Articles:

Teresa M. Alvarez-Diez and Jiang Zheng

DETECTION OF GLUTATHIONE CONJUGATES DERIVED FROM 4-IPOMEANOL METABOLISM IN BILE OF RATS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Drug Metab Dispos 2004 32: 1345-1350. Published online August 24, 2004; 10.1124/dmd.104.000406 [Abstract] [Full Text] [PDF]  

Hiroshi Iwata, Yasuhiro Tezuka, Shigetoshi Kadota, Akira Hiratsuka, and Tadashi Watabe

IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT
Drug Metab Dispos 2004 32: 1351-1358. Published online September 1, 2004; 10.1124/dmd.104.000646 [Abstract] [Full Text] [PDF]  

Harvey Wong, Scott J. Grossman, Stephen A. Bai, Sharon Diamond, Matthew R. Wright, James E. Grace, Jr., Mingxin Qian, Kan He, Krishnaswamy Yeleswaram, and David D. Christ

THE CHIMPANZEE (PAN TROGLODYTES) AS A PHARMACOKINETIC MODEL FOR SELECTION OF DRUG CANDIDATES: MODEL CHARACTERIZATION AND APPLICATION
Drug Metab Dispos 2004 32: 1359-1369. Published online August 27, 2004; 10.1124/dmd.104.000943 [Abstract] [Full Text] [PDF]  

Jasminder Sahi, Ralph H. Stern, Mark A. Milad, Kelly A. Rose, Gordon Gibson, Xianxian Zheng, Linda Stilgenbauer, Nalini Sadagopan, Summer Jolley, Darryl Gilbert, and Edward L. LeCluyse

EFFECTS OF AVASIMIBE ON CYTOCHROME P450 2C9 EXPRESSION IN VITRO AND IN VIVO
Drug Metab Dispos 2004 32: 1370-1376. Published online August 27, 2004; 10.1124/dmd.104.000208 [Abstract] [Full Text] [PDF]  

Thomas Walle, Faye Hsieh, Mark H. DeLegge, John E. Oatis, Jr., and U. Kristina Walle

HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Drug Metab Dispos 2004 32: 1377-1382. Published online August 27, 2004; 10.1124/dmd.104.000885 [Abstract] [Full Text] [PDF]  

Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike, and Toshiro Yamaguchi

MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS
Drug Metab Dispos 2004 32: 1383-1391. Published online September 2, 2004; 10.1124/dmd.104.000661 [Abstract] [Full Text] [PDF]  

Eileen Brantley, Valentina Trapani, Michael C. Alley, Curtis D. Hose, Tracey D. Bradshaw, Malcolm F. G. Stevens, Edward A. Sausville, and Sherman F. Stinson

FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS
Drug Metab Dispos 2004 32: 1392-1401. Published online September 8, 2004; 10.1124/dmd.104.001057 [Abstract] [Full Text] [PDF]  

Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Miho Kataoka, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato, and Tsuyoshi Yokoi

EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER
Drug Metab Dispos 2004 32: 1402-1410. Published online September 21, 2004; 10.1124/dmd.104.001347 [Abstract] [Full Text] [PDF]  

Aleksandra Galetin, Caroline Brown, David Hallifax, Kiyomi Ito, and J. Brian Houston

UTILITY OF RECOMBINANT ENZYME KINETICS IN PREDICTION OF HUMAN CLEARANCE: IMPACT OF VARIABILITY, CYP3A5, AND CYP2C19 ON CYP3A4 PROBE SUBSTRATES
Drug Metab Dispos 2004 32: 1411-1420. Published online September 1, 2004; 10.1124/dmd.104.000844 [Abstract] [Full Text] [PDF]  

Dirk R. J. Kuypers, Kathleen Claes, P. Evenepoel, B. Maes, and Yves Vanrenterghem

THE RATE OF GASTRIC EMPTYING DETERMINES THE TIMING BUT NOT THE EXTENT OF ORAL TACROLIMUS ABSORPTION: SIMULTANEOUS MEASUREMENT OF DRUG EXPOSURE AND GASTRIC EMPTYING BY CARBON-14-OCTANOIC ACID BREATH TEST IN STABLE RENAL ALLOGRAFT RECIPIENTS
Drug Metab Dispos 2004 32: 1421-1425. Published online September 21, 2004; 10.1124/dmd.104.001503 [Abstract] [Full Text] [PDF]  

Eivor Elovaara, Jouni Mikkola, Leena Luukkanen, Laurence Antonio, Sylvie Fournel-Gigleux, Brian Burchell, Jacques Magdalou, and Jyrki Taskinen

ASSESSMENT OF CATECHOL INDUCTION AND GLUCURONIDATION IN RAT LIVER MICROSOMES
Drug Metab Dispos 2004 32: 1426-1433. Published online September 15, 2004; 10.1124/dmd.104.000992 [Abstract] [Full Text] [PDF]  

Weili Huang, Yvonne S. Lin, Donavon J. McConn, II, Justina C. Calamia, Rheem A. Totah, Nina Isoherranen, Mary Glodowski, and Kenneth E. Thummel

EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM
Drug Metab Dispos 2004 32: 1434-1445. Published online September 21, 2004; 10.1124/dmd.104.001313 [Abstract] [Full Text] [PDF]  

Ragini Vuppugalla and Reza Mehvar

SHORT-TERM INHIBITORY EFFECTS OF NITRIC OXIDE ON CYTOCHROME P450-MEDIATED DRUG METABOLISM: TIME DEPENDENCY AND REVERSIBILITY PROFILES IN ISOLATED PERFUSED RAT LIVERS
Drug Metab Dispos 2004 32: 1446-1454. Published online September 21, 2004; 10.1124/dmd.104.001487 [Abstract] [Full Text] [PDF]  

Hong Lu, Chuan Chen, and Curtis Klaassen

TISSUE DISTRIBUTION OF CONCENTRATIVE AND EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS IN MALE AND FEMALE RATS AND MICE
Drug Metab Dispos 2004 32: 1455-1461. Published online September 15, 2004; 10.1124/dmd.104.001123 [Abstract] [Full Text] [PDF]  

Vandana N. Hirani, Judy L. Raucy, and Jerome M. Lasker

CONVERSION OF THE HIV PROTEASE INHIBITOR NELFINAVIR TO A BIOACTIVE METABOLITE BY HUMAN LIVER CYP2C19
Drug Metab Dispos 2004 32: 1462-1467. Published online September 24, 2004; 10.1124/dmd.104.001743 [Abstract] [Full Text] [PDF]  

Yoshihisa Shitara, Masaru Hirano, Yasuhisa Adachi, Tomoo Itoh, Hitoshi Sato, and Yuichi Sugiyama

IN VITRO AND IN VIVO CORRELATION OF THE INHIBITORY EFFECT OF CYCLOSPORIN A ON THE TRANSPORTER-MEDIATED HEPATIC UPTAKE OF CERIVASTATIN IN RATS
Drug Metab Dispos 2004 32: 1468-1475. [Abstract] [Full Text] [PDF]  

Yoshihiro Uesawa, Adam G. Staines, Audrey O'Sullivan, Kiminori Mohri, and Brian Burchell

IDENTIFICATION OF THE RABBIT LIVER UDP-GLUCURONOSYLTRANSFERASE CATALYZING THE GLUCURONIDATION OF 4-ETHOXYPHENYLUREA (DULCIN)
Drug Metab Dispos 2004 32: 1476-1481. Published online September 24, 2004; 10.1124/dmd.104.001206 [Abstract] [Full Text] [PDF]  

William L. Fitch, Pamela W. Berry, Yaping Tu, Ali Tabatabaei, Lee Lowrie, Francisco Lopez-Tapia, Yanzhou Liu, Dov Nitzan, Mohammad R. Masjedizadeh, and Aravamuthan Varadarajan

IDENTIFICATION OF GLUTATHIONE-DERIVED METABOLITES FROM AN IP RECEPTOR ANTAGONIST
Drug Metab Dispos 2004 32: 1482-1490. Published online September 15, 2004; 10.1124/dmd.104.000471 [Abstract] [Full Text] [PDF]  

Gondi N. Kumar, Christopher Sproul, Leszek Poppe, Sharon Turner, Mark Gohdes, Hesham Ghoborah, Desmond Padhi, and Lorin Roskos

METABOLISM AND DISPOSITION OF CALCIMIMETIC AGENT CINACALCET HCL IN HUMANS AND ANIMAL MODELS
Drug Metab Dispos 2004 32: 1491-1500. Published online August 24, 2004; 10.1124/dmd.104.000604 [Abstract] [Full Text] [PDF]  

T. Idil Apak and Michael W. Duffel

INTERACTIONS OF THE STEREOISOMERS OF -HYDROXYTAMOXIFEN WITH HUMAN HYDROXYSTEROID SULFOTRANSFERASE SULT2A1 AND RAT HYDROXYSTEROID SULFOTRANSFERASE STA
Drug Metab Dispos 2004 32: 1501-1508. Published online September 15, 2004; 10.1124/dmd.104.000919 [Abstract] [Full Text] [PDF]  

Deborah A. Nicoll-Griffith, Nathalie Chauret, Robert Houle, Stephen H. Day, Michelle D'Antoni, and José M. Silva

USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES
Drug Metab Dispos 2004 32: 1509-1515. [Abstract] [Full Text] [PDF]  

Xiao-Yang He, Jian Shen, Xinxin Ding, Anthony Y. H. Lu, and Jun-Yan Hong

IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN
Drug Metab Dispos 2004 32: 1516-1521. Published online August 27, 2004; 10.1124/dmd.104.001370 [Abstract] [Full Text] [PDF]  

Short Communications:

Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Jun-Sheng Wang, Bryan B. Gibson, Holly A. Gefroh, and John S. Markowitz

MULTIPLE NIGHT-TIME DOSES OF VALERIAN (Valeriana officinalis) HAD MINIMAL EFFECTS ON CYP3A4 ACTIVITY AND NO EFFECT ON CYP2D6 ACTIVITY IN HEALTHY VOLUNTEERS
Drug Metab Dispos 2004 32: 1333-1336. Published online August 24, 2004; 10.1124/dmd.104.001164 [Abstract] [Full Text] [PDF]  

Sharon K. Krueger, Lisbeth K. Siddens, Sarah R. Martin, Zhen Yu, Clifford B. Pereira, Erwin T. Cabacungan, Ronald N. Hines, Kristin G. Ardlie, Judy L. Raucy, and David E. Williams

DIFFERENCES IN FMO2^*1 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT
Drug Metab Dispos 2004 32: 1337-1340. Published online September 8, 2004; 10.1124/dmd.104.001099 [Abstract] [Full Text] [PDF]  

Joo-Youn Cho, Hyeong-Seok Lim, Jae-Yong Chung, Kyung-Sang Yu, Jung-Ryul Kim, Sang-Goo Shin, and In-Jin Jang

HAPLOTYPE STRUCTURE AND ALLELE FREQUENCIES OF CYP2B6 IN A KOREAN POPULATION
Drug Metab Dispos 2004 32: 1341-1344. Published online September 21, 2004; 10.1124/dmd.104.001107 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Karen Rowland Yeo, Eleanor M. Howgate, Geoffrey T. Tucker, and Amin Rostami-Hodjegan

PREDICTING THE CLEARANCE OF CYP2C9 SUBSTRATES
Drug Metab Dispos 2004 32: 1522. Published online December 1, 2004; 10.1124/dmd.104.001792 [Full Text] [PDF]  

Tommy B. Andersson, Eva Bredberg, Hans Ericsson, and Helena SjÖberg

RESPONSE: PREDICTING THE CLEARANCE OF CYP2C9 SUBSTRATES
Drug Metab Dispos 2004 32: 1523. Published online December 1, 2004; 10.1124/dmd.104.002329 [Full Text] [PDF]  

Nicolas Picard and Pierre Marquet

IN VITRO STUDY OF MYCOPHENOLIC ACID GLUCURONIDATION
Drug Metab Dispos 2004 32: 1524. Published online December 1, 2004; 10.1124/dmd.104.001982 [Full Text] [PDF]  

N. K. Basu, L. Kole, S. Kubota, and I. S. Owens

RESPONSE TO THE LETTER TO THE EDITOR BY DRS. N. PICARD AND P. MARQUET REGARDING A PUBLICATION: BASU ET AL., DRUG METABOLISM AND DISPOSITION 32: 768-773 (2004)
Drug Metab Dispos 2004 32: 1525. Published online December 1, 2004; 10.1124/dmd.104.002345 [Full Text] [PDF]  

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