RT Journal Article
SR Electronic
T1 Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 573
OP 578
VO 10
IS 6
A1 Diamond, G L
A1 Anders, M W
A1 Tremaine, L M
A1 Quebbemann, A J
YR 1982
UL http://dmd.aspetjournals.org/content/10/6/573.abstract
AB Salicylate administration increased glucuronyltransferase activity, with o-aminophenol as the substrate, in chicken kidney homogenates, but did not affect glucuronyltransferase activity in chicken liver homogenates. In addition, salicylate administration increased in vivo renal glucuronidation of catechol and p-nitrophenol without affecting renal sulfate conjugation of these compounds. These results suggest that salicylate administration selectively enhances renal glucuronide conjugation, thereby promoting a more rapid metabolism and elimination of circulating phenols, especially at high plasma phenol concentrations. Isolated human kidney perfusion experiments reveal that glucuronide and sulfate conjugates of phenol, p-nitrophenol, and 1-naphthol are formed in the human kidney, suggesting that the effect of salicylate treatment on renal glucuronidation may apply to humans.