DMD -- Table of Contents (36 [11])

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November 2008; 36 (11)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Articles:

Meng Huang, Lin Tang Goh, and Paul C. Ho: Identification of Stereoisomeric Metabolites of Meisoindigo in Rat Liver Microsomes by Achiral and Chiral Liquid Chromatography/Tandem Mass Spectrometry
Drug Metab Dispos 2008 36: 2171-2184. Published online August 18, 2008; 10.1124/dmd.108.021956 [Abstract] [Full Text] [PDF]

Deepak Dalvie, Weichao Chen, Chenghong Zhang, Alfin D. Vaz, Teresa A. Smolarek, Loretta M. Cox, Jian Lin, and R. Scott Obach: Pharmacokinetics, Metabolism, and Excretion of Torcetrapib, a Cholesteryl Ester Transfer Protein Inhibitor, in Humans
Drug Metab Dispos 2008 36: 2185-2198. Published online August 11, 2008; 10.1124/dmd.108.023176 [Abstract] [Full Text] [PDF]

Britta Bonn, Collen M. Masimirembwa, Yasmin Aristei, and Ismael Zamora: The Molecular Basis of CYP2D6-Mediated N-Dealkylation: Balance between Metabolic Clearance Routes and Enzyme Inhibition
Drug Metab Dispos 2008 36: 2199-2210. Published online August 25, 2008; 10.1124/dmd.108.022376 [Abstract] [Full Text] [PDF] [Data Supplement]

Grover P. Miller, Cheryl F. Lichti, Agnieszka K. Zielinska, Anna Mazur, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Jeffery H. Moran, and Anna Radominska-Pandya: Identification of Hydroxywarfarin Binding Site in Human UDP Glucuronosyltransferase 1A10: Phenylalanine⁹⁰ Is Crucial for the Glucuronidation of 6- and 7-Hydroxywarfarin but Not 8-Hydroxywarfarin
Drug Metab Dispos 2008 36: 2211-2218. Published online August 25, 2008; 10.1124/dmd.108.022863 [Abstract] [Full Text] [PDF]

Sonia R. Miranda, Jin Kyung Lee, Kim L. R. Brouwer, Zhiming Wen, Philip C. Smith, and Roy L. Hawke: Hepatic Metabolism and Biliary Excretion of Silymarin Flavonolignans in Isolated Perfused Rat Livers: Role of Multidrug Resistance-Associated Protein 2 (Abcc2)
Drug Metab Dispos 2008 36: 2219-2226. Published online August 7, 2008; 10.1124/dmd.108.021790 [Abstract] [Full Text] [PDF]

Xiaohui Wei, Guowei Dai, Zhongfa Liu, Hao Cheng, Zhiliang Xie, Rebecca Klisovic, Guido Marcucci, and Kenneth K. Chan: Enzyme Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting Ribonucleotide Reductase
Drug Metab Dispos 2008 36: 2227-2233. Published online July 24, 2008; 10.1124/dmd.108.021295 [Abstract] [Full Text] [PDF]

Chitra Sridar, Ute M. Kent, Kate Noon, Alecia McCall, Bill Alworth, Maryam Foroozesh, and Paul F. Hollenberg: Differential Inhibition of Cytochromes P450 3A4 and 3A5 by the Newly Synthesized Coumarin Derivatives 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether
Drug Metab Dispos 2008 36: 2234-2243. Published online July 24, 2008; 10.1124/dmd.108.021493 [Abstract] [Full Text] [PDF]

Qi Wang, Xiaodong Wang, and Marilyn E. Morris: Effects of L-Lactate and D-Mannitol on ${gamma}$ -Hydroxybutyrate Toxicokinetics and Toxicodynamics in Rats
Drug Metab Dispos 2008 36: 2244-2251. Published online August 21, 2008; 10.1124/dmd.108.022996 [Abstract] [Full Text] [PDF]

Joseph T. Dever and Adnan A. Elfarra: L-Methionine-dl-sulfoxide Metabolism and Toxicity in Freshly Isolated Mouse Hepatocytes: Gender Differences and Inhibition with Aminooxyacetic Acid
Drug Metab Dispos 2008 36: 2252-2260. Published online August 7, 2008; 10.1124/dmd.108.023390 [Abstract] [Full Text] [PDF]

René Kupfer, Leah Swanson, Sylvia Chow, Richard E. Staub, Yan Ling Zhang, Isaac Cohen, and Uwe Christians: Oxidative in Vitro Metabolism of Liquiritigenin, a Bioactive Compound Isolated from the Chinese Herbal Selective Estrogen β-Receptor Agonist MF101
Drug Metab Dispos 2008 36: 2261-2269. Published online July 31, 2008; 10.1124/dmd.108.021402 [Abstract] [Full Text] [PDF]

Eugene Y. H. Yeung, Tatsuya Sueyoshi, Masahiko Negishi, and Thomas K. H. Chang: Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor
Drug Metab Dispos 2008 36: 2270-2276. Published online August 25, 2008; 10.1124/dmd.108.023499 [Abstract] [Full Text] [PDF]

Beshay N. M. Zordoky, Mona E. Aboutabl, and Ayman O. S. El-Kadi: Modulation of Cytochrome P450 Gene Expression and Arachidonic Acid Metabolism during Isoproterenol-Induced Cardiac Hypertrophy in Rats
Drug Metab Dispos 2008 36: 2277-2286. Published online August 25, 2008; 10.1124/dmd.108.023077 [Abstract] [Full Text] [PDF]

Mitsue Miyazaki, Katsunori Nakamura, Yukiyoshi Fujita, F. Peter Guengerich, Ryuya Horiuchi, and Koujirou Yamamoto: Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone
Drug Metab Dispos 2008 36: 2287-2291. Published online July 31, 2008; 10.1124/dmd.108.021816 [Abstract] [Full Text] [PDF]

Jiang-Wei Zhang, Yong Liu, Jiu-Yang Zhao, Li-Ming Wang, Guang-Bo Ge, Yang Gao, Wei Li, Hong-Tao Liu, Hui-Xin Liu, Yan-Yan Zhang, Jie Sun, and Ling Yang: Metabolic Profiling and Cytochrome P450 Reaction Phenotyping of Medroxyprogesterone Acetate
Drug Metab Dispos 2008 36: 2292-2298. Published online August 25, 2008; 10.1124/dmd.108.022525 [Abstract] [Full Text] [PDF]

Sachiko Yokoo, Satohiro Masuda, Atsushi Yonezawa, Tomohiro Terada, Toshiya Katsura, and Ken-ichi Inui: Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer
Drug Metab Dispos 2008 36: 2299-2306. Published online August 18, 2008; 10.1124/dmd.108.023168 [Abstract] [Full Text] [PDF] [Data Supplement]

Katriina Itäaho, Peter I. Mackenzie, Shin-ichi Ikushiro, John O. Miners, and Moshe Finel: The Configuration of the 17-Hydroxy Group Variably Influences the Glucuronidation of β-Estradiol and Epiestradiol by Human UDP-Glucuronosyltransferases
Drug Metab Dispos 2008 36: 2307-2315. Published online August 21, 2008; 10.1124/dmd.108.022731 [Abstract] [Full Text] [PDF]

Jaime D'Agostino, Xiuling Zhang, Hong Wu, Guoyu Ling, Suping Wang, Qing-Yu Zhang, Fucai Liu, and Xinxin Ding: Characterization of CYP2A13^*2, a Variant Cytochrome P450 Allele Previously Found to Be Associated with Decreased Incidences of Lung Adenocarcinoma in Smokers
Drug Metab Dispos 2008 36: 2316-2323. Published online July 31, 2008; 10.1124/dmd.108.022822 [Abstract] [Full Text] [PDF]

Ying Mu, Megan M. Klamerus, Tricia M. Miller, Lisa C. Rohan, Steven H. Graham, and Samuel M. Poloyac: Intravenous Formulation of N-Hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for Inhibition of Rat Brain 20-Hydroxyeicosatetraenoic Acid Formation
Drug Metab Dispos 2008 36: 2324-2330. Published online August 25, 2008; 10.1124/dmd.108.023150 [Abstract] [Full Text] [PDF]

Sanna Siissalo, Hongbo Zhang, Eric Stilgenbauer, Ann Marie Kaukonen, Jouni Hirvonen, and Moshe Finel: The Expression of Most UDP-Glucuronosyltransferases (UGTs) Is Increased Significantly during Caco-2 Cell Differentiation, whereas UGT1A6 Is Highly Expressed Also in Undifferentiated Cells
Drug Metab Dispos 2008 36: 2331-2336. Published online August 11, 2008; 10.1124/dmd.108.022335 [Abstract] [Full Text] [PDF] [Data Supplement]

Stephen C. Hughes, Peter C. Shardlow, Frank J. Hollis, Rebecca J. Scott, Dimple S. Motivaras, Ann Allen, and Victoria M. Rousell: Metabolism and Disposition of Fluticasone Furoate, an Enhanced-Affinity Glucocorticoid, in Humans
Drug Metab Dispos 2008 36: 2337-2344. Published online August 11, 2008; 10.1124/dmd.108.022137 [Abstract] [Full Text] [PDF]

Markus R. Meyer, Frank T. Peters, and Hans H. Maurer: The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxy-Methamphetamine and Its Enantiomers
Drug Metab Dispos 2008 36: 2345-2354. Published online August 25, 2008; 10.1124/dmd.108.021543 [Abstract] [Full Text] [PDF]

Magang Shou, Mike Hayashi, Yvonne Pan, Yang Xu, Kari Morrissey, Lilly Xu, and Gary L. Skiles: Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction
Drug Metab Dispos 2008 36: 2355-2370. Published online July 31, 2008; 10.1124/dmd.108.020602 [Abstract] [Full Text] [PDF]

Youbin Tu, Rahul Deshmukh, Meena Sivaneri, and Grazyna D. Szklarz: Application of Molecular Modeling for Prediction of Substrate Specificity in Cytochrome P450 1A2 Mutants
Drug Metab Dispos 2008 36: 2371-2380. Published online August 14, 2008; 10.1124/dmd.108.022640 [Abstract] [Full Text] [PDF]

Lionel Perrin, Caroline Aninat, Véronique Hamon, Yoshio Hayashi, Catherine Abadie, Bruno Heyd, François André, and Marcel Delaforge: Metabolism of Phenylahistin Enantiomers by Cytochromes P450: A Possible Explanation for Their Different Cytotoxicity
Drug Metab Dispos 2008 36: 2381-2392. Published online August 7, 2008; 10.1124/dmd.107.019919 [Abstract] [Full Text] [PDF]

James M. Fujitaki, Edward E. Cable, Bruce R. Ito, Bao-Hong Zhang, Jinzhao Hou, Chun Yang, David A. Bullough, James L. Ferrero, Paul D. van Poelje, David L. Linemeyer, and Mark D. Erion: Preclinical Pharmacokinetics of a HepDirect Prodrug of a Novel Phosphonate-Containing Thyroid Hormone Receptor Agonist
Drug Metab Dispos 2008 36: 2393-2403. Published online August 14, 2008; 10.1124/dmd.108.021642 [Abstract] [Full Text] [PDF]

Short Communications:

Abhinav Nath and William Atkins: Principal Component Analysis of CYP2C9 and CYP3A4 Probe Substrate/Inhibitor Panels
Drug Metab Dispos 2008 36: 2151-2155. Published online June 19, 2008; 10.1124/dmd.108.022061 [Abstract] [Full Text] [PDF]

Maciej J. Zamek-Gliszczynski, Keith A. Hoffmaster, Ken-ichi Nezasa, and Kim L. R. Brouwer: Apparent Differences in Mechanisms of Harmol Sulfate Biliary Excretion in Mice and Rats
Drug Metab Dispos 2008 36: 2156-2158. Published online August 21, 2008; 10.1124/dmd.108.022053 [Abstract] [Full Text] [PDF]

Feng Qiu, Zhiyong Zhu, Ning Kang, Shujuan Piao, Gengyao Qin, and Xinsheng Yao: Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans
Drug Metab Dispos 2008 36: 2159-2165. Published online August 14, 2008; 10.1124/dmd.108.021659 [Abstract] [Full Text] [PDF]

Dong-Hyun Kim, Keon-Hee Kim, Dae-Hwan Kim, Kwang-Hyeon Liu, Heung-Chae Jung, Jae-Gu Pan, and Chul-Ho Yun: Generation of Human Metabolites of 7-Ethoxycoumarin by Bacterial Cytochrome P450 BM3
Drug Metab Dispos 2008 36: 2166-2170. Published online July 31, 2008; 10.1124/dmd.108.021220 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Simulated relationship of predicted DDIs as a function of in vivo free concentration of inducer ([Ind]_max,ss) and fraction of drug cleared by CYP3A4 (f_{m, CYP3A4}). See article by Shou et al. on page 2355 of this issue.