Minireviews:

J. Andrew Williams, Ruth Hyland, Barry C. Jones, Dennis A. Smith, Susan Hurst, Theunis C. Goosen, Vincent Peterkin, Jeffrey R. Koup, and Simon E. Ball

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
Drug Metab Dispos 2004 32: 1201-1208. Published online August 10, 2004; 10.1124/dmd.104.000794 [Abstract] [Full Text] [PDF]  

Articles:

Lovisa Afzelius, Florian Raubacher, Anders Karlén, Flemming Steen Jørgensen, Tommy B. Andersson, Collen M. Masimirembwa, and Ismael Zamora

STRUCTURAL ANALYSIS OF CYP2C9 AND CYP2C5 AND AN EVALUATION OF COMMONLY USED MOLECULAR MODELING TECHNIQUES
Drug Metab Dispos 2004 32: 1218-1229. [Abstract] [Full Text] [PDF]  

Hong Xiang, Cindy B. Nguyen, Sean K. Kelley, Noel Dybdal, and Enrique Escandón

TISSUE DISTRIBUTION, STABILITY, AND PHARMACOKINETICS OF APO2 LIGAND/TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND IN HUMAN COLON CARCINOMA COLO205 TUMOR-BEARING NUDE MICE
Drug Metab Dispos 2004 32: 1230-1238. Published online July 28, 2004; 10.1124/dmd.104.000323 [Abstract] [Full Text] [PDF] Correction  

Hong Sun, Yong Huang, Lynda Frassetto, and Leslie Z. Benet

EFFECTS OF UREMIC TOXINS ON HEPATIC UPTAKE AND METABOLISM OF ERYTHROMYCIN
Drug Metab Dispos 2004 32: 1239-1246. Published online July 30, 2004; 10.1124/dmd.104.000521 [Abstract] [Full Text] [PDF]  

Dermot F. McGinnity, Matthew G. Soars, Richard A. Urbanowicz, and Robert J. Riley

EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE
Drug Metab Dispos 2004 32: 1247-1253. Published online July 30, 2004; 10.1124/dmd.104.000026 [Abstract] [Full Text] [PDF]  

Punam Sandhu, John S. Vogel, Mark J. Rose, Esther A. Ubick, Janice E. Brunner, Michael A. Wallace, Jennifer K. Adelsberger, Maribeth P. Baker, Paul T. Henderson, Paul G. Pearson, and Thomas A. Baillie

EVALUATION OF MICRODOSING STRATEGIES FOR STUDIES IN PRECLINICAL DRUG DEVELOPMENT: DEMONSTRATION OF LINEAR PHARMACOKINETICS IN DOGS OF A NUCLEOSIDE ANALOG OVER A 50-FOLD DOSE RANGE
Drug Metab Dispos 2004 32: 1254-1259. Published online July 30, 2004; 10.1124/dmd.104.000422 [Abstract] [Full Text] [PDF]  

Donghui Cui, Catherine L. Booth-Genthe, Edward Carlini, Brian Carr, and Michael L. Schrag

HETEROTROPIC MODULATION OF SULFOTRANSFERASE 2A1 ACTIVITY BY CELECOXIB: PRODUCT RATIO SWITCHING OF ETHYNYLESTRADIOL SULFATION
Drug Metab Dispos 2004 32: 1260-1264. [Abstract] [Full Text] [PDF]  

Ning Li, Supratim Choudhuri, Nathan J. Cherrington, and Curtis D. Klaassen

DOWN-REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDE 4 (Oatp4; Oatp1b2; Slc21a10) mRNA BY LIPOPOLYSACCHARIDE THROUGH THE TOLL-LIKE RECEPTOR 4 (TLR4)
Drug Metab Dispos 2004 32: 1265-1271. [Abstract] [Full Text] [PDF]  

Tappei Takada, H. Markus Weiss, Olivier Kretz, Gerhard Gross, and Yuichi Sugiyama

HEPATIC TRANSPORT OF PKI166, AN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR OF THE PYRROLO-PYRIMIDINE CLASS, AND ITS MAIN METABOLITE, ACU154
Drug Metab Dispos 2004 32: 1272-1278. Published online July 27, 2004; 10.1124/dmd.104.000497 [Abstract] [Full Text] [PDF]  

Carole Giraud, Agnès Tran, Elisabeth Rey, Jean Vincent, Jean-Marc Tréluyer, and Gérard Pons

IN VITRO CHARACTERIZATION OF CLOBAZAM METABOLISM BY RECOMBINANT CYTOCHROME P450 ENZYMES: IMPORTANCE OF CYP2C19
Drug Metab Dispos 2004 32: 1279-1286. [Abstract] [Full Text] [PDF]  

Rosa I. Sanchez, Regina W. Wang, Deborah J. Newton, Ray Bakhtiar, Ping Lu, Shuet-Hing Lee Chiu, David C. Evans, and Su-Er W. Huskey

CYTOCHROME P450 3A4 IS THE MAJOR ENZYME INVOLVED IN THE METABOLISM OF THE SUBSTANCE P RECEPTOR ANTAGONIST APREPITANT
Drug Metab Dispos 2004 32: 1287-1292. Published online August 10, 2004; 10.1124/dmd.104.000216 [Abstract] [Full Text] [PDF]  

Jeevan R. Kunta, Sung-Hack Lee, Barbara A. Perry, Yong-Hee Lee, and Patrick J. Sinko

DIFFERENTIATION OF GUT AND HEPATIC FIRST-PASS LOSS OF VERAPAMIL IN INTESTINAL AND VASCULAR ACCESS-PORTED (IVAP) RABBITS
Drug Metab Dispos 2004 32: 1293-1298. Published online August 10, 2004; 10.1124/dmd.104.000752 [Abstract] [Full Text] [PDF]  

Michael L. Schrag, Donghui Cui, Thomas H. Rushmore, Magang Shou, Bennett Ma, and A. David Rodrigues

SULFOTRANSFERASE 1E1 IS A LOW K_M ISOFORM MEDIATING THE 3-O-SULFATION OF ETHINYL ESTRADIOL
Drug Metab Dispos 2004 32: 1299-1303. [Abstract] [Full Text] [PDF]  

Margarida F. B. Silva, Lodewijk IJlst, Paul Allers, Cornelis Jakobs, Marinus Duran, Isabel Tavares de Almeida, and Ronald J. A. Wanders

VALPROYL-DEPHOSPHOCoA: A NOVEL METABOLITE OF VALPROATE FORMED IN VITRO IN RAT LIVER MITOCHONDRIA
Drug Metab Dispos 2004 32: 1304-1310. [Abstract] [Full Text] [PDF]  

Justine L. Lam and Leslie Z. Benet

HEPATIC MICROSOME STUDIES ARE INSUFFICIENT TO CHARACTERIZE IN VIVO HEPATIC METABOLIC CLEARANCE AND METABOLIC DRUG-DRUG INTERACTIONS: STUDIES OF DIGOXIN METABOLISM IN PRIMARY RAT HEPATOCYTES VERSUS MICROSOMES
Drug Metab Dispos 2004 32: 1311-1316. [Abstract] [Full Text] [PDF]  

Yuzhong Ma, Karuna Sachdeva, Jirong Liu, Michael Ford, Dongfang Yang, Ikhlas A. Khan, Clinton O. Chichester, and Bingfang Yan

DESMETHOXYYANGONIN AND DIHYDROMETHYSTICIN ARE TWO MAJOR PHARMACOLOGICAL KAVALACTONES WITH MARKED ACTIVITY ON THE INDUCTION OF CYP3A23
Drug Metab Dispos 2004 32: 1317-1324. Published online July 28, 2004; 10.1124/dmd.104.000786 [Abstract] [Full Text] [PDF]  

Michael R. Uhing, David W. A. Beno, Vanida A. Jiyamapa-Serna, Yong Chen, Raymond E. Galinsky, Stephen D. Hall, and Robert E. Kimura

THE EFFECT OF ANESTHESIA AND SURGERY ON CYP3A ACTIVITY IN RATS
Drug Metab Dispos 2004 32: 1325-1330. Published online August 19, 2004; 10.1124/dmd.104.000927 [Abstract] [Full Text] [PDF]  

Short Communications:

Bonnie Wang, Rosa I. Sanchez, Ronald B. Franklin, David C. Evans, and Su-Er W. Huskey

THE INVOLVEMENT OF CYP3A4 AND CYP2C9 IN THE METABOLISM OF 17-ETHINYLESTRADIOL
Drug Metab Dispos 2004 32: 1209-1212. Published online August 10, 2004; 10.1124/dmd.104.000182 [Abstract] [Full Text] [PDF]  

A. Heydari, K. Rowland Yeo, M. S. Lennard, S. W. Ellis, G. T. Tucker, and A. Rostami-Hodjegan

MECHANISM-BASED INACTIVATION OF CYP2D6 BY METHYLENEDIOXYMETHAMPHETAMINE
Drug Metab Dispos 2004 32: 1213-1217. Published online August 24, 2004; 10.1124/dmd.104.001180 [Abstract] [Full Text] [PDF]  

Errata:

CORRECTION to September Issue of Drug Metabolism and Disposition
Drug Metab Dispos 2004 32: 1331. [Full Text] [PDF]  

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