Articles:

H. F. Perrett, Z. E. Barter, B. C. Jones, H. Yamazaki, G. T. Tucker, and A. Rostami-Hodjegan

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes
Drug Metab Dispos 2007 35: 1733-1736. Published online June 28, 2007; 10.1124/dmd.107.015743 [Abstract] [Full Text] [PDF]  

Annalise Di Marco, Antonella Cellucci, Ashok Chaudhary, Massimiliano Fonsi, and Ralph Laufer

High-Throughput Radiometric CYP2C19 Inhibition Assay Using Tritiated (S)-Mephenytoin
Drug Metab Dispos 2007 35: 1737-1743. Published online June 28, 2007; 10.1124/dmd.107.016345 [Abstract] [Full Text] [PDF]  

James P. Chovan, Feng Li, Erya Yu, and Steven C. Ring

Metabolic Profile of [¹⁴C]Bendamustine in Rat Urine and Bile: Preliminary Structural Identification of Metabolites
Drug Metab Dispos 2007 35: 1744-1753. Published online June 28, 2007; 10.1124/dmd.107.015958 [Abstract] [Full Text] [PDF]  

Su N. Kim, Ji Y. Seo, Da W. Jung, Min Y. Lee, Young S. Jung, and Young C. Kim

Induction of Hepatic CYP2E1 by a Subtoxic Dose of Acetaminophen in Rats: Increase in Dichloromethane Metabolism and Carboxyhemoglobin Elevation
Drug Metab Dispos 2007 35: 1754-1758. Published online July 9, 2007; 10.1124/dmd.107.015545 [Abstract] [Full Text] [PDF]  

Hye Hyun Yoo, Min Woo Lee, Young Choong Kim, Chul-Ho Yun, and Dong-Hyun Kim

Mechanism-Based Inactivation of Cytochrome P450 2A6 by Decursinol Angelate Isolated from Angelica Gigas
Drug Metab Dispos 2007 35: 1759-1765. Published online July 9, 2007; 10.1124/dmd.107.016584 [Abstract] [Full Text] [PDF]  

Stefan S. De Buck, Vikash K. Sinha, Luca A. Fenu, Marjoleen J. Nijsen, Claire E. Mackie, and Ron A. H. J. Gilissen

Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
Drug Metab Dispos 2007 35: 1766-1780. Published online July 9, 2007; 10.1124/dmd.107.015644 [Abstract] [Full Text] [PDF]  

Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh, and Tsuyoshi Yokoi

Interactions between Human UGT1A1, UGT1A4, and UGT1A6 Affect Their Enzymatic Activities
Drug Metab Dispos 2007 35: 1781-1787. Published online July 9, 2007; 10.1124/dmd.107.016402 [Abstract] [Full Text] [PDF]  

Kristina Lexmüller, Helena Gullstrand, Bengt-Olof Axelsson, Petter Sjölin, Solange H. Korn, David S. Silberstein, and Anna Miller-Larsson

Differences in Endogenous Esterification and Retention in the Rat Trachea between Budesonide and Ciclesonide Active Metabolite
Drug Metab Dispos 2007 35: 1788-1796. Published online July 12, 2007; 10.1124/dmd.107.015297 [Abstract] [Full Text] [PDF]  

G. I. Somers, N. Lindsay, B. M. Lowdon, A. E. Jones, C. Freathy, S. Ho, A. J. M. Woodrooffe, M. K. Bayliss, and G. R. Manchee

A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes
Drug Metab Dispos 2007 35: 1797-1805. Published online July 12, 2007; 10.1124/dmd.107.015966 [Abstract] [Full Text] [PDF]  

Jay S. Petrick and Curtis D. Klaassen

Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport
Drug Metab Dispos 2007 35: 1806-1815. Published online July 12, 2007; 10.1124/dmd.107.015974 [Abstract] [Full Text] [PDF]  

N. Plock, C. Buerger, C. Joukhadar, S. Kljucar, and C. Kloft

Does Linezolid Inhibit Its Own Metabolism?—Population Pharmacokinetics As a Tool to Explain the Observed Nonlinearity in Both Healthy Volunteers and Septic Patients
Drug Metab Dispos 2007 35: 1816-1823. Published online July 16, 2007; 10.1124/dmd.106.013755 [Abstract] [Full Text] [PDF]  

Nadiya Bakhiya, Monika Batke, Janet Laake, Bernhard H. Monien, Heinz Frank, Albrecht Seidel, Wolfram Engst, and Hansruedi Glatt

Directing Role of Organic Anion Transporters in the Excretion of Mercapturic Acids of Alkylated Polycyclic Aromatic Hydrocarbons
Drug Metab Dispos 2007 35: 1824-1831. Published online July 16, 2007; 10.1124/dmd.107.016964 [Abstract] [Full Text] [PDF]  

Jun Tang, Teruaki Akao, Norio Nakamura, Zheng-Tao Wang, Kiyoshi Takagawa, Masakiyo Sasahara, and Masao Hattori

In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors
Drug Metab Dispos 2007 35: 1832-1839. Published online July 16, 2007; 10.1124/dmd.107.016311 [Abstract] [Full Text] [PDF]  

Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul W. Czoty, David E. Nichols, and Michael A. Nader

Ambient Temperature Effects on 3,4-Methylenedioxymethamphetamine-Induced Thermodysregulation and Pharmacokinetics in Male Monkeys
Drug Metab Dispos 2007 35: 1840-1845. Published online July 19, 2007; 10.1124/dmd.107.016261 [Abstract] [Full Text] [PDF]  

Masataka Oitate, Takashi Hirota, Takahiro Murai, Shin-ichi Miura, and Toshihiko Ikeda

Covalent Binding of Rofecoxib, but Not Other Cyclooxygenase-2 Inhibitors, to Allysine Aldehyde in Elastin of Human Aorta
Drug Metab Dispos 2007 35: 1846-1852. Published online July 9, 2007; 10.1124/dmd.107.016121 [Abstract] [Full Text] [PDF]  

Vaishali Dixit, Niresh Hariparsad, Fang Li, Pankaj Desai, Kenneth E. Thummel, and Jashvant D. Unadkat

Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions
Drug Metab Dispos 2007 35: 1853-1859. Published online July 16, 2007; 10.1124/dmd.107.016089 [Abstract] [Full Text] [PDF]  

Kunio Itoh, Hiroaki Maruyama, Mayuko Adachi, Kouichi Hoshino, Nobuaki Watanabe, and Yorihisa Tanaka

Lack of Formation of Aldehyde Oxidase Dimer Possibly Due to 377G>A Nucleotide Substitution
Drug Metab Dispos 2007 35: 1860-1864. Published online July 16, 2007; 10.1124/dmd.107.015503 [Abstract] [Full Text] [PDF]  

Su-Ryang Kim, Kimie Sai, Toshiko Tanaka-Kagawa, Hideto Jinno, Shogo Ozawa, Nahoko Kaniwa, Yoshiro Saito, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito, Naoyuki Kamatani, Kuniaki Shirao, Noboru Yamamoto, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Nagahiro Saijo, and Jun-ichi Sawada

Haplotypes and a Novel Defective Allele of CES2 Found in a Japanese Population
Drug Metab Dispos 2007 35: 1865-1872. Published online July 19, 2007; 10.1124/dmd.107.015339 [Abstract] [Full Text] [PDF]  

Tomohiro Ando, Hiroyuki Kusuhara, Gracia Merino, Ana I. Alvarez, Alfred H. Schinkel, and Yuichi Sugiyama

Involvement of Breast Cancer Resistance Protein (ABCG2) in the Biliary Excretion Mechanism of Fluoroquinolones
Drug Metab Dispos 2007 35: 1873-1879. Published online July 16, 2007; 10.1124/dmd.107.014969 [Abstract] [Full Text] [PDF]  

Wattanaporn Bhadhprasit, Tsutomu Sakuma, Nobuyuki Hatakeyama, Masahiro Fuwa, Kaori Kitajima, and Nobuo Nemoto

Involvement of Glucocorticoid Receptor and Pregnane X Receptor in the Regulation of Mouse CYP3A44 Female-Predominant Expression by Glucocorticoid Hormone
Drug Metab Dispos 2007 35: 1880-1885. Published online July 19, 2007; 10.1124/dmd.107.016832 [Abstract] [Full Text] [PDF]  

Huadong Tang, Azher Hussain, Mauricio Leal, Michael Mayersohn, and Eric Fluhler

Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
Drug Metab Dispos 2007 35: 1886-1893. Published online July 23, 2007; 10.1124/dmd.107.016188 [Abstract] [Full Text] [PDF]  

Michael D. Cameron, Jason Wright, Christopher B. Black, and Naidong Ye

In Vitro Prediction and in Vivo Verification of Enantioselective Human Tofisopam Metabolite Profiles
Drug Metab Dispos 2007 35: 1894-1902. Published online July 23, 2007; 10.1124/dmd.107.015875 [Abstract] [Full Text] [PDF]  

Everett J. Perkins and Trent Abraham

Pharmacokinetics, Metabolism, and Excretion of the Intestinal Peptide Transporter 1 (SLC15A1)-Targeted Prodrug (1S,2S,5R,6S)-2-[(2'S)-(2-Amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid (LY544344) in Rats and Dogs: Assessment of First-Pass Bioactivation and Dose Linearity
Drug Metab Dispos 2007 35: 1903-1909. Published online July 23, 2007; 10.1124/dmd.107.016154 [Abstract] [Full Text] [PDF]  

R. K. Kuester and I. G. Sipes

Prediction of Metabolic Clearance of Bisphenol A (4,4 '-Dihydroxy-2,2-diphenylpropane) using Cryopreserved Human Hepatocytes
Drug Metab Dispos 2007 35: 1910-1915. Published online July 23, 2007; 10.1124/dmd.107.014787 [Abstract] [Full Text] [PDF] [Data Supplement]   

Mingxin Qian, Stephen A. Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, Maryanne B. Covington, Kris Vaddi, Robert C. Newton, Michael J. Fossler, C. Edwin Garner, Yuzhong Deng, Thomas Maduskuie, James Trzaskos, James J.-W. Duan, Carl P. Decicco, and David D. Christ

Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor -Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans
Drug Metab Dispos 2007 35: 1916-1925. Published online July 26, 2007; 10.1124/dmd.107.015933 [Abstract] [Full Text] [PDF]  

Dagmar Aimová, Lucie Svobodová, Vera Kotrbová, Barbora Mrázová, Petr Hodek, Jirí Hudecek, Radka Václavíková, Eva Frei, and Marie Stiborová

The Anticancer Drug Ellipticine Is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism
Drug Metab Dispos 2007 35: 1926-1934. Published online July 26, 2007; 10.1124/dmd.107.016048 [Abstract] [Full Text] [PDF] [Data Supplement]   

Eriko Higashi, Tatsuki Fukami, Masahiro Itoh, Satoru Kyo, Masaki Inoue, Tsuyoshi Yokoi, and Miki Nakajima

Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor
Drug Metab Dispos 2007 35: 1935-1941. Published online July 23, 2007; 10.1124/dmd.107.016568 [Abstract] [Full Text] [PDF]  

Yan Zheng, Dongxiao Sun, Arun K. Sharma, Gang Chen, Shantu Amin, and Philip Lazarus

Elimination of Antiestrogenic Effects of Active Tamoxifen Metabolites by Glucuronidation
Drug Metab Dispos 2007 35: 1942-1948. Published online July 9, 2007; 10.1124/dmd.107.016279 [Abstract] [Full Text] [PDF]  

Yoshihisa Kato, Shin-ichi Ikushiro, Rie Takiguchi, Koichi Haraguchi, Nobuyuki Koga, Shinya Uchida, Toshiyuki Sakaki, Shizuo Yamada, Jun Kanno, and Masakuni Degawa

A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats
Drug Metab Dispos 2007 35: 1949-1955. Published online July 16, 2007; 10.1124/dmd.107.017327 [Abstract] [Full Text] [PDF]  

Mingyan Zhou, Li Xia, and Joanne Wang

Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
Drug Metab Dispos 2007 35: 1956-1962. Published online June 28, 2007; 10.1124/dmd.107.015495 [Abstract] [Full Text] [PDF]  

Sarah N. Barnes, Lauren M. Aleksunes, Lisa Augustine, George L. Scheffer, Michael J. Goedken, Amy B. Jakowski, Ingrid M. Pruimboom-Brees, Nathan J. Cherrington, and José E. Manautou

Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases
Drug Metab Dispos 2007 35: 1963-1969. Published online July 12, 2007; 10.1124/dmd.107.016170 [Abstract] [Full Text] [PDF]  

Andrew J. Lickteig, Craig D. Fisher, Lisa M. Augustine, Lauren M. Aleksunes, David G. Besselsen, Angela L. Slitt, Jose E. Manautou, and Nathan J. Cherrington

Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease
Drug Metab Dispos 2007 35: 1970-1978. Published online July 19, 2007; 10.1124/dmd.107.015107 [Abstract] [Full Text] [PDF]  

Short Communications:

Svenja Kristin Brüggemann, Sonja Pfäffle, Stefan Oliver Peters, and Thomas Wagner

Influence of Short-Term Use of Dexamethasone on the Pharmacokinetics of Ifosfamide in Patients
Drug Metab Dispos 2007 35: 1721-1724. Published online June 28, 2007; 10.1124/dmd.106.014043 [Abstract] [Full Text] [PDF]  

Cuiping Chen, Jian Lin, Teresa Smolarek, and Larry Tremaine

P-glycoprotein Has Differential Effects on the Disposition of Statin Acid and Lactone Forms in mdr1a/b Knockout and Wild-Type Mice
Drug Metab Dispos 2007 35: 1725-1729. Published online July 19, 2007; 10.1124/dmd.107.015677 [Abstract] [Full Text] [PDF]  

Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa, and Michinao Mizugaki

Characterization of Human Cytochrome P450 Enzymes Involved in the Metabolism of Cilostazol
Drug Metab Dispos 2007 35: 1730-1732. Published online July 23, 2007; 10.1124/dmd.107.016758 [Abstract] [Full Text] [PDF]  

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