DMD -- Table of Contents (37 [1])

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January 2009; 37 (1)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich, and Hiroshi Yamazaki: Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
Drug Metab Dispos 2009 37: 18-23. Published online October 23, 2008; 10.1124/dmd.108.024679 [Abstract] [Full Text] [PDF]

Huai-Chia Chang, Ta-Liang Chen, and Ruei-Ming Chen: Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function
Drug Metab Dispos 2009 37: 24-31. Published online October 9, 2008; 10.1124/dmd.108.023325 [Abstract] [Full Text] [PDF]

Shuji Ohno and Shizuo Nakajin: Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
Drug Metab Dispos 2009 37: 32-40. Published online October 6, 2008; 10.1124/dmd.108.023598 [Abstract] [Full Text] [PDF]

Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka, and Tsuyoshi Yokoi: Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
Drug Metab Dispos 2009 37: 41-46. Published online October 2, 2008; 10.1124/dmd.108.022913 [Abstract] [Full Text] [PDF]

Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö, and Ulf Bredberg: The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CL_int), Maximum Velocity of the Metabolic Reaction (V_max), and Michaelis Constant (K_m): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
Drug Metab Dispos 2009 37: 47-58. Published online September 29, 2008; 10.1124/dmd.108.021477 [Abstract] [Full Text] [PDF]

J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar, and Timothy S. Tracy: Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
Drug Metab Dispos 2009 37: 59-65. Published online October 6, 2008; 10.1124/dmd.108.023358 [Abstract] [Full Text] [PDF]

Na Li, Yiqun Zhang, Fengmei Hua, and Yurong Lai: Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
Drug Metab Dispos 2009 37: 66-73. Published online October 2, 2008; 10.1124/dmd.108.023234 [Abstract] [Full Text] [PDF]

Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong, and Donglu Zhang: Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
Drug Metab Dispos 2009 37: 74-81. Published online October 2, 2008; 10.1124/dmd.108.023143 [Abstract] [Full Text] [PDF]

Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston, and Aleksandra Galetin: Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
Drug Metab Dispos 2009 37: 82-89. Published online October 2, 2008; 10.1124/dmd.108.023853 [Abstract] [Full Text] [PDF]

Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt, and Michael H. Court: Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b₅/NADH-b₅ Reductase in Variability of CYP3A Activity in Human Liver Microsomes
Drug Metab Dispos 2009 37: 90-96. Published online October 6, 2008; 10.1124/dmd.108.023424 [Abstract] [Full Text] [PDF]

Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari, and Yasushi Yamazoe: Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
Drug Metab Dispos 2009 37: 97-105. Published online October 2, 2008; 10.1124/dmd.108.021964 [Abstract] [Full Text] [PDF]

Yu-Kun Jennifer Zhang, Ronnie L. Yeager, and Curtis D. Klaassen: Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver
Drug Metab Dispos 2009 37: 106-115. Published online October 6, 2008; 10.1124/dmd.108.024174 [Abstract] [Full Text] [PDF]

Steven N. Hart, Yue Cui, Curtis D. Klaassen, and Xiao-bo Zhong: Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
Drug Metab Dispos 2009 37: 116-121. Published online October 9, 2008; 10.1124/dmd.108.023812 [Abstract] [Full Text] [PDF]

Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume, and Koichiro Fukuzaki: Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
Drug Metab Dispos 2009 37: 122-128. Published online October 14, 2008; 10.1124/dmd.108.022574 [Abstract] [Full Text] [PDF]

Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen, and Alfred H. Schinkel: Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
Drug Metab Dispos 2009 37: 129-136. Published online October 9, 2008; 10.1124/dmd.108.023200 [Abstract] [Full Text] [PDF]

William Kielbasa, J. Cory Kalvass, and Robert Stratford: Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats
Drug Metab Dispos 2009 37: 137-142. Published online October 20, 2008; 10.1124/dmd.108.023119 [Abstract] [Full Text] [PDF]

Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel, and Matthias Brandsch: High-Affinity Interaction of Sartans with H⁺/Peptide Transporters
Drug Metab Dispos 2009 37: 143-149. Published online September 29, 2008; 10.1124/dmd.108.022418 [Abstract] [Full Text] [PDF]

Xin Zhang, David R. Jones, and Stephen D. Hall: Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
Drug Metab Dispos 2009 37: 150-160. Published online October 14, 2008; 10.1124/dmd.108.022178 [Abstract] [Full Text] [PDF]

Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton, and Gregory R. J. Thatcher: Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
Drug Metab Dispos 2009 37: 161-169. Published online October 20, 2008; 10.1124/dmd.108.023408 [Abstract] [Full Text] [PDF]

Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao, and Xi-Ling Jiang: Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
Drug Metab Dispos 2009 37: 170-177. Published online October 2, 2008; 10.1124/dmd.108.024166 [Abstract] [Full Text] [PDF]

Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips, and Elizabeth A. Shephard: Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
Drug Metab Dispos 2009 37: 178-186. Published online October 23, 2008; 10.1124/dmd.108.024158 [Abstract] [Full Text] [PDF]

Huadong Sun and K. Sandy Pang: Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study
Drug Metab Dispos 2009 37: 187-202. Published online October 23, 2008; 10.1124/dmd.108.022483 [Abstract] [Full Text] [PDF]

Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver, and Curtis D. Klaassen: Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
Drug Metab Dispos 2009 37: 203-210. Published online October 14, 2008; 10.1124/dmd.108.023721 [Abstract] [Full Text] [PDF]

Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins, and Cheryl L. Zimmerman: Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
Drug Metab Dispos 2009 37: 211-220. Published online October 6, 2008; 10.1124/dmd.108.022012 [Abstract] [Full Text] [PDF]

Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito, and Michael F. Hughes: In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
Drug Metab Dispos 2009 37: 221-228. Published online October 23, 2008; 10.1124/dmd.108.022343 [Abstract] [Full Text] [PDF]

Upendra A. Argikar and Rory P. Remmel: Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
Drug Metab Dispos 2009 37: 229-236. Published online October 6, 2008; 10.1124/dmd.108.022426 [Abstract] [Full Text] [PDF]

Tai Ning Lam and C. Anthony Hunt: Discovering Plausible Mechanistic Details of Hepatic Drug Interactions
Drug Metab Dispos 2009 37: 237-246. Published online October 20, 2008; 10.1124/dmd.108.023820 [Abstract] [Full Text] [PDF] [Data Supplement]

Short Communications:

Wei-Yan Zhang, You-Bin Tu, Robert L. Haining, and Ai-Ming Yu: Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
Drug Metab Dispos 2009 37: 1-4. Published online October 6, 2008; 10.1124/dmd.108.023663 [Abstract] [Full Text] [PDF]

Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez, and Margarita M. Marques: Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
Drug Metab Dispos 2009 37: 5-9. Published online September 29, 2008; 10.1124/dmd.108.022715 [Abstract] [Full Text] [PDF]

Collette D. Linder, Nicole A. Renaud, and J. Matthew Hutzler: Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?
Drug Metab Dispos 2009 37: 10-13. Published online October 20, 2008; 10.1124/dmd.108.024075 [Abstract] [Full Text] [PDF]

Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki, and Ryoichi Nagata: A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
Drug Metab Dispos 2009 37: 14-17. Published online September 29, 2008; 10.1124/dmd.108.023622 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Docking simulation of thalidomide into a reported structure of P450 3A4 (A) and a homology model of P450 3A5 (B). See article by Okada et al. on page 18 of this issue.