DMD -- Table of Contents (36 [9])

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September 2008; 36 (9)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

       Accelerated Communications

       Erratum

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Hirotada Shiratani, Miki Katoh, Miki Nakajima, and Tsuyoshi Yokoi: Species Differences in UDP-Glucuronosyltransferase Activities in Mice and Rats
Drug Metab Dispos 2008 36: 1745-1752. Published online May 27, 2008; 10.1124/dmd.108.021469 [Abstract] [Full Text] [PDF]

Chandra Prakash, Kim A. Johnson, Clinton M. Schroeder, and Michael J. Potchoiba: Metabolism, Distribution, and Excretion of a Next Generation Selective Estrogen Receptor Modulator, Lasofoxifene, in Rats and Monkeys
Drug Metab Dispos 2008 36: 1753-1769. Published online May 30, 2008; 10.1124/dmd.108.021808 [Abstract] [Full Text] [PDF]

Hideo Takakusa, Hiroshi Masumoto, Hideo Yukinaga, Chie Makino, Shintaro Nakayama, Osamu Okazaki, and Kenichi Sudo: Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity
Drug Metab Dispos 2008 36: 1770-1779. Published online May 28, 2008; 10.1124/dmd.108.021725 [Abstract] [Full Text] [PDF]

Patricia E. Schroeder, Daywin Patel, and Brian B. Hasinoff: The Dihydroorotase Inhibitor 5-Aminoorotic Acid Inhibits the Metabolism in the Rat of the Cardioprotective Drug Dexrazoxane and Its One-Ring Open Metabolites
Drug Metab Dispos 2008 36: 1780-1785. Published online May 30, 2008; 10.1124/dmd.108.021626 [Abstract] [Full Text] [PDF]

Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa, and Yasuo Ohno: Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients
Drug Metab Dispos 2008 36: 1786-1793. Published online May 30, 2008; 10.1124/dmd.107.020073 [Abstract] [Full Text] [PDF]

Walter Brand, Petronella A. I. van der Wel, Maarit J. Rein, Denis Barron, Gary Williamson, Peter J. van Bladeren, and Ivonne M. C. M. Rietjens: Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers
Drug Metab Dispos 2008 36: 1794-1802. Published online May 30, 2008; 10.1124/dmd.107.019943 [Abstract] [Full Text] [PDF]

Rana M. Sawaya and David S. Riddick: Cytochrome P450 2C11 5'-Flanking Region and Promoter Mediate in Vivo Suppression by 3-Methylcholanthrene
Drug Metab Dispos 2008 36: 1803-1811. Published online June 4, 2008; 10.1124/dmd.108.020966 [Abstract] [Full Text] [PDF]

H. Markus Weiss, Marcel Fresneau, Thomas Moenius, Anton Stuetz, and Andreas Billich: Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application
Drug Metab Dispos 2008 36: 1812-1818. Published online June 4, 2008; 10.1124/dmd.108.021915 [Abstract] [Full Text] [PDF]

Anwar Anwar-Mohamed and Ayman O. S. El-Kadi: Down-Regulation of the Carcinogen-Metabolizing Enzyme Cytochrome P450 1a1 by Vanadium
Drug Metab Dispos 2008 36: 1819-1827. Published online June 9, 2008; 10.1124/dmd.108.021154 [Abstract] [Full Text] [PDF]

Lifei Wang, Lisa J. Christopher, Donghui Cui, Wenying Li, Ramaswamy Iyer, W. Griffith Humphreys, and Donglu Zhang: Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics
Drug Metab Dispos 2008 36: 1828-1839. Published online June 12, 2008; 10.1124/dmd.107.020255 [Abstract] [Full Text] [PDF]

Cuiping Chen, Jeffery L. Stock, Xingrong Liu, Jilin Shi, Jeffrey W. Van Deusen, Debra A. DiMattia, Robert G. Dullea, and Sonia M. de Morais: Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds
Drug Metab Dispos 2008 36: 1840-1845. Published online June 12, 2008; 10.1124/dmd.108.020594 [Abstract] [Full Text] [PDF]

Elisabeth Minthorn, Thomas Mencken, Andrew G. King, Art Shu, David Rominger, Richard R. Gontarek, Chao Han, Ramesh Bambal, and Charles B. Davis: Pharmacokinetics and Brain Penetration of Casopitant, a Potent and Selective Neurokinin-1 Receptor Antagonist, in the Ferret
Drug Metab Dispos 2008 36: 1846-1852. Published online June 12, 2008; 10.1124/dmd.108.021758 [Abstract] [Full Text] [PDF]

Andrew N. Gifford, Mel Pilar Espaillat, and S. John Gatley: Biodistribution of Radiolabeled Ethanol in Rodents
Drug Metab Dispos 2008 36: 1853-1858. Published online June 19, 2008; 10.1124/dmd.107.020271 [Abstract] [Full Text] [PDF]

Marianne Garland, Kirsten M. Abildskov, Tung-wah Kiu, Salha S. Daniel, Piper Weldy, and Raymond I. Stark: Placental Transfer and Fetal Elimination of Morphine-3-β-glucuronide in the Pregnant Baboon
Drug Metab Dispos 2008 36: 1859-1868. Published online June 19, 2008; 10.1124/dmd.108.021352 [Abstract] [Full Text] [PDF]

Deepak Dalvie, Theresa Cosker, Tracey Boyden, Sue Zhou, Clinton Schroeder, and Michael J. Potchoiba: Metabolism Distribution and Excretion of a Matrix Metalloproteinase-13 Inhibitor, 4-[4-(4-Fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic Acid Hydroxyamide (CP-544439), in Rats and Dogs: Assessment of the Metabolic Profile of CP-544439 in Plasma and Urine of Humans
Drug Metab Dispos 2008 36: 1869-1883. Published online June 19, 2008; 10.1124/dmd.108.022566 [Abstract] [Full Text] [PDF]

Chellappagounder Thangavel and Bernard H. Shapiro: Inherent Sexually Dimorphic Expression of Hepatic CYP2C12 Correlated with Repressed Activation of Growth Hormone-Regulated Signal Transduction in Male Rats
Drug Metab Dispos 2008 36: 1884-1895. Published online June 16, 2008; 10.1124/dmd.108.021451 [Abstract] [Full Text] [PDF]

Shringi Sharma, Junhai Ou, Stephen Strom, Don Mattison, Steve Caritis, and Raman Venkataramanan: Identification of Enzymes Involved in the Metabolism of 17 ${alpha}$ -Hydroxyprogesterone Caproate: An Effective Agent for Prevention of Preterm Birth
Drug Metab Dispos 2008 36: 1896-1902. Published online June 23, 2008; 10.1124/dmd.108.021444 [Abstract] [Full Text] [PDF]

Masashi Mise, Takanori Hashizume, and Setsuko Komuro: Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes
Drug Metab Dispos 2008 36: 1903-1908. Published online June 23, 2008; 10.1124/dmd.108.022301 [Abstract] [Full Text] [PDF]

Sarah J. Schrieber, Zhiming Wen, Manoli Vourvahis, Philip C. Smith, Michael W. Fried, Angela D. M. Kashuba, and Roy L. Hawke: The Pharmacokinetics of Silymarin Is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity
Drug Metab Dispos 2008 36: 1909-1916. Published online June 19, 2008; 10.1124/dmd.107.019604 [Abstract] [Full Text] [PDF]

Shuso Takeda, Koichiro Misawa, Ikuo Yamamoto, and Kazuhito Watanabe: Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis
Drug Metab Dispos 2008 36: 1917-1921. Published online June 12, 2008; 10.1124/dmd.108.020909 [Abstract] [Full Text] [PDF]

S Ehnert, A. K. Nussler, A. Lehmann, and S. Dooley: Blood Monocyte-Derived Neohepatocytes as in Vitro Test System for Drug Metabolism
Drug Metab Dispos 2008 36: 1922-1929. Published online June 16, 2008; 10.1124/dmd.108.020453 [Abstract] [Full Text] [PDF]

Katarina Stark, Zhong-Liu Wu, Cheryl J. Bartleson, and F. Peter Guengerich: mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1
Drug Metab Dispos 2008 36: 1930-1937. Published online June 9, 2008; 10.1124/dmd.108.022020 [Abstract] [Full Text] [PDF] [Data Supplement]

Masakatsu Kotsuma, Hiroyuki Hanzawa, Yoriko Iwata, Kenji Takahashi, and Taro Tokui: Novel Binding Mode of the Acidic CYP2D6 Substrates Pactimibe and Its Metabolite R-125528
Drug Metab Dispos 2008 36: 1938-1943. Published online June 4, 2008; 10.1124/dmd.108.020776 [Abstract] [Full Text] [PDF]

Vanja Petrovic, Jing-Hung Wang, and Micheline Piquette-Miller: Effect of Endotoxin on the Expression of Placental Drug Transporters and Glyburide Disposition in Pregnant Rats
Drug Metab Dispos 2008 36: 1944-1950. Published online May 27, 2008; 10.1124/dmd.107.019851 [Abstract] [Full Text] [PDF]

Neslihan Aygun Kocabas, Pinar Aksoy, Linda L. Pelleymounter, Irene Moon, Jeong-Seon Ryu, Judith A. Gilbert, Oreste Ezequel Salavaggione, Bruce W. Eckloff, Eric D. Wieben, Vivien Yee, Richard M. Weinshilboum, and Matthew M. Ames: Gemcitabine Pharmacogenomics: Deoxycytidine Kinase and Cytidylate Kinase Gene Resequencing and Functional Genomics
Drug Metab Dispos 2008 36: 1951-1959. Published online June 12, 2008; 10.1124/dmd.108.020925 [Abstract] [Full Text] [PDF] [Data Supplement]

Lauren M. Aleksunes, Yue Cui, and Curtis D. Klaassen: Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta
Drug Metab Dispos 2008 36: 1960-1970. Published online June 19, 2008; 10.1124/dmd.108.021337 [Abstract] [Full Text] [PDF]

Short Communications:

Stephan T. Stern, Melanie N. Tallman, Kristini K. Miles, Joseph K. Ritter, and Philip C. Smith: Androgen Regulation of Renal Uridine Diphosphoglucuronosyltransferase 1A1 in Rats
Drug Metab Dispos 2008 36: 1737-1739. Published online May 30, 2008; 10.1124/dmd.108.020610 [Abstract] [Full Text] [PDF]

Mark P. Grillo, Ji Ma, Yohannes Teffera, and Daniel J. Waldon: A Novel Bioactivation Pathway for 2-[2-(2,6-Dichlorophenyl)aminophenyl]ethanoic Acid (Diclofenac) Initiated by Cytochrome P450-Mediated Oxidative Decarboxylation
Drug Metab Dispos 2008 36: 1740-1744. Published online June 9, 2008; 10.1124/dmd.108.021287 [Abstract] [Full Text] [PDF]

Accelerated Communications:

Odette A. Fahmi, Sherri Boldt, Mary Kish, R. Scott Obach, and Larry M. Tremaine: PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA: Application of the Relative Induction Score Approach Using Cryopreserved Human Hepatocytes
Drug Metab Dispos 2008 36: 1971-1974. Published online June 2, 2008; 10.1124/dmd.108.021907 [Abstract] [Full Text] [PDF]

Erratum:

: CORRECTION TO "A COMBINED MODEL FOR PREDICTING CYP3A4 CLINICAL NET DRUG-DRUG INTERACTION BASED ON CYP3A4 INHIBITION, INACTIVATION, AND INDUCTION DETERMINED IN VITRO"
Drug Metab Dispos 2008 36: 1975. [Full Text] [PDF]

Cover Caption:

About the cover: Immunohistochemical detection of Bcrp in placentas of 24-h saline-treated (A\NC) and endotoxin-treated (0.5 mg/kg) (D\NF) rats. See article by Petrovic et al. on page 1944 of this issue.