Articles:

Aiming Liu, Andrew D. Patterson, Zongtao Yang, Xinying Zhang, Wei Liu, Fayang Qiu, He Sun, Kristopher W. Krausz, Jeffrey R. Idle, Frank J. Gonzalez, and Renke Dai

Fenofibrate Metabolism in the Cynomolgus Monkey using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics
Drug Metab Dispos 2009 37: 1157-1163. Published online February 27, 2009; 10.1124/dmd.108.025817 [Abstract] [Full Text] [PDF] [Data Supplement]   

Aberra Fura, Ashish Khanna, Viral Vyas, Barry Koplowitz, Shu-Ying Chang, Christian Caporuscio, David W. Boulton, Lisa J. Christopher, Kristina D. Chadwick, Lawrence G. Hamann, W. Griffith Humphreys, and Mark Kirby

Pharmacokinetics of the Dipeptidyl Peptidase 4 Inhibitor Saxagliptin in Rats, Dogs, and Monkeys and Clinical Projections
Drug Metab Dispos 2009 37: 1164-1171. Published online February 27, 2009; 10.1124/dmd.108.026088 [Abstract] [Full Text] [PDF]  

Yoshihisa Shitara, Yoshiko Nagamatsu, Satomi Wada, Yuichi Sugiyama, and Toshiharu Horie

Long-Lasting Inhibition of the Transporter-Mediated Hepatic Uptake of Sulfobromophthalein by Cyclosporin A in Rats
Drug Metab Dispos 2009 37: 1172-1178. Published online March 12, 2009; 10.1124/dmd.108.025544 [Abstract] [Full Text] [PDF]  

Walter Meinl, Silke Sczesny, Regina Brigelius-Flohé, Michael Blaut, and Hansruedi Glatt

Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat
Drug Metab Dispos 2009 37: 1179-1186. Published online March 12, 2009; 10.1124/dmd.108.025916 [Abstract] [Full Text] [PDF]  

Young Nam Kwon, Sang Mi Shin, Il Je Cho, and Sang Geon Kim

Oxidized Metabolites of Oltipraz Exert Cytoprotective Effects against Arachidonic Acid through AMP-Activated Protein Kinase-Dependent Cellular Antioxidant Effect and Mitochondrial Protection
Drug Metab Dispos 2009 37: 1187-1197. Published online March 19, 2009; 10.1124/dmd.108.025908 [Abstract] [Full Text] [PDF]  

Michal Siller, Pavel Anzenbacher, Eva Anzenbacherova, Karel Dolezal, Igor Popa, and Miroslav Strnad

Interactions of Olomoucine II with Human Liver Microsomal Cytochromes P450
Drug Metab Dispos 2009 37: 1198-1202. Published online February 27, 2009; 10.1124/dmd.108.025502 [Abstract] [Full Text] [PDF]  

Peng Duan and Guofeng You

Novobiocin Is a Potent Inhibitor for Human Organic Anion Transporters
Drug Metab Dispos 2009 37: 1203-1210. Published online March 12, 2009; 10.1124/dmd.109.026880 [Abstract] [Full Text] [PDF]  

Matthew T. Labenski, Ashley A. Fisher, Herng-Hsiang Lo, Terrence J. Monks, and Serrine S. Lau

Protein Electrophile-Binding Motifs: Lysine-Rich Proteins Are Preferential Targets of Quinones
Drug Metab Dispos 2009 37: 1211-1218. Published online February 27, 2009; 10.1124/dmd.108.026211 [Abstract] [Full Text] [PDF]  

Appavu Chandrasekaran, William E. McKeand, Pamela Sullivan, William DeMaio, Randall Stoltz, and JoAnn Scatina

Metabolic Disposition of [¹⁴C]Bazedoxifene in Healthy Postmenopausal Women
Drug Metab Dispos 2009 37: 1219-1225. Published online March 9, 2009; 10.1124/dmd.108.023861 [Abstract] [Full Text] [PDF]  

Markus Fridén, Frederic Ducrozet, Brian Middleton, Madeleine Antonsson, Ulf Bredberg, and Margareta Hammarlund-Udenaes

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System
Drug Metab Dispos 2009 37: 1226-1233. Published online March 19, 2009; 10.1124/dmd.108.026377 [Abstract] [Full Text] [PDF] [Data Supplement]   

Masanari Kozawa, Masashi Honma, and Hiroshi Suzuki

Quantitative Prediction of in Vivo Profiles of CYP3A4 Induction in Humans from in Vitro Results with a Reporter Gene Assay
Drug Metab Dispos 2009 37: 1234-1241. Published online March 12, 2009; 10.1124/dmd.108.025734 [Abstract] [Full Text] [PDF] [Data supplement]   

Xiaohai Li, Yuanjun He, Claudia H. Ruiz, Marcel Koenig, and Michael D. Cameron

Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways
Drug Metab Dispos 2009 37: 1242-1250. Published online March 12, 2009; 10.1124/dmd.108.025932 [Abstract] [Full Text] [PDF] [Erratum]   

Rong Zhao, Thomas J. Raub, Geri A. Sawada, Steven C. Kasper, James A. Bacon, Arlene S. Bridges, and Gary M. Pollack

Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier
Drug Metab Dispos 2009 37: 1251-1258. Published online March 9, 2009; 10.1124/dmd.108.025064 [Abstract] [Full Text] [PDF]  

Dermot F. McGinnity, George Zhang, Jane R. Kenny, Geraldine A. Hamilton, Sara Otmani, Karen R. Stams, Suzzette Haney, Patrick Brassil, David M. Stresser, and Robert J. Riley

Evaluation of Multiple in Vitro Systems for Assessment of CYP3A4 Induction in Drug Discovery: Human Hepatocytes, Pregnane X Receptor Reporter Gene, and Fa2N-4 and HepaRG Cells
Drug Metab Dispos 2009 37: 1259-1268. Published online March 23, 2009; 10.1124/dmd.109.026526 [Abstract] [Full Text] [PDF]  

Kevin R. Hayes, Brandon M. Young, and Mathew T. Pletcher

Expression Quantitative Trait Loci Mapping Identifies New Genetic Models of Glutathione S-Transferase Variation
Drug Metab Dispos 2009 37: 1269-1276. Published online March 26, 2009; 10.1124/dmd.109.026856 [Abstract] [Full Text] [PDF] [Data Supplement]   

Agostina Arias, Silvina S. M. Villanueva, María L. Ruiz, Marcelo G. Luquita, Luis M. Veggi, José M. Pellegrino, Mary Vore, Viviana A. Catania, and Aldo D. Mottino

Regulation of Expression and Activity of Rat Intestinal Multidrug Resistance-Associated Protein 2 by Cholestatic Estrogens
Drug Metab Dispos 2009 37: 1277-1285. Published online March 19, 2009; 10.1124/dmd.108.025643 [Abstract] [Full Text] [PDF]  

Roslyn S. Thelingwani, Simbarashe P. Zvada, Hugues Dolgos, Anna-Lena B. Ungell, and Collen M. Masimirembwa

In Vitro and in Silico Identification and Characterization of Thiabendazole as a Mechanism-Based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-Drug Interactions
Drug Metab Dispos 2009 37: 1286-1294. Published online March 19, 2009; 10.1124/dmd.108.024604 [Abstract] [Full Text] [PDF]  

Yvonne S. Lin, Kazuto Yasuda, Mahfoud Assem, Cynthia Cline, Joe Barber, Chia-Wei Li, Vladyslav Kholodovych, Ni Ai, J. Don Chen, William J. Welsh, Sean Ekins, and Erin G. Schuetz

The Major Human Pregnane X Receptor (PXR) Splice Variant, PXR.2, Exhibits Significantly Diminished Ligand-Activated Transcriptional Regulation
Drug Metab Dispos 2009 37: 1295-1304. Published online February 27, 2009; 10.1124/dmd.108.025213 [Abstract] [Full Text] [PDF] [Data Supplement]   

Karen Mathijs, Anne S. Kienhuis, Karen J. J. Brauers, Danyel G. J. Jennen, Agustin Lahoz, Jos C. S. Kleinjans, and Joost H. M. van Delft

Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes
Drug Metab Dispos 2009 37: 1305-1311. Published online February 27, 2009; 10.1124/dmd.108.025775 [Abstract] [Full Text] [PDF] [Data Supplement]   

Oliver Zolk, Thomas F. Solbach, Jörg König, and Martin F. Fromm

Functional Characterization of the Human Organic Cation Transporter 2 Variant p.270Ala>Ser
Drug Metab Dispos 2009 37: 1312-1318. Published online February 27, 2009; 10.1124/dmd.108.023762 [Abstract] [Full Text] [PDF]  

N. M. DeVore, B. D. Smith, J. L. Wang, G. H. Lushington, and E. E. Scott

Key Residues Controlling Binding of Diverse Ligands to Human Cytochrome P450 2A Enzymes
Drug Metab Dispos 2009 37: 1319-1327. Published online February 27, 2009; 10.1124/dmd.109.026765 [Abstract] [Full Text] [PDF]  

Santosh Kumar, Huan Qiu, Numan Oezguen, Holger Herlyn, James R. Halpert, and Leszek Wojnowski

Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection
Drug Metab Dispos 2009 37: 1328-1333. Published online March 19, 2009; 10.1124/dmd.108.024372 [Abstract] [Full Text] [PDF] [Data Supplement]   

Short Communications:

Pramod Upadhyaya, Bruce R. Lindgren, and Stephen S. Hecht

Comparative Levels of O⁶-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
Drug Metab Dispos 2009 37: 1147-1151. Published online March 26, 2009; 10.1124/dmd.109.027078 [Abstract] [Full Text] [PDF]  

Markus R. Meyer, Frank T. Peters, and Hans H. Maurer

The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxyethylamphetamine and Its Single Enantiomers
Drug Metab Dispos 2009 37: 1152-1156. Published online March 19, 2009; 10.1124/dmd.108.026203 [Abstract] [Full Text] [PDF] [Data Supplement]   

Accelerated Communications:

Raf Mols, Joachim Brouwers, Alfred H. Schinkel, Pieter Annaert, and Patrick Augustijns

INTESTINAL PERFUSION WITH MESENTERIC BLOOD SAMPLING IN WILD-TYPE AND KNOCKOUT MICE: Evaluation of a Novel Tool in Biopharmaceutical Drug Profiling
Drug Metab Dispos 2009 37: 1334-1337. Published online March 9, 2009; 10.1124/dmd.109.026591 [Abstract] [Full Text] [PDF]  

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