Symposium Report:

Edward T. Morgan, Kerry B. Goralski, Micheline Piquette-Miller, Kenneth W. Renton, Graham R. Robertson, Madhusudana R. Chaluvadi, Kellie A. Charles, Stephen J. Clarke, Marina Kacevska, Christopher Liddle, Terrilyn A. Richardson, Rohini Sharma, and Christopher J. Sinal

Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer
Drug Metab Dispos 2008 36: 205-216. [Abstract] [Full Text] [PDF]  

Articles:

Michael J. Liguori, Eric A.G. Blomme, and Jeffrey F. Waring

Trovafloxacin-Induced Gene Expression Changes in Liver-Derived in Vitro Systems: Comparison of Primary Human Hepatocytes to HepG2 Cells
Drug Metab Dispos 2008 36: 223-233. Published online October 29, 2007; 10.1124/dmd.107.017608 [Abstract] [Full Text] [PDF] [Data Supplement]   

Antonio Osorio-Lozada, Sekhar Surapaneni, Gary L. Skiles, and Raju Subramanian

Biosynthesis of Drug Metabolites Using Microbes in Hollow Fiber Cartridge Reactors: Case Study of Diclofenac Metabolism by Actinoplanes Species
Drug Metab Dispos 2008 36: 234-240. Published online November 15, 2007; 10.1124/dmd.107.019323 [Abstract] [Full Text] [PDF]  

Timothy J. Musick, Mark Gohdes, Andrea Duffy, David A. Erickson, and Philip A. Krieter

Pharmacokinetics, Disposition, and Metabolism of Bicifadine in the Mouse, Rat, and Monkey
Drug Metab Dispos 2008 36: 241-251. Published online November 8, 2007; 10.1124/dmd.107.017863 [Abstract] [Full Text] [PDF]  

Philip A. Krieter, Mark Gohdes, Timothy J. Musick, Frederick P. Duncanson, and William E. Bridson

Pharmacokinetics, Disposition, and Metabolism of Bicifadine in Humans
Drug Metab Dispos 2008 36: 252-259. Published online November 8, 2007; 10.1124/dmd.107.017871 [Abstract] [Full Text] [PDF]  

Sandra Osbild, Jérome Bour, Benoît Maunit, Cécile Guillaume, Carine Asensio, Jean-François Muller, Patrick Netter, Glbert Kirsch, Denyse Bagrel, Françoise Lapicque, and Eric Battaglia

Interaction of the Electrophilic Ketoprofenyl-Glucuronide and Ketoprofenyl-Coenzyme A Conjugates with Cytosolic Glutathione S-Transferases
Drug Metab Dispos 2008 36: 260-267. Published online October 25, 2007; 10.1124/dmd.107.016808 [Abstract] [Full Text] [PDF]  

Bo Feng, Jessica B. Mills, Ralph E. Davidson, Rouchelle J. Mireles, John S. Janiszewski, Matthew D. Troutman, and Sonia M. de Morais

In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System
Drug Metab Dispos 2008 36: 268-275. Published online October 25, 2007; 10.1124/dmd.107.017434 [Abstract] [Full Text] [PDF]  

Walter Meinl, Bettina Ebert, Hansruedi Glatt, and Alfonso Lampen

Sulfotransferase Forms Expressed in Human Intestinal Caco-2 and TC7 Cells at Varying Stages of Differentiation and Role in Benzo[a]pyrene Metabolism
Drug Metab Dispos 2008 36: 276-283. Published online October 29, 2007; 10.1124/dmd.107.018036 [Abstract] [Full Text] [PDF]  

I. G. Sipes, G. A. Knudsen, and R. K. Kuester

The Effects of Dose and Route on the Toxicokinetics and Disposition of 1-Butyl-3-methylimidazolium Chloride in Male F-344 Rats and Female B6C3F1 Mice
Drug Metab Dispos 2008 36: 284-293. Published online October 29, 2007; 10.1124/dmd.107.018515 [Abstract] [Full Text] [PDF]  

Makoto Osabe, Junko Sugatani, Tomoaki Fukuyama, Shin-ichi Ikushiro, Akira Ikari, and Masao Miwa

Expression of Hepatic UDP-Glucuronosyltransferase 1A1 and 1A6 Correlated with Increased Expression of the Nuclear Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor in Male Rats Fed a High-Fat and High-Sucrose Diet
Drug Metab Dispos 2008 36: 294-302. Published online October 29, 2007; 10.1124/dmd.107.017731 [Abstract] [Full Text] [PDF] [Data Supplement]   

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen, Haiying Zhang, Mimi Quan, Lloyd Lecureux, Laura M. Patrone, Patrick Y. S. Lam, Samuel J. Bonacorsi, Robert M. Knabb, Gary L. Skiles, and Kan He

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs
Drug Metab Dispos 2008 36: 303-315. Published online November 5, 2007; 10.1124/dmd.107.018416 [Abstract] [Full Text] [PDF]  

Ruchita Kapoor and Jonathan J. Sheng

Transfection of Human Prostate Cancer CA-HPV-10 Cells with Cytosolic Sulfotransferase SULT1E1 Affects Estrogen Signaling and Gene Transcription
Drug Metab Dispos 2008 36: 316-321. Published online November 5, 2007; 10.1124/dmd.107.017632 [Abstract] [Full Text] [PDF]  

Otito Frances Iwuchukwu and Swati Nagar

Resveratrol (trans-Resveratrol, 3,5,4'-Trihydroxy-trans-stilbene) Glucuronidation Exhibits Atypical Enzyme Kinetics in Various Protein Sources
Drug Metab Dispos 2008 36: 322-330. Published online November 8, 2007; 10.1124/dmd.107.018788 [Abstract] [Full Text] [PDF]  

Bing Zhu, David Bush, George A. Doss, Stella Vincent, Ronald B. Franklin, and Shiyao Xu

Characterization of 1'-Hydroxymidazolam Glucuronidation in Human Liver Microsomes
Drug Metab Dispos 2008 36: 331-338. Published online November 12, 2007; 10.1124/dmd.107.017962 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lucie Svecova, Radim Vrzal, Ladislav Burysek, Eva Anzenbacherova, Lukas Cerveny, Jiri Grim, Frantisek Trejtnar, Jiri Kunes, Milan Pour, Frantisek Staud, Pavel Anzenbacher, Zdenek Dvorak, and Petr Pavek

Azole Antimycotics Differentially Affect Rifampicin-Induced Pregnane X Receptor-Mediated CYP3A4 Gene Expression
Drug Metab Dispos 2008 36: 339-348. Published online November 12, 2007; 10.1124/dmd.107.018341 [Abstract] [Full Text] [PDF]  

Yoshiyuki Hanzawa, Takamitsu Sasaki, Michinao Mizugaki, Masaaki Ishikawa, and Masahiro Hiratsuka

Genetic Polymorphisms and Haplotype Structures of the Human CYP2W1 Gene in a Japanese Population
Drug Metab Dispos 2008 36: 349-352. Published online November 12, 2007; 10.1124/dmd.107.019141 [Abstract] [Full Text] [PDF]  

Nuala A. Helsby, Michael A. Goldthorpe, Magdalene H. Y. Tang, Graham J. Atwell, Eileen M. Smith, William R. Wilson, and Malcolm D. Tingle

Influence of Mustard Group Structure on Pathways of in Vitro Metabolism of Anticancer N-(2-Hydroxyethyl)-3,5-dinitrobenzamide 2-Mustard Prodrugs
Drug Metab Dispos 2008 36: 353-360. Published online November 12, 2007; 10.1124/dmd.107.018739 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, Miki Katoh, and Tsuyoshi Yokoi

Product Inhibition of UDP-Glucuronosyltransferase (UGT) Enzymes by UDP Obfuscates the Inhibitory Effects of UGT Substrates
Drug Metab Dispos 2008 36: 361-367. Published online November 12, 2007; 10.1124/dmd.107.018705 [Abstract] [Full Text] [PDF]  

Takahiro Murai, Naotoshi Yamamura, Takashi Nitanai, Naozumi Samata, Makoto Takei, Haruo Iwabuchi, Kohji Tanaka, Kei Mikamoto, and Toshihiko Ikeda

Isolation and Identification of Diglucuronides of Some Endogenous Steroids in Dogs
Drug Metab Dispos 2008 36: 368-374. Published online November 15, 2007; 10.1124/dmd.107.019059 [Abstract] [Full Text] [PDF]  

Derek W. Angus, James A. Baker, Rona Mason, and Iain J. Martin

The Potential Influence of CO₂, as an Agent for Euthanasia, on the Pharmacokinetics of Basic Compounds in Rodents
Drug Metab Dispos 2008 36: 375-379. Published online November 15, 2007; 10.1124/dmd.107.018879 [Abstract] [Full Text] [PDF]  

Damaris S. Diaz, Michael. P. Kozar, Kirsten S. Smith, Constance O. Asher, Jason C. Sousa, Guy A. Schiehser, David. P. Jacobus, Wilbur. K. Milhous, Donald. R. Skillman, and Todd. W. Shearer

Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines
Drug Metab Dispos 2008 36: 380-385. Published online November 15, 2007; 10.1124/dmd.106.013920 [Abstract] [Full Text] [PDF]  

Stefan Blech, Thomas Ebner, Eva Ludwig-Schwellinger, Joachim Stangier, and Willy Roth

The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans
Drug Metab Dispos 2008 36: 386-399. Published online November 15, 2007; 10.1124/dmd.107.019083 [Abstract] [Full Text] [PDF]  

Ru Yan, Nga Ling Ko, Song-Lin Li, Yun Kau Tam, and Ge Lin

Pharmacokinetics and Metabolism of Ligustilide, a Major Bioactive Component in Rhizoma Chuanxiong, in the Rat
Drug Metab Dispos 2008 36: 400-408. Published online November 26, 2007; 10.1124/dmd.107.017707 [Abstract] [Full Text] [PDF]  

K. C. Falkner, J. K. Ritter, and R. A. Prough

Regulation of the Rat UGT1A6 by Glucocorticoids Involves a Cryptic Glucocorticoid Response Element
Drug Metab Dispos 2008 36: 409-417. Published online November 26, 2007; 10.1124/dmd.107.018952 [Abstract] [Full Text] [PDF]  

Jiang-Wei Zhang, Guang-Bo Ge, Yong Liu, Li-Ming Wang, Xing-Bao Liu, Yan-Yan Zhang, Wei Li, Yu-Qi He, Zheng-Tao Wang, Jie Sun, Hong-Bin Xiao, and Ling Yang

Taxane's Substituents at C3' Affect Its Regioselective Metabolism: Different in Vitro Metabolism of Cephalomannine and Paclitaxel
Drug Metab Dispos 2008 36: 418-426. Published online November 26, 2007; 10.1124/dmd.107.018242 [Abstract] [Full Text] [PDF]  

Atsushi Ose, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Takuya Fujita, Akira Yamamoto, and Yuichi Sugiyama

P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier
Drug Metab Dispos 2008 36: 427-434. Published online November 26, 2007; 10.1124/dmd.107.018556 [Abstract] [Full Text] [PDF]  

Melanie A. Felmlee, Hoi-Kei Lon, Frank J. Gonzalez, and Ai-Ming Yu

Cytochrome P450 Expression and Regulation in CYP3A4/CYP2D6 Double Transgenic Humanized Mice
Drug Metab Dispos 2008 36: 435-441. Published online November 29, 2007; 10.1124/dmd.107.018838 [Abstract] [Full Text] [PDF] [Data Supplement]   

Anand K. Deo and Stelvio M. Bandiera

Biotransformation of Lithocholic Acid by Rat Hepatic Microsomes: Metabolite Analysis by Liquid Chromatography/Mass Spectrometry
Drug Metab Dispos 2008 36: 442-451. Published online November 26, 2007; 10.1124/dmd.107.017533 [Abstract] [Full Text] [PDF]  

Poulomi Acharya, Michael P. O'Connor, Joseph W. Polli, Andrew Ayrton, Harma Ellens, and Joe Bentz

Kinetic Identification of Membrane Transporters That Assist P-glycoprotein-Mediated Transport of Digoxin and Loperamide through a Confluent Monolayer of MDCKII-hMDR1 Cells
Drug Metab Dispos 2008 36: 452-460. Published online October 29, 2007; 10.1124/dmd.107.017301 [Abstract] [Full Text] [PDF]  

Jian Guo, Dongting Liu, Dejan Nikolic, Dongwei Zhu, John M. Pezzuto, and Richard B. van Breemen

In Vitro Metabolism of Isoliquiritigenin by Human Liver Microsomes
Drug Metab Dispos 2008 36: 461-468. Published online November 15, 2007; 10.1124/dmd.107.018721 [Abstract] [Full Text] [PDF]  

Short Communication:

Marc Le Vee, Philippe Gripon, Bruno Stieger, and Olivier Fardel

Down-Regulation of Organic Anion Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokine Interleukin 1β
Drug Metab Dispos 2008 36: 217-222. Published online November 8, 2007; 10.1124/dmd.107.016907 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Ying Li, J. Greg Slatter, Zhoupeng Zhang, Yan Li, George A. Doss, Matthew P. Braun, Ralph A. Stearns, Dennis C. Dean, Thomas A. Baillie, and Wei Tang

In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations
Drug Metab Dispos 2008 36: 469-473. Published online November 12, 2007; 10.1124/dmd.107.019018 [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.