PT - JOURNAL ARTICLE AU - G Hallström AU - R C Kammerer AU - C H Nguyen AU - D A Schmitz AU - E W Di Stefano AU - A K Cho TI - Phencyclidine metabolism in vitro. The formation of a carbinolamine and its metabolites by rabbit liver preparations. DP - 1983 Jan 01 TA - Drug Metabolism and Disposition PG - 47--53 VI - 11 IP - 1 4099 - http://dmd.aspetjournals.org/content/11/1/47.short 4100 - http://dmd.aspetjournals.org/content/11/1/47.full SO - Drug Metab Dispos1983 Jan 01; 11 AB - Four products of the in vitro oxidative metabolism of the piperidine ring of phencyclidine, 5-(1-phenylcyclohexylamino)valeraldehyde, V; N-(1-phenylcyclohexyl)-1,2,3,4-tetrahydropyridine, VIII; 5-(1-phenylcyclohexylamino)valeric acid, VII; and 1-phenylcyclohexylamine, IX, have been identified following derivatization, by GC/MS with stable isotope labeling and/or synthesis. The enamine, VIII, may be a work-up elimination product of a carbinolamine, alpha-hydroxy-N-(1-phenylcyclohexyl)piperidine, IV. The formation of all metabolites requires microsomal enzymes, but VII and the previously described N-(5-hydroxypentyl)-1-phenylcyclohexylamine, VI, also require soluble enzymes. Quantitative or semiquantitative data show that VI and VIII appear and disappear with time, whereas VII seems to be a terminal metabolite.