Perspective:

Qiang Ma and Anthony Y. H. Lu

CYP1A Induction and Human Risk Assessment: An Evolving Tale of in Vitro and in Vivo Studies
Drug Metab Dispos 2007 35: 1009-1016. Published online April 12, 2007; 10.1124/dmd.107.015826 [Abstract] [Full Text] [PDF]  

Articles:

Ping Li, Patrick S. Callery, Liang-Shang Gan, and Suresh K. Balani

Esterase Inhibition Attribute of Grapefruit Juice Leading to a New Drug Interaction
Drug Metab Dispos 2007 35: 1023-1031. Published online March 28, 2007; 10.1124/dmd.106.013268 [Abstract] [Full Text] [PDF]  

Lukas Cerveny, Lucie Svecova, Eva Anzenbacherova, Radim Vrzal, Frantisek Staud, Zdenek Dvorak, Jitka Ulrichova, Pavel Anzenbacher, and Petr Pavek

Valproic Acid Induces CYP3A4 and MDR1 Gene Expression by Activation of Constitutive Androstane Receptor and Pregnane X Receptor Pathways
Drug Metab Dispos 2007 35: 1032-1041. Published online March 28, 2007; 10.1124/dmd.106.014456 [Abstract] [Full Text] [PDF]  

Hsien-Tsung Yao, Yu-Shan Wu, Yi-Wei Chang, Hsing-Pang Hsieh, Wei-Cheng Chen, Shih-Jung Lan, Chiung-Tong Chen, Yu-Sheng Chao, Ling Chang, Hsu-Yi Sun, and Teng-Kuang Yeh

Biotransformation of 6-Methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a Novel Antimicrotubule Agent, by Mouse, Rat, Dog, and Human Liver Microsomes
Drug Metab Dispos 2007 35: 1042-1049. Published online April 2, 2007; 10.1124/dmd.106.014597 [Abstract] [Full Text] [PDF]  

Wei Lu and Jack P. Uetrecht

Possible Bioactivation Pathways of Lamotrigine
Drug Metab Dispos 2007 35: 1050-1056. Published online April 4, 2007; 10.1124/dmd.107.015271 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ganesh Cherala, Bernard H. Shapiro, and Anil P. D'mello

Effect of Perinatal Low Protein Diets on the Ontogeny of Select Hepatic Cytochrome P450 Enzymes and Cytochrome P450 Reductase in the Rat
Drug Metab Dispos 2007 35: 1057-1063. Published online March 28, 2007; 10.1124/dmd.106.013748 [Abstract] [Full Text] [PDF] [Data Supplement]   

K. S. Sugamori, D. Brenneman, S. Wong, A. Gaedigk, V. Yu, H. Abramovici, R. Rozmahel, and D. M. Grant

Effect of Arylamine Acetyltransferase Nat3 Gene Knockout on N-Acetylation in the Mouse
Drug Metab Dispos 2007 35: 1064-1070. Published online April 2, 2007; 10.1124/dmd.107.015396 [Abstract] [Full Text] [PDF]  

Chandra Prakash, John O'Donnell, and S. Cyrus Khojasteh-Bakht

Metabolism, Pharmacokinetics, and Excretion of a Nonpeptidic Substance P Receptor Antagonist, Ezlopitant, in Normal Healthy Male Volunteers: Characterization of Polar Metabolites by Chemical Derivatization with Dansyl Chloride
Drug Metab Dispos 2007 35: 1071-1080. Published online April 12, 2007; 10.1124/dmd.107.015362 [Abstract] [Full Text] [PDF]  

Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, and Alan Deese

Identification of a Novel Glutathione Conjugate of Flutamide in Incubations with Human Liver Microsomes
Drug Metab Dispos 2007 35: 1081-1088. Published online April 2, 2007; 10.1124/dmd.107.014860 [Abstract] [Full Text] [PDF]  

Kenji Masaki, Mitsuru Hashimoto, and Teruko Imai

Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum
Drug Metab Dispos 2007 35: 1089-1095. Published online March 28, 2007; 10.1124/dmd.106.013862 [Abstract] [Full Text] [PDF]  

Nagy A. Farid, Richard L. Smith, Todd A. Gillespie, T. James Rash, Patrick E. Blair, Atsushi Kurihara, and Mark J. Goldberg

The Disposition of Prasugrel, a Novel Thienopyridine, in Humans
Drug Metab Dispos 2007 35: 1096-1104. Published online April 2, 2007; 10.1124/dmd.106.014522 [Abstract] [Full Text] [PDF]  

H. A. M. Verheul, M. L. P. S. van Iersel, L. P. C. Delbressine, and H. J. Kloosterboer

Selective Tissue Distribution of Tibolone Metabolites in Mature Ovariectomized Female Cynomolgus Monkeys after Multiple Doses of Tibolone
Drug Metab Dispos 2007 35: 1105-1111. Published online April 9, 2007; 10.1124/dmd.106.014118 [Abstract] [Full Text] [PDF]  

H. A. M. Verheul, C. J. Timmer, M. L. P. S. van Iersel, L. P. C. Delbressine, and H. J. Kloosterboer

Pharmacokinetic Parameters of Tibolone and Metabolites in Plasma, Urine, Feces, and Bile from Ovariectomized Cynomolgus Monkeys after a Single Dose or Multiple Doses of Tibolone
Drug Metab Dispos 2007 35: 1112-1118. Published online April 9, 2007; 10.1124/dmd.106.014159 [Abstract] [Full Text] [PDF]  

Selma Sahin and Malcolm Rowland

Application of the Dispersion Model to Describe Disposition Kinetics of Markers in the Dual Perfused Rat Liver
Drug Metab Dispos 2007 35: 1119-1125. Published online April 12, 2007; 10.1124/dmd.106.013813 [Abstract] [Full Text] [PDF]  

Valerie Y. Ng, Yong Huang, L. Manmohan Reddy, John R. Falck, Emil T. Lin, and Deanna L. Kroetz

Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor
Drug Metab Dispos 2007 35: 1126-1134. Published online April 12, 2007; 10.1124/dmd.106.013839 [Abstract] [Full Text] [PDF]  

Marjo Volotinen, Miia Turpeinen, Ari Tolonen, Jouko Uusitalo, Jukka Mäenpää, and Olavi Pelkonen

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6
Drug Metab Dispos 2007 35: 1135-1141. Published online April 12, 2007; 10.1124/dmd.106.012906 [Abstract] [Full Text] [PDF]  

Tetsuo Yamagata, Hiroyuki Kusuhara, Mariko Morishita, Kozo Takayama, Hassan Benameur, and Yuichi Sugiyama

Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients
Drug Metab Dispos 2007 35: 1142-1148. Published online April 19, 2007; 10.1124/dmd.106.014217 [Abstract] [Full Text] [PDF]  

Marta Robert, Miquel Salvà, Rosa Segarra, Marco Pavesi, Ramón Esbri, David Roberts, and Georg Golor

The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole
Drug Metab Dispos 2007 35: 1149-1156. Published online April 16, 2007; 10.1124/dmd.106.010835 [Abstract] [Full Text] [PDF]  

Gregory S. Gorman, Lori Coward, Corenna Kerstner-Wood, Lea Cork, Izet M. Kapetanovic, Wayne J. Brouillette, and Donald D. Muccio

In Vitro Metabolic Characterization, Phenotyping, and Kinetic Studies of 9cUAB30, a Retinoid X Receptor-Specific Retinoid
Drug Metab Dispos 2007 35: 1157-1164. Published online April 19, 2007; 10.1124/dmd.106.013938 [Abstract] [Full Text] [PDF]  

Guoyu Pan, Nagdeep Giri, and William F. Elmquist

Abcg2/Bcrp1 Mediates the Polarized Transport of Antiretroviral Nucleosides Abacavir and Zidovudine
Drug Metab Dispos 2007 35: 1165-1173. Published online April 16, 2007; 10.1124/dmd.106.014274 [Abstract] [Full Text] [PDF]  

Charles W. Locuson, Larry C. Wienkers, Jeffrey P. Jones, and Timothy S. Tracy

CYP2C9 Protein Interactions with Cytochrome b₅: Effects on the Coupling of Catalysis
Drug Metab Dispos 2007 35: 1174-1181. Published online April 19, 2007; 10.1124/dmd.107.014910 [Abstract] [Full Text] [PDF]  

Yuji Mano, Takashi Usui, and Hidetaka Kamimura

Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in the Glucuronidation of Racemic Flurbiprofen in the Human Liver
Drug Metab Dispos 2007 35: 1182-1187. Published online April 19, 2007; 10.1124/dmd.107.015347 [Abstract] [Full Text] [PDF]  

Christopher L. Shaffer, Mithat Gunduz, Renato J. Scialis, and Annie F. Fang

Metabolism and Disposition of a Selective ₇ Nicotinic Acetylcholine Receptor Agonist in Humans
Drug Metab Dispos 2007 35: 1188-1195. Published online April 19, 2007; 10.1124/dmd.106.014449 [Abstract] [Full Text] [PDF]  

Bindhu Karanam, Maria Madeira, Scott Bradley, Larissa Wenning, Rajesh Desai, Eric Soli, David Schenk, Allen Jones, Brian Dean, George Doss, Graigory Garrett, Tami Crumley, Ajay Nirula, and Eseng Lai

Absorption, Metabolism, and Excretion of [¹⁴C]MK-0524, a Prostaglandin D₂ Receptor Antagonist, in Humans
Drug Metab Dispos 2007 35: 1196-1202. Published online April 12, 2007; 10.1124/dmd.107.014696 [Abstract] [Full Text] [PDF]  

Ping Li, Patrick S. Callery, Liang-Shang Gan, and Suresh K. Balani

Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction
Drug Metab Dispos 2007 35: 1203-1208. Published online April 23, 2007; 10.1124/dmd.106.013904 [Abstract] [Full Text] [PDF]  

Hong Shen, Scott M. Ocheltree, Yongjun Hu, Richard F. Keep, and David E. Smith

Impact of Genetic Knockout of PEPT2 on Cefadroxil Pharmacokinetics, Renal Tubular Reabsorption, and Brain Penetration in Mice
Drug Metab Dispos 2007 35: 1209-1216. Published online April 23, 2007; 10.1124/dmd.107.015263 [Abstract] [Full Text] [PDF]  

Shinya Shibutani, Huan Dong, Naomi Suzuki, Shiro Ueda, Frederick Miller, and Arthur P. Grollman

Selective Toxicity of Aristolochic Acids I and II
Drug Metab Dispos 2007 35: 1217-1222. Published online March 28, 2007; 10.1124/dmd.107.014688 [Abstract] [Full Text] [PDF]  

Kristina K. Wolf, Sheryl G. Wood, Jenna L. Allard, Jane A. Hunt, Nadia Gorman, Brooke W. Walton-Strong, Juliana G. Szakacs, Su X. Duan, Qin Hao, Michael H. Court, Lisa L. von Moltke, David J. Greenblatt, Vsevolod Kostrubsky, Elizabeth H. Jeffery, Steven A. Wrighton, Frank J. Gonzalez, Peter R. Sinclair, and Jacqueline F. Sinclair

Role of CYP3A and CYP2E1 in Alcohol-Mediated Increases in Acetaminophen Hepatotoxicity: Comparison of Wild-Type and Cyp2e1(–/–) Mice
Drug Metab Dispos 2007 35: 1223-1231. Published online March 28, 2007; 10.1124/dmd.107.014738 [Abstract] [Full Text] [PDF]  

Akiko Watanabe, Koichi Nakamura, Noriko Okudaira, Osamu Okazaki, and Ken-ichi Sudo

Risk Assessment for Drug-Drug Interaction Caused by Metabolism-Based Inhibition of CYP3A Using Automated in Vitro Assay Systems and Its Application in the Early Drug Discovery Process
Drug Metab Dispos 2007 35: 1232-1238. Published online March 28, 2007; 10.1124/dmd.107.015016 [Abstract] [Full Text] [PDF]  

Yasuna Kobayashi, Ayumi Tsuchiya, Tomofumi Hayashi, Noriko Kohyama, Masayuki Ohbayashi, and Toshinori Yamamoto

Isolation and Characterization of Polyspecific Mouse Organic Solute Carrier Protein 1 (mOscp1)
Drug Metab Dispos 2007 35: 1239-1245. Published online April 19, 2007; 10.1124/dmd.107.014795 [Abstract] [Full Text] [PDF]  

Short Communication:

Nicola E. Wilsher, Will J. Court, Ruth Ruddle, Yvette M. Newbatt, Wynne Aherne, Peter W. Sheldrake, Neil P. Jones, Matilda Katan, Suzanne A. Eccles, and Florence I. Raynaud

The Phosphoinositide-Specific Phospholipase C Inhibitor U73122 (1-(6-((17ß-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) Spontaneously Forms Conjugates with Common Components of Cell Culture Medium
Drug Metab Dispos 2007 35: 1017-1022. Published online April 2, 2007; 10.1124/dmd.106.014498 [Abstract] [Full Text] [PDF]  

Erratum:

CORRECTION TO "THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF HUMAN CYP51 INHIBITORS"
Drug Metab Dispos 2007 35: 1246. [Full Text] [PDF]  

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