DMD -- Table of Contents (37 [4])

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

Receive this page by email each issue: [Sign up for eTOCs]

Other Issues:
April 2009; 37 (4)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

Find articles in this issue containing these words:
[Search ALL Issues]

Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Donglu Zhang, Van T. Ly, Michael Lago, Yuan Tian, Jinping Gan, W. Griffith Humphreys, and S. Nilgün Çömezoglu: CYP3A4-Mediated Ester Cleavage as the Major Metabolic Pathway of the Oral Taxane 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183)
Drug Metab Dispos 2009 37: 710-718. Published online January 21, 2009; 10.1124/dmd.108.024398 [Abstract] [Full Text] [PDF]

Satyanarayana R. Pondugula, Cynthia Brimer-Cline, Jing Wu, Erin G. Schuetz, Rakesh K. Tyagi, and Taosheng Chen: A Phosphomimetic Mutation at Threonine-57 Abolishes Transactivation Activity and Alters Nuclear Localization Pattern of Human Pregnane X Receptor
Drug Metab Dispos 2009 37: 719-730. Published online January 26, 2009; 10.1124/dmd.108.024695 [Abstract] [Full Text] [PDF]

Yansheng Wei, Liomar A. A. Neves, Tammy Franklin, Nadya Klyuchnikova, Benjamin Placzek, Helen M. Hughes, and C. Gerald Curtis: Vascular Perfused Segments of Human Intestine as a Tool for Drug Absorption
Drug Metab Dispos 2009 37: 731-736. Published online December 31, 2008; 10.1124/dmd.108.023382 [Abstract] [Full Text] [PDF]

Wei Zhang, Jibin Li, Samantha M. Allen, Erica A. Weiskircher, Yuehua Huang, Rebecca A. George, Ramon G. Fong, Albert Owen, and Ismael J. Hidalgo: Silencing the Breast Cancer Resistance Protein Expression and Function in Caco-2 Cells Using Lentiviral Vector-Based Short Hairpin RNA
Drug Metab Dispos 2009 37: 737-744. Published online January 8, 2009; 10.1124/dmd.108.023309 [Abstract] [Full Text] [PDF]

Mohamad Shebley, Ute M. Kent, David P. Ballou, and Paul F. Hollenberg: Mechanistic Analysis of the Inactivation of Cytochrome P450 2B6 by Phencyclidine: Effects on Substrate Binding, Electron Transfer, and Uncoupling
Drug Metab Dispos 2009 37: 745-752. Published online January 14, 2009; 10.1124/dmd.108.024661 [Abstract] [Full Text] [PDF]

Jeanette Watson, Sara Wright, Adam Lucas, Kirsten L. Clarke, Jean Viggers, Sharon Cheetham, Phil Jeffrey, Rod Porter, and Kevin D. Read: Receptor Occupancy and Brain Free Fraction
Drug Metab Dispos 2009 37: 753-760. Published online January 21, 2009; 10.1124/dmd.108.022814 [Abstract] [Full Text] [PDF]

Minh N. Nguyen, Andrzej Slominski, Wei Li, Yun Rui Ng, and Robert C. Tuckey: Metabolism of Vitamin D2 to 17,20,24-Trihydroxyvitamin D2 by Cytochrome P450scc (CYP11A1)
Drug Metab Dispos 2009 37: 761-767. Published online December 30, 2008; 10.1124/dmd.108.025619 [Abstract] [Full Text] [PDF]

Katriina Itäaho, Michael H. Court, Päivi Uutela, Risto Kostiainen, Anna Radominska-Pandya, and Moshe Finel: Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10
Drug Metab Dispos 2009 37: 768-775. Published online December 30, 2008; 10.1124/dmd.108.025692 [Abstract] [Full Text] [PDF]

Matthew K. Ross, Toni L. Jones, and Nikolay M. Filipov: Disposition of the Herbicide 2-Chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine (Atrazine) and Its Major Metabolites in Mice: A Liquid Chromatography/Mass Spectrometry Analysis of Urine, Plasma, and Tissue Levels
Drug Metab Dispos 2009 37: 776-786. Published online December 30, 2008; 10.1124/dmd.108.024927 [Abstract] [Full Text] [PDF]

Xingrong Liu, Kristine Van Natta, Helen Yeo, Olga Vilenski, Paul E. Weller, Philip D. Worboys, and Mario Monshouwer: Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid
Drug Metab Dispos 2009 37: 787-793. Published online December 30, 2008; 10.1124/dmd.108.024125 [Abstract] [Full Text] [PDF]

K. Herédi-Szabó, H. Glavinas, E. Kis, D. Méhn, G. Báthori, Z. Veres, L. Kóbori, O. von Richter, K. Jemnitz, and P. Krajcsi: Multidrug Resistance Protein 2-Mediated Estradiol-17β-D-glucuronide Transport Potentiation: In Vitro-in Vivo Correlation and Species Specificity
Drug Metab Dispos 2009 37: 794-801. Published online December 31, 2008; 10.1124/dmd.108.023895 [Abstract] [Full Text] [PDF]

Lifei Wang, Nirmala Raghavan, Kan He, Joseph M. Luettgen, W. Griffith Humphreys, Robert M. Knabb, Donald J. Pinto, and Donglu Zhang: Sulfation of O-Demethyl Apixaban: Enzyme Identification and Species Comparison
Drug Metab Dispos 2009 37: 802-808. Published online January 8, 2009; 10.1124/dmd.108.025593 [Abstract] [Full Text] [PDF]

Marc Vermeir, Sophie Lachau-Durand, Geert Mannens, Filip Cuyckens, Bart van Hoof, and Araz Raoof: Absorption, Metabolism, and Excretion of Darunavir, a New Protease Inhibitor, Administered Alone and with Low-Dose Ritonavir in Healthy Subjects
Drug Metab Dispos 2009 37: 809-820. Published online January 8, 2009; 10.1124/dmd.108.024109 [Abstract] [Full Text] [PDF]

Keiko Hosohata, Satohiro Masuda, Toshiya Katsura, Yasutsugu Takada, Toshimi Kaido, Yasuhiro Ogura, Fumitaka Oike, Hiroto Egawa, Shinji Uemoto, and Ken-ichi Inui: Impact of Intestinal CYP2C19 Genotypes on the Interaction between Tacrolimus and Omeprazole, but Not Lansoprazole, in Adult Living-Donor Liver Transplant Patients
Drug Metab Dispos 2009 37: 821-826. Published online January 12, 2009; 10.1124/dmd.108.025833 [Abstract] [Full Text] [PDF]

Anne Gardin, Klaus Kucher, Beate Kiese, and Silke Appel-Dingemanse: Cannabinoid Receptor Agonist 13, a Novel Cannabinoid Agonist: First in Human Pharmacokinetics and Safety
Drug Metab Dispos 2009 37: 827-833. Published online January 14, 2009; 10.1124/dmd.108.024000 [Abstract] [Full Text] [PDF]

David B. Buckley and Curtis D. Klaassen: Mechanism of Gender-Divergent UDP-Glucuronosyltransferase mRNA Expression in Mouse Liver and Kidney
Drug Metab Dispos 2009 37: 834-840. Published online January 8, 2009; 10.1124/dmd.108.024224 [Abstract] [Full Text] [PDF]

Yiding Hu, Kathleen E. Sampson, Bruce R. Heyde, Kathy M. Mandrell, Na Li, Anup Zutshi, and Yurong Lai: Saturation of Multidrug-Resistant Protein 2 (Mrp2/Abcc2)-Mediated Hepatobiliary Secretion: Nonlinear Pharmacokinetics of a Heterocyclic Compound in Rats after Intravenous Bolus Administration
Drug Metab Dispos 2009 37: 841-846. Published online January 12, 2009; 10.1124/dmd.108.024059 [Abstract] [Full Text] [PDF]

David B. Buckley and Curtis D. Klaassen: Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor ${alpha}$ , and Nuclear Factor Erythroid 2-Related Factor 2
Drug Metab Dispos 2009 37: 847-856. Published online January 14, 2009; 10.1124/dmd.108.024190 [Abstract] [Full Text] [PDF]

Warren J. Huber, III, Christopher C. Marohnic, Michelle Peters, Jawed Alam, James R. Reed, Bettie Sue Siler Masters, and Wayne L. Backes: Measurement of Membrane-Bound Human Heme Oxygenase-1 Activity Using a Chemically Defined Assay System
Drug Metab Dispos 2009 37: 857-864. Published online January 8, 2009; 10.1124/dmd.108.025023 [Abstract] [Full Text] [PDF]

Choon-Myung Lee, Jan Pohl, and Edward T. Morgan: Dual Mechanisms of CYP3A Protein Regulation by Proinflammatory Cytokine Stimulation in Primary Hepatocyte Cultures
Drug Metab Dispos 2009 37: 865-872. Published online January 26, 2009; 10.1124/dmd.108.026187 [Abstract] [Full Text] [PDF] [Data Supplement]

Ralph Laufer, Odalys Gonzalez Paz, Annalise Di Marco, Fabio Bonelli, Edith Monteagudo, Vincenzo Summa, and Michael Rowley: Quantitative Prediction of Human Clearance Guiding the Development of Raltegravir (MK-0518, Isentress) and Related HIV Integrase Inhibitors
Drug Metab Dispos 2009 37: 873-883. Published online January 14, 2009; 10.1124/dmd.108.023804 [Abstract] [Full Text] [PDF] [Data Supplement]

Guanghua Gao and Francis C. P. Law: Physiologically Based Pharmacokinetics of Matrine in the Rat after Oral Administration of Pure Chemical and ACAPHA
Drug Metab Dispos 2009 37: 884-891. Published online January 8, 2009; 10.1124/dmd.108.023788 [Abstract] [Full Text] [PDF]

Mingli Yang, Jarod L. Kabulski, Lance Wollenberg, Xinqi Chen, Murali Subramanian, Timothy S. Tracy, David Lederman, Peter M. Gannett, and Nianqiang Wu: Electrocatalytic Drug Metabolism by CYP2C9 Bonded to A Self-Assembled Monolayer-Modified Electrode
Drug Metab Dispos 2009 37: 892-899. Published online January 26, 2009; 10.1124/dmd.108.025452 [Abstract] [Full Text] [PDF]

Zofia Duniec-Dmuchowski, Hai-Lin Fang, Stephen C. Strom, Ewa Ellis, Melissa Runge-Morris, and Thomas A. Kocarek: Human Pregnane X Receptor Activation and CYP3A4/CYP2B6 Induction by 2,3-Oxidosqualene:Lanosterol Cyclase Inhibition
Drug Metab Dispos 2009 37: 900-908. Published online January 21, 2009; 10.1124/dmd.108.025130 [Abstract] [Full Text] [PDF]

Y. Cheng, S. H. Wright, M. J. Hooth, and I. G. Sipes: Characterization of the Disposition and Toxicokinetics of N-Butylpyridinium Chloride in Male F-344 Rats and Female B6C3F1 Mice and Its Transport by Organic Cation Transporter 2
Drug Metab Dispos 2009 37: 909-916. Published online January 26, 2009; 10.1124/dmd.108.022681 [Abstract] [Full Text] [PDF]

Roos L. Oostendorp, Evita van de Steeg, Cornelia M. M. van der Kruijssen, Jos H. Beijnen, Kathryn E. Kenworthy, Alfred H. Schinkel, and Jan H. M. Schellens: Organic Anion-Transporting Polypeptide 1B1 Mediates Transport of Gimatecan and BNP1350 and Can Be Inhibited by Several Classic ATP-Binding Cassette (ABC) B1 and/or ABCG2 Inhibitors
Drug Metab Dispos 2009 37: 917-923. Published online January 12, 2009; 10.1124/dmd.108.024901 [Abstract] [Full Text] [PDF]

Short Communications:

David M. Stresser, Andrew K. Mason, Elke S. Perloff, Thuy Ho, Charles L. Crespi, Andre A. Dandeneau, Ling Morgan, and Shangara S. Dehal: Differential Time- and NADPH-Dependent Inhibition of CYP2C19 by Enantiomers of Fluoxetine
Drug Metab Dispos 2009 37: 695-698. Published online January 14, 2009; 10.1124/dmd.108.025726 [Abstract] [Full Text] [PDF]

Masayuki Matsunaga, Hiroshi Yamazaki, Kazuma Kiyotani, Shunsuke Iwano, Jyunji Saruwatari, Kazuko Nakagawa, Akiko Soyama, Shogo Ozawa, Jun-Ichi Sawada, Eiji Kashiyama, Moritoshi Kinoshita, and Tetsuya Kamataki: Two Novel CYP2D6*10 Haplotypes As Possible Causes of a Poor Metabolic Phenotype in Japanese
Drug Metab Dispos 2009 37: 699-701. Published online January 21, 2009; 10.1124/dmd.108.026096 [Abstract] [Full Text] [PDF]

M. L. Buchanan, T. R. Easterling, D. B. Carr, D. D. Shen, L. J. Risler, W. L. Nelson, D. R. Mattison, and M. F. Hebert: Clonidine Pharmacokinetics in Pregnancy
Drug Metab Dispos 2009 37: 702-705. Published online December 30, 2008; 10.1124/dmd.108.024984 [Abstract] [Full Text] [PDF]

Emily D. Salman, Susan A. Kadlubar, and Charles N. Falany: Expression and Localization of Cytosolic Sulfotransferase (SULT) 1A1 and SULT1A3 in Normal Human Brain
Drug Metab Dispos 2009 37: 706-709. Published online January 26, 2009; 10.1124/dmd.108.025767 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Relationship between receptor occupancy and brain unbound concentration normalized for the in vitro affinity for rat striatal D2 receptors. See article by Watson et al. on page 753 of this issue.