Articles:

Daisuke Tenmizu, Kiyoshi Noguchi, and Hidetaka Kamimura

Elucidation of the Effects of the CYP1A2 Deficiency Polymorphism in the Metabolism of 4-Cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1H)-one (YM-64227), a Phosphodiesterase Type 4 Inhibitor, and Its Metabolites in Dogs
Drug Metab Dispos 2006 34: 1811-1816. Published online August 1, 2006; 10.1124/dmd.106.011213 [Abstract] [Full Text] [PDF]  

Lorenz M. Jost, Hans-Peter Gschwind, Tarja Jalava, Yongyu Wang, Clemens Guenther, Claire Souppart, Antje Rottmann, Karsten Denner, Felix Waldmeier, Gerhard Gross, Eric Masson, and Dirk Laurent

Metabolism and Disposition of Vatalanib (PTK787/ZK-222584) in Cancer Patients
Drug Metab Dispos 2006 34: 1817-1828. Published online August 1, 2006; 10.1124/dmd.106.009944 [Abstract] [Full Text] [PDF]  

David Hallifax and J. Brian Houston

Uptake and Intracellular Binding of Lipophilic Amine Drugs by Isolated Rat Hepatocytes and Implications for Prediction of in Vivo Metabolic Clearance
Drug Metab Dispos 2006 34: 1829-1836. Published online August 1, 2006; 10.1124/dmd.106.010413 [Abstract] [Full Text] [PDF]  

Stephen W. J. Wang, Jun Chen, Xiaobin Jia, Vincent H. Tam, and Ming Hu

Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties
Drug Metab Dispos 2006 34: 1837-1848. Published online August 1, 2006; 10.1124/dmd.106.009910 [Abstract] [Full Text] [PDF]  

Chitra Sridar, Yoshimasa Kobayashi, Holly Brevig, Ute M. Kent, Satish G. Puppali, John M. Rimoldi, and Paul F. Hollenberg

Synthesis of Substituted Phenyl Diaziridines and Characterization as Mechanism-Based Inactivators of Human Cytochrome P450 2B6
Drug Metab Dispos 2006 34: 1849-1855. Published online August 1, 2006; 10.1124/dmd.106.010082 [Abstract] [Full Text] [PDF] [Data Supplement]   

A. I. Loureiro, M. J. Bonifácio, C. Fernandes-Lopes, L. Almeida, L. C. Wright, and P. Soares-Da-Silva

Human Metabolism of Nebicapone (BIA 3-202), a Novel Catechol-O-Methyltransferase Inhibitor: Characterization of in Vitro Glucuronidation
Drug Metab Dispos 2006 34: 1856-1862. Published online June 21, 2006; 10.1124/dmd.106.010447 [Abstract] [Full Text] [PDF]  

Xingguo Cheng and Curtis D. Klaassen

Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine
Drug Metab Dispos 2006 34: 1863-1867. Published online August 23, 2006; 10.1124/dmd.106.010520 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kin-ya Ohta, Katsuhisa Inoue, Yayoi Hayashi, and Hiroaki Yuasa

Molecular Identification and Functional Characterization of Rat Multidrug and Toxin Extrusion Type Transporter 1 as an Organic Cation/H⁺ Antiporter in the Kidney
Drug Metab Dispos 2006 34: 1868-1874. Published online August 23, 2006; 10.1124/dmd.106.010876 [Abstract] [Full Text] [PDF]  

Tsukasa Uno, Mikiko Shimizu, Kazunobu Sugawara, and Tomonori Tateishi

Lack of Dose-Dependent Effects of Itraconazole on the Pharmacokinetic Interaction with Fexofenadine
Drug Metab Dispos 2006 34: 1875-1879. Published online August 23, 2006; 10.1124/dmd.106.011023 [Abstract] [Full Text] [PDF]  

Takashi Nakazawa, Kengo Miyata, Koichi Omura, Takashi Iwanaga, and Osamu Nagata

Metabolic Profile of FYX-051 (4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile) in the Rat, Dog, Monkey, and Human: Identification of N-Glucuronides and N-Glucosides
Drug Metab Dispos 2006 34: 1880-1886. Published online August 16, 2006; 10.1124/dmd.106.011692 [Abstract] [Full Text] [PDF]  

Sebastian Luci, Holger Kluge, Frank Hirche, and Klaus Eder

Clofibrate Increases Hepatic Triiodothyronine (T₃)- and Thyroxine (T₄)-Glucuronosyltransferase Activities and Lowers Plasma T₃ and T₄ Concentrations in Pigs
Drug Metab Dispos 2006 34: 1887-1892. Published online August 8, 2006; 10.1124/dmd.106.011379 [Abstract] [Full Text] [PDF]  

Esther G. van de Kerkhof, Anna-Lena B. Ungell, Åsa K. Sjöberg, Marina H. de Jager, Constanze Hilgendorf, Inge A. M. de Graaf, and Geny M. M. Groothuis

Innovative Methods to Study Human Intestinal Drug Metabolism in Vitro: Precision-Cut Slices Compared with Ussing Chamber Preparations
Drug Metab Dispos 2006 34: 1893-1902. Published online August 16, 2006; 10.1124/dmd.106.011148 [Abstract] [Full Text] [PDF]  

Vikas Kumar, Dan A. Rock, Chad J. Warren, Timothy S. Tracy, and Jan L. Wahlstrom

Enzyme Source Effects on CYP2C9 Kinetics and Inhibition
Drug Metab Dispos 2006 34: 1903-1908. Published online August 23, 2006; 10.1124/dmd.106.010249 [Abstract] [Full Text] [PDF]  

Jennifer L. Burkey, Kristina M. Campanale, Robert Barbuch, Douglas O'Bannon, James Rash, Charles Benson, and David Small

Disposition of [¹⁴C]Ruboxistaurin in Humans
Drug Metab Dispos 2006 34: 1909-1917. Published online August 8, 2006; 10.1124/dmd.106.009894 [Abstract] [Full Text] [PDF]  

Angelo Paci, Keyvan Rezai, Alain Deroussent, Dominique De Valeriola, Micheline Re, Sophie Weill, Esteban Cvitkovic, Carmen Kahatt, Ajit Shah, Stephen Waters, Gary Weems, Gilles Vassal, and François Lokiec

Pharmacokinetics, Metabolism, and Routes of Excretion of Intravenous Irofulven in Patients with Advanced Solid Tumors
Drug Metab Dispos 2006 34: 1918-1926. Published online August 8, 2006; 10.1124/dmd.106.010512 [Abstract] [Full Text] [PDF]  

Chizuru Watanabe, Yukio Kato, Tomoko Sugiura, Yoshiyuki Kubo, Tomohiko Wakayama, Shoichi Iseki, and Akira Tsuji

PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression
Drug Metab Dispos 2006 34: 1927-1934. Published online August 8, 2006; 10.1124/dmd.106.010207 [Abstract] [Full Text] [PDF]  

Yan Zhang, Cheryl S. W. Li, Yuyang Ye, Kjell Johnson, Julie Poe, Shannon Johnson, Walter Bobrowski, Rosario Garrido, and Cherukury Madhu

Porcine Brain Microvessel Endothelial Cells as an in Vitro Model to Predict in Vivo Blood-Brain Barrier Permeability
Drug Metab Dispos 2006 34: 1935-1943. Published online August 8, 2006; 10.1124/dmd.105.006437 [Abstract] [Full Text] [PDF]  

Short Communications:

Kwang-Hyeon Liu, Mi-Gyung Kim, Dong-Jun Lee, Yune-Jung Yoon, Min-Jung Kim, Ji-Hong Shon, Chang Soo Choi, Young Kil Choi, Zeuresenay Desta, and Jae-Gook Shin

Characterization of Ebastine, Hydroxyebastine, and Carebastine Metabolism by Human Liver Microsomes and Expressed Cytochrome P450 Enzymes: Major Roles for CYP2J2 and CYP3A
Drug Metab Dispos 2006 34: 1793-1797. Published online August 8, 2006; 10.1124/dmd.106.010488 [Abstract] [Full Text] [PDF]  

Hai-Zhi Bu, Ping Zhao, Ping Kang, William F. Pool, and Ellen Y. Wu

Identification of Enzymes Responsible for Primary and Sequential Oxygenation Reactions of Capravirine in Human Liver Microsomes
Drug Metab Dispos 2006 34: 1798-1802. Published online August 16, 2006; 10.1124/dmd.106.011189 [Abstract] [Full Text] [PDF]  

Hiroshi Yamazaki, Makiko Shimizu, Takashi Nagashima, Masaki Minoshima, and Norie Murayama

Rat Cytochrome P450 2C11 in Liver Microsomes Involved in Oxidation of Anesthetic Agent Propofol and Deactivated by Prior Treatment with Propofol
Drug Metab Dispos 2006 34: 1803-1805. Published online August 8, 2006; 10.1124/dmd.106.011627 [Abstract] [Full Text] [PDF]  

Thomayant Prueksaritanont, Chunze Li, Cuyue Tang, Yuhsin Kuo, Kristie Strong-Basalyga, and Brian Carr

Rifampin Induces the in Vitro Oxidative Metabolism, but Not the in Vivo Clearance of Diclofenac in Rhesus Monkeys
Drug Metab Dispos 2006 34: 1806-1810. Published online August 23, 2006; 10.1124/dmd.106.011643 [Abstract] [Full Text] [PDF]  

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