Symposium Articles:

Jeffrey C. Stevens, Dennis C. Dean, Peter C. Preusch, and Maria Almira Correia

The Changing Environment of Graduate and Postdoctoral Training in Drug Metabolism: Viewpoints from Academia, Industry, and Government
Drug Metab Dispos 2003 31: 360-366. [Abstract] [Full Text] [PDF]  

Articles:

Osamu Ueda, Shigeyuki Kitamura, Koji Ohashi, Kazumi Sugihara, and Shigeru Ohta

Xanthine Oxidase-Catalyzed Metabolism of 2-Nitrofluorene, a Carcinogenic Air Pollutant, in Rat Skin
Drug Metab Dispos 2003 31: 367-372. [Abstract] [Full Text] [PDF]  

Debbie Tam, Rommel G. Tirona, and K. Sandy Pang

Segmental Intestinal Transporters and Metabolic Enzymes on Intestinal Drug Absorption
Drug Metab Dispos 2003 31: 373-383. [Abstract] [Full Text] [PDF]  

Khawja A. Usmani, Randy L. Rose, and Ernest Hodgson

Inhibition and Activation of the Human Liver Microsomal and Human Cytochrome P450 3A4 Metabolism of Testosterone by Deployment-Related Chemicals
Drug Metab Dispos 2003 31: 384-391. [Abstract] [Full Text] [PDF]  

Jinmei Pan, Qian Xiang, Simon Ball, JoAnn Scatina, John Kao, and Jun-Yan Hong

Lipopolysaccharide-Mediated Modulation of Cytochromes P450 in Stat1 Null Mice
Drug Metab Dispos 2003 31: 392-397. [Abstract] [Full Text] [PDF]  

Hideto Jinno, Toshiko Tanaka-Kagawa, Akiko Ohno, Yuko Makino, Erika Matsushima, Nobumitsu Hanioka, and Masanori Ando

Functional Characterization of Cytochrome P450 2B6 Allelic Variants
Drug Metab Dispos 2003 31: 398-403. [Abstract] [Full Text] [PDF]  

Miquel Salva, Josep M. Jansat, Antonio Martinez-Tobed, and Jose M. Palacios

Identification of the Human Liver Enzymes Involved in the Metabolism of the Antimigraine Agent Almotriptan
Drug Metab Dispos 2003 31: 404-411. [Abstract] [Full Text] [PDF]  

Jianguo Liu, Spencer S. Ericksen, Dan Besspiata, Charles W. Fisher, and Grazyna D. Szklarz

Characterization of Substrate Binding to Cytochrome P450 1A1 Using Molecular Modeling and Kinetic Analyses: Case of Residue 382
Drug Metab Dispos 2003 31: 412-420. [Abstract] [Full Text] [PDF]  

Ajay Madan, Richard A. Graham, Kathleen M. Carroll, Daniel R. Mudra, L. Alayne Burton, Linda A. Krueger, April D. Downey, Maciej Czerwinski, Jameson Forster, Maria D. Ribadeneira, Liang-Shang Gan, Edward L. LeCluyse, Karl Zech, Philmore Robertson, Jr., Patrick Koch, Lida Antonian, Greg Wagner, Li Yu, and Andrew Parkinson

Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes
Drug Metab Dispos 2003 31: 421-431. [Abstract] [Full Text] [PDF]  

Hiroyoshi Nakamura, Nao Torimoto, Itsuko Ishii, Noritaka Ariyoshi, Hiromitsu Nakasa, Shigeru Ohmori, and Mitsukazu Kitada

CYP3A4 and CYP3A7-Mediated Carbamazepine 10,11-Epoxidation Are Activated by Differential Endogenous Steroids
Drug Metab Dispos 2003 31: 432-438. [Abstract] [Full Text] [PDF]  

Jasminder Sahi, Christopher B. Black, Geraldine A. Hamilton, Xianxian Zheng, Summer Jolley, Kelly A. Rose, Darryl Gilbert, Edward L. LeCluyse, and Michael W. Sinz

Comparative Effects of Thiazolidinediones on in Vitro P450 Enzyme Induction and Inhibition
Drug Metab Dispos 2003 31: 439-446. [Abstract] [Full Text] [PDF]  

Robert Houle, Jennifer Raoul, Jean-François Lévesque, K. Sandy Pang, Deborah A. Nicoll-Griffith, and Jose M. Silva

Retention of Transporter Activities in Cryopreserved, Isolated Rat Hepatocytes
Drug Metab Dispos 2003 31: 447-451. [Abstract] [Full Text] [PDF]  

Hong Lu, Xiaofeng Meng, Chuan Li, Shengmin Sang, Christopher Patten, Shuqun Sheng, Jungil Hong, Naisheng Bai, Bozena Winnik, Chi-Tang Ho, and Chung S. Yang

Glucuronides of Tea Catechins: Enzymology of Biosynthesis and Biological Activities
Drug Metab Dispos 2003 31: 452-461. [Abstract] [Full Text] [PDF]  

Wonku Kang and Michael Weiss

Modeling the Metabolism of Idarubicin to Idarubicinol in Rat Heart: Effect of Rutin and Phenobarbital
Drug Metab Dispos 2003 31: 462-468. [Abstract] [Full Text] [PDF]  

Masaaki Miyata, Etsuko Tamura, Kazuko Motoki, Kiyoshi Nagata, and Yasushi Yamazoe

Thalidomide-induced Suppression of Embryo Fibroblast Proliferation Requires CYP1A1-Mediated Activation
Drug Metab Dispos 2003 31: 469-475. [Abstract] [Full Text] [PDF]  

Mayssa Attar, Dahai Dong, Kah-Hiing John Ling, and Diane D-S. Tang-Liu

Cytochrome P450 2C8 and Flavin-containing Monooxygenases are Involved in the Metabolism of Tazarotenic Acid in Humans
Drug Metab Dispos 2003 31: 476-481. [Abstract] [Full Text] [PDF]  

Im-Sook Song, Young-Mi Lee, Suk-Jae Chung, and Chang-Koo Shim

Multiple Alterations of Canalicular Membrane Transport Activities in Rats with CCl₄-induced Hepatic Injury
Drug Metab Dispos 2003 31: 482-490. [Abstract] [Full Text] [PDF]  

Ji Y. Zhang, Josh J. Yuan, Yue-Fen Wang, Roy H. Bible, Jr., and Alan P. Breau

Pharmacokinetics and Metabolism of a COX-2 Inhibitor, Valdecoxib, in Mice
Drug Metab Dispos 2003 31: 491-501. [Abstract] [Full Text] [PDF]  

Victor J. Wroblewski, Christy McCloud, Kelly Davis, Joseph Manetta, Radmila Micanovic, and Derrick R. Witcher

Pharmacokinetics, Metabolic Stability, and Subcutaneous Bioavailability of a Genetically Engineered Analog of DcR3, FLINT [DcR3(R218Q)], in Cynomolgus Monkeys and Mice
Drug Metab Dispos 2003 31: 502-507. [Abstract] [Full Text] [PDF]  

Commentary:

Anthony Y. H. Lu, Regina W. Wang, and Jiunn H. Lin

Cytochrome P450 In Vitro Reaction Phenotyping: A Re-evaluation of Approaches Used for P450 Isoform Identification
Drug Metab Dispos 2003 31: 345-350. [Abstract] [Full Text] [PDF]  

Short Communications:

Nadezhda Galeva, Dmitry Yakovlev, Yakov Koen, Tatyana Duzhak, and Michail Alterman

Direct Identification of Cytochrome P450 Isozymes by Matrix-assisted Laser Desorption/Ionization Time of Flight-Based Proteomic Approach
Drug Metab Dispos 2003 31: 351-355. [Abstract] [Full Text] [PDF]  

Kishore K. Khan, Hong Liu, and James R. Halpert

Homotropic Versus Heterotopic Cooperativity of Cytochrome P450eryF: A Substrate Oxidation and Spectral Titration Study
Drug Metab Dispos 2003 31: 356-359. [Abstract] [Full Text] [PDF]  

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