Articles:

Gang Luo, C. Edwin Garner, Hao Xiong, Hanbo Hu, Lauren E. Richards, Kim L. R. Brouwer, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Helen Shen, Frank W. Lee, and Liang-Shang Gan

Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor -Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A Transporter-Based Drug-Drug Interaction Case Study
Drug Metab Dispos 2007 35: 835-840. Published online March 1, 2007; 10.1124/dmd.106.013946 [Abstract] [Full Text] [PDF]  

Sirimas Sudsakorn, Jeffrey Skell, David A. Williams, Thomas J. O'Shea, and Hanlan Liu

Evaluation of 3-O-Methylfluorescein as a Selective Fluorometric Substrate for CYP2C19 in Human Liver Microsomes
Drug Metab Dispos 2007 35: 841-847. Published online March 1, 2007; 10.1124/dmd.106.014472 [Abstract] [Full Text] [PDF]  

Amit S. Kalgutkar, Deepak K. Dalvie, Jiri Aubrecht, Evan B. Smith, Stephanie L. Coffing, Jennifer R. Cheung, Chandra Vage, Mary E. Lame, Phoebe Chiang, Kim F. McClure, Tristan S. Maurer, Richard V. Coelho, Jr., Victor F. Soliman, and Klaas Schildknegt

Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine_2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation
Drug Metab Dispos 2007 35: 848-858. Published online March 7, 2007; 10.1124/dmd.106.013649 [Abstract] [Full Text] [PDF]  

Matthew G. Soars, Ken Grime, Joanne L. Sproston, Peter J. H. Webborn, and Robert J. Riley

Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
Drug Metab Dispos 2007 35: 859-865. Published online March 7, 2007; 10.1124/dmd.106.014464 [Abstract] [Full Text] [PDF]  

Wan Chan, Hai-Bin Luo, Yufang Zheng, Yuen-Kit Cheng, and Zongwei Cai

Investigation of the Metabolism and Reductive Activation of Carcinogenic Aristolochic Acids in Rats
Drug Metab Dispos 2007 35: 866-874. Published online March 7, 2007; 10.1124/dmd.106.013979 [Abstract] [Full Text] [PDF]  

Bernd Kammerer, Holger Scheible, Wolfgang Albrecht, Christoph H. Gleiter, and Stefan Laufer

Pharmacokinetics of ML3403 ({4-[5-(4-Fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-Type p38 Mitogen-Activated Protein Kinase Inhibitor
Drug Metab Dispos 2007 35: 875-883. Published online March 7, 2007; 10.1124/dmd.106.013409 [Abstract] [Full Text] [PDF]  

Kevin Colizza, Mohamed Awad, and Amin Kamel

Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy
Drug Metab Dispos 2007 35: 884-897. Published online March 14, 2007; 10.1124/dmd.106.014266 [Abstract] [Full Text] [PDF]  

E. G. van de Kerkhof, I. A. M. de Graaf, M. H. de Jager, and G. M. M. Groothuis

Induction of Phase I and II Drug Metabolism in Rat Small Intestine and Colon in Vitro
Drug Metab Dispos 2007 35: 898-907. Published online March 7, 2007; 10.1124/dmd.106.014563 [Abstract] [Full Text] [PDF]  

John C. L. Erve, Sarvesh C. Vashishtha, William DeMaio, and Rasmy E. Talaat

Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry
Drug Metab Dispos 2007 35: 908-916. Published online March 12, 2007; 10.1124/dmd.106.013219 [Abstract] [Full Text] [PDF]  

Enaksha R. Wickremsinhe, Ye Tian, Kenneth J. Ruterbories, Elizabeth M. Verburg, Govinda J. Weerakkody, Atsushi Kurihara, and Nagy A. Farid

Stereoselective Metabolism of Prasugrel in Humans Using a Novel Chiral Liquid Chromatography-Tandem Mass Spectrometry Method
Drug Metab Dispos 2007 35: 917-921. Published online March 12, 2007; 10.1124/dmd.106.014530 [Abstract] [Full Text] [PDF]  

Junichi Enokizono, Hiroyuki Kusuhara, and Yuichi Sugiyama

Regional Expression and Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Mouse Intestine: Overlapping Distribution with Sulfotransferases
Drug Metab Dispos 2007 35: 922-928. Published online March 12, 2007; 10.1124/dmd.106.011239 [Abstract] [Full Text] [PDF]  

Steven X. Hu, Richard Soll, Shiyin Yee, Daniel L. Lohse, Ahmed Kousba, Binqi Zeng, Xiyun Yu, Andrew McPherson, Joel Renick, Jianguo Cao, Arek Tabak, John Hood, John Doukas, Glenn Noronha, and Michael Martin

Metabolism and Pharmacokinetics of a Novel Src Kinase Inhibitor TG100435 ([7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and Its Active N-Oxide Metabolite TG100855 ([7-(2,6-Dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)
Drug Metab Dispos 2007 35: 929-936. Published online March 19, 2007; 10.1124/dmd.106.014290 [Abstract] [Full Text] [PDF]  

Yurong Lai, Li Xing, Gennadiy I. Poda, and Yiding Hu

Structure-Activity Relationships for Interaction with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angle for a Series of Biphenyl-Substituted Heterocycles
Drug Metab Dispos 2007 35: 937-945. Published online March 19, 2007; 10.1124/dmd.106.013250 [Abstract] [Full Text] [PDF]  

Heike Tegude, Anke Schnabel, Ulrich M. Zanger, Kathrin Klein, Michel Eichelbaum, and Oliver Burk

Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4: Evidence for Direct Regulation in the Intestine
Drug Metab Dispos 2007 35: 946-954. Published online March 7, 2007; 10.1124/dmd.106.013565 [Abstract] [Full Text] [PDF]  

Ian Midgley, Karen Fitzpatrick, Lynne M. Taylor, Tara L. Houchen, Simon J. Henderson, Sarah J. Wright, Zbigniew R. Cybulski, Brian A. John, Alan McBurney, David W. Boykin, and Kerri L. Trendler

Pharmacokinetics and Metabolism of the Prodrug DB289 (2,5-Bis[4-(N-methoxyamidino)phenyl]furan Monomaleate) in Rat and Monkey and Its Conversion to the Antiprotozoal/Antifungal Drug DB75 (2,5-Bis(4-guanylphenyl)furan Dihydrochloride)
Drug Metab Dispos 2007 35: 955-967. Published online March 14, 2007; 10.1124/dmd.106.013391 [Abstract] [Full Text] [PDF]  

Alessandra Valentini, Michela Biancolella, Francesca Amati, Paolo Gravina, Roberto Miano, Giovanni Chillemi, Alessio Farcomeni, Susana Bueno, Giuseppe Vespasiani, Alessandro Desideri, Giorgio Federici, Giuseppe Novelli, and Sergio Bernardini

Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line
Drug Metab Dispos 2007 35: 968-972. Published online March 19, 2007; 10.1124/dmd.107.014662 [Abstract] [Full Text] [PDF] [Data Supplement]   

Vanessa Gonzalez-Covarrubias, Debashis Ghosh, Sukhwinder S. Lakhman, Lakshmi Pendyala, and Javier G. Blanco

A Functional Genetic Polymorphism on Human Carbonyl Reductase 1 (CBR1 V88I) Impacts on Catalytic Activity and NADPH Binding Affinity
Drug Metab Dispos 2007 35: 973-980. Published online March 7, 2007; 10.1124/dmd.107.014779 [Abstract] [Full Text] [PDF]  

Zhifeng Yu, Wing Ping Fong, and Christopher H. K. Cheng

Morin (3,5,7,2',4'-Pentahydroxyflavone) Exhibits Potent Inhibitory Actions on Urate Transport by the Human Urate Anion Transporter (hURAT1) Expressed in Human Embryonic Kidney Cells
Drug Metab Dispos 2007 35: 981-986. Published online February 26, 2007; 10.1124/dmd.106.012187 [Abstract] [Full Text] [PDF]  

Dharamainder Choudhary, Ingela Jansson, Karim Rezaul, David K. M. Han, Mansoor Sarfarazi, and John B. Schenkman

Cyp1b1 Protein in the Mouse Eye during Development: An Immunohistochemical Study
Drug Metab Dispos 2007 35: 987-994. Published online February 26, 2007; 10.1124/dmd.106.014282 [Abstract] [Full Text] [PDF]  

Craig D. Fisher, Lisa M. Augustine, Jonathan M. Maher, David M. Nelson, Angela L. Slitt, Curtis D. Klaassen, Lois D. Lehman-McKeeman, and Nathan J. Cherrington

Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2
Drug Metab Dispos 2007 35: 995-1000. Published online March 12, 2007; 10.1124/dmd.106.014340 [Abstract] [Full Text] [PDF]  

Jason M. Walraven, John O. Trent, and David W. Hein

Computational and Experimental Analyses of Mammalian Arylamine N-Acetyltransferase Structure and Function
Drug Metab Dispos 2007 35: 1001-1007. Published online March 19, 2007; 10.1124/dmd.107.015040 [Abstract] [Full Text] [PDF] [Data Supplement]   

Short Communication:

Darja Herman, Vita Dolzan, and Magnus Ingelman-Sundberg

Characterization of the Novel Defective CYP2C9^*24 Allele
Drug Metab Dispos 2007 35: 831-834. Published online March 1, 2007; 10.1124/dmd.106.013722 [Abstract] [Full Text] [PDF]  

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