DMD -- Table of Contents (32 [10])

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October 2004; 32 (10)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

       Errata

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Articles:

Bindhu V. Karanam, Christopher J. Welch, Vijay G. Reddy, Jennifer Chilenski, Mirlinda Biba, and Stella Vincent: SPECIES DIFFERENTIAL STEREOSELECTIVE OXIDATION OF A METHYLSULFIDE METABOLITE OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DUAL AGONIST
Drug Metab Dispos 2004 32: 1061-1068. Published online June 30, 2004; 10.1124/dmd.104.000224 [Abstract] [Full Text] [PDF]

Koji Nishi, Naoko Fukunaga, and Masaki Otagiri: CONSTRUCTION OF EXPRESSION SYSTEM FOR HUMAN ${alpha}$ ₁-ACID GLYCOPROTEIN IN PICHIA PASTORIS AND EVALUATION OF ITS DRUG-BINDING PROPERTIES
Drug Metab Dispos 2004 32: 1069-1074. Published online June 30, 2004; 10.1124/dmd.104.000513 [Abstract] [Full Text] [PDF]

Changcheng Zhou, Michelle M. Tabb, Asal Sadatrafiei, Felix Grün, and Bruce Blumberg: TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES
Drug Metab Dispos 2004 32: 1075-1082. Published online July 21, 2004; 10.1124/dmd.104.000299 [Abstract] [Full Text] [PDF]

Donavon J. McConn, II, Yvonne S. Lin, Kyle Allen, Kent L. Kunze, and Kenneth E. Thummel: DIFFERENCES IN THE INHIBITION OF CYTOCHROMES P450 3A4 AND 3A5 BY METABOLITE-INHIBITOR COMPLEX-FORMING DRUGS
Drug Metab Dispos 2004 32: 1083-1091. [Abstract] [Full Text] [PDF]

Suresh K. Balani, Ping Li, Joanne Nguyen, Kym Cardoza, Hang Zeng, Dun-Xue Mu, Jing-Tao Wu, Liang-Shang Gan, and Frank W. Lee: EFFECTIVE DOSING REGIMEN OF 1-AMINOBENZOTRIAZOLE FOR INHIBITION OF ANTIPYRINE CLEARANCE IN GUINEA PIGS AND MICE USING SERIAL SAMPLING
Drug Metab Dispos 2004 32: 1092-1095. Published online June 24, 2004; 10.1124/dmd.104.000349 [Abstract] [Full Text] [PDF]

Tadashi Hashimoto, Shinichi Narikawa, Xiu-Lin Huang, Tsuyoshi Minematsu, Takashi Usui, Hidetaka Kamimura, and Hitoshi Endou: CHARACTERIZATION OF THE RENAL TUBULAR TRANSPORT OF ZONAMPANEL, A NOVEL ${alpha}$ -AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID RECEPTOR ANTAGONIST, BY HUMAN ORGANIC ANION TRANSPORTERS
Drug Metab Dispos 2004 32: 1096-1102. [Abstract] [Full Text] [PDF]

Toshiki Tabata, Miki Katoh, Shogo Tokudome, Miki Nakajima, and Tsuyoshi Yokoi: IDENTIFICATION OF THE CYTOSOLIC CARBOXYLESTERASE CATALYZING THE 5'-DEOXY-5-FLUOROCYTIDINE FORMATION FROM CAPECITABINE IN HUMAN LIVER
Drug Metab Dispos 2004 32: 1103-1110. Published online July 21, 2004; 10.1124/dmd.104.000554 [Abstract] [Full Text] [PDF]

Konstantin V. Balakin, Sean Ekins, Andrey Bugrim, Yan A. Ivanenkov, Dmitry Korolev, Yuri V. Nikolsky, Andrey A. Ivashchenko, Nikolay P. Savchuk, and Tatiana Nikolskaya: QUANTITATIVE STRUCTURE-METABOLISM RELATIONSHIP MODELING OF METABOLIC N-DEALKYLATION REACTION RATES
Drug Metab Dispos 2004 32: 1111-1120. Published online July 21, 2004; 10.1124/dmd.104.000364 [Abstract] [Full Text] [PDF]

Nina Isoherranen, Kent L. Kunze, Kyle E. Allen, Wendel L. Nelson, and Kenneth E. Thummel: ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION
Drug Metab Dispos 2004 32: 1121-1131. Published online July 8, 2004; 10.1124/dmd.104.000315 [Abstract] [Full Text] [PDF]

L. Sanderson, G. W. Taylor, E. O. Aboagye, J. P. Alao, J. R. Latigo, R. C. Coombes, and D. M. Vigushin: PLASMA PHARMACOKINETICS AND METABOLISM OF THE HISTONE DEACETYLASE INHIBITOR TRICHOSTATIN A AFTER INTRAPERITONEAL ADMINISTRATION TO MICE
Drug Metab Dispos 2004 32: 1132-1138. Published online July 21, 2004; 10.1124/dmd.104.000638 [Abstract] [Full Text] [PDF]

Phillip M. Gerk, Wei Li, and Mary Vore: ESTRADIOL 3-GLUCURONIDE IS TRANSPORTED BY THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 BUT DOES NOT ACTIVATE THE ALLOSTERIC SITE BOUND BY ESTRADIOL 17-GLUCURONIDE
Drug Metab Dispos 2004 32: 1139-1145. Published online July 27, 2004; 10.1124/dmd.104.000372 [Abstract] [Full Text] [PDF]

Mary F. Paine, Anne B. Criss, and Paul B. Watkins: TWO MAJOR GRAPEFRUIT JUICE COMPONENTS DIFFER IN INTESTINAL CYP3A4 INHIBITION KINETIC AND BINDING PROPERTIES
Drug Metab Dispos 2004 32: 1146-1153. Published online July 21, 2004; 10.1124/dmd.104.000547 [Abstract] [Full Text] [PDF]

Vijay Bhasker G. Reddy, George A. Doss, Mellissa Creighton, Christopher J. Kochansky, Stella H. Vincent, Ronald B. Franklin, and Bindhu V. Karanam: IDENTIFICATION AND METABOLISM OF A NOVEL DIHYDROHYDROXY-S-GLUTATHIONYL CONJUGATE OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST, MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], IN RATS
Drug Metab Dispos 2004 32: 1154-1161. Published online June 30, 2004; 10.1124/dmd.104.000240 [Abstract] [Full Text] [PDF]

Li-Quan Wang, Charles N. Falany, and Margaret O. James: TRICLOSAN AS A SUBSTRATE AND INHIBITOR OF 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE-SULFOTRANSFERASE AND UDP-GLUCURONOSYL TRANSFERASE IN HUMAN LIVER FRACTIONS
Drug Metab Dispos 2004 32: 1162-1169. Published online July 21, 2004; 10.1124/dmd.104.000273 [Abstract] [Full Text] [PDF]

Tomomi Furihata, Masakiyo Hosokawa, Nao Koyano, Takahiro Nakamura, Tetsuo Satoh, and Kan Chiba: IDENTIFICATION OF DI-(2-ETHYLHEXYL) PHTHALATE-INDUCED CARBOXYLESTERASE 1 IN C57BL/6 MOUSE LIVER MICROSOMES: PURIFICATION, CDNA CLONING, AND BACULOVIRUS-MEDIATED EXPRESSION
Drug Metab Dispos 2004 32: 1170-1177. Published online July 21, 2004; 10.1124/dmd.104.000620 [Abstract] [Full Text] [PDF]

Daigo Murata, Yoshio Endo, Tohru Obata, Kazuki Sakamoto, Yasuhiro Syouji, Masakazu Kadohira, Akira Matsuda, and Takuma Sasaki: A CRUCIAL ROLE OF URIDINE/CYTIDINE KINASE 2 IN ANTITUMOR ACTIVITY OF 3'-ETHYNYL NUCLEOSIDES
Drug Metab Dispos 2004 32: 1178-1182. Published online July 27, 2004; 10.1124/dmd.104.000737 [Abstract] [Full Text] [PDF]

Konstantin V. Balakin, Sean Ekins, Andrey Bugrim, Yan A. Ivanenkov, Dmitry Korolev, Yuri V. Nikolsky, Andrey V. Skorenko, Andrey A. Ivashchenko, Nikolay P. Savchuk, and Tatiana Nikolskaya: KOHONEN MAPS FOR PREDICTION OF BINDING TO HUMAN CYTOCHROME P450 3A4
Drug Metab Dispos 2004 32: 1183-1189. Published online July 1, 2004; 10.1124/dmd.104.000356 [Abstract] [Full Text] [PDF]

Michael J. Potchoiba and Mark R. Nocerini: UTILITY OF WHOLE-BODY AUTORADIOLUMINOGRAPHY IN DRUG DISCOVERY FOR THE QUANTIFICATION OF TRITIUM-LABELED DRUG CANDIDATES
Drug Metab Dispos 2004 32: 1190-1198. [Abstract] [Full Text] [PDF]

Short Communications:

Yuji Ishii, Aya Miyoshi, Daisuke Maji, Hideyuki Yamada, and Kazuta Oguri: SIMULTANEOUS EXPRESSION OF GUINEA PIG UDP-GLUCURONOSYLTRANSFERASE 2B21 (UGT2B21) AND 2B22 IN COS-7 CELLS ENHANCES UGT2B21-CATALYZED CHLORAMPHENICOL GLUCURONIDATION
Drug Metab Dispos 2004 32: 1057-1060. [Abstract] [Full Text] [PDF]

Errata:

: CORRECTION TO "COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (S,S)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS"
Drug Metab Dispos 2004 32: 1199. [Full Text] [PDF]

Cover Caption:

An SOM map of low K_m (K_m < 10 M) and high K_m (K_m > 100 M) molecules for the whole panel of 12 P450 isozymes. See the article by Balakin et al. on page 1183 of this issue.