Articles:

Santosh Kumar, Hong Liu, and James R. Halpert

Engineering of Cytochrome P450 3A4 for Enhanced Peroxide-Mediated Substrate Oxidation Using Directed Evolution and Site-Directed Mutagenesis
Drug Metab Dispos 2006 34: 1958-1965. Published online September 20, 2006; 10.1124/dmd.106.012054 [Abstract] [Full Text] [PDF]  

Vikas Kumar, Jan L. Wahlstrom, Dan A. Rock, Chad J. Warren, Lee A. Gorman, and Timothy S. Tracy

CYP2C9 Inhibition: Impact of Probe Selection and Pharmacogenetics on in Vitro Inhibition Profiles
Drug Metab Dispos 2006 34: 1966-1975. Published online September 8, 2006; 10.1124/dmd.106.010926 [Abstract] [Full Text] [PDF]  

Cheng Chang, Praveen M. Bahadduri, James E. Polli, Peter W. Swaan, and Sean Ekins

Rapid Identification of P-glycoprotein Substrates and Inhibitors
Drug Metab Dispos 2006 34: 1976-1984. Published online September 22, 2006; 10.1124/dmd.106.012351 [Abstract] [Full Text] [PDF]  

Michael Zhuo Wang, Janelle Y. Saulter, Etsuko Usuki, Yen-Ling Cheung, Michael Hall, Arlene S. Bridges, Greg Loewen, Oliver T. Parkinson, Chad E. Stephens, James L. Allen, Darryl C. Zeldin, David W. Boykin, Richard R. Tidwell, Andrew Parkinson, Mary F. Paine, and James Edwin Hall

CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]
Drug Metab Dispos 2006 34: 1985-1994. Published online September 22, 2006; 10.1124/dmd.106.010587 [Abstract] [Full Text] [PDF]  

Tímea Borbás, Jun Zhang, Matt A. Cerny, István Likó, and John R. Cashman

Investigation of Structure and Function of a Catalytically Efficient Variant of the Human Flavin-Containing Monooxygenase Form 3
Drug Metab Dispos 2006 34: 1995-2002. Published online September 19, 2006; 10.1124/dmd.106.010827 [Abstract] [Full Text] [PDF]  

Jonathan P. Jackson, Stephen S. Ferguson, Masahiko Negishi, and Joyce A. Goldstein

Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor
Drug Metab Dispos 2006 34: 2003-2010. Published online August 25, 2006; 10.1124/dmd.106.012005 [Abstract] [Full Text] [PDF]  

J. Tarning, Y. Bergqvist, N. P. Day, J. Bergquist, B. Arvidsson, N. J. White, M. Ashton, and N. Lindegårdh

Characterization of Human Urinary Metabolites of the Antimalarial Piperaquine
Drug Metab Dispos 2006 34: 2011-2019. Published online September 6, 2006; 10.1124/dmd.106.011494 [Abstract] [Full Text] [PDF]  

Dojung Kim and Burhan I. Ghanayem

Comparative Metabolism and Disposition of Trichloroethylene in Cyp2e1–/–and Wild-Type Mice
Drug Metab Dispos 2006 34: 2020-2027. Published online September 7, 2006; 10.1124/dmd.106.010538 [Abstract] [Full Text] [PDF]  

R. Frapolli, E. Marangon, M. Zaffaroni, T. Colombo, C. Falcioni, R. Bagnati, M. Simone, M. D'Incalci, C. Manzotti, G. Fontana, P. Morazzoni, and M. Zucchetti

Pharmacokinetics and Metabolism in Mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a New Oral C-seco-Taxane Derivative with Antiangiogenic Property Effective on Paclitaxel-Resistant Tumors
Drug Metab Dispos 2006 34: 2028-2035. Published online September 8, 2006; 10.1124/dmd.106.012153 [Abstract] [Full Text] [PDF]  

Joseph T. Dever and Adnan A. Elfarra

In Vivo Metabolism of L-Methionine in Mice: Evidence for Stereoselective Formation of Methionine-d-Sulfoxide and Quantitation of Other Major Metabolites
Drug Metab Dispos 2006 34: 2036-2043. Published online September 8, 2006; 10.1124/dmd.106.012104 [Abstract] [Full Text] [PDF]  

Chungang Gu, Roxane Collins, Daniel D. Holsworth, Gregory S. Walker, and Richard L. Voorman

Metabolic Aromatization of N-Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase
Drug Metab Dispos 2006 34: 2044-2055. Published online September 19, 2006; 10.1124/dmd.106.012286 [Abstract] [Full Text] [PDF]  

Mizuki Ninomiya, Kousei Ito, Remi Hiramatsu, and Toshiharu Horie

Functional Analysis of Mouse and Monkey Multidrug Resistance-Associated Protein 2 (Mrp2)
Drug Metab Dispos 2006 34: 2056-2063. Published online August 25, 2006; 10.1124/dmd.106.010991 [Abstract] [Full Text] [PDF] [Data Supplement]   

Feng Zuo, Norio Nakamura, Teruaki Akao, and Masao Hattori

Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry
Drug Metab Dispos 2006 34: 2064-2072. Published online September 6, 2006; 10.1124/dmd.106.011361 [Abstract] [Full Text] [PDF]  

Jae H. Chang, Christopher J. Kochansky, and Magang Shou

The Role of P-glycoprotein in the Bioactivation of Raloxifene
Drug Metab Dispos 2006 34: 2073-2078. Published online September 7, 2006; 10.1124/dmd.106.012179 [Abstract] [Full Text] [PDF]  

Maylee Chen, Anne N. Nafziger, and Joseph S. Bertino, Jr.

Drug-Metabolizing Enzyme Inhibition by Ketoconazole Does Not Reduce Interindividual Variability of CYP3A Activity as Measured by Oral Midazolam
Drug Metab Dispos 2006 34: 2079-2082. Published online September 22, 2006; 10.1124/dmd.106.011742 [Abstract] [Full Text] [PDF]  

Anne S. Kienhuis, Heleen M. Wortelboer, Jean-Christophe Hoflack, Edwin J. Moonen, Jos C.S. Kleinjans, Ben van Ommen, Joost H. M. van Delft, and Rob H. Stierum

Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach
Drug Metab Dispos 2006 34: 2083-2090. Published online September 8, 2006; 10.1124/dmd.106.011262 [Abstract] [Full Text] [PDF]  

Marjo J. Karjalainen, Pertti J. Neuvonen, and Janne T. Backman

Rofecoxib Is a Potent, Metabolism-Dependent Inhibitor of CYP1A2: Implications for in Vitro Prediction of Drug Interactions
Drug Metab Dispos 2006 34: 2091-2096. Published online September 19, 2006; 10.1124/dmd.106.011965 [Abstract] [Full Text] [PDF]  

Matthew J. Zaya, Ronald N. Hines, and Jeffrey C. Stevens

Epirubicin Glucuronidation and UGT2B7 Developmental Expression
Drug Metab Dispos 2006 34: 2097-2101. Published online September 19, 2006; 10.1124/dmd.106.011387 [Abstract] [Full Text] [PDF]  

Yoshimasa Kobayashi, Chitra Sridar, Ute M. Kent, Satish G. Puppali, John M. Rimoldi, Haoming Zhang, Lucy Waskell, and Paul F. Hollenberg

Structure-Activity Relationship and Elucidation of the Determinant Factor(s) Responsible for the Mechanism-Based Inactivation of Cytochrome P450 2B6 by Substituted Phenyl Diaziridines
Drug Metab Dispos 2006 34: 2102-2110. Published online September 22, 2006; 10.1124/dmd.106.011452 [Abstract] [Full Text] [PDF]  

Joshua D. Lambert, Shengmin Sang, Jungil Hong, Seok-Joo Kwon, Mao-Jung Lee, Chi-Tang Ho, and Chung S. Yang

Peracetylation as a Means of Enhancing in Vitro Bioactivity and Bioavailability of Epigallocatechin-3-Gallate
Drug Metab Dispos 2006 34: 2111-2116. Published online September 22, 2006; 10.1124/dmd.106.011460 [Abstract] [Full Text] [PDF]  

Short Communications:

Sébastien Bihorel, Gian Camenisch, Gerhard Gross, Michel Lemaire, and Jean-Michel Scherrmann

Influence of Hydroxyurea On Imatinib Mesylate (Gleevec) Transport at the Mouse Blood-Brain Barrier
Drug Metab Dispos 2006 34: 1945-1949. Published online August 25, 2006; 10.1124/dmd.106.010975 [Abstract] [Full Text] [PDF]  

Oranun Kerdpin, David J. Elliot, Peter I. Mackenzie, and John O. Miners

Sulfinpyrazone C-Glucuronidation Is Catalyzed Selectively by Human UDP-Glucuronosyltransferase 1A9
Drug Metab Dispos 2006 34: 1950-1953. Published online September 19, 2006; 10.1124/dmd.106.012385 [Abstract] [Full Text] [PDF]  

Charles W. Locuson and Timothy S. Tracy

Identification of Binding Sites of Non-I-Helix Water Molecules in Mammalian Cytochromes P450
Drug Metab Dispos 2006 34: 1954-1957. Published online September 6, 2006; 10.1124/dmd.106.011890 [Abstract] [Full Text] [PDF]  

Erratum:

CORRECTION TO "NEUROTOXIC PYRIDINIUM METABOLITES OF HALOPERIDOL ARE SUBSTRATES OF HUMAN ORGANIC CATION TRANSPORTERS"
Drug Metab Dispos 2006 34: 2117. [Full Text] [PDF]  

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