Articles:

Yoshihisa Kato, Hiroshi Suzuki, Shinichi Ikushiro, Shizuo Yamada, and Masakuni Degawa

DECREASE IN SERUM THYROXINE LEVEL BY PHENOBARBITAL IN RATS IS NOT NECESSARILY DEPENDENT ON INCREASE IN HEPATIC UDP-GLUCURONOSYLTRANSFERASE
Drug Metab Dispos 2005 33: 1608-1612. Published online July 27, 2005; 10.1124/dmd.105.005744 [Abstract] [Full Text] [PDF]  

Esther G. van de Kerkhof, Inge A. M. de Graaf, Marina H. de Jager, Dirk K. F. Meijer, and Geny M. M. Groothuis

CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES
Drug Metab Dispos 2005 33: 1613-1620. Published online July 28, 2005; 10.1124/dmd.105.005686 [Abstract] [Full Text] [PDF]  

Juntyma J. Engtrakul, Robert S. Foti, Timothy J. Strelevitz, and Michael B. Fisher

ALTERED AZT (3'-AZIDO-3'-DEOXYTHYMIDINE) GLUCURONIDATION KINETICS IN LIVER MICROSOMES AS AN EXPLANATION FOR UNDERPREDICTION OF IN VIVO CLEARANCE: COMPARISON TO HEPATOCYTES AND EFFECT OF INCUBATION ENVIRONMENT
Drug Metab Dispos 2005 33: 1621-1627. Published online July 27, 2005; 10.1124/dmd.105.005058 [Abstract] [Full Text] [PDF]  

Shuko Tachibana, Yuko Fujimaki, Hiroyuki Yokoyama, Osamu Okazaki, and Ken-ichi Sudo

IN VITRO METABOLISM OF THE CALMODULIN ANTAGONIST DY-9760e (3-[2-[4-(3-CHLORO-2-METHYLPHENYL)-1-PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-(4-IMIDAZOLYLMETHYL)-1H-INDAZOLE DIHYDROCHLORIDE 3.5 HYDRATE) BY HUMAN LIVER MICROSOMES: INVOLVEMENT OF CYTOCHROMES P450 IN ATYPICAL KINETICS AND POTENTIAL DRUG INTERACTIONS
Drug Metab Dispos 2005 33: 1628-1636. Published online July 27, 2005; 10.1124/dmd.105.004903 [Abstract] [Full Text] [PDF]  

Anthony Atkinson, Jane R. Kenny, and Ken Grime

AUTOMATED ASSESSMENT OF TIME-DEPENDENT INHIBITION OF HUMAN CYTOCHROME P450 ENZYMES USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ANALYSIS
Drug Metab Dispos 2005 33: 1637-1647. Published online July 27, 2005; 10.1124/dmd.105.005579 [Abstract] [Full Text] [PDF]  

Wolfgang Zwickenpflug, Stefan Tyroller, and Elmar Richter

METABOLISM OF MYOSMINE IN WISTAR RATS
Drug Metab Dispos 2005 33: 1648-1656. Published online August 3, 2005; 10.1124/dmd.104.003087 [Abstract] [Full Text] [PDF]  

Noriaki Sakai, Konomu Saito, Hyung-Sub Kim, Akio Kazusaka, Mayumi Ishizuka, Yoshihiko Funae, and Shoichi Fujita

IMPORTANCE OF CYP2D3 IN POLYMORPHISM OF DIAZEPAM P-HYDROXYLATION IN RATS
Drug Metab Dispos 2005 33: 1657-1660. Published online August 4, 2005; 10.1124/dmd.105.004242 [Abstract] [Full Text] [PDF]  

Yoshihisa Kato, Koichi Haraguchi, Tomoaki Yamazaki, Ryohei Kimura, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa

THE DECREASE IN LEVEL OF SERUM THYROXINE BY 2,2',4,5,5'-PENTACHLOROBIPHENYL IN RATS AND MICE: NO CORRELATION WITH FORMATION OF METHYLSULFONYL METABOLITES
Drug Metab Dispos 2005 33: 1661-1665. Published online August 18, 2005; 10.1124/dmd.105.006189 [Abstract] [Full Text] [PDF]  

Xiaodong Wang, Allan W. Wolkoff, and Marilyn E. Morris

FLAVONOIDS AS A NOVEL CLASS OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP1B1 (OATP-C) MODULATORS
Drug Metab Dispos 2005 33: 1666-1672. Published online August 4, 2005; 10.1124/dmd.105.005926 [Abstract] [Full Text] [PDF]  

Sung Yeon Kim, Y. R. Santosh Laxmi, Naomi Suzuki, Kenichiro Ogura, Tadashi Watabe, Michael W. Duffel, and Shinya Shibutani

FORMATION OF TAMOXIFEN-DNA ADDUCTS VIA O-SULFONATION, NOT O-ACETYLATION, OF -HYDROXYTAMOXIFEN IN RAT AND HUMAN LIVERS
Drug Metab Dispos 2005 33: 1673-1678. Published online August 11, 2005; 10.1124/dmd.105.005330 [Abstract] [Full Text] [PDF]  

Mitchell E. Taub, Lalitha Podila, Diane Ely, and Iliana Almeida

FUNCTIONAL ASSESSMENT OF MULTIPLE P-GLYCOPROTEIN (P-GP) PROBE SUBSTRATES: INFLUENCE OF CELL LINE AND MODULATOR CONCENTRATION ON P-GP ACTIVITY
Drug Metab Dispos 2005 33: 1679-1687. Published online August 10, 2005; 10.1124/dmd.105.005421 [Abstract] [Full Text] [PDF]  

Christopher L. Shaffer, Mithat Gunduz, Thomas N. O'Connell, R. Scott Obach, and Shiyin Yee

BIOTRANSFORMATION OF A GABA_A RECEPTOR PARTIAL AGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS: IDENTIFICATION OF TWO UNIQUE N-CARBAMOYL METABOLITES
Drug Metab Dispos 2005 33: 1688-1699. Published online August 4, 2005; 10.1124/dmd.105.004630 [Abstract] [Full Text] [PDF]  

Dermot F. McGinnity, James Tucker, Steve Trigg, and Robert J. Riley

PREDICTION OF CYP2C9-MEDIATED DRUG-DRUG INTERACTIONS: A COMPARISON USING DATA FROM RECOMBINANT ENZYMES AND HUMAN HEPATOCYTES
Drug Metab Dispos 2005 33: 1700-1707. Published online August 4, 2005; 10.1124/dmd.105.005884 [Abstract] [Full Text] [PDF]  

Katalin Monostory, Krisztina Kohalmy, Krisztina Ludányi, Gábor Czira, Sándor Holly, László Vereczkey, Iván Ürmös, Imre Klebovich, and László Kóbori

BIOTRANSFORMATION OF DERAMCICLANE IN PRIMARY HEPATOCYTES OF RAT, MOUSE, RABBIT, DOG, AND HUMAN
Drug Metab Dispos 2005 33: 1708-1716. Published online August 23, 2005; 10.1124/dmd.105.003764 [Abstract] [Full Text] [PDF]  

Katalin Monostory, Krisztina Köhalmy, Eszter Hazai, László Vereczkey, and László Kóbori

ROLE OF CYP2E1 IN DERAMCICLANE METABOLISM
Drug Metab Dispos 2005 33: 1717-1722. Published online June 2, 2005; 10.1124/dmd.105.003772 [Abstract] [Full Text] [PDF]  

Vinita Uttamsingh, Chuang Lu, Gerald Miwa, and Liang-Shang Gan

RELATIVE CONTRIBUTIONS OF THE FIVE MAJOR HUMAN CYTOCHROMES P450, 1A2, 2C9, 2C19, 2D6, AND 3A4, TO THE HEPATIC METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB
Drug Metab Dispos 2005 33: 1723-1728. Published online August 15, 2005; 10.1124/dmd.105.005710 [Abstract] [Full Text] [PDF]  

Donglu Zhang, Theodore J. Chando, Donald W. Everett, Christopher J. Patten, Shangara S. Dehal, and W. Griffith Humphreys

IN VITRO INHIBITION OF UDP GLUCURONOSYLTRANSFERASES BY ATAZANAVIR AND OTHER HIV PROTEASE INHIBITORS AND THE RELATIONSHIP OF THIS PROPERTY TO IN VIVO BILIRUBIN GLUCURONIDATION
Drug Metab Dispos 2005 33: 1729-1739. Published online August 23, 2005; 10.1124/dmd.105.005447 [Abstract] [Full Text] [PDF]  

Bernd Clement, Sabine Mau, Stephanie Deters, and Antje Havemeyer

HEPATIC, EXTRAHEPATIC, MICROSOMAL, AND MITOCHONDRIAL ACTIVATION OF THE N-HYDROXYLATED PRODRUGS BENZAMIDOXIME, GUANOXABENZ, AND RO 48-3656 ([[1-[(2S)-2-[[4-[(HYDROXYAMINO)IMINOMETHYL]BENZOYL]AMINO]-1-OXOPROPYL]-4-PIPERIDINYL]OXY]-ACETIC ACID)
Drug Metab Dispos 2005 33: 1740-1747. Published online August 23, 2005; 10.1124/dmd.105.005249 [Abstract] [Full Text] [PDF]  

Wolfgang Völkel, Nataly Bittner, and Wolfgang Dekant

QUANTITATION OF BISPHENOL A AND BISPHENOL A GLUCURONIDE IN BIOLOGICAL SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Drug Metab Dispos 2005 33: 1748-1757. Published online August 15, 2005; 10.1124/dmd.105.005454 [Abstract] [Full Text] [PDF]  

Commentaries:

A. David Rodrigues

IMPACT OF CYP2C9 GENOTYPE ON PHARMACOKINETICS: ARE ALL CYCLOOXYGENASE INHIBITORS THE SAME?
Drug Metab Dispos 2005 33: 1567-1575. Published online August 23, 2005; 10.1124/dmd.105.006452 [Abstract] [Full Text] [PDF]  

Short Communications:

Heike Lindenmaier, Melanie Becker, Walter Emil Haefeli, and Johanna Weiss

INTERACTION OF PROGESTINS WITH THE HUMAN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 (MRP2)
Drug Metab Dispos 2005 33: 1576-1579. Published online July 27, 2005; 10.1124/dmd.105.005314 [Abstract] [Full Text] [PDF]  

Johanna Weiss, Alexandra Sauer, Andreas Frank, and Matthias Unger

EXTRACTS AND KAVALACTONES OF PIPER METHYSTICUM G. FORST (KAVA-KAVA) INHIBIT P-GLYCOPROTEIN IN VITRO
Drug Metab Dispos 2005 33: 1580-1583. Published online July 28, 2005; 10.1124/dmd.105.005892 [Abstract] [Full Text] [PDF]  

Naoki Nishio, Toshiya Katsura, Kayoko Ashida, Masahiro Okuda, and Ken-ichi Inui

MODULATION OF P-GLYCOPROTEIN EXPRESSION IN HYPERTHYROID RAT TISSUES
Drug Metab Dispos 2005 33: 1584-1587. Published online August 3, 2005; 10.1124/dmd.105.004770 [Abstract] [Full Text] [PDF]  

Madoka Suzuki, Yutai Li, Philip C. Smith, James A. Swenberg, David E. Martin, Susan L. Morris-Natschke, and Kuo-Hsiung Lee

ANTI-AIDS AGENTS 65: INVESTIGATION OF THE IN VITRO OXIDATIVE METABOLISM OF 3',4'-DI-O-(–)-CAMPHANOYL-(+)-CIS-KHELLACTONE DERIVATIVES AS POTENT ANTI-HIV AGENTS
Drug Metab Dispos 2005 33: 1588-1592. Published online August 8, 2005; 10.1124/dmd.105.004218 [Abstract] [Full Text] [PDF]  

Kari T. Kivistö, Olaf Grisk, Ute Hofmann, Konrad Meissner, Klaus-Uwe Möritz, Christoph Ritter, Katja A. Arnold, Dieter Lutjöohann, Klaus von Bergmann, Ingrid Klöting, Michel Eichelbaum, and Heyo K. Kroemer

DISPOSITION OF ORAL AND INTRAVENOUS PRAVASTATIN IN MRP2-DEFICIENT TR^– RATS
Drug Metab Dispos 2005 33: 1593-1596. Published online August 17, 2005; 10.1124/dmd.105.006262 [Abstract] [Full Text] [PDF]  

Rhonda L. Stelck, Gregory L. Baker, Katherine M. Sutherland, and Laura S. Van Winkle

ESTROUS CYCLE ALTERS NAPHTHALENE METABOLISM IN FEMALE MOUSE AIRWAYS
Drug Metab Dispos 2005 33: 1597-1602. Published online August 5, 2005; 10.1124/dmd.105.005124 [Abstract] [Full Text] [PDF]  

May Fakhoury, Catherine Litalien, Yves Medard, Hélène Cavé, Nadia Ezzahir, Michel Peuchmaur, and Evelyne Jacqz-Aigrain

LOCALIZATION AND mRNA EXPRESSION OF CYP3A AND P-GLYCOPROTEIN IN HUMAN DUODENUM AS A FUNCTION OF AGE
Drug Metab Dispos 2005 33: 1603-1607. Published online July 27, 2005; 10.1124/dmd.105.005611 [Abstract] [Full Text] [PDF]  

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