DMD Noab BioDiscoveries - Shaping Drug Discovery

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February 2004; 32 (2)   [Index by Author]  [Cover Caption]
       Articles
       Short Communications
       Erratum
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Articles:

Keith W. Ward, Gary J. Stelman, Jayme A. Morgan, Kelli S. Zeigler, Leonard M. Azzarano, Jonathan R. Kehler, Jeanelle E. McSurdy-Freed, Joel W. Proksch, and Brian R. Smith
DEVELOPMENT OF AN IN VIVO PRECLINICAL SCREEN MODEL TO ESTIMATE ABSORPTION AND FIRST-PASS HEPATIC EXTRACTION OF XENOBIOTICS. II. USE OF KETOCONAZOLE TO IDENTIFY P-GLYCOPROTEIN/CYP3A-LIMITED BIOAVAILABILITY IN THE MONKEY
Drug Metab Dispos 2004 32: 172-177. [Abstract] [Full Text] [PDF]  

Randall R. Miller, George A. Doss, and Ralph A. Stearns
IDENTIFICATION OF A HYDROXYLAMINE GLUCURONIDE METABOLITE OF AN ORAL HYPOGLYCEMIC AGENT
Drug Metab Dispos 2004 32: 178-185. [Abstract] [Full Text] [PDF]  

Lixin Shen, John F. Fitzloff, and Chyung S. Cook
DIFFERENTIAL ENANTIOSELECTIVITY AND PRODUCT-DEPENDENT ACTIVATION AND INHIBITION IN METABOLISM OF VERAPAMIL BY HUMAN CYP3AS
Drug Metab Dispos 2004 32: 186-196. [Abstract] [Full Text] [PDF]  

Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby, and Paul Morgan
NONLINEAR ORAL PHARMACOKINETICS OF THE {alpha}-ANTAGONIST 4-AMINO-5-(4-FLUOROPHENYL)-6,7-DIMETHOXY-2-[4-(MORPHOLINOCARBONYL)-PERHYDRO-1,4-DIAZEPIN-1-YL]QUINOLINE IN HUMANS: USE OF PRECLINICAL DATA TO RATIONALIZE CLINICAL OBSERVATIONS
Drug Metab Dispos 2004 32: 197-204. [Abstract] [Full Text] [PDF]  

Akira Asai, Tatsuya Sugawara, Hiroshi Ono, and Akihiko Nagao
BIOTRANSFORMATION OF FUCOXANTHINOL INTO AMAROUCIAXANTHIN A IN MICE AND HEPG2 CELLS: FORMATION AND CYTOTOXICITY OF FUCOXANTHIN METABOLITES
Drug Metab Dispos 2004 32: 205-211. [Abstract] [Full Text] [PDF]  

John Kim, K. Wayne Riggs, and Dan W. Rurak
STEREOSELECTIVE PHARMACOKINETICS OF FLUOXETINE AND NORFLUOXETINE ENANTIOMERS IN PREGNANT SHEEP
Drug Metab Dispos 2004 32: 212-221. [Abstract] [Full Text] [PDF]  

John R. Cashman, Virginie Lattard, and Jing Lin
EFFECT OF TOTAL PARENTERAL NUTRITION AND CHOLINE ON HEPATIC FLAVIN-CONTAINING AND CYTOCHROME P-450 MONOOXYGENASE ACTIVITY IN RATS
Drug Metab Dispos 2004 32: 222-229. [Abstract] [Full Text] [PDF]  

Takako Kato, Kiyoshi Yamaoka, and Yoshinobu Takakura
AN EVALUATION METHOD FOR NONLINEAR LOCAL DISPOSITION IN RAT LIVER AND KIDNEY
Drug Metab Dispos 2004 32: 230-234. [Abstract] [Full Text] [PDF]  

Akiko Ohno, Yoshiro Saito, Nobumitsu Hanioka, Hideto Jinno, Mayumi Saeki, Masanori Ando, Shogo Ozawa, and Jun-ichi Sawada
INVOLVEMENT OF HUMAN HEPATIC UGT1A1, UGT2B4, AND UGT2B7 IN THE GLUCURONIDATION OF CARVEDILOL
Drug Metab Dispos 2004 32: 235-239. [Abstract] [Full Text] [PDF]  

Masashi Mise, Seiji Yadera, Michiaki Matsuda, Takanori Hashizume, Satoshi Matsumoto, Yoshiaki Terauchi, and Toshihiko Fujii
POLYMORPHIC EXPRESSION OF CYP1A2 LEADING TO INTERINDIVIDUAL VARIABILITY IN METABOLISM OF A NOVEL BENZODIAZEPINE RECEPTOR PARTIAL INVERSE AGONIST IN DOGS
Drug Metab Dispos 2004 32: 240-245. [Abstract] [Full Text] [PDF] Correction  

Su-Er W. Huskey, Brian J. Dean, George A. Doss, Zhen Wang, Cornelis E.C.A. Hop, Reza Anari, Paul E. Finke, Albert J. Robichaud, Minghua Zhang, Bonnie Wang, John R. Strauss, Paul K. Cunningham, William P. Feeney, Ronald B. Franklin, Thomas A. Baillie, and Shuet-Hing L. Chiu
THE METABOLIC DISPOSITION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN RATS AND DOGS
Drug Metab Dispos 2004 32: 246-258. [Abstract] [Full Text] [PDF]  

Ying-Hong Wang, David R. Jones, and Stephen D. Hall
PREDICTION OF CYTOCHROME P450 3A INHIBITION BY VERAPAMIL ENANTIOMERS AND THEIR METABOLITES
Drug Metab Dispos 2004 32: 259-266. [Abstract] [Full Text] [PDF]  

Anima Ghosal, Neil Hapangama, Yuan Yuan, Joana Achanfuo-Yeboah, Robert Iannucci, Swapan Chowdhury, Kevin Alton, James E. Patrick, and Shmuel Zbaida
IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ENZYME(S) RESPONSIBLE FOR THE GLUCURONIDATION OF POSACONAZOLE (NOXAFIL)
Drug Metab Dispos 2004 32: 267-271. [Abstract] [Full Text] [PDF]  

Dejan Nikolic, Yongmei Li, Lucas R. Chadwick, Simonida Grubjesic, Pia Schwab, Peter Metz, and Richard B. van Breemen
METABOLISM OF 8-PRENYLNARINGENIN, A POTENT PHYTOESTROGEN FROM HOPS (HUMULUS LUPULUS), BY HUMAN LIVER MICROSOMES
Drug Metab Dispos 2004 32: 272-279. [Abstract] [Full Text] [PDF]  

Short Communications:

Weisheng Zhang, Anthony F. Purchio, Richard Coffee, and David B. West
DIFFERENTIAL REGULATION OF THE HUMAN CYP3A4 PROMOTER IN TRANSGENIC MICE AND RATS
Drug Metab Dispos 2004 32: 163-167. [Abstract] [Full Text] [PDF]  

Vincent Castagne, Laurence Bonhomme-Faivre, Saik Urien, Makram Ben Reguiga, Mireille Soursac, Francois Gimenez, and Robert Farinotti
EFFECT OF RECOMBINANT INTERLEUKIN-2 PRETREATMENT ON ORAL AND INTRAVENOUS DIGOXIN PHARMACOKINETICS AND P-GLYCOPROTEIN ACTIVITY IN MICE
Drug Metab Dispos 2004 32: 168-171. [Abstract] [Full Text] [PDF]  

Erratum:

CORRECTION TO "TWO NEW POLYMORPHISMS OF THE FMO3 GENE IN CAUCASIAN AND AFRICAN-AMERICAN POPULATIONS: COMPARATIVE GENETIC AND FUNCTIONAL STUDIES"
Drug Metab Dispos 2004 32: 280. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

A, CYP3A4-luc rats (three per gender) were challenged i.p. with seven different drugs and with DMSO. B, time course of response to drug injection in CYP3A4-luc rats (male and female data were combined for this analysis). See the article by Zhang et al. on page 163 of this issue.



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