Articles:

Grzegorz Pitas, Elizabeth M. Laurenzana, D. Keith Williams, S. Michael Owens, and W. Brooks Gentry

ANTI-PHENCYCLIDINE MONOCLONAL ANTIBODY BINDING CAPACITY IS NOT THE ONLY DETERMINANT OF EFFECTIVENESS, DISPROVING THE CONCEPT THAT ANTIBODY CAPACITY IS EASILY SURMOUNTED
Drug Metab Dispos 2006 34: 906-912. Published online February 28, 2006; 10.1124/dmd.105.005934 [Abstract] [Full Text] [PDF]  

Feng Xu, Yue Zhang, Shengyuan Xiao, Xiaowei Lu, Donghui Yang, Xiaoda Yang, Changling Li, Mingying Shang, Pengfei Tu, and Shaoqing Cai

ABSORPTION AND METABOLISM OF ASTRAGALI RADIX DECOCTION: IN SILICO, IN VITRO, AND A CASE STUDY IN VIVO
Drug Metab Dispos 2006 34: 913-924. Published online February 28, 2006; 10.1124/dmd.105.008300 [Abstract] [Full Text] [PDF] [Data Supplement]   

Milton Zmijewski, Todd A. Gillespie, David A. Jackson, Douglas F. Schmidt, Ping Yi, and Palaniappan Kulanthaivel

APPLICATION OF BIOCATALYSIS TO DRUG METABOLISM: PREPARATION OF MAMMALIAN METABOLITES OF A BIARYL-BIS-SULFONAMIDE AMPA (-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID) RECEPTOR POTENTIATOR USING Actinoplanes missouriensis
Drug Metab Dispos 2006 34: 925-931. Published online February 28, 2006; 10.1124/dmd.106.009522 [Abstract] [Full Text] [PDF]  

Leah D. Stuchal, Kevin M. Kleinow, John J. Stegeman, and Margaret O. James

DEMETHYLATION OF THE PESTICIDE METHOXYCHLOR IN LIVER AND INTESTINE FROM UNTREATED, METHOXYCHLOR-TREATED, AND 3-METHYLCHOLANTHRENE-TREATED CHANNEL CATFISH (ICTALURUS PUNCTATUS): EVIDENCE FOR ROLES OF CYP1 AND CYP3A FAMILY ISOZYMES
Drug Metab Dispos 2006 34: 932-938. Published online March 1, 2006; 10.1124/dmd.105.009068 [Abstract] [Full Text] [PDF]  

Vikram Arya, Vincent G. Demarco, Manish Issar, and Günther Hochhaus

CONTRARY TO ADULT, NEONATAL RATS SHOW PRONOUNCED BRAIN UPTAKE OF CORTICOSTEROIDS
Drug Metab Dispos 2006 34: 939-942. Published online February 28, 2006; 10.1124/dmd.105.007419 [Abstract] [Full Text] [PDF]  

Ryan W. Dellinger, Jia-Long Fang, Gang Chen, Rebecca Weinberg, and Philip Lazarus

IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A10 (UGT1A10) IN THE DETOXIFICATION OF POLYCYCLIC AROMATIC HYDROCARBONS: DECREASED GLUCURONIDATIVE ACTIVITY OF THE UGT1A10^139LYS ISOFORM
Drug Metab Dispos 2006 34: 943-949. Published online March 1, 2006; 10.1124/dmd.105.009100 [Abstract] [Full Text] [PDF]  

Toshiyuki Shimizu, Kei Akimoto, Takuya Yoshimura, Takuro Niwa, Kaoru Kobayashi, Michio Tsunoo, and Kan Chiba

AUTOINDUCTION OF MKC-963 [(R)-1-(1-CYCLOHEXYLETHYLAMINO)-4-PHENYLPHTHALAZINE] METABOLISM IN HEALTHY VOLUNTEERS AND ITS RETROSPECTIVE EVALUATION USING PRIMARY HUMAN HEPATOCYTES AND CDNA-EXPRESSED ENZYMES
Drug Metab Dispos 2006 34: 950-954. Published online March 10, 2006; 10.1124/dmd.105.007997 [Abstract] [Full Text] [PDF]  

Sam C. S. Au-Yeung, Dan W. Rurak, Nancy Gruber, and K. Wayne Riggs

A PHARMACOKINETIC STUDY OF DIPHENHYDRAMINE TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER IN ADULT SHEEP: POTENTIAL INVOLVEMENT OF A CARRIER-MEDIATED MECHANISM
Drug Metab Dispos 2006 34: 955-960. Published online March 1, 2006; 10.1124/dmd.105.007898 [Abstract] [Full Text] [PDF]  

Jill C. M. Wait, Nimish Vaccharajani, James Mitroka, Mohammed Jemal, Sanaullah Khan, Samuel J. Bonacorsi, J. Kent Rinehart, and Ramaswamy A. Iyer

METABOLISM OF [¹⁴C]GEMOPATRILAT AFTER ORAL ADMINISTRATION TO RATS, DOGS, AND HUMANS
Drug Metab Dispos 2006 34: 961-970. Published online March 15, 2006; 10.1124/dmd.105.007500 [Abstract] [Full Text] [PDF]  

H. Markus Weiss, Marcel Fresneau, Gian P. Camenisch, Olivier Kretz, and Gerhard Gross

IN VITRO BLOOD DISTRIBUTION AND PLASMA PROTEIN BINDING OF THE IRON CHELATOR DEFERASIROX (ICL670) AND ITS IRON COMPLEX FE-[ICL670]₂ FOR RAT, MARMOSET, RABBIT, MOUSE, DOG, AND HUMAN
Drug Metab Dispos 2006 34: 971-975. Published online March 10, 2006; 10.1124/dmd.105.006429 [Abstract] [Full Text] [PDF]  

Diansong Zhou, Lovisa Afzelius, Scott W. Grimm, Tommy B. Andersson, Randy J. Zauhar, and Ismael Zamora

COMPARISON OF METHODS FOR THE PREDICTION OF THE METABOLIC SITES FOR CYP3A4-MEDIATED METABOLIC REACTIONS
Drug Metab Dispos 2006 34: 976-983. Published online March 15, 2006; 10.1124/dmd.105.008631 [Abstract] [Full Text] [PDF]  

Annica Tevell, Hans Lennernäs, Mats Jönsson, Maria Norlin, Bo Lennernäs, Ulf Bondesson, and Mikael Hedeland

FLUTAMIDE METABOLISM IN FOUR DIFFERENT SPECIES IN VITRO AND IDENTIFICATION OF FLUTAMIDE METABOLITES IN HUMAN PATIENT URINE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY
Drug Metab Dispos 2006 34: 984-992. Published online March 15, 2006; 10.1124/dmd.105.008516 [Abstract] [Full Text] [PDF]  

Fernando A. Crocenzi, José M. Pellegrino, Viviana A. Catania, Marcelo G. Luquita, Marcelo G. Roma, Aldo D. Mottino, and Enrique J. Sánchez Pozzi

GALACTOSAMINE PREVENTS ETHINYLESTRADIOL-INDUCED CHOLESTASIS
Drug Metab Dispos 2006 34: 993-997. Published online March 22, 2006; 10.1124/dmd.106.009308 [Abstract] [Full Text] [PDF]  

Corbin J. Bachmeier, William J. Trickler, and Donald W. Miller

COMPARISON OF DRUG EFFLUX TRANSPORT KINETICS IN VARIOUS BLOOD-BRAIN BARRIER MODELS
Drug Metab Dispos 2006 34: 998-1003. Published online March 22, 2006; 10.1124/dmd.105.006999 [Abstract] [Full Text] [PDF]  

Stacey L. Polsky-Fisher, Stanley Vickers, Donghui Cui, Raju Subramanian, Byron H. Arison, Nancy G. B. Agrawal, Thanh V. Goel, Laura K. Vessey, M. Gail Murphy, Kenneth C. Lasseter, Richard C. Simpson, Jose M. Vega, and A. David Rodrigues

METABOLISM AND DISPOSITION OF A POTENT AND SELECTIVE GABA-A_2/3 RECEPTOR AGONIST IN HEALTHY MALE VOLUNTEERS
Drug Metab Dispos 2006 34: 1004-1011. Published online March 1, 2006; 10.1124/dmd.105.008193 [Abstract] [Full Text] [PDF]  

Sachiyo Kawashima, Kaoru Kobayashi, Kaori Takama, Tomoaki Higuchi, Tomomi Furihata, Masakiyo Hosokawa, and Kan Chiba

INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4 IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER
Drug Metab Dispos 2006 34: 1012-1018. Published online March 15, 2006; 10.1124/dmd.106.009365 [Abstract] [Full Text] [PDF]  

Raymond A. Kemper, Diane L. Nabb, Shawn A. Gannon, Timothy A. Snow, and Anne Marie Api

COMPARATIVE METABOLISM OF GERANYL NITRILE AND CITRONELLYL NITRILE IN MOUSE, RAT, AND HUMAN HEPATOCYTES
Drug Metab Dispos 2006 34: 1019-1029. Published online March 15, 2006; 10.1124/dmd.105.005496 [Abstract] [Full Text] [PDF]  

María L. Ruiz, Silvina S. M. Villanueva, Marcelo G. Luquita, Mary Vore, Aldo D. Mottino, and Viviana A. Catania

ETHYNYLESTRADIOL INCREASES EXPRESSION AND ACTIVITY OF RAT LIVER MRP3
Drug Metab Dispos 2006 34: 1030-1034. Published online March 22, 2006; 10.1124/dmd.106.009316 [Abstract] [Full Text] [PDF]  

Robin E. Pearce, J. Steven Leeder, and Gregory L. Kearns

BIOTRANSFORMATION OF FLUTICASONE: IN VITRO CHARACTERIZATION
Drug Metab Dispos 2006 34: 1035-1040. Published online March 24, 2006; 10.1124/dmd.105.009043 [Abstract] [Full Text] [PDF]  

Anthe S. Zandvliet, William Copalu, Jan H. M. Schellens, Jos H. Beijnen, and Alwin D. R. Huitema

SATURABLE BINDING OF INDISULAM TO PLASMA PROTEINS AND DISTRIBUTION TO HUMAN ERYTHROCYTES
Drug Metab Dispos 2006 34: 1041-1046. Published online March 24, 2006; 10.1124/dmd.105.008326 [Abstract] [Full Text] [PDF]  

Marcella Martignoni, Geny Groothuis, and Ruben de Kanter

COMPARISON OF MOUSE AND RAT CYTOCHROME P450-MEDIATED METABOLISM IN LIVER AND INTESTINE
Drug Metab Dispos 2006 34: 1047-1054. Published online March 24, 2006; 10.1124/dmd.105.009035 [Abstract] [Full Text] [PDF]  

Andrew Rowland, David J. Elliot, J. Andrew Williams, Peter I. Mackenzie, Ronald G. Dickinson, and John O. Miners

IN VITRO CHARACTERIZATION OF LAMOTRIGINE N2-GLUCURONIDATION AND THE LAMOTRIGINE-VALPROIC ACID INTERACTION
Drug Metab Dispos 2006 34: 1055-1062. Published online March 24, 2006; 10.1124/dmd.106.009340 [Abstract] [Full Text] [PDF]  

Sandra J. Baldwin, Jo L. Bramhall, Charlotte A. Ashby, Lin Yue, Paul R. Murdock, Steven R. Hood, Andrew D. Ayrton, and Stephen E. Clarke

CYTOCHROME P450 GENE INDUCTION IN RATS EX VIVO ASSESSED BY QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (TAQMAN)
Drug Metab Dispos 2006 34: 1063-1069. Published online March 10, 2006; 10.1124/dmd.105.008185 [Abstract] [Full Text] [PDF]  

Philip L. Lorenzi, Christopher P. Landowski, Andrea Brancale, Xueqin Song, Leroy B. Townsend, John C. Drach, and Gordon L. Amidon

N-METHYLPURINE DNA GLYCOSYLASE AND 8-OXOGUANINE DNA GLYCOSYLASE METABOLIZE THE ANTIVIRAL NUCLEOSIDE 2-BROMO-5,6-DICHLORO-1-(ß-D-RIBOFURANOSYL)BENZIMIDAZOLE
Drug Metab Dispos 2006 34: 1070-1077. Published online March 24, 2006; 10.1124/dmd.105.009209 [Abstract] [Full Text] [PDF] [Data Supplement]   

Short Communications:

Gordon P. Black, Kathy S. Collins, Dylan P. Blacquiere, and Poh-Gek Forkert

FORMATION OF N-ALKYLPROTOPORPHYRIN IX FROM METABOLISM OF DIALLYL SULFONE IN LUNG AND LIVER
Drug Metab Dispos 2006 34: 895-900. Published online March 1, 2006; 10.1124/dmd.106.009928 [Abstract] [Full Text] [PDF]  

Chun Li, Sekhar Surapaneni, QingPing Zeng, Brian Marquez, David Chow, and Gondi Kumar

IDENTIFICATION OF A NOVEL IN VITRO METABONATE FROM LIVER MICROSOMAL INCUBATIONS
Drug Metab Dispos 2006 34: 901-905. Published online March 22, 2006; 10.1124/dmd.105.008367 [Abstract] [Full Text] [PDF]  

Errata:

CORRECTION TO "BINDING OF DRUGS TO HEPATIC MICROSOMES: COMMENT AND ASSESSMENT OF CURRENT PREDICTION METHODOLOGY WITH RECOMMENDATION FOR IMPROVEMENT"
Drug Metab Dispos 2006 34: 1078. [Full Text] [PDF]  

CORRECTION TO "P-GLYCOPROTEIN PLAYS A MAJOR ROLE IN THE EFFLUX OF FEXOFENADINE IN THE SMALL INTESTINE AND BLOOD-BRAIN BARRIER, BUT ONLY A LIMITED ROLE IN ITS BILIARY EXCRETION"
Drug Metab Dispos 2006 34: 1079. [Full Text] [PDF]  

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