Articles:

Dermot F. McGinnity, Amanda J. Berry, Jane R. Kenny, Ken Grime, and Robert J. Riley

EVALUATION OF TIME-DEPENDENT CYTOCHROME P450 INHIBITION USING CULTURED HUMAN HEPATOCYTES
Drug Metab Dispos 2006 34: 1291-1300. Published online May 5, 2006; 10.1124/dmd.106.009969 [Abstract] [Full Text] [PDF]  

Silvina S. M. Villanueva, María L. Ruiz, Carol J. Soroka, Shi-Ying Cai, Marcelo G. Luquita, Adriana M. Torres, Enrique J. Sánchez Pozzi, José M. Pellegrino, James L. Boyer, Viviana A. Catania, and Aldo D. Mottino

HEPATIC AND EXTRAHEPATIC SYNTHESIS AND DISPOSITION OF DINITROPHENYL-S-GLUTATHIONE IN BILE DUCT-LIGATED RATS
Drug Metab Dispos 2006 34: 1301-1309. Published online May 5, 2006; 10.1124/dmd.106.009415 [Abstract] [Full Text] [PDF]  

R. Scott Obach and Deepak K. Dalvie

METABOLISM OF NOMIFENSINE TO A DIHYDROISOQUINOLINIUM ION METABOLITE BY HUMAN MYELOPEROXIDASE, HEMOGLOBIN, MONOAMINE OXIDASE A, AND CYTOCHROME P450 ENZYMES
Drug Metab Dispos 2006 34: 1310-1316. Published online May 5, 2006; 10.1124/dmd.106.010173 [Abstract] [Full Text] [PDF]  

Jennifer B. Dennison, Palaniappan Kulanthaivel, Robert J. Barbuch, Jamie L. Renbarger, William J. Ehlhardt, and Stephen D. Hall

SELECTIVE METABOLISM OF VINCRISTINE IN VITRO BY CYP3A5
Drug Metab Dispos 2006 34: 1317-1327. Published online May 5, 2006; 10.1124/dmd.106.009902 [Abstract] [Full Text] [PDF]  

Yvonne Schrader, Mario Thevis, and Wilhelm Schänzer

QUANTITATIVE DETERMINATION OF METABOLIC PRODUCTS OF 19-NORANDROSTENEDIOL IN HUMAN PLASMA USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Drug Metab Dispos 2006 34: 1328-1335. Published online May 19, 2006; 10.1124/dmd.106.010165 [Abstract] [Full Text] [PDF]  

Justine L. Lam, Hideaki Okochi, Yong Huang, and Leslie Z. Benet

IN VITRO AND IN VIVO CORRELATION OF HEPATIC TRANSPORTER EFFECTS ON ERYTHROMYCIN METABOLISM: CHARACTERIZING THE IMPORTANCE OF TRANSPORTER-ENZYME INTERPLAY
Drug Metab Dispos 2006 34: 1336-1344. Published online May 12, 2006; 10.1124/dmd.106.009258 [Abstract] [Full Text] [PDF]  

Xiaoyan Chen, Liang Cui, Xiaotao Duan, Bin Ma, and Dafang Zhong

PHARMACOKINETICS AND METABOLISM OF THE FLAVONOID SCUTELLARIN IN HUMANS AFTER A SINGLE ORAL ADMINISTRATION
Drug Metab Dispos 2006 34: 1345-1352. Published online May 19, 2006; 10.1124/dmd.106.009779 [Abstract] [Full Text] [PDF]  

Myong Suk Ko, Seung Jin Lee, Jin Wan Kim, Jee Woong Lim, and Sang Geon Kim

DIFFERENTIAL EFFECTS OF THE OXIDIZED METABOLITES OF OLTIPRAZ ON THE ACTIVATION OF CCAAT/ENHANCER BINDING PROTEIN-ß AND NF-E2-RELATED FACTOR-2 FOR GSTA2 GENE INDUCTION
Drug Metab Dispos 2006 34: 1353-1360. Published online May 19, 2006; 10.1124/dmd.106.009514 [Abstract] [Full Text] [PDF]  

Stacey L. Polsky-Fisher, Hong Cao, Ping Lu, and Christopher R. Gibson

EFFECT OF CYTOCHROMES P450 CHEMICAL INHIBITORS AND MONOCLONAL ANTIBODIES ON HUMAN LIVER MICROSOMAL ESTERASE ACTIVITY
Drug Metab Dispos 2006 34: 1361-1366. Published online May 23, 2006; 10.1124/dmd.106.009704 [Abstract] [Full Text] [PDF]  

M. Reza Anari, Mellissa D. Creighton, Jason S. Ngui, Richard A. Tschirret-Guth, Yohannes Teffera, George A. Doss, Wei Tang, Nathan X. Yu, Suzanne L. Ciccotto, Donald F. Hobra, Jr., John B. Coleman, Stella H. Vincent, and David C. Evans

SPECIES DIFFERENCES IN METABOLISM AND PHARMACOKINETICS OF A SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST IN RATS AND DOGS: FORMATION OF A UNIQUE GLUTATHIONE ADDUCT IN THE RAT
Drug Metab Dispos 2006 34: 1367-1375. Published online May 12, 2006; 10.1124/dmd.105.009027 [Abstract] [Full Text] [PDF]  

Silvia Diani-Moore, Fotini Papachristou, Erin Labitzke, and Arleen B. Rifkind

INDUCTION OF CYP1A AND CYP2-MEDIATED ARACHIDONIC ACID EPOXYGENATION AND SUPPRESSION OF 20-HYDROXYEICOSATETRAENOIC ACID BY IMIDAZOLE DERIVATIVES INCLUDING THE AROMATASE INHIBITOR VOROZOLE
Drug Metab Dispos 2006 34: 1376-1385. Published online May 19, 2006; 10.1124/dmd.106.009498 [Abstract] [Full Text] [PDF] [Data Supplement]   

Jinglei Yu, Mark J. I. Paine, Jean-Didier Maréchal, Carol A. Kemp, Clive J. Ward, Simon Brown, Michael J. Sutcliffe, Gordon C. K. Roberts, Elaine M. Rankin, and C. Roland Wolf

IN SILICO PREDICTION OF DRUG BINDING TO CYP2D6: IDENTIFICATION OF A NEW METABOLITE OF METOCLOPRAMIDE
Drug Metab Dispos 2006 34: 1386-1392. Published online May 12, 2006; 10.1124/dmd.106.009852 [Abstract] [Full Text] [PDF]  

Femke M. van de Water, Otto C. Boerman, Alfons C. Wouterse, Janny G. P. Peters, Frans G. M. Russel, and Rosalinde Masereeuw

INTRAVENOUSLY ADMINISTERED SHORT INTERFERING RNA ACCUMULATES IN THE KIDNEY AND SELECTIVELY SUPPRESSES GENE FUNCTION IN RENAL PROXIMAL TUBULES
Drug Metab Dispos 2006 34: 1393-1397. Published online May 19, 2006; 10.1124/dmd.106.009555 [Abstract] [Full Text] [PDF]  

Marie Stiborová, Helena Dracínská, Jana Hájková, Pavla Kaderábková, Eva Frei, Heinz H. Schmeiser, Pavel Soucek, David H. Phillips, and Volker M. Arlt

THE ENVIRONMENTAL POLLUTANT AND CARCINOGEN 3-NITROBENZANTHRONE AND ITS HUMAN METABOLITE 3-AMINOBENZANTHRONE ARE POTENT INDUCERS OF RAT HEPATIC CYTOCHROMES P450 1A1 AND -1A2 AND NAD(P)H:QUINONE OXIDOREDUCTASE
Drug Metab Dispos 2006 34: 1398-1405. Published online May 19, 2006; 10.1124/dmd.106.009373 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lin Xu, Daria M. Krenitsky, Andrew M. Seacat, John L. Butenhoff, Thomas R. Tephly, and M. W. Anders

N-GLUCURONIDATION OF PERFLUOROOCTANESULFONAMIDE BY HUMAN, RAT, DOG, AND MONKEY LIVER MICROSOMES AND BY EXPRESSED RAT AND HUMAN UDP-GLUCURONOSYLTRANSFERASES
Drug Metab Dispos 2006 34: 1406-1410. Published online May 23, 2006; 10.1124/dmd.106.009399 [Abstract] [Full Text] [PDF]  

Li Li, Run-Mei Pan, Todd D. Porter, Neil S. Jensen, Paul Silber, Guy Russo, John A. Tine, John Heim, Barbara Ring, and Peter J. Wedlund

NEW CYTOCHROME P450 2D6*56 ALLELE IDENTIFIED BY GENOTYPE/PHENOTYPE ANALYSIS OF CRYOPRESERVED HUMAN HEPATOCYTES
Drug Metab Dispos 2006 34: 1411-1416. Published online May 5, 2006; 10.1124/dmd.106.009548 [Abstract] [Full Text] [PDF]  

Masataka Oitate, Takashi Hirota, Kumiko Koyama, Shin-ichi Inoue, Kenji Kawai, and Toshihiko Ikeda

COVALENT BINDING OF RADIOACTIVITY FROM [¹⁴C]ROFECOXIB, BUT NOT [¹⁴C]CELECOXIB OR [¹⁴C]CS-706, TO THE ARTERIAL ELASTIN OF RATS
Drug Metab Dispos 2006 34: 1417-1422. Published online May 5, 2006; 10.1124/dmd.106.009860 [Abstract] [Full Text] [PDF]  

Yoshimichi Sai, Yosuke Kaneko, Satsuki Ito, Keisuke Mitsuoka, Yukio Kato, Ikumi Tamai, Per Artursson, and Akira Tsuji

PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS
Drug Metab Dispos 2006 34: 1423-1431. Published online May 19, 2006; 10.1124/dmd.106.009530 [Abstract] [Full Text] [PDF]  

Short Communications:

Shuso Takeda, Yurie Kitajima, Yuji Ishii, Yoshio Nishimura, Peter I. Mackenzie, Kazuta Oguri, and Hideyuki Yamada

INHIBITION OF UDP-GLUCURONOSYLTRANSFERASE 2B7-CATALYZED MORPHINE GLUCURONIDATION BY KETOCONAZOLE: DUAL MECHANISMS INVOLVING A NOVEL NONCOMPETITIVE MODE
Drug Metab Dispos 2006 34: 1277-1282. Published online May 5, 2006; 10.1124/dmd.106.009738 [Abstract] [Full Text] [PDF]  

Kelly A. Keating, Oliver McConnell, Yingru Zhang, Li Shen, William Demaio, Larry Mallis, Sayed Elmarakby, and Appavu Chandrasekaran

NMR CHARACTERIZATION OF AN S-LINKED GLUCURONIDE METABOLITE OF THE POTENT, NOVEL, NONSTEROIDAL PROGESTERONE AGONIST TANAPROGET
Drug Metab Dispos 2006 34: 1283-1287. Published online May 12, 2006; 10.1124/dmd.105.008763 [Abstract] [Full Text] [PDF]  

Tamara S. Dowers and Jeffrey P. Jones

KINETIC ISOTOPE EFFECTS IMPLICATE A SINGLE OXIDANT FOR CYTOCHROME P450-MEDIATED O-DEALKYLATION, N-OXYGENATION, AND AROMATIC HYDROXYLATION OF 6-METHOXYQUINOLINE
Drug Metab Dispos 2006 34: 1288-1290. Published online May 19, 2006; 10.1124/dmd.106.010280 [Abstract] [Full Text] [PDF]  

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