DMD -- Table of Contents (35 [11])

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November 2007; 35 (11)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

       Erratum

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Articles:

Han-Joo Maeng, Mi-Hwa Kim, Hyo-Eon Jin, Sang Mi Shin, Takasi Tsuruo, Sang Geon Kim, Dae-Duk Kim, Chang-Koo Shim, and Suk-Jae Chung: Functional Induction of P-glycoprotein in the Blood-Brain Barrier of Streptozotocin-Induced Diabetic Rats: Evidence for the Involvement of Nuclear Factor- ${kappa}$ B, a Nitrosative Stress-Sensitive Transcription Factor, in the Regulation
Drug Metab Dispos 2007 35: 1996-2005. Published online July 30, 2007; 10.1124/dmd.107.015800 [Abstract] [Full Text] [PDF]

Dongxiao Sun, Arun K. Sharma, Ryan W. Dellinger, Andrea S. Blevins-Primeau, Renee M. Balliet, Gang Chen, Telih Boyiri, Shantu Amin, and Philip Lazarus: Glucuronidation of Active Tamoxifen Metabolites by the Human UDP Glucuronosyltransferases
Drug Metab Dispos 2007 35: 2006-2014. Published online July 30, 2007; 10.1124/dmd.107.017145 [Abstract] [Full Text] [PDF]

Christopher Jewell, Chrisita Ackermann, N. Ann Payne, Gwendolyn Fate, Richard Voorman, and Faith M. Williams: Specificity of Procaine and Ester Hydrolysis by Human, Minipig, and Rat Skin and Liver
Drug Metab Dispos 2007 35: 2015-2022. Published online July 30, 2007; 10.1124/dmd.107.015727 [Abstract] [Full Text] [PDF]

Minh Hien Pham, Nicolas Auzeil, Anne Regazzetti, Daniel Dauzonne, Annabelle Dugay, Marie-Claude Menet, Daniel Scherman, and Guy G. Chabot: Identification of New Flavone-8-Acetic Acid Metabolites Using Mouse Microsomes and Comparison with Human Microsomes
Drug Metab Dispos 2007 35: 2023-2034. Published online July 30, 2007; 10.1124/dmd.107.017012 [Abstract] [Full Text] [PDF] [Data Supplement]

Petra Jancová, Eva Anzenbacherová, Barbora Papousková, Karel Lemr, Pavla Luzná, Alena Veinlichová, Pavel Anzenbacher, and Vilím Simánek: Silybin Is Metabolized by Cytochrome P450 2C8 in Vitro
Drug Metab Dispos 2007 35: 2035-2039. Published online August 1, 2007; 10.1124/dmd.107.016410 [Abstract] [Full Text] [PDF]

Yuji Mano, Takashi Usui, and Hidetaka Kamimura: The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver
Drug Metab Dispos 2007 35: 2040-2044. Published online August 1, 2007; 10.1124/dmd.107.017269 [Abstract] [Full Text] [PDF]

Naomi Mizuno, Tsuyoshi Takahashi, Hiroyuki Kusuhara, John D. Schuetz, Takuro Niwa, and Yuichi Sugiyama: Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one)
Drug Metab Dispos 2007 35: 2045-2052. Published online August 6, 2007; 10.1124/dmd.107.016352 [Abstract] [Full Text] [PDF]

Robert L. Walsky and R. Scott Obach: A Comparison of 2-Phenyl-2-(1-piperidinyl)propane (PPP), 1,1',1''-Phosphinothioylidynetrisaziridine (ThioTEPA), Clopidogrel, and Ticlopidine as Selective Inactivators of Human Cytochrome P450 2B6
Drug Metab Dispos 2007 35: 2053-2059. Published online August 6, 2007; 10.1124/dmd.107.015883 [Abstract] [Full Text] [PDF]

María L. Ruiz, Silvina S.M. Villanueva, Marcelo G. Luquita, Shin-ichi Ikushiro, Aldo D. Mottino, and Viviana A. Catania: Beneficial Effect of Spironolactone Administration on Ethynylestradiol-Induced Cholestasis in the Rat: Involvement of Up-Regulation of Multidrug Resistance-Associated Protein 2
Drug Metab Dispos 2007 35: 2060-2066. Published online August 8, 2007; 10.1124/dmd.107.016519 [Abstract] [Full Text] [PDF]

Michael Zhuo Wang, Judy Qiju Wu, Arlene S. Bridges, Darryl C. Zeldin, Sally Kornbluth, Richard R. Tidwell, James Edwin Hall, and Mary F. Paine: Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine
Drug Metab Dispos 2007 35: 2067-2075. Published online August 20, 2007; 10.1124/dmd.107.016428 [Abstract] [Full Text] [PDF]

Naveed Shaik, Nagdeep Giri, Guoyu Pan, and William F. Elmquist: P-glycoprotein-Mediated Active Efflux of the Anti-HIV1 Nucleoside Abacavir Limits Cellular Accumulation and Brain Distribution
Drug Metab Dispos 2007 35: 2076-2085. Published online August 20, 2007; 10.1124/dmd.107.017723 [Abstract] [Full Text] [PDF]

Pamela J. Brown, Leanne L. Bedard, Ken R. Reid, Dimitri Petsikas, and Thomas E. Massey: Analysis of CYP2A Contributions to Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Human Peripheral Lung Microsomes
Drug Metab Dispos 2007 35: 2086-2094. Published online August 23, 2007; 10.1124/dmd.107.017343 [Abstract] [Full Text] [PDF]

Su-Jun Lee, Sang Seop Lee, Hye-Eun Jeong, Ji-Hong Shon, Ji-Young Ryu, Yu Eun Sunwoo, Kwang-Hyeon Liu, Wonku Kang, Young-Ju Park, Chi-Mann Shin, and Jae-Gook Shin: The CYP3A4^*18 Allele, the Most Frequent Coding Variant in Asian Populations, Does Not Significantly Affect the Midazolam Disposition in Heterozygous Individuals
Drug Metab Dispos 2007 35: 2095-2101. Published online August 27, 2007; 10.1124/dmd.107.016733 [Abstract] [Full Text] [PDF]

Ravindra N. Dhir, Chellappagounder Thangavel, and Bernard H. Shapiro: Attenuated Expression of Episodic Growth Hormone-Induced CYP2C11 in Female Rats Associated with Suboptimal Activation of the Jak2/Stat5B and Other Modulating Signaling Pathways
Drug Metab Dispos 2007 35: 2102-2110. Published online August 6, 2007; 10.1124/dmd.107.017475 [Abstract] [Full Text] [PDF]

Amit S. Kalgutkar, Bo Feng, Hang T. Nguyen, Kosea S. Frederick, Scott D. Campbell, Heather L. Hatch, Yi-An Bi, Diana C. Kazolias, Ralph E. Davidson, Rouchelle J. Mireles, David B. Duignan, Edna F. Choo, and Sabrina X. Zhao: Role of Transporters in the Disposition of the Selective Phosphodiesterase-4 Inhibitor (+)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic Acid in Rat and Human
Drug Metab Dispos 2007 35: 2111-2118. Published online August 8, 2007; 10.1124/dmd.107.016162 [Abstract] [Full Text] [PDF]

Hayley S. Brown, Anthony Chadwick, and J. Brian Houston: Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for K_i Determination
Drug Metab Dispos 2007 35: 2119-2126. Published online August 27, 2007; 10.1124/dmd.107.017095 [Abstract] [Full Text] [PDF] [Erratum]

Wen-Ni Chang, Jen-Ning Tsai, Bing-Hung Chen, Huei-Sheng Huang, and Tzu-Fun Fu: Serine Hydroxymethyltransferase Isoforms Are Differentially Inhibited by Leucovorin: Characterization and Comparison of Recombinant Zebrafish Serine Hydroxymethyltransferases
Drug Metab Dispos 2007 35: 2127-2137. Published online July 30, 2007; 10.1124/dmd.107.016840 [Abstract] [Full Text] [PDF]

Short Communications:

Kim G. Toft, Judith A. Johnson, Inger Oulie, and Tore Skotland: NC100668, a New Tracer Tested for Imaging of Venous Thromboembolism: Pharmacokinetics and Metabolism in Humans
Drug Metab Dispos 2007 35: 1979-1984. Published online August 6, 2007; 10.1124/dmd.106.014126 [Abstract] [Full Text] [PDF]

U. Kristina Walle and Thomas Walle: Bioavailable Flavonoids: Cytochrome P450-Mediated Metabolism of Methoxyflavones
Drug Metab Dispos 2007 35: 1985-1989. Published online August 20, 2007; 10.1124/dmd.107.016782 [Abstract] [Full Text] [PDF]

Ragini Vuppugalla, Shu-Ying Chang, Hongjian Zhang, Punit H. Marathe, and David A. Rodrigues: Effect of Commonly Used Organic Solvents on the Kinetics of Cytochrome P450 2B6- and 2C8-Dependent Activity in Human Liver Microsomes
Drug Metab Dispos 2007 35: 1990-1995. Published online August 20, 2007; 10.1124/dmd.107.016816 [Abstract] [Full Text] [PDF]

Erratum:

: CORRECTION TO "IN VITRO METABOLIC STUDY OF TEMSIROLIMUS: PREPARATION, ISOLATION, AND IDENTIFICATION OF THE METABOLITES"
Drug Metab Dispos 2007 35: 2138. [Full Text] [PDF]

Cover Caption:

About the cover: Metabolism of NNK. Metabolites I and II are detoxification products produced by pyridine N-oxidation; metabolites III to VI are endpoint products of |ga-hydroxylation and are indicative of the formation of unstable reactive metabolites which methylate or pyridyloxobutylate DNA*. See the article by Brown et al. on page 2086 of this issue.