Minireviews:

Charles W. Locuson and Jan L. Wahlstrom

THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF CYTOCHROMES P450: EFFECT OF INCORPORATING HIGHER-AFFINITY LIGANDS AND POTENTIAL NEW APPLICATIONS
Drug Metab Dispos 2005 33: 873-878. Published online April 20, 2005; 10.1124/dmd.105.004325 [Abstract] [Full Text] [PDF]  

Articles:

Henriette E. Meyer zu Schwabedissen, Gabriele Jedlitschky, Matthias Gratz, Sierk Haenisch, Knud Linnemann, Christoph Fusch, Ingolf Cascorbi, and Heyo K. Kroemer

VARIABLE EXPRESSION OF MRP2 (ABCC2) IN HUMAN PLACENTA: INFLUENCE OF GESTATIONAL AGE AND CELLULAR DIFFERENTIATION
Drug Metab Dispos 2005 33: 896-904. Published online April 8, 2005; 10.1124/dmd.104.003335 [Abstract] [Full Text] [PDF]  

Tappei Takada, Hiroshi Suzuki, Yukiko Gotoh, and Yuichi Sugiyama

REGULATION OF THE CELL SURFACE EXPRESSION OF HUMAN BCRP/ABCG2 BY THE PHOSPHORYLATION STATE OF AKT IN POLARIZED CELLS
Drug Metab Dispos 2005 33: 905-909. Published online April 20, 2005; 10.1124/dmd.104.003228 [Abstract] [Full Text] [PDF]  

Weihua Li, Hong Liu, Emily E. Scott, Frauke Gräter, James R. Halpert, Xiaoming Luo, Jianhua Shen, and Hualiang Jiang

POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION
Drug Metab Dispos 2005 33: 910-919. Published online April 8, 2005; 10.1124/dmd.105.004200 [Abstract] [Full Text] [PDF]  

Michael A. Mohutsky, David M. Petullo, and Steven A. Wrighton

THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES
Drug Metab Dispos 2005 33: 920-923. Published online March 31, 2005; 10.1124/dmd.105.004291 [Abstract] [Full Text] [PDF]  

Kaoru Kobayashi, Yosuke Yamanaka, Norihiko Iwazaki, Ikumi Nakajo, Masakiyo Hosokawa, Masahiko Negishi, and Kan Chiba

IDENTIFICATION OF HMG-CoA REDUCTASE INHIBITORS AS ACTIVATORS FOR HUMAN, MOUSE AND RAT CONSTITUTIVE ANDROSTANE RECEPTOR
Drug Metab Dispos 2005 33: 924-929. Published online March 31, 2005; 10.1124/dmd.104.002741 [Abstract] [Full Text] [PDF]  

Bo Yang, Zhiyun Meng, Junxing Dong, Liangping Yan, Libo Zou, Zhongming Tang, and Guifang Dou

METABOLIC PROFILE OF 1,5-DICAFFEOYLQUINIC ACID IN RATS, AN IN VIVO AND IN VITRO STUDY
Drug Metab Dispos 2005 33: 930-936. Published online March 31, 2005; 10.1124/dmd.104.002154 [Abstract] [Full Text] [PDF]  

Yuan Lu, Jean-Marie Heydel, Xin Li, Stacie Bratton, Tim Lindblom, and Anna Radominska-Pandya

LITHOCHOLIC ACID DECREASES EXPRESSION OF UGT2B7 IN CACO-2 CELLS: A POTENTIAL ROLE FOR A NEGATIVE FARNESOID X RECEPTOR RESPONSE ELEMENT
Drug Metab Dispos 2005 33: 937-946. Published online April 8, 2005; 10.1124/dmd.104.003061 [Abstract] [Full Text] [PDF]  

Jonathan M. Maher, Angela L. Slitt, Nathan J. Cherrington, Xingguo Cheng, and Curtis D. Klaassen

TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE
Drug Metab Dispos 2005 33: 947-955. Published online March 31, 2005; 10.1124/dmd.105.003780 [Abstract] [Full Text] [PDF]  

Jonathan M. Maher, Xingguo Cheng, Angela L. Slitt, Matthew Z. Dieter, and Curtis D. Klaassen

INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER
Drug Metab Dispos 2005 33: 956-962. Published online April 15, 2005; 10.1124/dmd.105.003798 [Abstract] [Full Text] [PDF]  

Harunobu Tahara, Hiroyuki Kusuhara, Eiichi Fuse, and Yuichi Sugiyama

P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION
Drug Metab Dispos 2005 33: 963-968. Published online April 8, 2005; 10.1124/dmd.105.004192 [Abstract] [Full Text] [PDF] [Erratum]   

Helen R. Winter and Jashvant D. Unadkat

IDENTIFICATION OF CYTOCHROME P450 AND ARYLAMINE N-ACETYLTRANSFERASE ISOFORMS INVOLVED IN SULFADIAZINE METABOLISM
Drug Metab Dispos 2005 33: 969-976. Published online April 20, 2005; 10.1124/dmd.104.002998 [Abstract] [Full Text] [PDF]  

Melanie N. Tallman, Joseph K. Ritter, and Philip C. Smith

DIFFERENTIAL RATES OF GLUCURONIDATION FOR 7-ETHYL-10-HYDROXY-CAMPTOTHECIN (SN-38) LACTONE AND CARBOXYLATE IN HUMAN AND RAT MICROSOMES AND RECOMBINANT UDP-GLUCURONOSYLTRANSFERASE ISOFORMS
Drug Metab Dispos 2005 33: 977-983. Published online April 15, 2005; 10.1124/dmd.104.003491 [Abstract] [Full Text] [PDF]  

Jens Teichert, Reinhard Sohr, Frank Baumann, Lothar Hennig, Karlheinz Merkle, Karel Caca, and Rainer Preiss

SYNTHESIS AND CHARACTERIZATION OF SOME NEW PHASE II METABOLITES OF THE ALKYLATOR BENDAMUSTINE AND THEIR IDENTIFICATION IN HUMAN BILE, URINE, AND PLASMA FROM PATIENTS WITH CHOLANGIOCARCINOMA
Drug Metab Dispos 2005 33: 984-992. Published online April 21, 2005; 10.1124/dmd.105.003624 [Abstract] [Full Text] [PDF]  

Trisha L. Noreault, Vsevolod E. Kostrubsky, Sheryl G. Wood, Ralph C. Nichols, Stephen C. Strom, Heidi W. Trask, Steven A. Wrighton, Ronald M. Evans, Judith M. Jacobs, Peter R. Sinclair, and Jacqueline F. Sinclair

ARSENITE DECREASES CYP3A4 AND RXR IN PRIMARY HUMAN HEPATOCYTES
Drug Metab Dispos 2005 33: 993-1003. Published online April 15, 2005; 10.1124/dmd.105.003954 [Abstract] [Full Text] [PDF]  

Dirk Roymans, Pieter Annaert, Jos Van Houdt, Adri Weygers, Jan Noukens, Carlo Sensenhauser, José Silva, Cis Van Looveren, Jan Hendrickx, Geert Mannens, and Willem Meuldermans

EXPRESSION AND INDUCTION POTENTIAL OF CYTOCHROMES P450 IN HUMAN CRYOPRESERVED HEPATOCYTES
Drug Metab Dispos 2005 33: 1004-1016. Published online March 31, 2005; 10.1124/dmd.104.003046 [Abstract] [Full Text] [PDF]  

Leena Luukkanen, Jyrki Taskinen, Mika Kurkela, Risto Kostiainen, Jouni Hirvonen, and Moshe Finel

KINETIC CHARACTERIZATION OF THE 1A SUBFAMILY OF RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES
Drug Metab Dispos 2005 33: 1017-1026. Published online March 31, 2005; 10.1124/dmd.105.004093 [Abstract] [Full Text] [PDF]  

Gwendolyn E. Kuehl, Johanna W. Lampe, John D. Potter, and Jeannette Bigler

GLUCURONIDATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: IDENTIFYING THE ENZYMES RESPONSIBLE IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2005 33: 1027-1035. Published online April 20, 2005; 10.1124/dmd.104.002527 [Abstract] [Full Text] [PDF]  

Brigitte A. Graf, William Mullen, Stuart T. Caldwell, Richard C. Hartley, Garry G. Duthie, Michael E. J. Lean, Alan Crozier, and Christine A. Edwards

DISPOSITION AND METABOLISM OF [2-¹⁴C]QUERCETIN-4'-GLUCOSIDE IN RATS
Drug Metab Dispos 2005 33: 1036-1043. Published online April 15, 2005; 10.1124/dmd.104.002691 [Abstract] [Full Text] [PDF]  

Christopher R. Gibson, Charles Lin, Rominder Singh, Cheri M. Brown, Karen Richards, Janice Brunner, Kimberly Michel, Jennifer Adelsberger, Edward Carlini, Catherine Boothe-Genthe, Conrad Raab, Minh Luu, Aimee Michael, Mona Parikh, Patrice Ciecko, Raju Subramanian, Paul Krolikowski, A. David Rodrigues, Thomas A. Baillie, and Thomas H. Rushmore

INDUCTION OF CYP1A IN THE BEAGLE DOG BY AN INHIBITOR OF KINASE INSERT DOMAIN-CONTAINING RECEPTOR: DIFFERENTIAL EFFECTS IN VITRO AND IN VIVO ON MRNA AND FUNCTIONAL ACTIVITY
Drug Metab Dispos 2005 33: 1044-1051. Published online April 15, 2005; 10.1124/dmd.105.003913 [Abstract] [Full Text] [PDF]  

Silvana Borges, Lang Li, Mitchell A. Hamman, David R. Jones, Stephen D. Hall, and J. Christopher Gorski

DEXTROMETHORPHAN TO DEXTRORPHAN URINARY METABOLIC RATIO DOES NOT REFLECT DEXTROMETHORPHAN ORAL CLEARANCE
Drug Metab Dispos 2005 33: 1052-1055. Published online April 8, 2005; 10.1124/dmd.104.003459 [Abstract] [Full Text] [PDF]  

D. E. Keyler, S. A. Roiko, E. Benlhabib, M. G. LeSage, J. V. St. Peter, S. Stewart, S. Fuller, C. T. Le, and P. R. Pentel

MONOCLONAL NICOTINE-SPECIFIC ANTIBODIES REDUCE NICOTINE DISTRIBUTION TO BRAIN IN RATS: DOSE- AND AFFINITY-RESPONSE RELATIONSHIPS
Drug Metab Dispos 2005 33: 1056-1061. Published online April 20, 2005; 10.1124/dmd.105.004234 [Abstract] [Full Text] [PDF]  

Xingguo Cheng, Jonathan Maher, Chuan Chen, and Curtis D. Klaassen

TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS)
Drug Metab Dispos 2005 33: 1062-1073. Published online April 20, 2005; 10.1124/dmd.105.003640 [Abstract] [Full Text] [PDF]  

Jeannine S. McCune, Linda J. Risler, Brian R. Phillips, Kenneth E. Thummel, David Blough, and Danny D. Shen

CONTRIBUTION OF CYP3A5 TO HEPATIC AND RENAL IFOSFAMIDE N-DECHLOROETHYLATION
Drug Metab Dispos 2005 33: 1074-1081. Published online April 8, 2005; 10.1124/dmd.104.002279 [Abstract] [Full Text] [PDF]  

Short Communications:

Zhuang Miao, Amin Kamel, and Chandra Prakash

CHARACTERIZATION OF A NOVEL METABOLITE INTERMEDIATE OF ZIPRASIDONE IN HEPATIC CYTOSOLIC FRACTIONS OF RAT, DOG, AND HUMAN BY ESI-MS/MS, HYDROGEN/DEUTERIUM EXCHANGE, AND CHEMICAL DERIVATIZATION
Drug Metab Dispos 2005 33: 879-883. Published online April 8, 2005; 10.1124/dmd.105.004036 [Abstract] [Full Text] [PDF]  

Jean-Nicholas Roy, Julie Lajoie, Lynn S. Zijenah, Azemi Barama, Charles Poirier, Brian J. Ward, and Michel Roger

CYP3A5 GENETIC POLYMORPHISMS IN DIFFERENT ETHNIC POPULATIONS
Drug Metab Dispos 2005 33: 884-887. Published online April 15, 2005; 10.1124/dmd.105.003822 [Abstract] [Full Text] [PDF]  

Fernando A. Crocenzi, Vanesa D'Andrea, Viviana A. Catania, Marcelo G. Luquita, José M. Pellegrino, J. Elena Ochoa, Aldo D. Mottino, and Enrique J. Sánchez Pozzi

PREVENTION OF MRP2 ACTIVITY IMPAIRMENT IN ETHINYLESTRADIOL-INDUCED CHOLESTASIS BY URSODEOXYCHOLATE IN THE RAT
Drug Metab Dispos 2005 33: 888-891. Published online April 20, 2005; 10.1124/dmd.104.003533 [Abstract] [Full Text] [PDF]  

Antonius E. van Herwaarden, Johan W. Smit, Rolf W. Sparidans, Els Wagenaar, Cornelia M. M. van der Kruijssen, Jan H. M. Schellens, Jos H. Beijnen, and Alfred H. Schinkel

MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4
Drug Metab Dispos 2005 33: 892-895. Published online April 21, 2005; 10.1124/dmd.105.004721 [Abstract] [Full Text] [PDF]  

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