CENTENNIAL PERSPECTIVE:

Patrick J. Murphy

The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983
Drug Metab Dispos 2008 36: 981-985. Published online March 5, 2008; 10.1124/dmd.108.021113 [Abstract] [Full Text] [PDF]  

Articles:

Junichi Enokizono, Hiroyuki Kusuhara, Atsushi Ose, Alfred H. Schinkel, and Yuichi Sugiyama

Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds
Drug Metab Dispos 2008 36: 995-1002. Published online March 5, 2008; 10.1124/dmd.107.019257 [Abstract] [Full Text] [PDF]  

Ryuichi Kitamura, Hisae Asanoma, Sekio Nagayama, and Masaki Otagiri

Identification of Human Liver Cytochrome P450 Isoforms Involved in Autoinduced Metabolism of the Antiangiogenic Agent (Z)-5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic Acid (TSU-68)
Drug Metab Dispos 2008 36: 1003-1009. Published online March 5, 2008; 10.1124/dmd.107.019877 [Abstract] [Full Text] [PDF]  

Hyunmi Kim, Kwon-Bok Kim, Hei-Young Ku, Soo-Jin Park, Hoon Choi, Joon-Kwan Moon, Byeoung-Soo Park, Jeong-Han Kim, Sung Su Yea, Choong-Hwan Lee, Hye Suk Lee, Jae-Gook Shin, and Kwang-Hyeon Liu

Identification and Characterization of Potent CYP2B6 Inhibitors in Woohwangcheongsimwon Suspension, an Herbal Preparation Used in the Treatment and Prevention of Apoplexy in Korea and China
Drug Metab Dispos 2008 36: 1010-1015. Published online March 10, 2008; 10.1124/dmd.107.019612 [Abstract] [Full Text] [PDF] [Erratum]   

Jonathan N. Bauman, Kosea S. Frederick, Aarti Sawant, Robert L. Walsky, Loretta M. Cox, Ronald S. Obach, and Amit S. Kalgutkar

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug
Drug Metab Dispos 2008 36: 1016-1029. Published online March 10, 2008; 10.1124/dmd.108.020545 [Abstract] [Full Text] [PDF]  

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui, and Hidetaka Kamimura

Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans
Drug Metab Dispos 2008 36: 1030-1038. Published online March 10, 2008; 10.1124/dmd.108.020669 [Abstract] [Full Text] [PDF]  

Doreen Mitschke, Andreas Reichel, Gert Fricker, and Ursula Moenning

Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats
Drug Metab Dispos 2008 36: 1039-1045. Published online March 10, 2008; 10.1124/dmd.107.019687 [Abstract] [Full Text] [PDF]  

Niresh Hariparsad, Brian A. Carr, Raymond Evers, and Xiaoyan Chu

Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction
Drug Metab Dispos 2008 36: 1046-1055. Published online March 10, 2008; 10.1124/dmd.108.020677 [Abstract] [Full Text] [PDF]  

Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie, and John O. Miners

The "Albumin Effect" and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities
Drug Metab Dispos 2008 36: 1056-1062. Published online March 24, 2008; 10.1124/dmd.108.021105 [Abstract] [Full Text] [PDF]  

Maya Pascual, M. José Gómez-Lechón, José V. Castell, and Ramiro Jover

ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses
Drug Metab Dispos 2008 36: 1063-1072. Published online March 10, 2008; 10.1124/dmd.107.019380 [Abstract] [Full Text] [PDF]  

Katrina L. Mealey, Stephen Greene, Rodney Bagley, John Gay, Russ Tucker, Patrick Gavin, Kari Schmidt, and Frederick Nelson

P-Glycoprotein Contributes to the Blood-Brain, but Not Blood-Cerebrospinal Fluid, Barrier in a Spontaneous Canine P-Glycoprotein Knockout Model
Drug Metab Dispos 2008 36: 1073-1079. Published online March 10, 2008; 10.1124/dmd.107.018978 [Abstract] [Full Text] [PDF] [Data Supplement]   

Tadahiro Hashita, Tsutomu Sakuma, Mami Akada, Asuka Nakajima, Hirofumi Yamahara, Sumiyo Ito, Hidekazu Takesako, and Nobuo Nemoto

Forkhead Box A2–Mediated Regulation of Female-Predominant Expression of the Mouse Cyp2b9 Gene
Drug Metab Dispos 2008 36: 1080-1087. Published online March 13, 2008; 10.1124/dmd.107.019729 [Abstract] [Full Text] [PDF]  

Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi, and Akira Tsuji

Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics
Drug Metab Dispos 2008 36: 1088-1096. Published online March 13, 2008; 10.1124/dmd.107.019125 [Abstract] [Full Text] [PDF]  

Sara K. Quinney, Raymond E. Galinsky, Vanida A. Jiyamapa-Serna, Yong Chen, Mitchell A. Hamman, Stephen D. Hall, and Robert E. Kimura

Hydroxyitraconazole, Formed During Intestinal First-Pass Metabolism of Itraconazole, Controls the Time Course of Hepatic CYP3A Inhibition and the Bioavailability of Itraconazole in Rats
Drug Metab Dispos 2008 36: 1097-1101. Published online March 13, 2008; 10.1124/dmd.108.020644 [Abstract] [Full Text] [PDF]  

C. Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Kevin Jones, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Stephen E. Mercer, Lian-Shen Gan, Mingxin Qian, Shimoga Prakash, Huey-Shin Shen, and Frank W. Lee

Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents
Drug Metab Dispos 2008 36: 1102-1110. Published online March 17, 2008; 10.1124/dmd.107.017038 [Abstract] [Full Text] [PDF]  

Rozenn Jossé, Caroline Aninat, Denise Glaise, Julie Dumont, Valérie Fessard, Fabrice Morel, Jean-Michel Poul, Christiane Guguen-Guillouzo, and André Guillouzo

Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies
Drug Metab Dispos 2008 36: 1111-1118. Published online March 17, 2008; 10.1124/dmd.107.019901 [Abstract] [Full Text] [PDF]  

Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Arlene Bridges, Yan Gao, Daniel K. Benjamin, Jr., and Dhiren R. Thakker

Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes
Drug Metab Dispos 2008 36: 1119-1125. Published online March 24, 2008; 10.1124/dmd.107.019646 [Abstract] [Full Text] [PDF]  

Dermot F. McGinnity, Nigel J. Waters, James Tucker, and Robert J. Riley

Integrated in Vitro Analysis for the in Vivo Prediction of Cytochrome P450-Mediated Drug-Drug Interactions
Drug Metab Dispos 2008 36: 1126-1134. Published online March 20, 2008; 10.1124/dmd.108.020446 [Abstract] [Full Text] [PDF]  

Phillip Krüger, Rambod Daneshfar, Gunter P. Eckert, Jochen Klein, Dietrich A. Volmer, Ute Bahr, Walter E. Müller, Michael Karas, Manfred Schubert-Zsilavecz, and Mona Abdel-Tawab

Metabolism of Boswellic Acids in Vitro and in Vivo
Drug Metab Dispos 2008 36: 1135-1142. Published online March 20, 2008; 10.1124/dmd.107.018424 [Abstract] [Full Text] [PDF]  

Vijaya M. Lakshmi, Fong Fu Hsu, and Terry V. Zenser

N-Demethylation Is a Major Route of 2-Amino-3-Methylimidazo[4,5-f]quinoline Metabolism in Mouse
Drug Metab Dispos 2008 36: 1143-1152. Published online March 20, 2008; 10.1124/dmd.107.019166 [Abstract] [Full Text] [PDF]  

Lanyan Fang and Duxin Sun

Predictive Physiologically Based Pharmacokinetic Model for Antibody-Directed Enzyme Prodrug Therapy
Drug Metab Dispos 2008 36: 1153-1165. Published online March 20, 2008; 10.1124/dmd.107.019182 [Abstract] [Full Text] [PDF]  

S. Harmsen, A. S. Koster, J. H. Beijnen, J. H. M. Schellens, and I. Meijerman

Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction
Drug Metab Dispos 2008 36: 1166-1171. Published online March 17, 2008; 10.1124/dmd.107.017335 [Abstract] [Full Text] [PDF]  

Anshul Gupta, Ganesh M. Mugundu, Pankaj B. Desai, Kenneth E. Thummel, and Jashvant D. Unadkat

Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors
Drug Metab Dispos 2008 36: 1172-1180. Published online March 10, 2008; 10.1124/dmd.107.018689 [Abstract] [Full Text] [PDF]  

Tomoko Sugiura, Yukio Kato, Tomohiko Wakayama, David L. Silver, Yoshiyuki Kubo, Shoichi Iseki, and Akira Tsuji

PDZK1 Regulates Two Intestinal Solute Carriers (Slc15a1 and Slc22a5) in Mice
Drug Metab Dispos 2008 36: 1181-1188. Published online March 5, 2008; 10.1124/dmd.107.020321 [Abstract] [Full Text] [PDF]  

Short Communications:

Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon, and Kwang-Hyeon Liu

The Contributions of Cytochromes P450 3A4 and 3A5 to the Metabolism of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Udenafil, and Vardenafil
Drug Metab Dispos 2008 36: 986-990. Published online February 28, 2008; 10.1124/dmd.107.020099 [Abstract] [Full Text] [PDF]  

Ryan H. Takahashi, Onkar S. Bains, Tom A. Pfeifer, Thomas A. Grigliatti, Ronald E. Reid, and K. Wayne Riggs

Aldo-Keto Reductase 1C2 Fails to Metabolize Doxorubicin and Daunorubicin in Vitro
Drug Metab Dispos 2008 36: 991-994. Published online March 5, 2008; 10.1124/dmd.108.020388 [Abstract] [Full Text] [PDF]  

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