Articles:

Kouichi Yoshinari, Nao Okino, Takeshi Sato, Junko Sugatani, and Masao Miwa

INDUCTION OF DETOXIFYING ENZYMES IN RODENT WHITE ADIPOSE TISSUE BY ARYL HYDROCARBON RECEPTOR AGONISTS AND ANTIOXIDANTS
Drug Metab Dispos 2006 34: 1081-1089. Published online March 31, 2006; 10.1124/dmd.105.007286 [Abstract] [Full Text] [PDF]  

Hwa-Kyung Lee, Joon-Kwan Moon, Chul-Hee Chang, Hoon Choi, Hee-Won Park, Byeoung-Soo Park, Hye-Suk Lee, Eul-Chul Hwang, Young-Deuk Lee, Kwang-Hyeon Liu, and Jeong-Han Kim

STEREOSELECTIVE METABOLISM OF ENDOSULFAN BY HUMAN LIVER MICROSOMES AND HUMAN CYTOCHROME P450 ISOFORMS
Drug Metab Dispos 2006 34: 1090-1095. Published online March 31, 2006; 10.1124/dmd.105.009134 [Abstract] [Full Text] [PDF] [Erratum]   

Thomas D. Schreiber, Christoph Köhle, Felicitas Buckler, Stefan Schmohl, Albert Braeuning, Alexander Schmiechen, Michael Schwarz, and Peter A. Münzel

REGULATION OF CYP1A1 GENE EXPRESSION BY THE ANTIOXIDANT TERT-BUTYLHYDROQUINONE
Drug Metab Dispos 2006 34: 1096-1101. Published online March 31, 2006; 10.1124/dmd.106.009662 [Abstract] [Full Text] [PDF]  

Takahiro Murai, Naozumi Samata, Haruo Iwabuchi, and Toshihiko Ikeda

HUMAN UDP-GLUCURONOSYLTRANSFERASE, UGT1A8, GLUCURONIDATES DIHYDROTESTOSTERONE TO A MONOGLUCURONIDE AND FURTHER TO A STRUCTURALLY NOVEL DIGLUCURONIDE
Drug Metab Dispos 2006 34: 1102-1108. Published online April 4, 2006; 10.1124/dmd.106.009621 [Abstract] [Full Text] [PDF]  

Naoki Ishiguro, Kazuya Maeda, Wataru Kishimoto, Asami Saito, Akiko Harada, Thomas Ebner, Willy Roth, Takashi Igarashi, and Yuichi Sugiyama

PREDOMINANT CONTRIBUTION OF OATP1B3 TO THE HEPATIC UPTAKE OF TELMISARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, IN HUMANS
Drug Metab Dispos 2006 34: 1109-1115. Published online April 12, 2006; 10.1124/dmd.105.009175 [Abstract] [Full Text] [PDF]  

Hao-Jie Zhu, Jun-Sheng Wang, C. Lindsay DeVane, Robin L. Williard, Jennifer L. Donovan, Lawrence D. Middaugh, Brian B. Gibson, Kennerly S. Patrick, and John S. Markowitz

THE ROLE OF THE POLYMORPHIC EFFLUX TRANSPORTER P-GLYCOPROTEIN ON THE BRAIN ACCUMULATION OF d-METHYLPHENIDATE AND d-AMPHETAMINE
Drug Metab Dispos 2006 34: 1116-1121. Published online April 18, 2006; 10.1124/dmd.106.009605 [Abstract] [Full Text] [PDF]  

Huan Dong, Naomi Suzuki, Maria C. Torres, Radha R. Bonala, Francis Johnson, Arthur P. Grollman, and Shinya Shibutani

QUANTITATIVE DETERMINATION OF ARISTOLOCHIC ACID-DERIVED DNA ADDUCTS IN RATS USING ³²P-POSTLABELING/POLYACRYLAMIDE GEL ELECTROPHORESIS ANALYSIS
Drug Metab Dispos 2006 34: 1122-1127. Published online April 12, 2006; 10.1124/dmd.105.008706 [Abstract] [Full Text] [PDF]  

David Edwards, Mark Battle, Rochelle Lear, Gill Farrar, D. Jon Barnett, Vanessa Godden, Catherine Coombes, Alexandra Oliveira, and Håkan Ahlström

THE IN VIVO AND IN VITRO METABOLIC PROFILE OF ^99MTC-NC100668, A NEW TRACER FOR IMAGING VENOUS THROMBOEMBOLISM: IDENTIFICATION AND BIODISTRIBUTION OF THE PRINCIPAL RADIOLABELED METABOLITE
Drug Metab Dispos 2006 34: 1128-1135. Published online April 12, 2006; 10.1124/dmd.106.009696 [Abstract] [Full Text] [PDF]  

Yong Huang, Hideaki Okochi, Barnaby C. H. May, Giuseppe Legname, Stanley B. Prusiner, Leslie Z. Benet, B. Joseph Guglielmo, and Emil T. Lin

QUINACRINE IS MAINLY METABOLIZED TO MONO-DESETHYL QUINACRINE BY CYP3A4/5 AND ITS BRAIN ACCUMULATION IS LIMITED BY P-GLYCOPROTEIN
Drug Metab Dispos 2006 34: 1136-1144. Published online March 31, 2006; 10.1124/dmd.105.008664 [Abstract] [Full Text] [PDF]  

Ho-Jin Kang, Sang-Seop Lee, Chung-Hee Lee, Ju-Cheol Shim, Ho Jung Shin, Kwang-Hyeon Liu, Mi-Ae Yoo, and Jae-Gook Shin

NEUROTOXIC PYRIDINIUM METABOLITES OF HALOPERIDOL ARE SUBSTRATES OF HUMAN ORGANIC CATION TRANSPORTERS
Drug Metab Dispos 2006 34: 1145-1151. Published online April 19, 2006; 10.1124/dmd.105.009126 [Abstract] [Full Text] [PDF] [Erratum]   

Jian Guo, Dejan Nikolic, Lucas R. Chadwick, Guido F. Pauli, and Richard B. van Breemen

IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF 8-PRENYLNARINGENIN AND ISOXANTHOHUMOL FROM HOPS (HUMULUS LUPULUS L.)
Drug Metab Dispos 2006 34: 1152-1159. Published online April 12, 2006; 10.1124/dmd.105.008250 [Abstract] [Full Text] [PDF]  

Ragini Vuppugalla and Reza Mehvar

SELECTIVE EFFECTS OF NITRIC OXIDE ON THE DISPOSITION OF CHLORZOXAZONE AND DEXTROMETHORPHAN IN ISOLATED PERFUSED RAT LIVERS
Drug Metab Dispos 2006 34: 1160-1166. Published online April 18, 2006; 10.1124/dmd.105.009050 [Abstract] [Full Text] [PDF]  

Ai-Ming Yu and Robert L. Haining

EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF MOUSE CYP2D22
Drug Metab Dispos 2006 34: 1167-1174. Published online April 4, 2006; 10.1124/dmd.105.008870 [Abstract] [Full Text] [PDF]  

Yvonne Y. Lau, Hideaki Okochi, Yong Huang, and Leslie Z. Benet

PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM
Drug Metab Dispos 2006 34: 1175-1181. Published online April 19, 2006; 10.1124/dmd.105.009076 [Abstract] [Full Text] [PDF]  

Niclas Petri, Ebba Bergman, Patrik Forsell, Mikael Hedeland, Ulf Bondesson, Lars Knutson, and Hans Lennernäs

FIRST-PASS EFFECTS OF VERAPAMIL ON THE INTESTINAL ABSORPTION AND LIVER DISPOSITION OF FEXOFENADINE IN THE PORCINE MODEL
Drug Metab Dispos 2006 34: 1182-1189. Published online April 18, 2006; 10.1124/dmd.105.008409 [Abstract] [Full Text] [PDF]  

A. L. Slitt, N. J. Cherrington, C. D. Fisher, M. Negishi, and C. D. Klaassen

INDUCTION OF GENES FOR METABOLISM AND TRANSPORT BY TRANS-STILBENE OXIDE IN LIVERS OF SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS
Drug Metab Dispos 2006 34: 1190-1197. Published online April 18, 2006; 10.1124/dmd.105.007542 [Abstract] [Full Text] [PDF]  

Ping He, Michael H. Court, David J. Greenblatt, and Lisa L. von Moltke

FACTORS INFLUENCING MIDAZOLAM HYDROXYLATION ACTIVITY IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2006 34: 1198-1207. Published online April 25, 2006; 10.1124/dmd.105.008904 [Abstract] [Full Text] [PDF]  

Jenny Y. Chien, Aroonrut Lucksiri, Charles S. Ernest, II, J. Christopher Gorski, Steven A. Wrighton, and Stephen D. Hall

STOCHASTIC PREDICTION OF CYP3A-MEDIATED INHIBITION OF MIDAZOLAM CLEARANCE BY KETOCONAZOLE
Drug Metab Dispos 2006 34: 1208-1219. Published online April 12, 2006; 10.1124/dmd.105.008730 [Abstract] [Full Text] [PDF]  

Hugo Girard, Lyne Villeneuve, Michael H. Court, Louis-Charles Fortier, Patrick Caron, Qin Hao, Lisa L. von Moltke, David J. Greenblatt, and Chantal Guillemette

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER
Drug Metab Dispos 2006 34: 1220-1228. Published online April 4, 2006; 10.1124/dmd.106.009787 [Abstract] [Full Text] [PDF]  

Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara, and Yuichi Sugiyama

DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1
Drug Metab Dispos 2006 34: 1229-1236. Published online April 4, 2006; 10.1124/dmd.106.009290 [Abstract] [Full Text] [PDF]  

Baidehi Mukherjee, Oreste E. Salavaggione, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Daniel J. Schaid, Eric D. Wieben, and Richard M. Weinshilboum

GLUTATHIONE S-TRANSFERASE OMEGA 1 AND OMEGA 2 PHARMACOGENOMICS
Drug Metab Dispos 2006 34: 1237-1246. Published online April 25, 2006; 10.1124/dmd.106.009613 [Abstract] [Full Text] [PDF] [Data Supplement] [Erratum]   

Wakaba Yamashiro, Kazuya Maeda, Masakazu Hirouchi, Yasuhisa Adachi, Zhuohan Hu, and Yuichi Sugiyama

INVOLVEMENT OF TRANSPORTERS IN THE HEPATIC UPTAKE AND BILIARY EXCRETION OF VALSARTAN, A SELECTIVE ANTAGONIST OF THE ANGIOTENSIN II AT1-RECEPTOR, IN HUMANS
Drug Metab Dispos 2006 34: 1247-1254. Published online April 19, 2006; 10.1124/dmd.105.008938 [Abstract] [Full Text] [PDF]  

Christopher A. Evans, Larry J. Jolivette, Rakesh Nagilla, and Keith W. Ward

EXTRAPOLATION OF PRECLINICAL PHARMACOKINETICS AND MOLECULAR FEATURE ANALYSIS OF "DISCOVERY-LIKE" MOLECULES TO PREDICT HUMAN PHARMACOKINETICS
Drug Metab Dispos 2006 34: 1255-1265. Published online April 18, 2006; 10.1124/dmd.105.006619 [Abstract] [Full Text] [PDF]  

Kevin J. Coe, Sidney D. Nelson, Roger G. Ulrich, Yudong He, Xudong Dai, Olivia Cheng, Michelle Caguyong, Chris J. Roberts, and J. Greg Slatter

PROFILING THE HEPATIC EFFECTS OF FLUTAMIDE IN RATS: A MICROARRAY COMPARISON WITH CLASSICAL ARYL HYDROCARBON RECEPTOR LIGANDS AND ATYPICAL CYP1A INDUCERS
Drug Metab Dispos 2006 34: 1266-1275. Published online April 12, 2006; 10.1124/dmd.105.009159 [Abstract] [Full Text] [PDF] [Data Supplement]   

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