DMD -- Table of Contents (36 [5])

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May 2008; 36 (5)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Hideo Takakusa, Hiroshi Masumoto, Ayako Mitsuru, Osamu Okazaki, and Kenichi Sudo: Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes
Drug Metab Dispos 2008 36: 816-823. Published online January 28, 2008; 10.1124/dmd.107.018002 [Abstract] [Full Text] [PDF]

Gang Chen, Ryan W. Dellinger, Dongxiao Sun, Thomas E. Spratt, and Philip Lazarus: Glucuronidation of Tobacco-Specific Nitrosamines by UGT2B10
Drug Metab Dispos 2008 36: 824-830. Published online January 31, 2008; 10.1124/dmd.107.019406 [Abstract] [Full Text] [PDF]

Kouichi Minato, Ryota Suzuki, Akira Asagarasu, Teruaki Matsui, and Michitaka Sato: Biotransformation of 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a Novel 5-Hydroxytryptamine (5-HT)_1A Agonist/5-HT₃ Antagonist, in Human Hepatic Cytochrome P450 Enzymes
Drug Metab Dispos 2008 36: 831-840. Published online January 31, 2008; 10.1124/dmd.107.018168 [Abstract] [Full Text] [PDF]

Bo Wen, Li Ma, A. David Rodrigues, and Mingshe Zhu: Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine
Drug Metab Dispos 2008 36: 841-850. Published online January 31, 2008; 10.1124/dmd.107.019471 [Abstract] [Full Text] [PDF]

Sylvie Klieber, Sébastien Hugla, Robert Ngo, Catherine Arabeyre-Fabre, Viviane Meunier, Freddy Sadoun, Olivier Fedeli, Martine Rival, Martine Bourrie, François Guillou, Patrick Maurel, and Gérard Fabre: Contribution of the N-Glucuronidation Pathway to the Overall in Vitro Metabolic Clearance of Midazolam in Humans
Drug Metab Dispos 2008 36: 851-862. Published online February 6, 2008; 10.1124/dmd.107.019539 [Abstract] [Full Text] [PDF]

Helen H. Usansky, Peidi Hu, and Patrick J. Sinko: Differential Roles of P-Glycoprotein, Multidrug Resistance-Associated Protein 2, and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats
Drug Metab Dispos 2008 36: 863-869. Published online February 6, 2008; 10.1124/dmd.107.017483 [Abstract] [Full Text] [PDF]

Andrew Rowland, David J. Elliot, Kathleen M. Knights, Peter I. Mackenzie, and John O. Miners: The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9
Drug Metab Dispos 2008 36: 870-877. Published online February 6, 2008; 10.1124/dmd.107.019885 [Abstract] [Full Text] [PDF]

Tsutomu Sakuma, Wattanaporn Bhadhprasit, Tadahiro Hashita, and Nobuo Nemoto: Synergism of Glucocorticoid Hormone with Growth Hormone for Female-Specific Mouse Cyp3a44 Gene Expression
Drug Metab Dispos 2008 36: 878-884. Published online February 6, 2008; 10.1124/dmd.107.019935 [Abstract] [Full Text] [PDF]

Mery Giantin, Monica Carletti, Francesca Capolongo, Sara Pegolo, Rosa Maria Lopparelli, Federica Gusson, Carlo Nebbia, Michela Cantiello, Pascal Martin, Thierry Pineau, and Mauro Dacasto: Effect of Breed upon Cytochromes P450 and Phase II Enzyme Expression in Cattle Liver
Drug Metab Dispos 2008 36: 885-893. Published online February 11, 2008; 10.1124/dmd.107.019042 [Abstract] [Full Text] [PDF]

Wolfgang Albrecht, Anke Unger, Andreas K. Nussler, and Stefan Laufer: In Vitro Metabolism of 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] Acetic Acid (Licofelone, ML3000), an Inhibitor of Cyclooxygenase-1 and -2 and 5-Lipoxygenase
Drug Metab Dispos 2008 36: 894-903. Published online February 11, 2008; 10.1124/dmd.108.020347 [Abstract] [Full Text] [PDF]

Onkar S. Bains, Ryan H. Takahashi, Tom A. Pfeifer, Thomas A. Grigliatti, Ronald E. Reid, and K. Wayne Riggs: Two Allelic Variants of Aldo-Keto Reductase 1A1 Exhibit Reduced in Vitro Metabolism of Daunorubicin
Drug Metab Dispos 2008 36: 904-910. Published online February 14, 2008; 10.1124/dmd.107.018895 [Abstract] [Full Text] [PDF]

Xianbin Tian, Brandon Swift, Maciej J. Zamek-Gliszczynski, Martin G. Belinsky, Gary D. Kruh, and Kim L. R. Brouwer: Impact of Basolateral Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 on the Hepatobiliary Disposition of Fexofenadine in Perfused Mouse Livers
Drug Metab Dispos 2008 36: 911-915. Published online February 14, 2008; 10.1124/dmd.107.019273 [Abstract] [Full Text] [PDF]

Yoshiyuki Shirasaka, Yoshie Masaoka, Makoto Kataoka, Shinji Sakuma, and Shinji Yamashita: Scaling of in Vitro Membrane Permeability to Predict P-glycoprotein-Mediated Drug Absorption in Vivo
Drug Metab Dispos 2008 36: 916-922. Published online February 14, 2008; 10.1124/dmd.107.020040 [Abstract] [Full Text] [PDF]

Leslie M. Tompkins, Tim L. Sit, and Andrew D. Wallace: Unique Transcription Start Sites and Distinct Promoter Regions Differentiate the Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2
Drug Metab Dispos 2008 36: 923-929. Published online February 14, 2008; 10.1124/dmd.107.018317 [Abstract] [Full Text] [PDF]

Antony F. McDonagh, Stefan E. Boiadjiev, and David A. Lightner: Slipping Past UGT1A1 and Multidrug Resistance-Associated Protein 2 in the Liver: Effects of Steric Compression and Hydrogen Bonding on the Hepatobiliary Elimination of Synthetic Bilirubins
Drug Metab Dispos 2008 36: 930-936. Published online February 25, 2008; 10.1124/dmd.107.019778 [Abstract] [Full Text] [PDF]

Edwin C. Y. Chow, Lichuan Liu, Noam Ship, Ronald H. Kluger, and K. Sandy Pang: Role of Haptoglobin on the Uptake of Native and β-Chain [Trimesoyl-(Lys82)β-(Lys82)β] Cross-Linked Human Hemoglobins in Isolated Perfused Rat Livers
Drug Metab Dispos 2008 36: 937-945. Published online February 14, 2008; 10.1124/dmd.107.019174 [Abstract] [Full Text] [PDF]

Rucha S. Sane, Donna J. Buckley, Arthur R. Buckley, Srikanth C. Nallani, and Pankaj B. Desai: Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T Cells
Drug Metab Dispos 2008 36: 946-954. Published online February 25, 2008; 10.1124/dmd.107.018598 [Abstract] [Full Text] [PDF]

Susanne Löfgren, R. Michael Baldwin, Masahiro Hiratsuka, Annelie Lindqvist, Anne Carlberg, Sarah C. Sim, Meint Schülke, Michael Snait, Anne Edenro, Ronny Fransson-Steen, Ylva Terelius, and Magnus Ingelman-Sundberg: Generation of Mice Transgenic for Human CYP2C18 and CYP2C19: Characterization of the Sexually Dimorphic Gene and Enzyme Expression
Drug Metab Dispos 2008 36: 955-962. Published online February 14, 2008; 10.1124/dmd.107.019349 [Abstract] [Full Text] [PDF]

Mostafizur Rahman, Sigurd F. Lax, Carrie H. Sutter, Quynh T. Tran, Gaylene L. Stevens, Gary L. Emmert, Jose Russo, Richard J. Santen, and Thomas R. Sutter: CYP1B1 Is Not a Major Determinant of the Disposition of Aromatase Inhibitors in Epithelial Cells of Invasive Ductal Carcinoma
Drug Metab Dispos 2008 36: 963-970. Published online February 6, 2008; 10.1124/dmd.107.018960 [Abstract] [Full Text] [PDF]

Elke Dopp, Ursula von Recklinghausen, Louise M. Hartmann, Inga Stueckradt, Ilona Pollok, Sasan Rabieh, Liping Hao, Andreas Nussler, Cindy Katier, Alfred V. Hirner, and Albert W. Rettenmeier: Subcellular Distribution of Inorganic and Methylated Arsenic Compounds in Human Urothelial Cells and Human Hepatocytes
Drug Metab Dispos 2008 36: 971-979. Published online February 6, 2008; 10.1124/dmd.107.019034 [Abstract] [Full Text] [PDF]

Short Communications:

Yoshiaki Kitamura, Hisao Koto, Shinobu Matsuura, Takeshi Kawabata, Hiroshi Tsuchiya, Hiroyuki Kusuhara, Hajime Tsujimoto, and Yuichi Sugiyama: Modest Effect of Impaired P-glycoprotein on the Plasma Concentrations of Fexofenadine, Quinidine, and Loperamide following Oral Administration in Collies
Drug Metab Dispos 2008 36: 807-810. Published online February 25, 2008; 10.1124/dmd.107.017624 [Abstract] [Full Text] [PDF]

Kyung H. Yang, Young S. Jung, Dae Y. Lee, Joo H. Lee, Young C. Kim, and Myung G. Lee: Time-Dependent Effects of Klebsiella Pneumoniae Endotoxin (KPLPS) on the Pharmacokinetics of Theophylline in Rats: Return of the Parameters in 96-Hour KPLPS Rats to the Control Levels
Drug Metab Dispos 2008 36: 811-815. Published online February 28, 2008; 10.1124/dmd.107.018499 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Fluorescent in situ hybridization analysis to determine the chromosomal location of the CYP2C18/19 transgene. See article by Löfgren et al. on page 955 of this issue.