DMD -- Table of Contents (36 [7])

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July 2008; 36 (7)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Gabriela Rodríguez-Fuentes, Rosaura Aparicio-Fabre, Qi Li, and Daniel Schlenk: Osmotic Regulation of a Novel Flavin-Containing Monooxygenase in Primary Cultured Cells from Rainbow Trout (Oncorhynchus mykiss)
Drug Metab Dispos 2008 36: 1212-1217. Published online March 27, 2008; 10.1124/dmd.107.019968 [Abstract] [Full Text] [PDF]

Chandra Prakash, Kim A. Johnson, and Mark J. Gardner: Disposition of Lasofoxifene, a Next-Generation Selective Estrogen Receptor Modulator, in Healthy Male Subjects
Drug Metab Dispos 2008 36: 1218-1226. Published online March 27, 2008; 10.1124/dmd.108.020404 [Abstract] [Full Text] [PDF]

Eric T. Williams, Karen O. Jones, G. Douglas Ponsler, Shane M. Lowery, Everett J. Perkins, Steven A. Wrighton, Kenneth J. Ruterbories, Miho Kazui, and Nagy A. Farid: The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2
Drug Metab Dispos 2008 36: 1227-1232. Published online March 27, 2008; 10.1124/dmd.107.020248 [Abstract] [Full Text] [PDF]

Choong Y. Ahn, Soo K. Bae, Young S. Jung, Inchul Lee, Young C. Kim, Myung G. Lee, and Wan G. Shin: Pharmacokinetic Parameters of Chlorzoxazone and Its Main Metabolite, 6-Hydroxychlorzoxazone, after Intravenous and Oral Administration of Chlorzoxazone to Liver Cirrhotic Rats with Diabetes Mellitus
Drug Metab Dispos 2008 36: 1233-1241. Published online March 31, 2008; 10.1124/dmd.107.017442 [Abstract] [Full Text] [PDF]

Vikas Kumar, Richard C. Brundage, William S. Oetting, Ilo E. Leppik, and Timothy S. Tracy: Differential Genotype Dependent Inhibition of CYP2C9 in Humans
Drug Metab Dispos 2008 36: 1242-1248. Published online March 31, 2008; 10.1124/dmd.108.020396 [Abstract] [Full Text] [PDF]

Caroline MacLean, Ulla Moenning, Andreas Reichel, and Gert Fricker: Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats
Drug Metab Dispos 2008 36: 1249-1254. Published online March 31, 2008; 10.1124/dmd.108.020859 [Abstract] [Full Text] [PDF]

Chuang Lu, Panos Hatsis, Cicely Berg, Frank W. Lee, and Suresh K. Balani: Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole
Drug Metab Dispos 2008 36: 1255-1260. Published online April 1, 2008; 10.1124/dmd.107.018796 [Abstract] [Full Text] [PDF]

Chuang Lu, Cicely Berg, Shimoga R. Prakash, Frank W. Lee, and Suresh K. Balani: Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. III. In Vitro-in Vivo Correlation with Fluconazole
Drug Metab Dispos 2008 36: 1261-1266. Published online April 1, 2008; 10.1124/dmd.107.019000 [Abstract] [Full Text] [PDF]

Shinji Yamazaki, Judith Skaptason, David Romero, Joseph H. Lee, Helen Y. Zou, James G. Christensen, Jeffrey R. Koup, Bill J. Smith, and Tatiana Koudriakova: Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available cMet Kinase Inhibitor in Human Tumor Xenograft Mouse Models
Drug Metab Dispos 2008 36: 1267-1274. Published online April 1, 2008; 10.1124/dmd.107.019711 [Abstract] [Full Text] [PDF]

Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto, and Ikumi Tamai: Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes
Drug Metab Dispos 2008 36: 1275-1282. Published online April 3, 2008; 10.1124/dmd.107.019026 [Abstract] [Full Text] [PDF]

Wenxia Zhang and Lee-Yong Lim: Effects of Spice Constituents on P-Glycoprotein-Mediated Transport and CYP3A4-Mediated Metabolism in Vitro
Drug Metab Dispos 2008 36: 1283-1290. Published online April 2, 2008; 10.1124/dmd.107.019737 [Abstract] [Full Text] [PDF]

Peter H. Bui, Arnulfo Quesada, Adrian Handforth, and Oliver Hankinson: The Mibefradil Derivative NNC55-0396, a Specific T-Type Calcium Channel Antagonist, Exhibits Less CYP3A4 Inhibition than Mibefradil
Drug Metab Dispos 2008 36: 1291-1299. Published online April 14, 2008; 10.1124/dmd.107.020115 [Abstract] [Full Text] [PDF]

Tao Zhang, Cathie D. Xiang, David Gale, Samantha Carreiro, Ellen Y. Wu, and Eric Y. Zhang: Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition
Drug Metab Dispos 2008 36: 1300-1307. Published online April 14, 2008; 10.1124/dmd.108.021121 [Abstract] [Full Text] [PDF]

Furong Qiu, Rong Zhang, Jianguo Sun, Jiye A, Haiping Hao, Ying Peng, Hua Ai, and Guangji Wang: Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450 Enzyme in Human Liver Microsomes
Drug Metab Dispos 2008 36: 1308-1314. Published online April 14, 2008; 10.1124/dmd.108.021030 [Abstract] [Full Text] [PDF]

Zhi-wei Ye, Patrick Augustijns, and Pieter Annaert: Cellular Accumulation of Cholyl-Glycylamido-Fluorescein in Sandwich-Cultured Rat Hepatocytes: Kinetic Characterization, Transport Mechanisms, and Effect of Human Immunodeficiency Virus Protease Inhibitors
Drug Metab Dispos 2008 36: 1315-1321. Published online April 17, 2008; 10.1124/dmd.107.019398 [Abstract] [Full Text] [PDF]

Lesley A. McLaughlin, Leslie J. Dickmann, C. Roland Wolf, and Colin J. Henderson: Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening
Drug Metab Dispos 2008 36: 1322-1331. Published online April 17, 2008; 10.1124/dmd.108.021261 [Abstract] [Full Text] [PDF] [Data Supplement]

Jamie Henshall, Aleksandra Galetin, Anthony Harrison, and J. Brian Houston: Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications
Drug Metab Dispos 2008 36: 1332-1340. Published online April 17, 2008; 10.1124/dmd.108.021279 [Abstract] [Full Text] [PDF]

Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony Barros, Jr., Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A. Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys, and Ramaswamy A. Iyer: Biotransformation of [¹⁴C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys
Drug Metab Dispos 2008 36: 1341-1356. Published online April 17, 2008; 10.1124/dmd.107.018234 [Abstract] [Full Text] [PDF]

Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbraith, Donald P. Reitberg, Kan He, Anthony Barros, Jr., Anne Blackwood-Chirchir, W. Griffith Humphreys, and Ramaswamy A. Iyer: Metabolism and Disposition of Dasatinib after Oral Administration to Humans
Drug Metab Dispos 2008 36: 1357-1364. Published online April 17, 2008; 10.1124/dmd.107.018267 [Abstract] [Full Text] [PDF]

Stuart W. Paine, Alison J. Parker, Philip Gardiner, Peter J. H. Webborn, and Robert J. Riley: Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
Drug Metab Dispos 2008 36: 1365-1374. Published online April 21, 2008; 10.1124/dmd.107.019455 [Abstract] [Full Text] [PDF] [Data Supplement]

Alison J. Parker and J. Brian Houston: Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir
Drug Metab Dispos 2008 36: 1375-1384. Published online April 21, 2008; 10.1124/dmd.108.020917 [Abstract] [Full Text] [PDF]

R. Scott Obach, Franco Lombardo, and Nigel J. Waters: Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds
Drug Metab Dispos 2008 36: 1385-1405. Published online April 21, 2008; 10.1124/dmd.108.020479 [Abstract] [Full Text] [PDF] [Data Supplement]

John W. Nichols, Alex D. Hoffman, Patrick N. Fitzsimmons, Gregory J. Lien, and Correne T. Jenson: Use of Online Microdialysis Sampling to Determine the in Vivo Rate of Phenol Glucuronidation in Rainbow Trout
Drug Metab Dispos 2008 36: 1406-1413. Published online April 17, 2008; 10.1124/dmd.107.020123 [Abstract] [Full Text] [PDF]

Lana X. Garmire and C. Anthony Hunt: In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism-Efflux Transport Interactions
Drug Metab Dispos 2008 36: 1414-1424. Published online April 24, 2008; 10.1124/dmd.107.020164 [Abstract] [Full Text] [PDF]

Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, Alan Deese, and James A. Nieman: Bioactivation of Flutamide Metabolites by Human Liver Microsomes
Drug Metab Dispos 2008 36: 1425-1437. Published online April 14, 2008; 10.1124/dmd.108.020370 [Abstract] [Full Text] [PDF] [Data Supplement]

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue, and Hajime Mizukami: Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury
Drug Metab Dispos 2008 36: 1438-1443. Published online March 24, 2008; 10.1124/dmd.108.021089 [Abstract] [Full Text] [PDF]

Kajsa P. Kanebratt and Tommy B. Andersson: Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies
Drug Metab Dispos 2008 36: 1444-1452. Published online April 2, 2008; 10.1124/dmd.107.020016 [Abstract] [Full Text] [PDF] [Data Supplement]

Short Communications:

Yukio Yamamoto and Masahiko Negishi: The Antiapoptotic Factor Growth Arrest and DNA-Damage-Inducible 45 β Regulates the Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Transcription
Drug Metab Dispos 2008 36: 1189-1193. Published online March 24, 2008; 10.1124/dmd.108.020628 [Abstract] [Full Text] [PDF]

Peter J. Kilford, Michael Gertz, J. Brian Houston, and Aleksandra Galetin: Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data
Drug Metab Dispos 2008 36: 1194-1197. Published online April 14, 2008; 10.1124/dmd.108.020834 [Abstract] [Full Text] [PDF]

Melinda J. Reese, Robert M. Wurm, Keith T. Muir, Grant T. Generaux, Lisa St. John-Williams, and Donavon J. Mcconn: An in Vitro Mechanistic Study to Elucidate the Desipramine/Bupropion Clinical Drug-Drug Interaction
Drug Metab Dispos 2008 36: 1198-1201. Published online April 17, 2008; 10.1124/dmd.107.020198 [Abstract] [Full Text] [PDF]

Shigeyuki Kitamura, Kayoko Nitta, Yoshitaka Tayama, Chiaki Tanoue, Kazumi Sugihara, Tae Inoue, Toru Horie, and Shigeru Ohta: Aldehyde Oxidase-Catalyzed Metabolism of N¹-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver
Drug Metab Dispos 2008 36: 1202-1205. Published online March 10, 2008; 10.1124/dmd.107.019075 [Abstract] [Full Text] [PDF]

Naoko Yoshida, Tappei Takada, Yoshikazu Yamamura, Isao Adachi, Hiroshi Suzuki, and Junichi Kawakami: Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport
Drug Metab Dispos 2008 36: 1206-1211. Published online April 24, 2008; 10.1124/dmd.107.019513 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Expression of mRNA for 44 genes in cryopreserved human hepatocytes and in differentiated HepaRG cells cultured with and without dimethyl sulfoxide (n = 3, human hepatocyte batches 1, 4, and 5). See article by Kanebratt and Andersson on page 1444 of this issue.