Articles:

Anwar Y. Dunbar, Gary J. Jenkins, Suree Jianmongkol, Mikiya Nakatsuka, Ezra R. Lowe, Miranda Lau, and Yoichi Osawa

Tetrahydrobiopterin Protects against Guanabenz-Mediated Inhibition of Neuronal Nitric-Oxide Synthase in Vitro and in Vivo
Drug Metab Dispos 2006 34: 1448-1456. Published online May 31, 2006; 10.1124/dmd.106.009951 [Abstract] [Full Text] [PDF]  

Christopher J. Kochansky, Ronda K. Rippley, Kerri X. Yan, Hengchang Song, Michael A. Wallace, Dennis Dean, Allen N. Jones, Kenneth Lasseter, Jules Schwartz, Stella H. Vincent, Ronald B. Franklin, and John Wagner

Absorption, Metabolism, and Excretion of [¹⁴C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in Humans
Drug Metab Dispos 2006 34: 1457-1461. Published online June 13, 2006; 10.1124/dmd.106.010231 [Abstract] [Full Text] [PDF]  

Yakun Chen, Shuqing Chen, Xin Li, Xiewei Wang, and Su Zeng

Genetic Variants of Human UGT1A3: Functional Characterization and Frequency Distribution in a Chinese Han Population
Drug Metab Dispos 2006 34: 1462-1467. Published online May 31, 2006; 10.1124/dmd.106.009761 [Abstract] [Full Text] [PDF]  

Shanjun Liu, Debbie Tam, Xianghai Chen, and K. Sandy Pang

P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16-carbonitrile
Drug Metab Dispos 2006 34: 1468-1479. Published online June 2, 2006; 10.1124/dmd.105.008227 [Abstract] [Full Text] [PDF]  

Guy M. L. Meno-Tetang, Hongshan Li, Suzette Mis, Nancy Pyszczynski, Peter Heining, Philip Lowe, and William J. Jusko

Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses
Drug Metab Dispos 2006 34: 1480-1487. Published online June 2, 2006; 10.1124/dmd.105.009001 [Abstract] [Full Text] [PDF]  

Taina Sten, Saana Qvisen, Päivi Uutela, Leena Luukkanen, Risto Kostiainen, and Moshe Finel

Prominent but Reverse Stereoselectivity in Propranolol Glucuronidation by Human UDP-Glucuronosyltransferases 1A9 and 1A10
Drug Metab Dispos 2006 34: 1488-1494. Published online June 8, 2006; 10.1124/dmd.106.010371 [Abstract] [Full Text] [PDF]  

Kazunori Fujimoto, Shingo Arakawa, Yukari Shibaya, Hiroaki Miida, Yosuke Ando, Hiroaki Yasumo, Ayako Hara, Minoru Uchiyama, Haruo Iwabuchi, Wataru Takasaki, Sunao Manabe, and Takashi Yamoto

Characterization of Phenotypes in Gstm1-null Mice by Cytosolic and in Vivo Metabolic Studies Using 1,2-Dichloro-4-Nitrobenzene
Drug Metab Dispos 2006 34: 1495-1501. Published online June 7, 2006; 10.1124/dmd.106.010009 [Abstract] [Full Text] [PDF]  

Iain J. Martin, Richard J. Lewis, Michael A. Bernstein, Iain G. Beattie, Craig A. Martin, Robert J. Riley, and Brian Springthorpe

Which Hydroxy? Evidence for Species Differences in the Regioselectivity of Glucuronidation in Rat, Dog, and Human in Vitro Systems and Dog in Vivo
Drug Metab Dispos 2006 34: 1502-1507. Published online June 8, 2006; 10.1124/dmd.106.009282 [Abstract] [Full Text] [PDF]  

Anna M. Lee, Jiang Yue, and Rachel F. Tyndale

In Vivo and in Vitro Characterization of Chlorzoxazone Metabolism and Hepatic CYP2E1 Levels in African Green Monkeys: Induction by Chronic Nicotine Treatment
Drug Metab Dispos 2006 34: 1508-1515. Published online June 8, 2006; 10.1124/dmd.106.010363 [Abstract] [Full Text] [PDF]  

John P. Gibbs, Ruth Hyland, and Kuresh Youdim

Minimizing Polymorphic Metabolism in Drug Discovery: Evaluation of the Utility of in Vitro Methods for Predicting Pharmacokinetic Consequences Associated with CYP2D6 Metabolism
Drug Metab Dispos 2006 34: 1516-1522. Published online June 8, 2006; 10.1124/dmd.105.008714 [Abstract] [Full Text] [PDF]  

Monica I. Jushchyshyn, Jan L. Wahlstrom, Paul F. Hollenberg, and Larry C. Wienkers

Mechanism of Inactivation of Human Cytochrome P450 2B6 by Phencyclidine
Drug Metab Dispos 2006 34: 1523-1529. Published online June 16, 2006; 10.1124/dmd.106.010579 [Abstract] [Full Text] [PDF]  

Chunja Lee, Janine R. Hutson, Vivien Kok-Fung Tzau, and David S. Riddick

Regulation of Constitutive Mouse Hepatic Cytochromes P450 and Growth Hormone Signaling Components by 3-Methylcholanthrene
Drug Metab Dispos 2006 34: 1530-1538. Published online June 16, 2006; 10.1124/dmd.106.009936 [Abstract] [Full Text] [PDF]  

Olivier Bernard, Jelena Tojcic, Kim Journault, Louis Perusse, and Chantal Guillemette

Influence of Nonsynonymous Polymorphisms of UGT1A8 and UGT2B7 Metabolizing Enzymes on the Formation of Phenolic and Acyl Glucuronides of Mycophenolic Acid
Drug Metab Dispos 2006 34: 1539-1545. Published online June 21, 2006; 10.1124/dmd.106.010553 [Abstract] [Full Text] [PDF]  

Thomayant Prueksaritanont, Yuhsin Kuo, Cuyue Tang, Chunze Li, Yue Qiu, Bing Lu, Kristie Strong-Basalyga, Karen Richards, Brian Carr, and Jiunn H. Lin

In Vitro and in Vivo CYP3A64 Induction and Inhibition Studies in Rhesus Monkeys: A Preclinical Approach for CYP3A-Mediated Drug Interaction Studies
Drug Metab Dispos 2006 34: 1546-1555. Published online June 16, 2006; 10.1124/dmd.106.009878 [Abstract] [Full Text] [PDF]  

M. Teresa Donato, Agustín Lahoz, Nuria Jiménez, Gabriela Pérez, Alfonso Serralta, José Mir, José V. Castell, and M. José Gómez-Lechón

Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts
Drug Metab Dispos 2006 34: 1556-1562. Published online June 8, 2006; 10.1124/dmd.106.009670 [Abstract] [Full Text] [PDF]  

Yueying Zhen, Ondrej Slanar, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, Frantisek Perlík, Frank J. Gonzalez, and Jeffrey R. Idle

3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio
Drug Metab Dispos 2006 34: 1563-1574. Published online June 16, 2006; 10.1124/dmd.105.008920 [Abstract] [Full Text] [PDF]  

Sachiko Mita, Hiroshi Suzuki, Hidetaka Akita, Hisamitsu Hayashi, Reiko Onuki, Alan F. Hofmann, and Yuichi Sugiyama

Inhibition of Bile Acid Transport across Na⁺/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing Drugs
Drug Metab Dispos 2006 34: 1575-1581. Published online June 7, 2006; 10.1124/dmd.105.008748 [Abstract] [Full Text] [PDF]  

Thomas Lang, Michael Haberl, Diana Jung, Anja Drescher, Robert Schlagenhaufer, Andrea Keil, Esther Mornhinweg, Bruno Stieger, Gerd A. Kullak-Ublick, and Reinhold Kerb

Genetic Variability, Haplotype Structures, and Ethnic Diversity of Hepatic Transporters MDR3 (ABCB4) and Bile Salt Export Pump (ABCB11)
Drug Metab Dispos 2006 34: 1582-1599. Published online June 8, 2006; 10.1124/dmd.105.008854 [Abstract] [Full Text] [PDF]  

Chuang Lu, Ping Li, Richard Gallegos, Vinita Uttamsingh, Cindy Q. Xia, Gerald T. Miwa, Suresh K. Balani, and Liang-Shang Gan

Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes
Drug Metab Dispos 2006 34: 1600-1605. Published online June 21, 2006; 10.1124/dmd.106.010793 [Abstract] [Full Text] [PDF]  

Khawja A. Usmani, Taehyeon M. Cho, Randy L. Rose, and Ernest Hodgson

Inhibition of the Human Liver Microsomal and Human Cytochrome P450 1A2 and 3A4 Metabolism of Estradiol by Deployment-Related and Other Chemicals
Drug Metab Dispos 2006 34: 1606-1614. Published online June 21, 2006; 10.1124/dmd.106.010439 [Abstract] [Full Text] [PDF]  

Christopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh, and Gwendolyn D. Fate

Using a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange Risk
Drug Metab Dispos 2006 34: 1615-1623. Published online June 21, 2006; 10.1124/dmd.106.010934 [Abstract] [Full Text] [PDF]  

Emma Boström, Ulrika S. H. Simonsson, and Margareta Hammarlund-Udenaes

In Vivo Blood-Brain Barrier Transport of Oxycodone in the Rat: Indications for Active Influx and Implications for Pharmacokinetics/Pharmacodynamics
Drug Metab Dispos 2006 34: 1624-1631. Published online June 8, 2006; 10.1124/dmd.106.009746 [Abstract] [Full Text] [PDF]  

Kristini K. Miles, Fay K. Kessler, Philip C. Smith, and Joseph K. Ritter

Characterization of Rat Intestinal Microsomal UDP-Glucuronosyltransferase Activity toward Mycophenolic Acid
Drug Metab Dispos 2006 34: 1632-1639. Published online June 21, 2006; 10.1124/dmd.106.010140 [Abstract] [Full Text] [PDF]  

S. M. van Liempd, J. Kool, W. M. A. Niessen, D. E. van Elswijk, H. Irth, and N. P. E. Vermeulen

On-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor Modulators
Drug Metab Dispos 2006 34: 1640-1649. Published online June 21, 2006; 10.1124/dmd.106.010355 [Abstract] [Full Text] [PDF]  

Jie Chen, Xiao-Xia Yang, Min Huang, Ze-Ping Hu, Ming He, Wei Duan, Eli Chan, Fwu-Shan Sheu, Xiao Chen, and Shu-Feng Zhou

Small Interfering RNA-Mediated Silencing of Cytochrome P450 3A4 Gene
Drug Metab Dispos 2006 34: 1650-1657. Published online June 7, 2006; 10.1124/dmd.106.009837 [Abstract] [Full Text] [PDF]  

Yi-an Bi, Diana Kazolias, and David B. Duignan

Use of Cryopreserved Human Hepatocytes in Sandwich Culture to Measure Hepatobiliary Transport
Drug Metab Dispos 2006 34: 1658-1665. Published online June 16, 2006; 10.1124/dmd.105.009118 [Abstract] [Full Text] [PDF]  

Short Communications:

Abhinav Nath and William M. Atkins

A Theoretical Validation of the Substrate Depletion Approach to Determining Kinetic Parameters
Drug Metab Dispos 2006 34: 1433-1435. Published online June 2, 2006; 10.1124/dmd.106.010777 [Abstract] [Full Text] [PDF]  

Zhiming Wen, Stephan T. Stern, David E. Martin, Kuo-Hsiung Lee, and Philip C. Smith

Structural Characterization of Anti-HIV Drug Candidate PA-457 [3-O-(3',3'-Dimethylsuccinyl)-betulinic acid] and Its Acyl Glucuronides in Rat Bile and Evaluation of in Vitro Stability in Human and Animal Liver Microsomes and Plasma
Drug Metab Dispos 2006 34: 1436-1442. Published online June 2, 2006; 10.1124/dmd.106.009233 [Abstract] [Full Text] [PDF]  

Xingrong Liu, Bill J. Smith, Cuiping Chen, Ernesto Callegari, Stacey L. Becker, Xi Chen, Julie Cianfrogna, Angela C. Doran, Shawn D. Doran, John P. Gibbs, Natilie Hosea, Jianhua Liu, Frederick R. Nelson, Mark A. Szewc, and Jeffrey Van Deusen

Evaluation of Cerebrospinal Fluid Concentration and Plasma Free Concentration As a Surrogate Measurement for Brain Free Concentration
Drug Metab Dispos 2006 34: 1443-1447. Published online June 7, 2006; 10.1124/dmd.105.008201 [Abstract] [Full Text] [PDF]  

Erratum:

Correction To "Glutathione S-Transferase Omega 1 and Omega 2 Pharmacogenomics"
Drug Metab Dispos 2006 34: 1666. [Full Text] [PDF]  

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