@article {Florence312, author = {V M Florence and E W Di Stefano and C Y Sum and A K Cho}, title = {The metabolism of (R)-(-)-amphetamine by rabbit liver microsomes. Initial products.}, volume = {10}, number = {4}, pages = {312--315}, year = {1982}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The metabolism of 1-amphetamine in rabbit liver is complex in that several routes may give rise to the same intermediate. In this study, the subsequent metabolism of the primary products of N- and C-oxidation were blocked by selecting appropriate incubation conditions. The resulting simplified system was used to investigate the enzymes involved in the two pathways. Phenobarbital treatment increased N- and C-hydroxylation, whereas 3-methylcholanthrene treatment had an inhibitory effect on both pathways. Inhibitors of cytochrome P-450 were either nonselective or were partially selective in inhibiting the two routes of amphetamine metabolism. Induction modulated the sensitivity toward the inhibitors of N- and C-oxidation.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/10/4/312}, eprint = {https://dmd.aspetjournals.org/content/10/4/312.full.pdf}, journal = {Drug Metabolism and Disposition} }