Articles:

Poh-Gek Forkert, R. Michael Baldwin, Brandie Millen, Lawrence H. Lash, David A. Putt, Michael A. Shultz, and Kathy S. Collins

PULMONARY BIOACTIVATION OF TRICHLOROETHYLENE TO CHLORAL HYDRATE: RELATIVE CONTRIBUTIONS OF CYP2E1, CYP2F, AND CYP2B1
Drug Metab Dispos 2005 33: 1429-1437. Published online June 29, 2005; 10.1124/dmd.105.005074 [Abstract] [Full Text] [PDF]  

Hai-Zhi Bu, Ping Kang, Ping Zhao, William F. Pool, and Ellen Y. Wu

A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS
Drug Metab Dispos 2005 33: 1438-1445. Published online July 8, 2005; 10.1124/dmd.105.005413 [Abstract] [Full Text] [PDF]  

Priyanka Parte and David Kupfer

OXIDATION OF TAMOXIFEN BY HUMAN FLAVIN-CONTAINING MONOOXYGENASE (FMO) 1 AND FMO3 TO TAMOXIFEN-N-OXIDE AND ITS NOVEL REDUCTION BACK TO TAMOXIFEN BY HUMAN CYTOCHROMES P450 AND HEMOGLOBIN
Drug Metab Dispos 2005 33: 1446-1452. Published online June 29, 2005; 10.1124/dmd.104.000802 [Abstract] [Full Text] [PDF]  

Lisa A. Peterson, Meredith E. Cummings, Choua C. Vu, and Brock A. Matter

GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO CIS-2-BUTENE-1,4-DIAL
Drug Metab Dispos 2005 33: 1453-1458. Published online July 8, 2005; 10.1124/dmd.105.004432 [Abstract] [Full Text] [PDF]  

Yanyan Cui, Mona I. Churchwell, Letha H. Couch, Daniel R. Doerge, and Paul C. Howard

METABOLISM OF PIGMENT YELLOW 74 BY RAT AND HUMAN MICROSOMAL PROTEINS
Drug Metab Dispos 2005 33: 1459-1465. Published online July 13, 2005; 10.1124/dmd.104.003285 [Abstract] [Full Text] [PDF]  

Tomo Daidoji, Keisuke Gozu, Hidetomo Iwano, Hiroki Inoue, and Hiroshi Yokota

UDP-GLUCURONOSYLTRANSFERASE ISOFORMS CATALYZING GLUCURONIDATION OF HYDROXY-POLYCHLORINATED BIPHENYLS IN RAT
Drug Metab Dispos 2005 33: 1466-1476. Published online July 8, 2005; 10.1124/dmd.105.004416 [Abstract] [Full Text] [PDF] Data Supplement  

Maki Shimizu, Kaori Fuse, Kazuho Okudaira, Ryuichiro Nishigaki, Kazuya Maeda, Hiroyuki Kusuhara, and Yuichi Sugiyama

CONTRIBUTION OF OATP (ORGANIC ANION-TRANSPORTING POLYPEPTIDE) FAMILY TRANSPORTERS TO THE HEPATIC UPTAKE OF FEXOFENADINE IN HUMANS
Drug Metab Dispos 2005 33: 1477-1481. Published online July 13, 2005; 10.1124/dmd.105.004622 [Abstract] [Full Text] [PDF]  

Takashi Kubo, Su-Ryang Kim, Kimie Sai, Yoshiro Saito, Toshiharu Nakajima, Kenji Matsumoto, Hirohisa Saito, Kuniaki Shirao, Noboru Yamamoto, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, Yasuo Ohno, Shogo Ozawa, and Jun-ichi Sawada

FUNCTIONAL CHARACTERIZATION OF THREE NATURALLY OCCURRING SINGLE NUCLEOTIDE POLYMORPHISMS IN THE CES2 GENE ENCODING CARBOXYLESTERASE 2 (HCE-2)
Drug Metab Dispos 2005 33: 1482-1487. Published online July 20, 2005; 10.1124/dmd.105.005587 [Abstract] [Full Text] [PDF]  

Risa Nasu, Yoichi Kumagai, Hirokuni Kogetsu, Masayuki Tsujimoto, Hisakazu Ohtani, and Yasufumi Sawada

PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PRALMORELIN HYDROCHLORIDE IN RATS
Drug Metab Dispos 2005 33: 1488-1494. Published online July 20, 2005; 10.1124/dmd.104.001040 [Abstract] [Full Text] [PDF]  

Sharon L. Miksys, Connie Cheung, Frank J. Gonzalez, and Rachel F. Tyndale

HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL
Drug Metab Dispos 2005 33: 1495-1502. Published online July 20, 2005; 10.1124/dmd.105.005488 [Abstract] [Full Text] [PDF]  

Hans-Peter Gschwind, Ulrike Pfaar, Felix Waldmeier, Markus Zollinger, Claudia Sayer, Peter Zbinden, Michael Hayes, Rolf Pokorny, Michael Seiberling, Monique Ben-Am, Bin Peng, and Gerhard Gross

METABOLISM AND DISPOSITION OF IMATINIB MESYLATE IN HEALTHY VOLUNTEERS
Drug Metab Dispos 2005 33: 1503-1512. Published online July 8, 2005; 10.1124/dmd.105.004283 [Abstract] [Full Text] [PDF]  

Kristini K. Miles, Stephan T. Stern, Philip C. Smith, Fay K. Kessler, Shazia Ali, and Joseph K. Ritter

AN INVESTIGATION OF HUMAN AND RAT LIVER MICROSOMAL MYCOPHENOLIC ACID GLUCURONIDATION: EVIDENCE FOR A PRINCIPAL ROLE OF UGT1A ENZYMES AND SPECIES DIFFERENCES IN UGT1A SPECIFICITY
Drug Metab Dispos 2005 33: 1513-1520. Published online July 20, 2005; 10.1124/dmd.105.004663 [Abstract] [Full Text] [PDF]  

Dalya Abdulla, Kerry B. Goralski, Elena Garcia Del Busto Cano, and Kenneth W. Renton

THE SIGNAL TRANSDUCTION PATHWAYS INVOLVED IN HEPATIC CYTOCHROME P450 REGULATION IN THE RAT DURING A LIPOPOLYSACCHARIDE-INDUCED MODEL OF CENTRAL NERVOUS SYSTEM INFLAMMATION
Drug Metab Dispos 2005 33: 1521-1531. Published online July 8, 2005; 10.1124/dmd.105.004564 [Abstract] [Full Text] [PDF]  

Anja Kristina Froehlich, Ulrich Girreser, and Bernd Clement

METABOLISM OF N-HYDROXYGUANIDINES (N-HYDROXYDEBRISOQUINE) IN HUMAN AND PORCINE HEPATOCYTES: REDUCTION AND FORMATION OF GLUCURONIDES
Drug Metab Dispos 2005 33: 1532-1537. Published online July 20, 2005; 10.1124/dmd.105.004572 [Abstract] [Full Text] [PDF]  

Eyal Sobol, Boris Yagen, Ilan Winkler, Malka Britzi, Dan Gibson, and Meir Bialer

PHARMACOKINETICS AND METABOLISM OF A NEW POTENT ANTIEPILEPTIC DRUG, 2,2,3,3-TETRAMETHYCYCLOPROPANECARBONYLUREA, IN RATS
Drug Metab Dispos 2005 33: 1538-1546. Published online July 21, 2005; 10.1124/dmd.105.005637 [Abstract] [Full Text] [PDF]  

Seonghee Park and Patrick J. Sinko

THE BLOOD-BRAIN BARRIER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER: A MOLECULAR FUNCTIONAL IN VITRO-IN SITU CORRELATION
Drug Metab Dispos 2005 33: 1547-1554. Published online July 20, 2005; 10.1124/dmd.105.005231 [Abstract] [Full Text] [PDF]  

James M. Mathews, Amy S. Etheridge, John L. Valentine, Sherry R. Black, Donna P. Coleman, Purvi Patel, James So, and Leo T. Burka

PHARMACOKINETICS AND DISPOSITION OF THE KAVALACTONE KAWAIN: INTERACTION WITH KAVA EXTRACT AND KAVALACTONES IN VIVO AND IN VITRO
Drug Metab Dispos 2005 33: 1555-1563. Published online July 20, 2005; 10.1124/dmd.105.004317 [Abstract] [Full Text] [PDF]  

Commentaries:

Dennis A. Smith and R. Scott Obach

SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING
Drug Metab Dispos 2005 33: 1409-1417. Published online June 28, 2005; 10.1124/dmd.105.005041 [Abstract] [Full Text] [PDF]  

Short Communications:

Emilie Jigorel, Marc Le Vee, Claire Boursier-Neyret, Marc Bertrand, and Olivier Fardel

FUNCTIONAL EXPRESSION OF SINUSOIDAL DRUG TRANSPORTERS IN PRIMARY HUMAN AND RAT HEPATOCYTES
Drug Metab Dispos 2005 33: 1418-1422. Published online July 13, 2005; 10.1124/dmd.105.004762 [Abstract] [Full Text] [PDF]  

Xiuling Zhang, Qing-Yu Zhang, Dazhi Liu, Ting Su, Yan Weng, Guoyu Ling, Ying Chen, Jun Gu, Boris Schilling, and Xinxin Ding

EXPRESSION OF CYTOCHROME P450 AND OTHER BIOTRANSFORMATION GENES IN FETAL AND ADULT HUMAN NASAL MUCOSA
Drug Metab Dispos 2005 33: 1423-1428. Published online July 13, 2005; 10.1124/dmd.105.005769 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Janelle M. Hoskins, Sharon Marsh, and Howard L. McLeod

COMMENT ON "A FRAMESHIFT MUTATION AND ALTERNATE SPLICING IN HUMAN BRAIN GENERATE A FUNCTIONAL FORM OF THE PSEUDOGENE CYTOCHROME P4502D7 THAT DEMETHYLATES CODEINE TO MORPHINE"
Drug Metab Dispos 2005 33: 1564-1565. [Full Text] [PDF]  

Harish V. Pai and Vijayalakshmi Ravindranath

RESPONSE TO COMMENT ON "A FRAMESHIFT MUTATION AND ALTERNATE SPLICING IN HUMAN BRAIN GENERATE A FUNCTIONAL FORM OF THE PSEUDOGENE CYTOCHROME P4502D7 THAT DEMETHYLATES CODEINE TO MORPHINE"
Drug Metab Dispos 2005 33: 1566. [Full Text] [PDF]  

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