@article {Fenselau316, author = {C Fenselau and P C Feng and T Chen and L P Johnson}, title = {Stable isotope analysis by fast-atom bombardment labeling of UDP-glucuronic acid.}, volume = {10}, number = {4}, pages = {316--318}, year = {1982}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Fast-atom bombardment mass spectrometry is found to provide a method for analysis of isotopes in the enzyme cofactor uridine-5{\textquoteright}-diphosphoglucuronic acid, heretofore unsusceptible to mass-spectral characterization. This technique was used to determine optimal conditions for the introduction of 18O by acid-catalyzed exchange in H218O and to evaluate the loss of the isotope when labeled cofactor is used in enzymatic incubations. Fast-atom bombardment mass spectrometry provided a quantitative assessment of various isotopic species and also permitted the location of the isotopes in the molecule to be determined.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/10/4/316}, eprint = {https://dmd.aspetjournals.org/content/10/4/316.full.pdf}, journal = {Drug Metabolism and Disposition} }