The 2006 Bernard B. Brodie Award Lecture:

Frank J. Gonzalez

CYP2E1
Drug Metab Dispos 2007 35: 1-8. Published online October 4, 2006; 10.1124/dmd.106.012492 [Abstract] [Full Text] [PDF]  

Minireview:

Rob Webster, Eric Didier, Philip Harris, Ned Siegel, Jeanne Stadler, Lorraine Tilbury, and Dennis Smith

PEGylated Proteins: Evaluation of Their Safety in the Absence of Definitive Metabolism Studies
Drug Metab Dispos 2007 35: 9-16. Published online October 4, 2006; 10.1124/dmd.106.012419 [Abstract] [Full Text] [PDF]  

Articles:

Wensheng Lang, Gary W. Caldwell, Jian Li, Gregory C. Leo, William J. Jones, and John A. Masucci

Biotransformation of Geldanamycin and 17-Allylamino-17-Demethoxygeldanamycin by Human Liver Microsomes: Reductive versus Oxidative Metabolism and Implications
Drug Metab Dispos 2007 35: 21-29. Published online September 29, 2006; 10.1124/dmd.106.009639 [Abstract] [Full Text] [PDF]  

Markus Grube, Sebastian Reuther, Henriette Meyer zu Schwabedissen, Kathleen Köck, Katrin Draber, Christoph A. Ritter, Christoph Fusch, Gabriele Jedlitschky, and Heyo K. Kroemer

Organic Anion Transporting Polypeptide 2B1 and Breast Cancer Resistance Protein Interact in the Transepithelial Transport of Steroid Sulfates in Human Placenta
Drug Metab Dispos 2007 35: 30-35. Published online October 4, 2006; 10.1124/dmd.106.011411 [Abstract] [Full Text] [PDF]  

Sayeepriyadarshini Anakk, Wendong Huang, Jeffrey L. Staudinger, Kheng Tan, Timothy J. Cole, David D. Moore, and Henry W. Strobel

Gender Dictates the Nuclear Receptor-Mediated Regulation of CYP3A44
Drug Metab Dispos 2007 35: 36-42. Published online October 4, 2006; 10.1124/dmd.106.011270 [Abstract] [Full Text] [PDF]  

Debra Newman, Natalia Abuladze, Karoline Scholz, Wolfgang Dekant, Vladimir Tsuprun, Sergey Ryazantsev, Galyna Bondar, Pakan Sassani, Ira Kurtz, and Alexander Pushkin

Specificity of Aminoacylase III-Mediated Deacetylation of Mercapturic Acids
Drug Metab Dispos 2007 35: 43-50. Published online September 29, 2006; 10.1124/dmd.106.012062 [Abstract] [Full Text] [PDF]  

Ping Yi, Chad E. Hadden, William F. Annes, David A. Jackson, Barry C. Peterson, Todd A. Gillespie, and Jason T. Johnson

The Disposition and Metabolism of Naveglitazar, a Peroxisome Proliferator-Activated Receptor - Dual, -Dominant Agonist in Mice, Rats, and Monkeys
Drug Metab Dispos 2007 35: 51-61. Published online September 29, 2006; 10.1124/dmd.106.012328 [Abstract] [Full Text] [PDF]  

Mayumi Ishizuka, Fumie Okajima, Tsutomu Tanikawa, Heewon Min, Kazuyuki D. Tanaka, Kentaro Q. Sakamoto, and Shoichi Fujita

Elevated Warfarin Metabolism in Warfarin-Resistant Roof Rats (Rattus rattus) in Tokyo
Drug Metab Dispos 2007 35: 62-66. Published online September 29, 2006; 10.1124/dmd.106.011775 [Abstract] [Full Text] [PDF]  

Su-Jun Lee, Ilse P. van der Heiden, Joyce A. Goldstein, and Ron H. N. van Schaik

A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression System
Drug Metab Dispos 2007 35: 67-71. Published online October 11, 2006; 10.1124/dmd.106.012310 [Abstract] [Full Text] [PDF]  

Tomoko Akutsu, Kaoru Kobayashi, Koichi Sakurada, Hiroshi Ikegaya, Tomomi Furihata, and Kan Chiba

Identification of Human Cytochrome P450 Isozymes Involved in Diphenhydramine N-Demethylation
Drug Metab Dispos 2007 35: 72-78. Published online October 4, 2006; 10.1124/dmd.106.012088 [Abstract] [Full Text] [PDF]  

Chuang Lu, Gerald T. Miwa, Shimoga R. Prakash, Liang-Shang Gan, and Suresh K. Balani

A Novel Model for the Prediction of Drug-Drug Interactions in Humans Based on in Vitro Cytochrome P450 Phenotypic Data
Drug Metab Dispos 2007 35: 79-85. Published online October 4, 2006; 10.1124/dmd.106.011346 [Abstract] [Full Text] [PDF]  

Amita Datta-Mannan, Derrick R. Witcher, Ying Tang, Jeffry Watkins, Weidong Jiang, and Victor J. Wroblewski

Humanized IgG₁ Variants with Differential Binding Properties to the Neonatal Fc Receptor: Relationship to Pharmacokinetics in Mice and Primates
Drug Metab Dispos 2007 35: 86-94. Published online October 18, 2006; 10.1124/dmd.106.011734 [Abstract] [Full Text] [PDF]  

Irma M. Medina-Díaz, Georgina Arteaga-Illán, Mario Bermudez de León, Bulmaro Cisneros, Adolfo Sierra-Santoyo, Libia Vega, Frank J. Gonzalez, and Guillermo Elizondo

Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p'-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane
Drug Metab Dispos 2007 35: 95-102. Published online October 11, 2006; 10.1124/dmd.106.011759 [Abstract] [Full Text] [PDF]  

Richard T. Mayer, E. Kurt Dolence, and Gabriele E. Mayer

A Real-Time Fluorescence Assay for Measuring N-Dealkylation
Drug Metab Dispos 2007 35: 103-109. Published online October 11, 2006; 10.1124/dmd.106.011601 [Abstract] [Full Text] [PDF]  

Wenxia Zhang, Theresa May Chin Tan, and Lee-Yong Lim

Impact of Curcumin-Induced Changes in P-Glycoprotein and CYP3A Expression on the Pharmacokinetics of Peroral Celiprolol and Midazolam in Rats
Drug Metab Dispos 2007 35: 110-115. Published online October 18, 2006; 10.1124/dmd.106.011072 [Abstract] [Full Text] [PDF]  

Dione A. Gardner-Stephen and Peter I. Mackenzie

Isolation of the UDP-Glucuronosyltransferase 1A3 and 1A4 Proximal Promoters and Characterization of Their Dependence on the Transcription Factor Hepatocyte Nuclear Factor 1
Drug Metab Dispos 2007 35: 116-120. Published online October 18, 2006; 10.1124/dmd.106.012203 [Abstract] [Full Text] [PDF]  

David B. Buckley and Curtis D. Klaassen

Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice
Drug Metab Dispos 2007 35: 121-127. Published online October 18, 2006; 10.1124/dmd.106.012070 [Abstract] [Full Text] [PDF] [Data Supplement]   

Benjamin J. Davies, Janet K. Coller, Andrew A. Somogyi, Robert W. Milne, and Benedetta C. Sallustio

CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative Metabolism of Perhexiline Enantiomers by Human Liver Microsomes
Drug Metab Dispos 2007 35: 128-138. Published online October 18, 2006; 10.1124/dmd.106.012252 [Abstract] [Full Text] [PDF]  

Donglu Zhang, Lifei Wang, Gamini Chandrasena, Li Ma, Mingshe Zhu, Hongjian Zhang, Carl D. Davis, and W. Griffith Humphreys

Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar
Drug Metab Dispos 2007 35: 139-149. Published online October 24, 2006; 10.1124/dmd.106.011932 [Abstract] [Full Text] [PDF]  

Donglu Zhang, Lifei Wang, Nirmala Raghavan, Haiying Zhang, Wenying Li, Peter T. Cheng, Ming Yao, Litao Zhang, Mingshe Zhu, Samuel Bonacorsi, Suresh Yeola, James Mitroka, Narayanan Hariharan, Vinayak Hosagrahara, Gamini Chandrasena, Wen Chyi Shyu, and W. Griffith Humphreys

Comparative Metabolism of Radiolabeled Muraglitazar in Animals and Humans by Quantitative and Qualitative Metabolite Profiling
Drug Metab Dispos 2007 35: 150-167. Published online October 24, 2006; 10.1124/dmd.106.012450 [Abstract] [Full Text] [PDF]  

Jing Shao, Patricia L. Stapleton, Yvonne S. Lin, and Evan P. Gallagher

Cytochrome P450 and Glutathione S-Transferase mRNA Expression in Human Fetal Liver Hematopoietic Stem Cells
Drug Metab Dispos 2007 35: 168-175. Published online October 18, 2006; 10.1124/dmd.106.012757 [Abstract] [Full Text] [PDF]  

Shou-Lin Wang, Jing-Fen Han, Xiao-Yang He, Xin-Ru Wang, and Jun-Yan Hong

Genetic Variation of Human Cytochrome P450 Reductase as a Potential Biomarker for Mitomycin C-Induced Cytotoxicity
Drug Metab Dispos 2007 35: 176-179. Published online October 24, 2006; 10.1124/dmd.106.011056 [Abstract] [Full Text] [PDF]  

Suma Krishnan and Scott Moncrief

An Evaluation of the Cytochrome P450 Inhibition Potential of Lisdexamfetamine in Human Liver Microsomes
Drug Metab Dispos 2007 35: 180-184. Published online October 11, 2006; 10.1124/dmd.106.011973 [Abstract] [Full Text] [PDF]  

Short Communication:

Ruchita Kapoor, Deepthi Nimmagadda, and Jonathan J. Sheng

Cellular Localization Studies on Human Estrogen Sulfotransferase SULT1E1 in Human Embryonic Kidney 293 Cells
Drug Metab Dispos 2007 35: 17-20. Published online October 11, 2006; 10.1124/dmd.106.011247 [Abstract] [Full Text] [PDF]  

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