DMD -- Table of Contents (37 [7])

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July 2009; 37 (7)   [Index by Author] [Cover Caption]

       Perspective

       Articles

       Short Communications

       Accelerated Communications

       Erratum

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Perspective:

Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz, and Andrej Skerjanec: In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
Drug Metab Dispos 2009 37: 1339-1354. Published online April 23, 2009; 10.1124/dmd.109.027029 [Abstract] [Full Text] [PDF] [Data Supplement]

Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang, and R. Scott Obach: The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
Drug Metab Dispos 2009 37: 1355-1370. Published online April 9, 2009; 10.1124/dmd.109.026716 [Abstract] [Full Text] [PDF]

Articles:

Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar, and Sekhar Surapaneni: In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
Drug Metab Dispos 2009 37: 1378-1394. Published online April 16, 2009; 10.1124/dmd.108.025742 [Abstract] [Full Text] [PDF]

Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie, and John O. Miners: Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
Drug Metab Dispos 2009 37: 1395-1403. Published online April 27, 2009; 10.1124/dmd.109.027656 [Abstract] [Full Text] [PDF] [Data Supplement]

Dapeng Cui and Marilyn E. Morris: The Drug of Abuse ${gamma}$ -Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition
Drug Metab Dispos 2009 37: 1404-1410. Published online April 23, 2009; 10.1124/dmd.109.027169 [Abstract] [Full Text] [PDF]

Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley, and Susan P. C. Cole: Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
Drug Metab Dispos 2009 37: 1411-1420. Published online April 27, 2009; 10.1124/dmd.109.026633 [Abstract] [Full Text] [PDF]

Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker, and Günther Hochhaus: Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
Drug Metab Dispos 2009 37: 1421-1426. Published online April 13, 2009; 10.1124/dmd.108.026039 [Abstract] [Full Text] [PDF] [Data Supplement]

Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui, and Hidetaka Kamimura: Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a "Funny" If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
Drug Metab Dispos 2009 37: 1427-1433. Published online April 9, 2009; 10.1124/dmd.108.026385 [Abstract] [Full Text] [PDF]

Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún, and Matilde Sierra: Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
Drug Metab Dispos 2009 37: 1434-1442. Published online April 23, 2009; 10.1124/dmd.108.026229 [Abstract] [Full Text] [PDF]

Haodan Yuan, Na Li, and Yurong Lai: Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
Drug Metab Dispos 2009 37: 1443-1447. Published online April 16, 2009; 10.1124/dmd.108.026245 [Abstract] [Full Text] [PDF]

Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar, and Rafael de la Torre: Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
Drug Metab Dispos 2009 37: 1448-1455. Published online April 6, 2009; 10.1124/dmd.108.026393 [Abstract] [Full Text] [PDF] [Data Supplement]

Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai, and Masaki Otagiri: Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
Drug Metab Dispos 2009 37: 1456-1463. Published online April 13, 2009; 10.1124/dmd.109.027094 [Abstract] [Full Text] [PDF]

Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo, and Jae-Gook Shin: Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
Drug Metab Dispos 2009 37: 1464-1470. Published online April 13, 2009; 10.1124/dmd.108.022368 [Abstract] [Full Text] [PDF]

Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara, and Yuichi Sugiyama: Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
Drug Metab Dispos 2009 37: 1471-1479. Published online April 13, 2009; 10.1124/dmd.108.026062 [Abstract] [Full Text] [PDF] [Data Supplement]

Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne, and Thomas N. O'Connell: Biotransformation of an ${alpha}$ ₄β₂ Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
Drug Metab Dispos 2009 37: 1480-1489. Published online April 1, 2009; 10.1124/dmd.109.027037 [Abstract] [Full Text] [PDF] [Data Supplement]

Simone Helmig, Bahar Hadzaad, Juliane Döhrel, and Joachim Schneider: Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
Drug Metab Dispos 2009 37: 1490-1495. Published online April 6, 2009; 10.1124/dmd.109.027060 [Abstract] [Full Text] [PDF]

Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radominska-Pandya, and Jeffery H. Moran: Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
Drug Metab Dispos 2009 37: 1496-1504. Published online April 1, 2009; 10.1124/dmd.109.026898 [Abstract] [Full Text] [PDF]

Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman, and Magnus Ingelman-Sundberg: Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
Drug Metab Dispos 2009 37: 1505-1512. Published online April 1, 2009; 10.1124/dmd.109.026963 [Abstract] [Full Text] [PDF] [Data Supplement]

Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki, and Tsuyoshi Yokoi: Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
Drug Metab Dispos 2009 37: 1513-1520. Published online April 1, 2009; 10.1124/dmd.109.026567 [Abstract] [Full Text] [PDF]

Takafumi Nakano, Shuichi Sekine, Kousei Ito, and Toshiharu Horie: Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
Drug Metab Dispos 2009 37: 1521-1527. Published online April 1, 2009; 10.1124/dmd.108.024836 [Abstract] [Full Text] [PDF]

Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts, and Marie-Anne Loriot: Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
Drug Metab Dispos 2009 37: 1528-1538. Published online April 9, 2009; 10.1124/dmd.109.027011 [Abstract] [Full Text] [PDF] [Data Supplement]

Chenshu Xu, Xinkun Wang, and Jeff L. Staudinger: Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
Drug Metab Dispos 2009 37: 1539-1547. Published online April 9, 2009; 10.1124/dmd.109.026989 [Abstract] [Full Text] [PDF]

Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram, and Robert Weikert: Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
Drug Metab Dispos 2009 37: 1548-1556. Published online April 23, 2009; 10.1124/dmd.109.026674 [Abstract] [Full Text] [PDF]

Short Communications:

Joachim Geyer, Olga Gavrilova, and Ernst Petzinger: The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
Drug Metab Dispos 2009 37: 1371-1374. Published online April 23, 2009; 10.1124/dmd.109.027144 [Abstract] [Full Text] [PDF]

K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose, and Y. Sasaki: Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
Drug Metab Dispos 2009 37: 1375-1377. Published online April 23, 2009; 10.1124/dmd.109.027052 [Abstract] [Full Text] [PDF]

Accelerated Communications:

Bo Wen, Yuan Chen, and William L. Fitch: Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
Drug Metab Dispos 2009 37: 1557-1562. Published online April 13, 2009; 10.1124/dmd.108.024851 [Abstract] [Full Text] [PDF] [Data Supplement]

Erratum:

: CORRECTION TO "CYTOCHROME P450 EXPRESSION AND REGULATION IN CYP3A4/CYP2D6 DOUBLE TRANSGENIC HUMANIZED MICE"
Drug Metab Dispos 2009 37: 1563. [Full Text] [PDF]

Cover Caption:

About the cover: Effect of Thx treatment on the expression levels and distribution of p-ezrin (phosphorylation at Thr567) in the rat jejunum, and immunofluorescence and confocal laser scanning microscopy of rat intestinal villi. See article by Nakano et al. on page 1521 of this issue.