TY - JOUR T1 - The metabolism and elimination of S-carboxymethyl-L-cysteine in man. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 61 LP - 62 VL - 10 IS - 1 AU - R H Waring AU - S C Mitchell Y1 - 1982/01/01 UR - http://dmd.aspetjournals.org/content/10/1/61.abstract N2 - The metabolism of 14C- and 35S-labeled S-carboxymethylcysteine (SCMC) has been compared. The majority of the dose appeared in urine in the first 24 hr; no activity was detectable in feces. Use of 25S-labeled compound gave small amounts of inorganic 35S-sulfate, whereas 14C-labeled material was degraded to give some [14C]urea. Peak excretion of the parent compound occurred first after administration of SCMC; metabolites requiring one chemical modification for their formation were maximally excreted 1-4 hr after the dose and those involving more metabolic processes appeared later (4-8 hr). ER -