DMD -- Table of Contents (36 [3])

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March 2008; 36 (3)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

       Erratum

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Articles:

Ping Kang, Mingxiang Liao, Michael R. Wester, J. Steven Leeder, Robin E. Pearce, and Maria Almira Correia: CYP3A4-Mediated Carbamazepine (CBZ) Metabolism: Formation of a Covalent CBZ-CYP3A4 Adduct and Alteration of the Enzyme Kinetic Profile
Drug Metab Dispos 2008 36: 490-499. Published online December 20, 2007; 10.1124/dmd.107.016501 [Abstract] [Full Text] [PDF]

Christine Healan-Greenberg, Jeffrey F. Waring, Dale J. Kempf, Eric A. G. Blomme, Rommel G. Tirona, and Richard B. Kim: A Human Immunodeficiency Virus Protease Inhibitor Is a Novel Functional Inhibitor of Human Pregnane X Receptor
Drug Metab Dispos 2008 36: 500-507. Published online December 20, 2007; 10.1124/dmd.107.019547 [Abstract] [Full Text] [PDF]

Tseng-Ting Kao, Kuan-Chieh Wang, Wen-Ni Chang, Chia-Ying Lin, Bing-Hung Chen, Hua-Lin Wu, Guey-Yueh Shi, Jen-Ning Tsai, and Tzu-Fun Fu: Characterization and Comparative Studies of Zebrafish and Human Recombinant Dihydrofolate Reductases—Inhibition by Folic Acid and Polyphenols
Drug Metab Dispos 2008 36: 508-516. Published online December 3, 2007; 10.1124/dmd.107.019299 [Abstract] [Full Text] [PDF]

Yan Xiong, Anne-Sisko Patana, Michael J. Miley, Agnieszka K. Zielinska, Stacie M. Bratton, Grover P. Miller, Adrian Goldman, Moshe Finel, Matt R. Redinbo, and Anna Radominska-Pandya: The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis
Drug Metab Dispos 2008 36: 517-522. Published online November 29, 2007; 10.1124/dmd.107.016469 [Abstract] [Full Text] [PDF]

Robert S. Foti and Jan L. Wahlstrom: CYP2C19 Inhibition: The Impact of Substrate Probe Selection on in Vitro Inhibition Profiles
Drug Metab Dispos 2008 36: 523-528. Published online November 29, 2007; 10.1124/dmd.107.019265 [Abstract] [Full Text] [PDF]

Masakatsu Kotsuma, Taro Tokui, Tomoko Ishizuka-Ozeki, Tomoyo Honda, Haruo Iwabuchi, Takahiro Murai, Toshihiko Ikeda, and Hideo Saji: CYP2D6-Mediated Metabolism of a Novel Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor, Pactimibe, and Its Unique Plasma Metabolite, R-125528
Drug Metab Dispos 2008 36: 529-534. Published online December 3, 2007; 10.1124/dmd.107.018853 [Abstract] [Full Text] [PDF]

Michael Gertz, Peter J. Kilford, J. Brian Houston, and Aleksandra Galetin: Drug Lipophilicity and Microsomal Protein Concentration as Determinants in the Prediction of the Fraction Unbound in Microsomal Incubations
Drug Metab Dispos 2008 36: 535-542. Published online December 20, 2007; 10.1124/dmd.107.018713 [Abstract] [Full Text] [PDF]

Kirsten A. Bielefeld, Chunja Lee, and David S. Riddick: Regulation of Aryl Hydrocarbon Receptor Expression and Function by Glucocorticoids in Mouse Hepatoma Cells
Drug Metab Dispos 2008 36: 543-551. Published online December 17, 2007; 10.1124/dmd.107.019703 [Abstract] [Full Text] [PDF]

Andrew J. Slot, Dana D. Wise, Roger G. Deeley, Terrence J. Monks, and Susan P. C. Cole: Modulation of Human Multidrug Resistance Protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) Transport Activities by Endogenous and Exogenous Glutathione-Conjugated Catechol Metabolites
Drug Metab Dispos 2008 36: 552-560. Published online December 13, 2007; 10.1124/dmd.107.019661 [Abstract] [Full Text] [PDF]

Steven J. McClue and Iain Stuart: Metabolism of the Trisubstituted Purine Cyclin-Dependent Kinase Inhibitor Seliciclib (R-Roscovitine) in Vitro and in Vivo
Drug Metab Dispos 2008 36: 561-570. Published online November 29, 2007; 10.1124/dmd.107.019232 [Abstract] [Full Text] [PDF]

Tiia Kuuranne, Antti Leinonen, Wilhelm Schänzer, Matthias Kamber, Risto Kostiainen, and Mario Thevis: Aryl-Propionamide-Derived Selective Androgen Receptor Modulators: Liquid Chromatography-Tandem Mass Spectrometry Characterization of the in Vitro Synthesized Metabolites for Doping Control Purposes
Drug Metab Dispos 2008 36: 571-581. Published online December 17, 2007; 10.1124/dmd.107.017954 [Abstract] [Full Text] [PDF]

James R. Reed, Lauren M. Brignac-Huber, and Wayne L. Backes: Physical Incorporation of NADPH-Cytochrome P450 Reductase and Cytochrome P450 into Phospholipid Vesicles Using Glycocholate and Bio-Beads
Drug Metab Dispos 2008 36: 582-588. Published online November 29, 2007; 10.1124/dmd.107.018473 [Abstract] [Full Text] [PDF]

Jhy-Wen Wu, Lie-Chwen Lin, Shih-Chieh Hung, Chi-Hung Lin, Chin-Wen Chi, and Tung-Hu Tsai: Hepatobiliary Excretion of Silibinin in Normal and Liver Cirrhotic Rats
Drug Metab Dispos 2008 36: 589-596. Published online November 29, 2007; 10.1124/dmd.107.017004 [Abstract] [Full Text] [PDF]

Yasuhiro Masubuchi, Kanako Enoki, and Toshiharu Horie: Down-Regulation of Hepatic Cytochrome P450 Enzymes in Rats with Trinitrobenzene Sulfonic Acid-Induced Colitis
Drug Metab Dispos 2008 36: 597-603. Published online December 13, 2007; 10.1124/dmd.107.018754 [Abstract] [Full Text] [PDF]

Esther G. van de Kerkhof, Inge A. M. de Graaf, Anna-Lena B. Ungell, and Geny M. M. Groothuis: Induction of Metabolism and Transport in Human Intestine: Validation of Precision-Cut Slices as a Tool to Study Induction of Drug Metabolism in Human Intestine in Vitro
Drug Metab Dispos 2008 36: 604-613. Published online December 19, 2007; 10.1124/dmd.107.018820 [Abstract] [Full Text] [PDF]

Rebecca Stadel, Jun Yang, Julia W. Nalwalk, James G. Phillips, and Lindsay B. Hough: High-Affinity Binding of [³H]Cimetidine to a Heme-Containing Protein in Rat Brain
Drug Metab Dispos 2008 36: 614-621. Published online December 19, 2007; 10.1124/dmd.107.017889 [Abstract] [Full Text] [PDF]

Short Communications:

Silvina S. M. Villanueva, María L. Ruiz, Carolina I. Ghanem, Marcelo G. Luquita, Viviana A. Catania, and Aldo D. Mottino: Hepatic Synthesis and Urinary Elimination of Acetaminophen Glucuronide Are Exacerbated in Bile Duct-Ligated Rats
Drug Metab Dispos 2008 36: 475-480. Published online December 20, 2007; 10.1124/dmd.107.018127 [Abstract] [Full Text] [PDF]

Peng Hsiao, Tot Bui, Rodney J. Y. Ho, and Jashvant D. Unadkat: In Vitro-to-in Vivo Prediction of P-glycoprotein-Based Drug Interactions at the Human and Rodent Blood-Brain Barrier
Drug Metab Dispos 2008 36: 481-484. Published online December 5, 2007; 10.1124/dmd.107.018176 [Abstract] [Full Text] [PDF]

Hye Hyun Yoo, Hye Jin Chung, Jaeick Lee, Chang-Seok Lee, Min Jung Kang, and Dong-Hyun Kim: Enzymatic C-Demethylation of 1-[2-(5-tert-Butyl-[1,3,4] oxadiazole-2-carbonyl)-4-fluoro-pyrrolidin-1-yl]-2-(2-hydroxy-1,1-dimethyl-ethylamino)-ethanone (LC15-0133) in Rat Liver Microsomes
Drug Metab Dispos 2008 36: 485-489. Published online December 5, 2007; 10.1124/dmd.107.019133 [Abstract] [Full Text] [PDF] [Data Supplement]

Erratum:

: CORRECTION TO "THE DEVELOPMENT OF DRUG METABOLISM RESEARCH AS EXPRESSED IN THE PUBLICATIONS OF ASPET: PART 1, 1909–1958"
Drug Metab Dispos 2008 36: 622. [Full Text] [PDF]

Cover Caption:

About the cover: Docking of carbamazepine, testosterone, and erythromycin into the active site of CYP3A4. See article by Kang et al. on page 490 of this issue.