PT  - JOURNAL ARTICLE
AU  - H Egger
AU  - F Bartlett
AU  - W Itterly
AU  - R Rodebaugh
AU  - C Shimanskas
TI  - Metabolism of aminoglutethimide in the rat.
DP  - 1982 Jul 01
TA  - Drug Metabolism and Disposition
PG  - 405--412
VI  - 10
IP  - 4
4099  - http://dmd.aspetjournals.org/content/10/4/405.short
4100  - http://dmd.aspetjournals.org/content/10/4/405.full
SO  - Drug Metab Dispos1982 Jul 01; 10
AB  - The metabolism of aminoglutethimide was studied in the rat by use of the 14C-labeled compound. Following oral doses of 5 and 50 mg/kg, the drug was almost completely eliminated within 48 hr into urine and feces, mostly in the form of metabolites. In bile duct-cannulated rats, biliary excretion of radioactivity amounted to about 52% within 24 hr of an orally administered 50 mg/kg dose, with the remainder of the dose being eliminated into urine. The major urinary metabolites resulted from acetylation of the aniline moiety, hydroxylation of the glutarimide ring at positions 3 and 4, and oxidative elimination of the ethyl sidechain. The polar metabolites are accounted for by aromatic hydroxylation with subsequent sulfate conjugation and by a glutarimide ring-opened compound. In addition, a gamma-butyrolactone derivative was also identified.