Minireviews:

Todd D. Porter

JUD COON: 35 YEARS OF P450 RESEARCH, A SYNOPSIS OF P450 HISTORY
Drug Metab Dispos 2004 32: 1-6. [Abstract] [Full Text] [PDF]  

Articles:

Takhar Kasumov, Laura L. Brunengraber, Blandine Comte, Michelle A. Puchowicz, Kathryn Jobbins, Katherine Thomas, France David, Renee Kinman, Suzanne Wehrli, William Dahms, Douglas Kerr, Itzhak Nissim, and Henri Brunengraber

NEW SECONDARY METABOLITES OF PHENYLBUTYRATE IN HUMANS AND RATS
Drug Metab Dispos 2004 32: 10-19. [Abstract] [Full Text] [PDF]  

J. Kalitsky-Szirtes, A. Shayeganpour, D.R. Brocks, and M. Piquette-Miller

SUPPRESSION OF DRUG-METABOLIZING ENZYMES AND EFFLUX TRANSPORTERS IN THE INTESTINE OF ENDOTOXIN-TREATED RATS
Drug Metab Dispos 2004 32: 20-27. [Abstract] [Full Text] [PDF]  

Yanyan Cui, Catharina Y.W. Ang, Richard D. Beger, Thomas M. Heinze, Lihong Hu, and Julian Leakey

IN VITRO METABOLISM OF HYPERFORIN IN RAT LIVER MICROSOMAL SYSTEMS
Drug Metab Dispos 2004 32: 28-34. [Abstract] [Full Text] [PDF]  

Xiulong Song, Mingxing Xie, He Zhang, Yuxin Li, Karuna Sachdeva, and Bingfang Yan

THE PREGNANE X RECEPTOR BINDS TO RESPONSE ELEMENTS IN A GENOMIC CONTEXT-DEPENDENT MANNER, AND PXR ACTIVATOR RIFAMPICIN SELECTIVELY ALTERS THE BINDING AMONG TARGET GENES
Drug Metab Dispos 2004 32: 35-42. [Abstract] [Full Text] [PDF]  

Wenji Yin, George A. Doss, Ralph A. Stearns, and Sanjeev Kumar

N-ACETYLATION OF THE GLUTAMATE RESIDUE OF INTACT GLUTATHIONE CONJUGATES IN RATS: A NOVEL PATHWAY FOR THE METABOLIC PROCESSING OF THIOL ADDUCTS OF XENOBIOTICS
Drug Metab Dispos 2004 32: 43-48. [Abstract] [Full Text] [PDF]  

Deepak K. Dalvie and Thomas N. O'Connell

CHARACTERIZATION OF NOVEL DIHYDROTHIENOPYRIDINIUM AND THIENOPYRIDINIUM METABOLITES OF TICLOPIDINE IN VITRO: ROLE OF PEROXIDASES, CYTOCHROMES P450, AND MONOAMINE OXIDASES
Drug Metab Dispos 2004 32: 49-57. [Abstract] [Full Text] [PDF]  

Angéline Gradolatto, Marie-Chantal Canivenc-Lavier, Jean-Philippe Basly, Marie-Hélène Siess, and Caroline Teyssier

METABOLISM OF APIGENIN BY RAT LIVER PHASE I AND PHASE II ENZYMES AND BY ISOLATED PERFUSED RAT LIVER
Drug Metab Dispos 2004 32: 58-65. [Abstract] [Full Text] [PDF]  

Sarita D. Shenoy, Thomas A. Spencer, Nancy A. Mercer-Haines, Masumeh Alipour, Mary D. Gargano, Melissa Runge-Morris, and Thomas A. Kocarek

CYP3A INDUCTION BY LIVER X RECEPTOR LIGANDS IN PRIMARY CULTURED RAT AND MOUSE HEPATOCYTES IS MEDIATED BY THE PREGNANE X RECEPTOR
Drug Metab Dispos 2004 32: 66-71. [Abstract] [Full Text] [PDF]  

Doris Wiener, Daniel R. Doerge, Jia-Long Fang, Pramod Upadhyaya, and Philip Lazarus

CHARACTERIZATION OF N-GLUCURONIDATION OF THE LUNG CARCINOGEN 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANOL (NNAL) IN HUMAN LIVER: IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A4
Drug Metab Dispos 2004 32: 72-79. [Abstract] [Full Text] [PDF]  

Lydiane Pichard-Garcia, Richard John Weaver, Nina Eckett, Graeme Scarfe, Jean-Michel Fabre, Catherine Lucas, and Patrick Maurel

THE OLIVACINE DERIVATIVE S 16020 (9-HYDROXY-5,6-DIMETHYL-N-[2-(DIMETHYLAMINO)ETHYL)-6H-PYRIDO(4,3-B)-CARBAZOLE-1-CARBOXAMIDE) INDUCES CYP1A AND ITS OWN METABOLISM IN HUMAN HEPATOCYTES IN PRIMARY CULTURE
Drug Metab Dispos 2004 32: 80-88. [Abstract] [Full Text] [PDF]  

R. Scott Obach

POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE
Drug Metab Dispos 2004 32: 89-97. [Abstract] [Full Text] [PDF]  

Swati Nagar, Rory P. Remmel, Robert P. Hebbel, and Cheryl L. Zimmerman

METABOLISM OF OPIOIDS IS ALTERED IN LIVER MICROSOMES OF SICKLE CELL TRANSGENIC MICE
Drug Metab Dispos 2004 32: 98-104. [Abstract] [Full Text] [PDF]  

David M. Stresser, Marc I. Broudy, Thuy Ho, Catherine E. Cargill, Andrew P. Blanchard, Raman Sharma, Andre A. Dandeneau, Joseph J. Goodwin, Stephanie D. Turner, John C. L. Erve, Christopher J. Patten, Shangara S. Dehal, and Charles L. Crespi

HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE
Drug Metab Dispos 2004 32: 105-112. [Abstract] [Full Text] [PDF]  

Rory P. Remmel, Brenda C. Crews, Kevin R. Kozak, Amit S. Kalgutkar, and Lawrence J. Marnett

STUDIES ON THE METABOLISM OF THE NOVEL, SELECTIVE CYCLOOXYGENASE-2 INHIBITOR INDOMETHACIN PHENETHYLAMIDE IN RAT, MOUSE, AND HUMAN LIVER MICROSOMES: IDENTIFICATION OF ACTIVE METABOLITES
Drug Metab Dispos 2004 32: 113-122. [Abstract] [Full Text] [PDF]  

Rogelio Tornero-Velez, Matthew K. Ross, Courtney Granville, John Laskey, Jeffrey P. Jones, David M. DeMarini, and Marina V. Evans

METABOLISM AND MUTAGENICITY OF SOURCE WATER CONTAMINANTS 1,3-DICHLOROPROPANE AND 2,2-DICHLOROPROPANE
Drug Metab Dispos 2004 32: 123-131. [Abstract] [Full Text] [PDF]  

Xingrong Liu, Meihua Tu, Rebecca S. Kelly, Cuiping Chen, and Bill J. Smith

DEVELOPMENT OF A COMPUTATIONAL APPROACH TO PREDICT BLOOD-BRAIN BARRIER PERMEABILITY
Drug Metab Dispos 2004 32: 132-139. [Abstract] [Full Text] [PDF]  

Matthew G. Soars, David M. Petullo, James A. Eckstein, Steve C. Kasper, and Steven A. Wrighton

AN ASSESSMENT OF UDP-GLUCURONOSYLTRANSFERASE INDUCTION USING PRIMARY HUMAN HEPATOCYTES
Drug Metab Dispos 2004 32: 140-148. [Abstract] [Full Text] [PDF]  

Satoru Koyano, Kouichi Kurose, Yoshiro Saito, Shogo Ozawa, Ryuichi Hasegawa, Kazuo Komamura, Kazuyuki Ueno, Shiro Kamakura, Masafumi Kitakaze, Toshiharu Nakajima, Kenji Matsumoto, Akira Akasawa, Hirohisa Saito, and Jun-Ichi Sawada

FUNCTIONAL CHARACTERIZATION OF FOUR NATURALLY OCCURRING VARIANTS OF HUMAN PREGNANE X RECEPTOR (PXR): ONE VARIANT CAUSES DRAMATIC LOSS OF BOTH DNA BINDING ACTIVITY AND THE TRANSACTIVATION OF THE CYP3A4 PROMOTER/ENHANCER REGION
Drug Metab Dispos 2004 32: 149-154. [Abstract] [Full Text] [PDF]  

Yoshitaka Yamaguchi, Kishore K. Khan, You Ai He, You Qun He, and James R. Halpert

TOPOLOGICAL CHANGES IN THE CYP3A4 ACTIVE SITE PROBED WITH PHENYLDIAZENE: EFFECT OF INTERACTION WITH NADPH-CYTOCHROME P450 REDUCTASE AND CYTOCHROME B₅ AND OF SITE-DIRECTED MUTAGENESIS
Drug Metab Dispos 2004 32: 155-161. [Abstract] [Full Text] [PDF]  

Short Communications:

Izumi Iida, Atsunori Miyata, Masayuki Arai, Mitsuyo Hirota, Masayuki Akimoto, Shohei Higuchi, Kaoru Kobayashi, and Kan Chiba

CATALYTIC ROLES OF CYP2C9 AND ITS VARIANTS (CYP2C9*2 AND CYP2C9*3) IN LORNOXICAM 5'-HYDROXYLATION
Drug Metab Dispos 2004 32: 7-9. [Abstract] [Full Text] [PDF]  

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