DMD -- Table of Contents (35 [12])

Noab BioDiscoveries - Shaping Drug Discovery

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December 2007; 35 (12)   [Index by Author] [Cover Caption]

       Articles

       Short Communication

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Articles:

Koichi Omura, Takashi Nakazawa, Takahiro Sato, Takashi Iwanaga, and Osamu Nagata: Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor
Drug Metab Dispos 2007 35: 2143-2148. Published online August 30, 2007; 10.1124/dmd.107.017251 [Abstract] [Full Text] [PDF]

Jacqueline Ramírez, Wanqing Liu, Snezana Mirkov, Apurva A. Desai, Peixian Chen, Soma Das, Federico Innocenti, and Mark J. Ratain: Lack of Association between Common Polymorphisms in UGT1A9 and Gene Expression and Activity
Drug Metab Dispos 2007 35: 2149-2153. Published online August 30, 2007; 10.1124/dmd.107.015446 [Abstract] [Full Text] [PDF]

Yi Zhang, Honggang Wang, Jashvant D. Unadkat, and Qingcheng Mao: Breast Cancer Resistance Protein 1 Limits Fetal Distribution of Nitrofurantoin in the Pregnant Mouse
Drug Metab Dispos 2007 35: 2154-2158. Published online September 4, 2007; 10.1124/dmd.107.018044 [Abstract] [Full Text] [PDF]

D. A. Fairman, C. Collins, and S. Chapple: Progress Curve Analysis of CYP1A2 Inhibition: A More Informative Approach to the Assessment of Mechanism-Based Inactivation?
Drug Metab Dispos 2007 35: 2159-2165. Published online September 6, 2007; 10.1124/dmd.107.017236 [Abstract] [Full Text] [PDF]

Akihiro Yamada, Kazuya Maeda, Emi Kamiyama, Daisuke Sugiyama, Tsunenori Kondo, Yoshiyuki Shiroyanagi, Hayakazu Nakazawa, Teruo Okano, Masashi Adachi, John D. Schuetz, Yasuhisa Adachi, Zhuohan Hu, Hiroyuki Kusuhara, and Yuichi Sugiyama: Multiple Human Isoforms of Drug Transporters Contribute to the Hepatic and Renal Transport of Olmesartan, a Selective Antagonist of the Angiotensin II AT1-Receptor
Drug Metab Dispos 2007 35: 2166-2176. Published online September 6, 2007; 10.1124/dmd.107.017459 [Abstract] [Full Text] [PDF]

Wayne A. Johnston, Weiliang Huang, James J. De Voss, Martin A. Hayes, and Elizabeth M.J. Gillam: A Shuffled CYP1A Library Shows Both Structural Integrity and Functional Diversity
Drug Metab Dispos 2007 35: 2177-2185. Published online September 6, 2007; 10.1124/dmd.107.017939 [Abstract] [Full Text] [PDF] [Data Supplement]

Anima Ghosal, Ragu Ramanathan, Yuan Yuan, Neil Hapangama, Swapan K. Chowdhury, Narendra S. Kishnani, and Kevin B. Alton: Identification of Human Liver Cytochrome P450 Enzymes Involved in Biotransformation of Vicriviroc, a CCR5 Receptor Antagonist
Drug Metab Dispos 2007 35: 2186-2195. Published online September 7, 2007; 10.1124/dmd.107.017517 [Abstract] [Full Text] [PDF]

Kazunori Fujimoto, Shingo Arakawa, Toshiyuki Watanabe, Hiroaki Yasumo, Yosuke Ando, Wataru Takasaki, Sunao Manabe, Takashi Yamoto, and Sen-ichi Oda: Generation and Functional Characterization of Mice with a Disrupted Glutathione S-Transferase, Theta 1 Gene
Drug Metab Dispos 2007 35: 2196-2202. Published online September 7, 2007; 10.1124/dmd.107.017905 [Abstract] [Full Text] [PDF]

Zeen Tong, Hongshan Li, Igor Goljer, Oliver McConnell, and Appavu Chandrasekaran: In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP-Glucuronosyltransferases
Drug Metab Dispos 2007 35: 2203-2210. Published online September 17, 2007; 10.1124/dmd.107.016972 [Abstract] [Full Text] [PDF]

Jagannath Kota, Krishna K. Machavaram, Danielle N. McLennan, Glenn A. Edwards, Christopher J. H. Porter, and Susan A. Charman: Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model
Drug Metab Dispos 2007 35: 2211-2217. Published online September 17, 2007; 10.1124/dmd.107.015669 [Abstract] [Full Text] [PDF]

L.-J. Chen, E. H. Lebetkin, E. I. Nwakpuda, and L. T. Burka: Metabolism and Disposition of n-Butyl Glycidyl Ether in F344 Rats and B6C3F1 Mice
Drug Metab Dispos 2007 35: 2218-2224. Published online September 17, 2007; 10.1124/dmd.107.016931 [Abstract] [Full Text] [PDF]

Jane Alcorn, Fawzy A. Elbarbry, Mohammed Z. Allouh, and Patrick J. McNamara: Evaluation of the Assumptions of an Ontogeny Model of Rat Hepatic Cytochrome P450 Activity
Drug Metab Dispos 2007 35: 2225-2231. Published online September 19, 2007; 10.1124/dmd.107.017590 [Abstract] [Full Text] [PDF]

David A. Erickson, Stacy Hollfelder, Justin Tenge, Mark Gohdes, Jeffrey J. Burkhardt, and Philip A. Krieter: In Vitro Metabolism of the Analgesic Bicifadine in the Mouse, Rat, Monkey, and Human
Drug Metab Dispos 2007 35: 2232-2241. Published online September 19, 2007; 10.1124/dmd.107.016055 [Abstract] [Full Text] [PDF] [Data Supplement]

Ahmed Kousba, Richard Soll, Shiyin Yee, and Michael Martin: Cyclic Conversion of the Novel Src Kinase Inhibitor [7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-Oxide Metabolite by Flavin-Containing Monoxygenases and Cytochrome P450 Reductase
Drug Metab Dispos 2007 35: 2242-2251. Published online September 19, 2007; 10.1124/dmd.107.017384 [Abstract] [Full Text] [PDF]

Silvio Aprile, Erika Del Grosso, Gian Cesare Tron, and Giorgio Grosa: In Vitro Metabolism Study of Combretastatin A-4 in Rat and Human Liver Microsomes
Drug Metab Dispos 2007 35: 2252-2261. Published online September 21, 2007; 10.1124/dmd.107.016998 [Abstract] [Full Text] [PDF] [Data Supplement]

Thomas Haarmann-Stemmann, Hanno Bothe, Amitabh Kohli, Ulrich Sydlik, Josef Abel, and Ellen Fritsche: Analysis of the Transcriptional Regulation and Molecular Function of the Aryl Hydrocarbon Receptor Repressor in Human Cell Lines
Drug Metab Dispos 2007 35: 2262-2269. Published online September 21, 2007; 10.1124/dmd.107.016253 [Abstract] [Full Text] [PDF]

Donglu Zhang, Duxi Zhang, Dan Cui, Janice Gambardella, Li Ma, Anthony Barros, Lifei Wang, Yunlin Fu, Sandhya Rahematpura, Julia Nielsen, Michael Donegan, Hongjian Zhang, and W. Griffith Humphreys: Characterization of the UDP Glucuronosyltransferase Activity of Human Liver Microsomes Genotyped for the UGT1A1*28 Polymorphism
Drug Metab Dispos 2007 35: 2270-2280. Published online September 26, 2007; 10.1124/dmd.107.017806 [Abstract] [Full Text] [PDF]

Short Communication:

Huadong Tang and Michael Mayersohn: Utility of the Coefficient of Determination (r²) in Assessing the Accuracy of Interspecies Allometric Predictions: Illumination or Illusion?
Drug Metab Dispos 2007 35: 2139-2142. Published online August 30, 2007; 10.1124/dmd.107.016444 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Identification of functional XRE sites within intron 1 of the human AhRR gene. Schematic structure (not scaled) of the human AhRR gene and localization of the cloned regulatory region of intron 1. See the article by Haarmann-Stemmann et al. on page 2262 of this issue.