Minireview:

Magang Shou and Anthony Y. H. Lu

Antibodies as a Probe in Cytochrome P450 Research
Drug Metab Dispos 2009 37: 925-931. Published online February 5, 2009; 10.1124/dmd.108.025718 [Abstract] [Full Text] [PDF]  

Articles:

Shinji Yamazaki, Lisa N. Toth, Emi Kimoto, Janice Bower, Judith Skaptason, David Romero, and Timothy G. Heath

Application of Stable Isotope Methodology in the Evaluation of the Pharmacokinetics of (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride in Rats
Drug Metab Dispos 2009 37: 937-945. Published online February 23, 2009; 10.1124/dmd.108.025478 [Abstract] [Full Text] [PDF]  

Lin Zhou, Kari Schmidt, Frederick R. Nelson, Veronica Zelesky, Matthew D. Troutman, and Bo Feng

The Effect of Breast Cancer Resistance Protein and P-Glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-Methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice
Drug Metab Dispos 2009 37: 946-955. Published online February 18, 2009; 10.1124/dmd.108.024489 [Abstract] [Full Text] [PDF]  

Shiori Takahashi, Miki Katoh, Takashi Saitoh, Miki Nakajima, and Tsuyoshi Yokoi

Different Inhibitory Effects in Rat and Human Carboxylesterases
Drug Metab Dispos 2009 37: 956-961. Published online February 18, 2009; 10.1124/dmd.108.024331 [Abstract] [Full Text] [PDF]  

Kyohei Shintaku, Satoko Hori, Masayuki Tsujimoto, Hideaki Nagata, Shoji Satoh, Kiyomi Tsukimori, Hitoo Nakano, Tomoyuki Fujii, Yuji Taketani, Hisakazu Ohtani, and Yasufumi Sawada

Transplacental Pharmacokinetics of Diclofenac in Perfused Human Placenta
Drug Metab Dispos 2009 37: 962-968. Published online February 9, 2009; 10.1124/dmd.108.024349 [Abstract] [Full Text] [PDF]  

John H. Ansede, Matthew R. Wright, Robert L. St. Claire, III, Robert W. Hart, Holly A. Gefroh, and Kenneth R. Brouwer

Characterization of Sandwich-Cultured Hepatocytes As an in Vitro Model to Assess the Hepatobiliary Disposition of Copper
Drug Metab Dispos 2009 37: 969-976. Published online February 23, 2009; 10.1124/dmd.108.024638 [Abstract] [Full Text] [PDF]  

Lin-Lin Wang, Yong Li, and Shu-Feng Zhou

A Bioinformatics Approach for the Phenotype Prediction of Nonsynonymous Single Nucleotide Polymorphisms in Human Cytochromes P450
Drug Metab Dispos 2009 37: 977-991. Published online February 9, 2009; 10.1124/dmd.108.026047 [Abstract] [Full Text] [PDF] [Data Supplement]   

Cathie D. Xiang, Minerva Batugo, David C. Gale, Tao Zhang, Jingjing Ye, Chunze Li, Sue Zhou, Ellen Y. Wu, and Eric Y. Zhang

Characterization of Human Corneal Epithelial Cell Model As a Surrogate for Corneal Permeability Assessment: Metabolism and Transport
Drug Metab Dispos 2009 37: 992-998. Published online February 12, 2009; 10.1124/dmd.108.026286 [Abstract] [Full Text] [PDF]  

David Boyer, Jonathan N. Bauman, Daniel P. Walker, Brendon Kapinos, Kapil Karki, and Amit S. Kalgutkar

Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide
Drug Metab Dispos 2009 37: 999-1008. Published online February 5, 2009; 10.1124/dmd.108.026112 [Abstract] [Full Text] [PDF]  

Takashi Kano, Yukio Kato, Kimihiro Ito, Takuo Ogihara, Yoshiyuki Kubo, and Akira Tsuji

Carnitine/Organic Cation Transporter OCTN2 (Slc22a5) Is Responsible for Renal Secretion of Cephaloridine in Mice
Drug Metab Dispos 2009 37: 1009-1016. Published online February 12, 2009; 10.1124/dmd.108.025015 [Abstract] [Full Text] [PDF]  

Miia Turpeinen, Ute Hofmann, Kathrin Klein, Thomas Mürdter, Matthias Schwab, and Ulrich M. Zanger

A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes
Drug Metab Dispos 2009 37: 1017-1024. Published online February 9, 2009; 10.1124/dmd.108.025700 [Abstract] [Full Text] [PDF]  

Rowan A. Stringer, Claire Strain-Damerell, Paul Nicklin, and J. Brian Houston

Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions
Drug Metab Dispos 2009 37: 1025-1034. Published online February 5, 2009; 10.1124/dmd.108.024810 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lisa D. Beilke, Lauren M. Aleksunes, Ricky D. Holland, David G. Besselsen, Rick D. Beger, Curtis D. Klaassen, and Nathan J. Cherrington

Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice
Drug Metab Dispos 2009 37: 1035-1045. Published online February 5, 2009; 10.1124/dmd.108.023317 [Abstract] [Full Text] [PDF] [Data Supplement]   

D. Lang, C. Freudenberger, and C. Weinz

In Vitro Metabolism of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans
Drug Metab Dispos 2009 37: 1046-1055. Published online February 5, 2009; 10.1124/dmd.108.025551 [Abstract] [Full Text] [PDF]  

C. Weinz, T. Schwarz, D. Kubitza, W. Mueck, and D. Lang

Metabolism and Excretion of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Rats, Dogs, and Humans
Drug Metab Dispos 2009 37: 1056-1064. Published online February 5, 2009; 10.1124/dmd.108.025569 [Abstract] [Full Text] [PDF]  

Yungang Liu, Jason T. Smart, Yang Song, Hans-Joachim Lehmler, Larry W. Robertson, and Michael W. Duffel

Structure-Activity Relationships for Hydroxylated Polychlorinated Biphenyls as Substrates and Inhibitors of Rat Sulfotransferases and Modification of These Relationships by Changes in Thiol Status
Drug Metab Dispos 2009 37: 1065-1072. Published online February 5, 2009; 10.1124/dmd.108.026021 [Abstract] [Full Text] [PDF]  

Mark P. Grillo and Michelle Tadano Lohr

Covalent Binding of Phenylacetic Acid to Protein in Incubations with Freshly Isolated Rat Hepatocytes
Drug Metab Dispos 2009 37: 1073-1082. Published online February 5, 2009; 10.1124/dmd.108.026153 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lu-Yi Lu, Han-Ping Chiang, Wei-Ti Chen, and Yuh-Shyong Yang

Dimerization Is Responsible for the Structural Stability of Human Sulfotransferase 1A1
Drug Metab Dispos 2009 37: 1083-1088. Published online February 23, 2009; 10.1124/dmd.108.025395 [Abstract] [Full Text] [PDF]  

Jason P. Burgess, Jonathan S. Green, Judith M. Hill, Qiao Zhan, Matthew Lindeblad, Alexander Lyubimov, Izet M. Kapetanovic, Arthur Schwartz, and Brian F. Thomas

Identification of [¹⁴C]Fluasterone Metabolites in Urine and Feces Collected from Dogs after Subcutaneous and Oral Administration of [¹⁴C]Fluasterone
Drug Metab Dispos 2009 37: 1089-1097. Published online February 5, 2009; 10.1124/dmd.108.023614 [Abstract] [Full Text] [PDF]  

Haishan Li, Tao Chen, John Cottrell, and Hongbing Wang

Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes
Drug Metab Dispos 2009 37: 1098-1106. Published online February 5, 2009; 10.1124/dmd.108.026005 [Abstract] [Full Text] [PDF] [Data Supplement]   

Onkar S. Bains, Morgan J. Karkling, Thomas A. Grigliatti, Ronald E. Reid, and K. Wayne Riggs

Two Nonsynonymous Single Nucleotide Polymorphisms of Human Carbonyl Reductase 1 Demonstrate Reduced in Vitro Metabolism of Daunorubicin and Doxorubicin
Drug Metab Dispos 2009 37: 1107-1114. Published online February 9, 2009; 10.1124/dmd.108.024711 [Abstract] [Full Text] [PDF]  

Van T. Ly, Janet Caceres-Cortes, Donglu Zhang, W. Griffith Humphreys, Ihoezo V. Ekhato, Donald Everett, and S. Nilgün Çömezoglu

Metabolism and Excretion of an Oral Taxane Analog, [¹⁴C]3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs
Drug Metab Dispos 2009 37: 1115-1128. Published online February 5, 2009; 10.1124/dmd.108.025809 [Abstract] [Full Text] [PDF] [Data Supplement]   

Juliane Niessen, Gabriele Jedlitschky, Markus Grube, Sandra Bien, Hansjörg Schwertz, Sumio Ohtsuki, Hirotaka Kawakami, Junichi Kamiie, Stefan Oswald, Katharina Starke, Ulrike Strobel, Werner Siegmund, Dieter Rosskopf, Andreas Greinacher, Tetsuya Terasaki, and Heyo K. Kroemer

Human Platelets Express Organic Anion-Transporting Peptide 2B1, an Uptake Transporter for Atorvastatin
Drug Metab Dispos 2009 37: 1129-1137. Published online February 23, 2009; 10.1124/dmd.108.024570 [Abstract] [Full Text] [PDF]  

Albert Braeuning, Riccardo Sanna, Joerg Huelsken, and Michael Schwarz

Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1
Drug Metab Dispos 2009 37: 1138-1145. Published online February 23, 2009; 10.1124/dmd.108.026179 [Abstract] [Full Text] [PDF] [Data Supplement]   

Short Communication:

Dong-Hyun Kim, Taeho Ahn, Heung-Chae Jung, Jae-Gu Pan, and Chul-Ho Yun

Generation of the Human Metabolite Piceatannol from the Anticancer-Preventive Agent Resveratrol by Bacterial Cytochrome P450 BM3
Drug Metab Dispos 2009 37: 932-936. Published online February 23, 2009; 10.1124/dmd.108.026484 [Abstract] [Full Text] [PDF] [Data Supplement]   

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