Shackleton, Brian John, James Burke, Larry Wheeler, and Diane Tang-Liu

Distribution of Brimonidine into Anterior and Posterior Tissues of Monkey, Rabbit, and Rat Eyes
Drug Metab Dispos 2002 30: 421-429. [Abstract] [Full Text] [PDF]  

James E. Patrick, Teddy Kosoglou, Kathe L. Stauber, Kevin B. Alton, Stephen E. Maxwell, Yali Zhu, Paul Statkevich, Robert Iannucci, Swapan Chowdhury, Melton Affrime, and Mitchell N. Cayen

Disposition of the Selective Cholesterol Absorption Inhibitor Ezetimibe in Healthy Male Subjects
Drug Metab Dispos 2002 30: 430-437. [Abstract] [Full Text] [PDF]  

Thierry Cresteil, Bernard Monsarrat, Joelle Dubois, Michelle Sonnier, Paul Alvinerie, and Françoise Gueritte

Regioselective Metabolism of Taxoids by Human CYP3A4 and 2C8: Structure-Activity Relationship
Drug Metab Dispos 2002 30: 438-445. [Abstract] [Full Text] [PDF]  

Kenneth L. Muldrew, Laura P. James, Leslie Coop, Sandra S. McCullough, Howard P. Hendrickson, Jack A. Hinson, and Philip R. Mayeux

Determination of Acetaminophen-Protein Adducts in Mouse Liver and Serum and Human Serum after Hepatotoxic Doses of Acetaminophen Using High-Performance Liquid Chromatography with Electrochemical Detection
Drug Metab Dispos 2002 30: 446-451. [Abstract] [Full Text] [PDF]  

Stephen M. Fowler, John M. Taylor, Thomas Friedberg, C. Roland Wolf, and Robert J. Riley

CYP3A4 Active Site Volume Modification by Mutagenesis of Leucine 211
Drug Metab Dispos 2002 30: 452-456. [Abstract] [Full Text] [PDF]  

Ailan Guo, William Marinaro, Peidi Hu, and Patrick J. Sinko

Delineating the Contribution of Secretory Transporters in the Efflux of Etoposide Using Madin-Darby Canine Kidney (MDCK) Cells Overexpressing P-Glycoprotein (Pgp), Multidrug Resistance-Associated Protein (MRP1), and Canalicular Multispecific Organic Anion Transporter (cMOAT)
Drug Metab Dispos 2002 30: 457-463. [Abstract] [Full Text] [PDF]  

Ulf D. Renner, Georgios Piperopoulos, Rolf Gebhardt, Gerhard Ehninger, and Klaus-Peter Zeller

The Oxidative Biotransformation of Losoxantrone (CI-941)
Drug Metab Dispos 2002 30: 464-478. [Abstract] [Full Text] [PDF]  

Short Communications:

Masaya Itoda, Yoshiro Saito, Akiko Soyama, Mayumi Saeki, Norie Murayama, Seiichi Ishida, Kimie Sai, Michiyo Nagano, Hiroshi Suzuki, Yuichi Sugiyama, Shogo Ozawa, and Jun-ichi Sawada

Polymorphisms in the ABCC2 (cMOAT/MRP2) Gene Found in 72 Established Cell Lines Derived from Japanese Individuals: An Association between Single Nucleotide Polymorphisms in the 5'-Untranslated Region and Exon 28
Drug Metab Dispos 2002 30: 363-364. [Abstract] [Full Text] [PDF]  

Gracia Merino, Ana I. Alvarez, Julio G. Prieto, and Richard B. Kim

The Anthelminthic Agent Albendazole Does Not Interact with P-Glycoprotein
Drug Metab Dispos 2002 30: 365-369. [Abstract] [Full Text] [PDF]  

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