DMD -- Table of Contents (36 [12])

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December 2008; 36 (12)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Tae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura, and Shigeru Ohta: CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver
Drug Metab Dispos 2008 36: 2429-2433. Published online September 10, 2008; 10.1124/dmd.108.022830 [Abstract] [Full Text] [PDF]

Agnès Poirier, Thierry Lavé, Renée Portmann, Marie-Elise Brun, Frank Senner, Manfred Kansy, Hans-Peter Grimm, and Christoph Funk: Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model
Drug Metab Dispos 2008 36: 2434-2444. Published online September 22, 2008; 10.1124/dmd.108.020750 [Abstract] [Full Text] [PDF]

David F. Barker, Jason M. Walraven, Elizabeth H. Ristagno, Mark A. Doll, J. Christopher States, and David W. Hein: Quantitative Tissue and Gene-Specific Differences and Developmental Changes in Nat1, Nat2, and Nat3 mRNA Expression in the Rat
Drug Metab Dispos 2008 36: 2445-2451. Published online September 17, 2008; 10.1124/dmd.108.023564 [Abstract] [Full Text] [PDF]

David W. Hein, Jean Bendaly, Jason R. Neale, and Mark A. Doll: Systemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic Rat
Drug Metab Dispos 2008 36: 2452-2459. Published online September 17, 2008; 10.1124/dmd.108.023960 [Abstract] [Full Text] [PDF]

Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa, and Masahiro Hiratsuka: Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)
Drug Metab Dispos 2008 36: 2460-2467. Published online September 10, 2008; 10.1124/dmd.108.023242 [Abstract] [Full Text] [PDF]

Rachel M. Novick and Adnan A. Elfarra: Purification and Characterization of Flavin-Containing Monooxygenase Isoform 3 from Rat Kidney Microsomes
Drug Metab Dispos 2008 36: 2468-2474. Published online September 5, 2008; 10.1124/dmd.108.021436 [Abstract] [Full Text] [PDF]

Benjamin M. Johnson, Amrita V. Kamath, John E. Leet, Xiaohong Liu, Rajeev S. Bhide, Ravindra W. Tejwani, Yueping Zhang, Ligang Qian, Donna D. Wei, Louis J. Lombardo, and Yue-Zhong Shu: Metabolism of 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): Identification of an Unusual N-Acetylglucosamine Conjugate in the Cynomolgus Monkey
Drug Metab Dispos 2008 36: 2475-2483. Published online September 11, 2008; 10.1124/dmd.108.022624 [Abstract] [Full Text] [PDF]

Albena Patroneva, Sandra M. Connolly, Penny Fatato, Ron Pedersen, Qin Jiang, Jeffrey Paul, Christine Guico-Pabia, Jennifer A. Isler, Michael E. Burczynski, and Alice I. Nichols: An Assessment of Drug-Drug Interactions: The Effect of Desvenlafaxine and Duloxetine on the Pharmacokinetics of the CYP2D6 Probe Desipramine in Healthy Subjects
Drug Metab Dispos 2008 36: 2484-2491. Published online September 22, 2008; 10.1124/dmd.108.021527 [Abstract] [Full Text] [PDF]

Eric Garver, Erin D. Hugger, Shawn P. Shearn, Anuradha Rao, Paul A. Dawson, Charles B. Davis, and Chao Han: Involvement of Intestinal Uptake Transporters in the Absorption of Azithromycin and Clarithromycin in the Rat
Drug Metab Dispos 2008 36: 2492-2498. Published online August 28, 2008; 10.1124/dmd.108.022285 [Abstract] [Full Text] [PDF]

Trine Celius, Steven Roblin, Patricia A. Harper, Jason Matthews, Paul C. Boutros, Raimo Pohjanvirta, and Allan B. Okey: Aryl Hydrocarbon Receptor-Dependent Induction of Flavin-Containing Monooxygenase mRNAs in Mouse Liver
Drug Metab Dispos 2008 36: 2499-2505. Published online September 2, 2008; 10.1124/dmd.108.023457 [Abstract] [Full Text] [PDF] [Data Supplement]

Xiaochao Ma, Connie Cheung, Kristopher W. Krausz, Yatrik M. Shah, Ting Wang, Jeffrey R. Idle, and Frank J. Gonzalez: A Double Transgenic Mouse Model Expressing Human Pregnane X Receptor and Cytochrome P450 3A4
Drug Metab Dispos 2008 36: 2506-2512. Published online September 17, 2008; 10.1124/dmd.108.022723 [Abstract] [Full Text] [PDF]

Shu-Ying Chang, Wenying Li, Sarah C. Traeger, Bei Wang, Donghui Cui, Hongjian Zhang, Bo Wen, and A. David Rodrigues: Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro
Drug Metab Dispos 2008 36: 2513-2522. Published online September 11, 2008; 10.1124/dmd.108.022970 [Abstract] [Full Text] [PDF]

Gerard J. M. Bruin, Thomas Faller, Hansjörg Wiegand, Alain Schweitzer, Hanspeter Nick, Josef Schneider, K.-Olaf Boernsen, and Felix Waldmeier: Pharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in Rats
Drug Metab Dispos 2008 36: 2523-2538. Published online September 5, 2008; 10.1124/dmd.108.022962 [Abstract] [Full Text] [PDF]

Michael R. Franklin and Laura B. Hathaway: 2-Diethylaminoethyl-2,2-diphenylvalerate-HCl (SKF525A) Revisited: Comparative Cytochrome P450 Inhibition in Human Liver Microsomes by SKF525A, Its Metabolites, and SKF-Acid and SKF-Alcohol
Drug Metab Dispos 2008 36: 2539-2546. Published online September 17, 2008; 10.1124/dmd.108.023549 [Abstract] [Full Text] [PDF]

Wei V. Zhang, Fabrizio D'Esposito, Robert J. Edwards, Iqbal Ramzan, and Michael Murray: Interindividual Variation in Relative CYP1A2/3A4 Phenotype Influences Susceptibility of Clozapine Oxidation to Cytochrome P450-Specific Inhibition in Human Hepatic Microsomes
Drug Metab Dispos 2008 36: 2547-2555. Published online September 22, 2008; 10.1124/dmd.108.023671 [Abstract] [Full Text] [PDF]

Patricia Monteiro, David Gilot, Sophie Langouet, and Olivier Fardel: Activation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)
Drug Metab Dispos 2008 36: 2556-2563. Published online August 28, 2008; 10.1124/dmd.108.023333 [Abstract] [Full Text] [PDF]

Kan He, Michael W. Lago, Ramaswamy A. Iyer, Wen-Chyi Shyu, William G. Humphreys, and Lisa J. Christopher: Lacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in Rats
Drug Metab Dispos 2008 36: 2564-2570. Published online September 11, 2008; 10.1124/dmd.108.022764 [Abstract] [Full Text] [PDF]

Caroline E. Grant, Mian Gao, Marianne K. DeGorter, Susan P. C. Cole, and Roger G. Deeley: Structural Determinants of Substrate Specificity Differences between Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
Drug Metab Dispos 2008 36: 2571-2581. Published online September 5, 2008; 10.1124/dmd.108.022491 [Abstract] [Full Text] [PDF] [Data Supplement]

Natasha M. DeVore, Brian D. Smith, Michael J. Urban, and Emily E. Scott: Key Residues Controlling Phenacetin Metabolism by Human Cytochrome P450 2A Enzymes
Drug Metab Dispos 2008 36: 2582-2590. Published online September 8, 2008; 10.1124/dmd.108.023770 [Abstract] [Full Text] [PDF]

Lipeng Wang, Markos Leggas, Mamta Goswami, Philip E. Empey, and Patrick J. McNamara: N-(4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine Carboxamide (GF120918) As a Chemical ATP-Binding Cassette Transporter Family G Member 2 (Abcg2) Knockout Model to Study Nitrofurantoin Transfer into Milk
Drug Metab Dispos 2008 36: 2591-2596. Published online September 17, 2008; 10.1124/dmd.108.021980 [Abstract] [Full Text] [PDF]

Short Communications:

Z. E. Barter, J. E. Chowdry, J. R. Harlow, J. E. Snawder, J. C. Lipscomb, and A. Rostami-Hodjegan: Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling
Drug Metab Dispos 2008 36: 2405-2409. Published online September 5, 2008; 10.1124/dmd.108.021311 [Abstract] [Full Text] [PDF]

Dan A. Rock, Robert S. Foti, and Josh T. Pearson: The Combination of Chemical and Antibody Inhibitors for Superior P450 3A Inhibition in Reaction Phenotyping Studies
Drug Metab Dispos 2008 36: 2410-2413. Published online September 2, 2008; 10.1124/dmd.108.023572 [Abstract] [Full Text] [PDF]

Shuguang Ma, Raju Subramanian, Yang Xu, Michael Schrag, and Magang Shou: Structural Characterization of Novel Adenine Dinucleotide Phosphate Conjugates of Imatinib in Incubations with Rat and Human Liver Microsomes
Drug Metab Dispos 2008 36: 2414-2418. Published online September 17, 2008; 10.1124/dmd.108.023085 [Abstract] [Full Text] [PDF]

L. P. Jordheim, T. Nguyen-Dumont, X. Thomas, C. Dumontet, and S. V. Tavtigian: Differential Allelic Expression in Leukoblast from Patients with Acute Myeloid Leukemia Suggests Genetic Regulation of CDA, DCK, NT5C2, NT5C3, and TP53
Drug Metab Dispos 2008 36: 2419-2423. Published online September 5, 2008; 10.1124/dmd.108.023184 [Abstract] [Full Text] [PDF] [Data Supplement]

Joseph P. Sanderson, Frank J. Hollis, James L. Maggs, Stephen E. Clarke, Dean J. Naisbitt, and B. Kevin Park: Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes: Implications for Bioanalysis of Sulfamethoxazole Metabolites
Drug Metab Dispos 2008 36: 2424-2428. Published online September 2, 2008; 10.1124/dmd.108.021246 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Comparison of the active sites of CYP2A6 (purple, PDB IZ10, molecule B), CYP2A6 I208S/I300F/G301A/G369S with phenacetin (green, molecule A), and CYP2A13 (orange, PDB 2P85, molecule A). See article by DeVore et al. on page 2582.