Articles:

David R. Jones, Sean Ekins, Lang Li, and Stephen D. Hall

Computational Approaches That Predict Metabolic Intermediate Complex Formation with CYP3A4 (+b₅)
Drug Metab Dispos 2007 35: 1466-1475. Published online May 30, 2007; 10.1124/dmd.106.014613 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kilian Bartholomé, Maria Rius, Katrin Letschert, Daniela Keller, Jens Timmer, and Dietrich Keppler

Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized Cells
Drug Metab Dispos 2007 35: 1476-1481. Published online June 4, 2007; 10.1124/dmd.107.015636 [Abstract] [Full Text] [PDF] [Data Supplement]   

Naoko Urushino, Sachie Nakabayashi, Midori A. Arai, Atsushi Kittaka, Tai C. Chen, Keiko Yamamoto, Keiko Hayashi, Shigeaki Kato, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro, and Toshiyuki Sakaki

Kinetic Studies of 25-Hydroxy-19-nor-vitamin D₃ and 1,25-Dihydroxy-19-nor-vitamin D₃ Hydroxylation by CYP27B1 and CYP24A1
Drug Metab Dispos 2007 35: 1482-1488. Published online June 6, 2007; 10.1124/dmd.107.015602 [Abstract] [Full Text] [PDF]  

Jun Xia and Byron Kemper

Subcellular Trafficking Signals of Constitutive Androstane Receptor: Evidence for a Nuclear Export Signal in the DNA-Binding Domain
Drug Metab Dispos 2007 35: 1489-1494. Published online June 13, 2007; 10.1124/dmd.107.016493 [Abstract] [Full Text] [PDF]  

Krisztina Kohalmy, Viola Tamási, László Kóbori, Eniko Sárváry, Jean-Marc Pascussi, Pálma Porrogi, Damjana Rozman, Russell A. Prough, Urs A. Meyer, and Katalin Monostory

Dehydroepiandrosterone Induces Human CYP2B6 through the Constitutive Androstane Receptor
Drug Metab Dispos 2007 35: 1495-1501. Published online June 25, 2007; 10.1124/dmd.107.016303 [Abstract] [Full Text] [PDF]  

Nami Akaho, Jiro Takata, Takeshi Fukushima, Kazuhisa Matsunaga, Akihiro Hattori, Ryoji Hidaka, Kosuke Fukui, Miyako Yoshida, Toshihiro Fujioka, Yoshiharu Karube, and Kazuhiro Imai

Preparation and In Vivo Evaluation of a Water-Soluble Prodrug for 2R--Tocotrienol and as a Two-Step Prodrug for 2,7,8-Trimethyl-2S-(ß-carboxyethyl)-6-hydroxychroman (S--CEHC) in Rat
Drug Metab Dispos 2007 35: 1502-1510. Published online May 30, 2007; 10.1124/dmd.106.014365 [Abstract] [Full Text] [PDF]  

Koji Yokoo, Akinobu Hamada, Hiroshi Watanabe, Takanobu Matsuzaki, Tomoyuki Imai, Hiromi Fujimoto, Kengo Masa, Teruko Imai, and Hideyuki Saito

Involvement of Up-Regulation of Hepatic Breast Cancer Resistance Protein in Decreased Plasma Concentration of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Coadministration of S-1 in Rats
Drug Metab Dispos 2007 35: 1511-1517. Published online May 30, 2007; 10.1124/dmd.107.015164 [Abstract] [Full Text] [PDF]  

Yune-Jung Yoon, Kwon-Bok Kim, Hyunmi Kim, Kyung-Ah Seo, Ho-Sook Kim, In-June Cha, Eun-Young Kim, Kwang-Hyeon Liu, and Jae-Gook Shin

Characterization of Benidipine and Its Enantiomers' Metabolism by Human Liver Cytochrome P450 Enzymes
Drug Metab Dispos 2007 35: 1518-1524. Published online May 30, 2007; 10.1124/dmd.106.013607 [Abstract] [Full Text] [PDF]  

Michael Weiss, Tom C. Krejcie, and Michael J. Avram

A Minimal Physiological Model of Thiopental Distribution Kinetics Based on a Multiple Indicator Approach
Drug Metab Dispos 2007 35: 1525-1532. Published online May 30, 2007; 10.1124/dmd.106.014209 [Abstract] [Full Text] [PDF]  

Hristos Glavinas, Emese Kis, Ákos Pál, Rita Kovács, Márton Jani, Erika Vági, Éva Molnár, Száva Bánsághi, Zoltán Kele, Tamás Janáky, György Báthori, Oliver von Richter, Gerrit-Jan Koomen, and Péter Krajcsi

ABCG2 (Breast Cancer Resistance Protein/Mitoxantrone Resistance-Associated Protein) ATPase Assay: A Useful Tool to Detect Drug-Transporter Interactions
Drug Metab Dispos 2007 35: 1533-1542. Published online May 30, 2007; 10.1124/dmd.106.014605 [Abstract] [Full Text] [PDF]  

Matthew Hoffmann, William DeMaio, Ronald A. Jordan, Rasmy Talaat, Dawn Harper, John Speth, and JoAnn Scatina

Metabolism, Excretion, and Pharmacokinetics of [¹⁴C]Tigecycline, a First-In-Class Glycylcycline Antibiotic, after Intravenous Infusion to Healthy Male Subjects
Drug Metab Dispos 2007 35: 1543-1553. Published online May 30, 2007; 10.1124/dmd.107.015735 [Abstract] [Full Text] [PDF]  

Ping Cai, Rushung Tsao, and Mark E. Ruppen

In Vitro Metabolic Study of Temsirolimus: Preparation, Isolation, and Identification of the Metabolites
Drug Metab Dispos 2007 35: 1554-1563. Published online May 31, 2007; 10.1124/dmd.107.014746 [Abstract] [Full Text] [PDF] [Erratum]   

Yongchi Zeng, Feng Qiu, Yuan Liu, Gexia Qu, and Xinsheng Yao

Isolation and Identification of Phase 1 Metabolites of Demethoxycurcumin in Rats
Drug Metab Dispos 2007 35: 1564-1573. Published online June 6, 2007; 10.1124/dmd.107.015008 [Abstract] [Full Text] [PDF]  

Timo Korjamo, Heidi Kemiläinen, Aki T. Heikkinen, and Jukka Mönkkönen

Decrease in Intracellular Concentration Causes the Shift in K_m Value of Efflux Pump Substrates
Drug Metab Dispos 2007 35: 1574-1579. Published online June 4, 2007; 10.1124/dmd.107.016014 [Abstract] [Full Text] [PDF]  

Tomoji Maeda, Masanobu Oyabu, Takafumi Yotsumoto, Ryunosuke Higashi, Kiyoshi Nagata, Yasushi Yamazoe, and Ikumi Tamai

Effect of Pregnane X Receptor Ligand on Pharmacokinetics of Substrates of Organic Cation Transporter Oct1 in Rats
Drug Metab Dispos 2007 35: 1580-1586. Published online June 6, 2007; 10.1124/dmd.107.015842 [Abstract] [Full Text] [PDF]  

Shogo J. Miyagi and Abby C. Collier

Pediatric Development of Glucuronidation: The Ontogeny of Hepatic UGT1A4
Drug Metab Dispos 2007 35: 1587-1592. Published online June 7, 2007; 10.1124/dmd.107.015214 [Abstract] [Full Text] [PDF]  

Hai-Zhi Bu, Ping Zhao, Ping Kang, William F. Pool, Ellen Y. Wu, and Bhasker V. Shetty

Evaluation of Capravirine as a CYP3A Probe Substrate: In Vitro and in Vivo Metabolism of Capravirine in Rats and Dogs
Drug Metab Dispos 2007 35: 1593-1602. Published online June 13, 2007; 10.1124/dmd.107.016147 [Abstract] [Full Text] [PDF]  

Jhy-Wen Wu and Tung-Hu Tsai

Effect of Silibinin on the Pharmacokinetics of Pyrazinamide and Pyrazinoic Acid in Rats
Drug Metab Dispos 2007 35: 1603-1610. Published online May 31, 2007; 10.1124/dmd.107.014894 [Abstract] [Full Text] [PDF]  

Ryuichi Kitamura, Yoshio Yamamoto, Sekio Nagayama, and Masaki Otagiri

Decrease in Plasma Concentrations of Antiangiogenic Agent TSU-68 ((Z)-5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid) during Oral Administration Twice a Day to Rats
Drug Metab Dispos 2007 35: 1611-1616. Published online June 13, 2007; 10.1124/dmd.106.014068 [Abstract] [Full Text] [PDF]  

Qing-Yu Zhang, Laurence S. Kaminsky, Deborah Dunbar, Jin Zhang, and Xinxin Ding

Role of Small Intestinal Cytochromes P450 in the Bioavailability of Oral Nifedipine
Drug Metab Dispos 2007 35: 1617-1623. Published online June 13, 2007; 10.1124/dmd.107.016543 [Abstract] [Full Text] [PDF]  

Satoshi Ohmori, Masahiro Miura, Chifuyu Toriumi, Yoshiaki Satoh, and Tsuyoshi Ooie

Absorption, Metabolism, and Excretion of [¹⁴C]Imidafenacin, a New Compound for Treatment of Overactive Bladder, After Oral Administration to Healthy Male Subjects
Drug Metab Dispos 2007 35: 1624-1633. Published online June 13, 2007; 10.1124/dmd.107.016030 [Abstract] [Full Text] [PDF]  

Khaled Abass, Petri Reponen, Miia Turpeinen, Jorma Jalonen, and Olavi Pelkonen

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes
Drug Metab Dispos 2007 35: 1634-1641. Published online June 18, 2007; 10.1124/dmd.107.016295 [Abstract] [Full Text] [PDF]  

Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh, and Tsuyoshi Yokoi

Glucuronidation of Thyroxine in Human Liver, Jejunum, and Kidney Microsomes
Drug Metab Dispos 2007 35: 1642-1648. Published online June 25, 2007; 10.1124/dmd.107.016097 [Abstract] [Full Text] [PDF]  

Anwar Husain, Xiaoyan Zhang, Mark A. Doll, J. Christopher States, David F. Barker, and David W. Hein

Functional Analysis of the Human N-Acetyltransferase 1 Major Promoter: Quantitation of Tissue Expression and Identification of Critical Sequence Elements
Drug Metab Dispos 2007 35: 1649-1656. Published online June 25, 2007; 10.1124/dmd.107.016485 [Abstract] [Full Text] [PDF]  

Kelem Kassahun, Ian McIntosh, Donghui Cui, David Hreniuk, Shelia Merschman, Kenneth Lasseter, Neal Azrolan, Marian Iwamoto, John A. Wagner, and Larissa A. Wenning

Metabolism and Disposition in Humans of Raltegravir (MK-0518), an Anti-AIDS Drug Targeting the Human Immunodeficiency Virus 1 Integrase Enzyme
Drug Metab Dispos 2007 35: 1657-1663. Published online June 25, 2007; 10.1124/dmd.107.016196 [Abstract] [Full Text] [PDF]  

Stephen J. Godin, J. Allen Crow, Edward J. Scollon, Michael F. Hughes, Michael J. DeVito, and Matthew K. Ross

Identification of Rat and Human Cytochrome P450 Isoforms and a Rat Serum Esterase That Metabolize the Pyrethroid Insecticides Deltamethrin and Esfenvalerate
Drug Metab Dispos 2007 35: 1664-1671. Published online June 18, 2007; 10.1124/dmd.107.015388 [Abstract] [Full Text] [PDF]  

Sukyung Woo and William J. Jusko

Interspecies Comparisons of Pharmacokinetics and Pharmacodynamics of Recombinant Human Erythropoietin
Drug Metab Dispos 2007 35: 1672-1678. Published online June 18, 2007; 10.1124/dmd.107.015248 [Abstract] [Full Text] [PDF]  

Miki Nakajima, Hiroyuki Yamanaka, Ryoichi Fujiwara, Miki Katoh, and Tsuyoshi Yokoi

Stereoselective Glucuronidation of 5-(4'-Hydroxyphenyl)-5-phenylhydantoin by Human UDP-Glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: Effects of UGT-UGT Interactions
Drug Metab Dispos 2007 35: 1679-1686. Published online June 18, 2007; 10.1124/dmd.107.015909 [Abstract] [Full Text] [PDF]  

Alison E. Aitken and Edward T. Morgan

Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
Drug Metab Dispos 2007 35: 1687-1693. Published online June 18, 2007; 10.1124/dmd.107.015511 [Abstract] [Full Text] [PDF]  

Martin Wagner, Gernot Zollner, Peter Fickert, Judith Gumhold, Dagmar Silbert, Andrea Fuchsbichler, Jaspreet S. Gujral, Kurt Zatloukal, Helmut Denk, Hartmut Jaeschke, and Michael Trauner

Hepatobiliary Transporter Expression in Intercellular Adhesion Molecule 1 Knockout and Fas Receptor-Deficient Mice after Common Bile Duct Ligation Is Independent of the Degree of Inflammation and Oxidative Stress
Drug Metab Dispos 2007 35: 1694-1699. Published online June 18, 2007; 10.1124/dmd.107.015610 [Abstract] [Full Text] [PDF]  

Matthew Wortham, Maciej Czerwinski, Lin He, Andrew Parkinson, and Yu-Jui Yvonne Wan

Expression of Constitutive Androstane Receptor, Hepatic Nuclear Factor 4, and P450 Oxidoreductase Genes Determines Interindividual Variability in Basal Expression and Activity of a Broad Scope of Xenobiotic Metabolism Genes in the Human Liver
Drug Metab Dispos 2007 35: 1700-1710. Published online June 18, 2007; 10.1124/dmd.107.016436 [Abstract] [Full Text] [PDF]  

Markus Fridén, Anubha Gupta, Madeleine Antonsson, Ulf Bredberg, and Margareta Hammarlund-Udenaes

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids
Drug Metab Dispos 2007 35: 1711-1719. Published online June 25, 2007; 10.1124/dmd.107.015222 [Abstract] [Full Text] [PDF] [Data Supplement]   

Short Communications:

J. E. Ballard, T. Prueksaritanont, and C. Tang

Hepatic Metabolism of MK-0457, a Potent Aurora Kinase Inhibitor: Interspecies Comparison and Role of Human Cytochrome P450 and Flavin-Containing Monooxygenase
Drug Metab Dispos 2007 35: 1447-1451. Published online May 30, 2007; 10.1124/dmd.107.015438 [Abstract] [Full Text] [PDF]  

Kersti Oselin and Kaili Anier

Inhibition of Human Thiopurine S-Methyltransferase by Various Nonsteroidal Anti-inflammatory Drugs in Vitro: A Mechanism for Possible Drug Interactions
Drug Metab Dispos 2007 35: 1452-1454. Published online June 6, 2007; 10.1124/dmd.107.016287 [Abstract] [Full Text] [PDF]  

Takehito Yamamoto, Kousei Ito, Masashi Honma, Tappei Takada, and Hiroshi Suzuki

Cholesterol-Lowering Effect of Ezetimibe in Uridine Diphosphate Glucuronosyltransferase 1A-Deficient (Gunn) Rats
Drug Metab Dispos 2007 35: 1455-1458. Published online June 13, 2007; 10.1124/dmd.107.015628 [Abstract] [Full Text] [PDF]  

Amal Kaddoumi, Sung-Up Choi, Loren Kinman, Dale Whittington, Che-Chung Tsai, Rodney J.Y. Ho, Bradley D. Anderson, and Jashvant D. Unadkat

Inhibition of P-glycoprotein Activity at the Primate Blood-Brain Barrier Increases the Distribution of Nelfinavir into the Brain but Not into the Cerebrospinal Fluid
Drug Metab Dispos 2007 35: 1459-1462. Published online June 25, 2007; 10.1124/dmd.107.016220 [Abstract] [Full Text] [PDF]  

Sanjoy Roychowdhury, Albert E. Cram, Al Aly, and Craig K. Svensson

Detection of Haptenated Proteins in Organotypic Human Skin Explant Cultures Exposed to Dapsone
Drug Metab Dispos 2007 35: 1463-1465. Published online June 6, 2007; 10.1124/dmd.107.015560 [Abstract] [Full Text] [PDF]  

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