Articles:

Vikram Arora, Melissa L. Cate, Chandramallika Ghosh, and Patrick L. Iversen

Phosphorodiamidate Morpholino Antisense Oligomers Inhibit Expression of Human Cytochrome P450 3A4 and Alter Selected Drug Metabolism
Drug Metab Dispos 2002 30: 757-762. [Abstract] [Full Text] [PDF]  

Feng R. Luo, Pankaj V. Paranjpe, Ailan Guo, Eric Rubin, and Patrick Sinko

Intestinal Transport of Irinotecan in Caco-2 Cells and MDCK II Cells Overexpressing Efflux Transporters Pgp, cMOAT, and MRP1
Drug Metab Dispos 2002 30: 763-770. [Abstract] [Full Text] [PDF]  

Ralph A. Stearns, Randy R. Miller, Wei Tang, Gloria Y. Kwei, Frank S. Tang, Robert J. Mathvink, Elizabeth M. Naylor, Dawn Chitty, Vincent J. Colandrea, Ann E. Weber, Adria E. Colletti, John R. Strauss, Carol Ann Keohane, William P. Feeney, Susan A. Iliff, and Shuet-Hing Lee Chiu

The Pharmacokinetics of a Thiazole Benzenesulfonamide ₃-Adrenergic Receptor Agonist and Its Analogs in Rats, Dogs, and Monkeys: Improving Oral Bioavailability
Drug Metab Dispos 2002 30: 771-777. [Abstract] [Full Text] [PDF]  

Wei Tang, Ralph A. Stearns, Randall R. Miller, Jason S. Ngui, Robert J. Mathvink, Ann E. Weber, Gloria Y. Kwei, John R. Strauss, Carol A. Keohane, George A. Doss, Shuet-Hing L. Chiu, and Thomas A. Baillie

Metabolism of a Thiazole Benzenesulfonamide Derivative, a Potent and Selective Agonist of the Human ₃-Adrenergic Receptor, in Rats: Identification of a Novel Isethionic Acid Conjugate
Drug Metab Dispos 2002 30: 778-787. [Abstract] [Full Text] [PDF]  

James A. Lavigne, Kanji Nakatsu, and Gerald S. Marks

Identification of Human Hepatic Cytochrome P450 Sources of N-alkylprotoporphyrin IX after Interaction with Porphyrinogenic Xenobiotics, Implications for Detection of Xenobiotic-Induced Porphyria in Humans
Drug Metab Dispos 2002 30: 788-794. [Abstract] [Full Text] [PDF]  

Gang Luo, Mark Cunningham, Sean Kim, Tim Burn, Jianrong Lin, Michael Sinz, Geraldine Hamilton, Christopher Rizzo, Summer Jolley, Darryl Gilbert, April Downey, Daniel Mudra, Richard Graham, Kathy Carroll, Jindong Xie, Ajay Madan, Andrew Parkinson, Dave Christ, Bernard Selling, Edward LeCluyse, and Liang-Shang Gan

CYP3A4 Induction by Drugs: Correlation between a Pregnane X Receptor Reporter Gene Assay and CYP3A4 Expression in Human Hepatocytes
Drug Metab Dispos 2002 30: 795-804. [Abstract] [Full Text] [PDF]  

Zhi-Yi Zhang, Belinda M. King, Nevena N. Mollova, and Y. Nancy Wong

In Vitro Interactions between a Potential Muscle Relaxant E2101 and Human Cytochromes P450
Drug Metab Dispos 2002 30: 805-813. [Abstract] [Full Text] [PDF]  

Celeste Lindley, Geraldine Hamilton, Jeannine S. McCune, Stephanie Faucette, Stacy S. Shord, Roy L. Hawke, Hongbing Wang, Darryl Gilbert, Summer Jolley, Bingfang Yan, and Edward L. LeCluyse

The Effect of Cyclophosphamide with and without Dexamethasone on Cytochrome P450 3A4 and 2B6 in Human Hepatocytes
Drug Metab Dispos 2002 30: 814-822. [Abstract] [Full Text] [PDF]  

R. C. Garner, I. Goris, A. A. E. Laenen, E. Vanhoutte, W. Meuldermans, S. Gregory, J. V. Garner, D. Leong, M. Whattam, A. Calam, and C. A. W. Snel

Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetic Study-Experience with ¹⁴C-labeled (R)-6-[Amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a Farnesyl Transferase Inhibitor
Drug Metab Dispos 2002 30: 823-830. [Abstract] [Full Text] [PDF]  

R. Scott Obach and Anne E. Reed-Hagen

Measurement of Michaelis Constants for Cytochrome P450-Mediated Biotransformation Reactions Using a Substrate Depletion Approach
Drug Metab Dispos 2002 30: 831-837. [Abstract] [Full Text] [PDF]  

James M. Brady, Nathan J. Cherrington, Dylan P. Hartley, Susan C. Buist, Ning Li, and Curtis D. Klaassen

Tissue Distribution and Chemical Induction of Multiple Drug Resistance Genes in Rats
Drug Metab Dispos 2002 30: 838-844. [Abstract] [Full Text] [PDF]  

David M. Stresser, Stephanie D. Turner, Andrew P. Blanchard, Vaughn P. Miller, and Charles L. Crespi

Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4.
Drug Metab Dispos 2002 30: 845-852. [Abstract] [Full Text] [PDF]  

Youssef Hijazi and Roselyne Boulieu

Contribution of CYP3A4, CYP2B6, and CYP2C9 Isoforms to N-Demethylation of Ketamine in Human Liver Microsomes
Drug Metab Dispos 2002 30: 853-858. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Marta Boffito, Katiusha Sciolè, Riccardo Raiteri, Stefano Bonora, Patrick G. Hoggard, David J. Back, and Giovanni Di Perri

₁-Acid Glycoprotein Levels in Human Immunodeficiency Virus-Infected Subjects on Antiretroviral Regimens
Drug Metab Dispos 2002 30: 859-860. [Full Text] [PDF]  

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