Minireviews:

Irina A. Pikuleva

CHOLESTEROL-METABOLIZING CYTOCHROMES P450
Drug Metab Dispos 2006 34: 513-520. Published online January 24, 2006; 10.1124/dmd.105.008789 [Abstract] [Full Text] [PDF]  

Articles:

Henriette E. Meyer zu Schwabedissen, Markus Grube, Annette Dreisbach, Gabriele Jedlitschky, Konrad Meissner, Knud Linnemann, Christoph Fusch, Christoph A. Ritter, Uwe Völker, and Heyo K. Kroemer

EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG2 (BCRP)
Drug Metab Dispos 2006 34: 524-533. Published online January 13, 2006; 10.1124/dmd.105.007591 [Abstract] [Full Text] [PDF]  

Jean-Didier Marechal, Jinglei Yu, Simon Brown, Iouri Kapelioukh, Elaine M. Rankin, C. Roland Wolf, Gordon C. K. Roberts, Mark. J. I. Paine, and Michael J. Sutcliffe

IN SILICO AND IN VITRO SCREENING FOR INHIBITION OF CYTOCHROME P450 CYP3A4 BY COMEDICATIONS COMMONLY USED BY PATIENTS WITH CANCER
Drug Metab Dispos 2006 34: 534-538. Published online January 13, 2006; 10.1124/dmd.105.007625 [Abstract] [Full Text] [PDF]  

Da-Wei Zhang, Kenichi Nunoya, Monika Vasa, Hong-Mei Gu, Susan P. C. Cole, and Roger G. Deeley

MUTATIONAL ANALYSIS OF POLAR AMINO ACID RESIDUES WITHIN PREDICTED TRANSMEMBRANE HELICES 10 AND 16 OF MULTIDRUG RESISTANCE PROTEIN 1 (ABCC1): EFFECT ON SUBSTRATE SPECIFICITY
Drug Metab Dispos 2006 34: 539-546. Published online January 13, 2006; 10.1124/dmd.105.007740 [Abstract] [Full Text] [PDF]  

Meng Li, Gail D. Anderson, Brian R. Phillips, Wei Kong, Danny D. Shen, and Joanne Wang

INTERACTIONS OF AMOXICILLIN AND CEFACLOR WITH HUMAN RENAL ORGANIC ANION AND PEPTIDE TRANSPORTERS
Drug Metab Dispos 2006 34: 547-555. Published online January 24, 2006; 10.1124/dmd.105.006791 [Abstract] [Full Text] [PDF]  

Brendan M. Johnson, Peijin Zhang, John D. Schuetz, and Kim L. R. Brouwer

CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS
Drug Metab Dispos 2006 34: 556-562. Published online October 4, 2005; 10.1124/dmd.105.005793 [Abstract] [Full Text] [PDF] [Data Supplement] [Authors' Note]   

Andrea Gaedigk, L. DiAnne Bradford, Sarah W. Alander, and J. Steven Leeder

CYP2D6*36 GENE ARRANGEMENTS WITHIN THE CYP2D6 LOCUS: ASSOCIATION OF CYP2D6*36 WITH POOR METABOLIZER STATUS
Drug Metab Dispos 2006 34: 563-569. Published online January 13, 2006; 10.1124/dmd.105.008292 [Abstract] [Full Text] [PDF]  

Dirk Bier, Marcus H. Holschbach, Walter Wutz, Ray A. Olsson, and Heinz H. Coenen

METABOLISM OF THE A₁ ADENOSINE RECEPTOR POSITRON EMISSION TOMOGRAPHY LIGAND [¹⁸F]8-CYCLOPENTYL-3-(3-FLUOROPROPYL)-1-PROPYLXANTHINE ([¹⁸F]CPFPX) IN RODENTS AND HUMANS
Drug Metab Dispos 2006 34: 570-576. Published online January 13, 2006; 10.1124/dmd.105.006411 [Abstract] [Full Text] [PDF]  

Hiromi Fuchikami, Hiroki Satoh, Masayuki Tsujimoto, Shigehiro Ohdo, Hisakazu Ohtani, and Yasufumi Sawada

EFFECTS OF HERBAL EXTRACTS ON THE FUNCTION OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP-B
Drug Metab Dispos 2006 34: 577-582. Published online January 13, 2006; 10.1124/dmd.105.007872 [Abstract] [Full Text] [PDF]  

Kent L. Kunze, Wendel L. Nelson, Evan D. Kharasch, Kenneth E. Thummel, and Nina Isoherranen

STEREOCHEMICAL ASPECTS OF ITRACONAZOLE METABOLISM IN VITRO AND IN VIVO
Drug Metab Dispos 2006 34: 583-590. Published online January 13, 2006; 10.1124/dmd.105.008508 [Abstract] [Full Text] [PDF]  

Inge A. M. de Graaf, Ruben de Kanter, Marina H. de Jager, Raquel Camacho, Elise Langenkamp, Esther G. van de Kerkhof, and Geny M. M. Groothuis

EMPIRICAL VALIDATION OF A RAT IN VITRO ORGAN SLICE MODEL AS A TOOL FOR IN VIVO CLEARANCE PREDICTION
Drug Metab Dispos 2006 34: 591-599. Published online January 13, 2006; 10.1124/dmd.105.006726 [Abstract] [Full Text] [PDF]  

Jessica L. Fayer Rehmel, James A. Eckstein, Nagy A. Farid, John B. Heim, Steve C. Kasper, Atsushi Kurihara, Steven A. Wrighton, and Barbara J. Ring

INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450
Drug Metab Dispos 2006 34: 600-607. Published online January 13, 2006; 10.1124/dmd.105.007989 [Abstract] [Full Text] [PDF]  

Carole Giraud, Jean-Marc Treluyer, Elisabeth Rey, Catherine Chiron, Jean Vincent, Gérard Pons, and Agnès Tran

IN VITRO AND IN VIVO INHIBITORY EFFECT OF STIRIPENTOL ON CLOBAZAM METABOLISM
Drug Metab Dispos 2006 34: 608-611. Published online January 13, 2006; 10.1124/dmd.105.007237 [Abstract] [Full Text] [PDF]  

Daniel Eikel, Katrin Hoffmann, Karolin Zoll, Alfonso Lampen, and Heinz Nau

S-2-PENTYL-4-PENTYNOIC HYDROXAMIC ACID AND ITS METABOLITE S-2-PENTYL-4-PENTYNOIC ACID IN THE NMRI-EXENCEPHALY-MOUSE MODEL: PHARMACOKINETIC PROFILES, TERATOGENIC EFFECTS, AND HISTONE DEACETYLASE INHIBITION ABILITIES OF FURTHER VALPROIC ACID HYDROXAMATES AND AMIDES
Drug Metab Dispos 2006 34: 612-620. Published online January 13, 2006; 10.1124/dmd.105.008078 [Abstract] [Full Text] [PDF]  

Chuanhui Yu, Joseph K. Ritter, Richard J. Krieg, Bhaskar Rege, Thomas H. Karnes, and Mohamadi A. Sarkar

EFFECT OF CHRONIC RENAL INSUFFICIENCY ON HEPATIC AND RENAL UDP-GLUCURONYLTRANSFERASES IN RATS
Drug Metab Dispos 2006 34: 621-627. Published online January 13, 2006; 10.1124/dmd.105.006601 [Abstract] [Full Text] [PDF]  

Anima Ghosal, Swapan K. Chowdhury, Wei Tong, Neil Hapangama, Yuan Yuan, Ai-Duen Su, and Shmuel Zbaida

IDENTIFICATION OF HUMAN LIVER CYTOCHROME P450 ENZYMES RESPONSIBLE FOR THE METABOLISM OF LONAFARNIB (SARASAR)
Drug Metab Dispos 2006 34: 628-635. Published online January 27, 2006; 10.1124/dmd.105.007906 [Abstract] [Full Text] [PDF]  

Marianne Garland, Kirsten M. Abildskov, Samantha Taylor, Kenza Benzeroual, Casper S. Caspersen, Sylvia E. Arroyo, Tung-wah Kiu, Boris Reznik, Piper Weldy, Salha S. Daniel, and Raymond I. Stark

FETAL MORPHINE METABOLISM AND CLEARANCE ARE CONSTANT DURING LATE GESTATION
Drug Metab Dispos 2006 34: 636-646. Published online January 27, 2006; 10.1124/dmd.105.007567 [Abstract] [Full Text] [PDF]  

Meenal Joshi and Rachel F. Tyndale

INDUCTION AND RECOVERY TIME COURSE OF RAT BRAIN CYP2E1 AFTER NICOTINE TREATMENT
Drug Metab Dispos 2006 34: 647-652. Published online January 24, 2006; 10.1124/dmd.105.008029 [Abstract] [Full Text] [PDF]  

Bradley D. Anderson, Melissa J. May, Sherri Jordan, Lin Song, Michael J. Roberts, and Markos Leggas

DEPENDENCE OF NELFINAVIR BRAIN UPTAKE ON DOSE AND TISSUE CONCENTRATIONS OF THE SELECTIVE P-GLYCOPROTEIN INHIBITOR ZOSUQUIDAR IN RATS
Drug Metab Dispos 2006 34: 653-659. Published online January 24, 2006; 10.1124/dmd.105.006536 [Abstract] [Full Text] [PDF]  

James R. Reed, Rusty W. Kelley, and Wayne L. Backes

AN EVALUATION OF METHODS FOR THE RECONSTITUTION OF CYTOCHROMES P450 AND NADPH P450 REDUCTASE INTO LIPID VESICLES
Drug Metab Dispos 2006 34: 660-666. Published online January 13, 2006; 10.1124/dmd.105.006825 [Abstract] [Full Text] [PDF]  

Wassim Daher, Lydie Pelinski, Sylvie Klieber, Freddy Sadoun, Viviane Meunier, Martine Bourrié, Christophe Biot, François Guillou, Gérard Fabre, Jacques Brocard, Laurent Fraisse, Jean-Pierre Maffrand, Jamal Khalife, and Daniel Dive

IN VITRO METABOLISM OF FERROQUINE (SSR97193) IN ANIMAL AND HUMAN HEPATIC MODELS AND ANTIMALARIAL ACTIVITY OF MAJOR METABOLITES ON PLASMODIUM FALCIPARUM
Drug Metab Dispos 2006 34: 667-682. Published online January 13, 2006; 10.1124/dmd.104.003202 [Abstract] [Full Text] [PDF]  

Sang K. Kim, Mohamed A. Abdelmegeed, and Raymond F. Novak

THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK
Drug Metab Dispos 2006 34: 683-689. Published online January 27, 2006; 10.1124/dmd.105.007666 [Abstract] [Full Text] [PDF]  

Gracia Merino, Ana I. Álvarez, Mivis M. Pulido, Antonio J. Molina, Alfred H. Schinkel, and Julio G. Prieto

BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) TRANSPORTS FLUOROQUINOLONE ANTIBIOTICS AND AFFECTS THEIR ORAL AVAILABILITY, PHARMACOKINETICS, AND MILK SECRETION
Drug Metab Dispos 2006 34: 690-695. Published online January 24, 2006; 10.1124/dmd.105.008219 [Abstract] [Full Text] [PDF]  

Masaru Tsutsui, Shinichiro Ogawa, Yoichi Inada, Eisuke Tomioka, Akiko Kamiyoshi, Satoru Tanaka, Tomoyuki Kishida, Masahiko Nishiyama, Makoto Murakami, Junji Kuroda, Yasuhiko Hashikura, Shinichi Miyagawa, Fumiyasu Satoh, Nobuo Shibata, and Yoh-ichi Tagawa

CHARACTERIZATION OF CYTOCHROME P450 EXPRESSION IN MURINE EMBRYONIC STEM CELL-DERIVED HEPATIC TISSUE SYSTEM
Drug Metab Dispos 2006 34: 696-701. Published online January 13, 2006; 10.1124/dmd.105.007674 [Abstract] [Full Text] [PDF]  

Chuang Lu, Richard Gallegos, Ping Li, Cindy Q. Xia, Sandeepraj Pusalkar, Vinita Uttamsingh, Darrell Nix, Gerald T. Miwa, and Liang-Shang Gan

INVESTIGATION OF DRUG-DRUG INTERACTION POTENTIAL OF BORTEZOMIB IN VIVO IN FEMALE SPRAGUE-DAWLEY RATS AND IN VITRO IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2006 34: 702-708. Published online January 27, 2006; 10.1124/dmd.105.008060 [Abstract] [Full Text] [PDF]  

Deepak Dalvie, Evan Smith, Alan Deese, and Stephen Bowlin

IN VITRO METABOLIC ACTIVATION OF THIABENDAZOLE VIA 5-HYDROXYTHIABENDAZOLE: IDENTIFICATION OF A GLUTATHIONE CONJUGATE OF 5-HYDROXYTHIABENDAZOLE
Drug Metab Dispos 2006 34: 709-717. Published online January 24, 2006; 10.1124/dmd.105.008094 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ken-ichi Nezasa, Xianbin Tian, Maciej J. Zamek-Gliszczynski, Nita J. Patel, Thomas J. Raub, and Kim L. R. Brouwer

ALTERED HEPATOBILIARY DISPOSITION OF 5 (AND 6)-CARBOXY-2',7'-DICHLOROFLUORESCEIN IN Abcg2 (Bcrp1) AND Abcc2 (Mrp2) KNOCKOUT MICE
Drug Metab Dispos 2006 34: 718-723. Published online January 24, 2006; 10.1124/dmd.105.007922 [Abstract] [Full Text] [PDF]  

Short Communications:

Hyunmi Kim, Yune-Jung Yoon, Ji-Hong Shon, In-June Cha, Jae-Gook Shin, and Kwang-Hyeon Liu

INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY
Drug Metab Dispos 2006 34: 521-523. Published online January 13, 2006; 10.1124/dmd.105.007930 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

David Hallifax and J. Brian Houston

BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT
Drug Metab Dispos 2006 34: 724-726. [Full Text] [PDF] [Erratum]   

R. P. Austin, P. Barton, and R. J. Riley

RESPONSE TO "BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT"
Drug Metab Dispos 2006 34: 727. [Full Text] [PDF]  

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